Toward the blood-borne miRNome of human diseases
Abstract
In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.
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Aberrant expression of small ncRNAs is associated with cancer, autoimmune disease, and several neurodegenerative disorders.
“Aberrant expression of small ncRNAs, in turn, has been associated with diseases such as cancer, autoimmune disease, and several neurodegenerative disorders (9, 10).”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [9]
Cites
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works
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Circulating microRNAs as novel biomarkers for diabetes mellitus
Guay, C., & Regazzi, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.86 · Cited by 563 · see citing works
Ameling, S., Kacprowski, T., Chilukoti, R. K., Malsch, C., Liebscher, V., Suhre, K., Pietzner, M., Friedrich, N., Homuth, G., Hammer, E., et al. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0136-7 · Cited by 181 · see citing works
A mouse tissue atlas of small noncoding RNA
Isakova, A., Fehlmann, T., Keller, A., & Quake, S. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002277117 · Cited by 119 · see citing works
Self-citation
- Authors
- Keller, A., Leidinger, P., Bauer, A., ElSharawy, A., Haas, J., Backes, C., Wendschlag, A., Giese, N., Tjaden, C., Ott, K., Werner, J., Hackert, T., Ruprecht, K., Huwer, H., Huebers, J., Jacobs, G., Rosenstiel, P., Dommisch, H., Schaefer, A., Müller-Quernheim, J., Wullich, B., Keck, B., Graf, N., Reichrath, J., Vogel, B., Nebel, A., Jager, S. U., Staehler, P., Amarantos, I., Boisguerin, V., Staehler, C., Beier, M., Scheffler, M., Büchler, M. W., Wischhusen, J., Haeusler, S. F. M., Dietl, J., Hofmann, S., Lenhof, H.-P., Schreiber, S., Katus, H. A., Rottbauer, W., Meder, B., Hoheisel, J. D., Franke, A., & Meese, E.
- Venue
- Nature Methods
- Published
- 2011-09-04
- Volume
- 8
- Issue
- 10
- Pages
- 841-843
- ISSN
- 1548-7091
- 1548-7105
- Cited by
- 312
- References
- 1
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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