Circulating microRNAs as novel biomarkers for diabetes mellitus
Open accessAbstract
Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications.
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Diagnosis and Classification of Diabetes Mellitus
Basevi, V. (2011) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 21,302 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969 · see citing works
IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040
Ogurtsova, K., Fernandes, J. D. D. R., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., Cavan, D. A., Shaw, J. E., & Makaroff, L. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.024 · Cited by 6,977 · see citing works
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560 · see citing works
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,381 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
Whiting, D. R., Guariguata, L., Weil, C., & Shaw, J. E. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.10.029 · Cited by 3,994 · see citing works
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294 · see citing works
Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · see citing works
The MicroRNA Spectrum in 12 Body Fluids
Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y. C., Huang, K., Lee, M., Galas, D. J., & Wang, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147405 · Cited by 2,754 · see citing works
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741 · see citing works
Type 2 diabetes: principles of pathogenesis and therapy
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662 · see citing works
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102 · see citing works
Identification of Mammalian microRNA Host Genes and Transcription UnitsPreprint
Rodríguez, A., Griffiths‐Jones, S., Ashurst, J. L., & Bradley, A. (2004) · Genome Research · doi:10.1101/gr.2722704 · Cited by 2,033 · see citing works
Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,950 · see citing works
Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,936 · see citing works
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., McAnally, J., Hill, J. A., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.002 · Cited by 1,832 · see citing works
Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works
Lawrie, C. H., Gal, S., Dunlop, H. M., Pushkaran, B., Liggins, A. P., Pulford, K. A. F., Banham, A. H., Pezzella, F., Boultwood, J., Wainscoat, J. S., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07077.x · Cited by 1,739 · see citing works
miR-126 Regulates Angiogenic Signaling and Vascular Integrity
Fish, J. E., Santoro, M. M., Morton, S. U., Yu, S., Yeh, R.-F., Wythe, J. D., Ivey, K. N., Bruneau, B. G., Stainier, D. Y. R., & Srivastava, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.008 · Cited by 1,728 · see citing works
Intronic microRNA precursors that bypass Drosha processing
Ruby, J., Jan, C. H., & Bartel, D. (2007) · Nature · doi:10.1038/nature05983 · Cited by 1,695 · see citing works
Islet cell failure in type 2 diabetes
Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690 · see citing works
Specificity of microRNA target selection in translational repressionPreprint
Doench, J. G., & Sharp, P. A. (2004) · Genes & Development · doi:10.1101/gad.1184404 · Cited by 1,642 · see citing works
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Zampetaki, A., Kiechl, S. J., Drozdov, I. A., Willeit, P., Mayr, U., Prokopi, M., Mayr, A., Weger, S., Oberhollenzer, F., Bonora, E., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.226357 · Cited by 1,457 · see citing works
Serum MicroRNAs Are Promising Novel Biomarkers
Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., Melamed, N., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003148 · Cited by 1,349 · see citing works
Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242 · see citing works
Circulating MicroRNAs in Patients With Coronary Artery Disease
Fichtlscherer, S., Rosa, S. D., Fox, H., Schwietz, T., Fischer, A., Liebetrau, C., Weber, M. A., Hamm, C. W., Roexe, T., Müller-Ardogan, M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.215566 · Cited by 1,222 · see citing works
Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration
Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., Sun, F., Lu, J., Yin, Y., Cai, X. F., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.010 · Cited by 1,190 · see citing works
Kroh, E. M., Parkin, R. K., Mitchell, P. S., & Tewari, M. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.032 · Cited by 1,177 · see citing works
Exfoliation of membrane ecto-enzymes in the form of micro-vesicles
Trams, E. G., Lauter, C. J., Salem, N., & Heine, U. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90512-5 · Cited by 1,094 · see citing works
Creemers, E. E., Tijsen, A. J., & Pinto, Y. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.247452 · Cited by 1,012 · see citing works
MicroRNAs 103 and 107 regulate insulin sensitivity
Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M., Heim, M. H., & Stoffel, M. (2011) · Nature · doi:10.1038/nature10112 · Cited by 1,000 · see citing works
Gibbings, D., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 990 · see citing works
Detection and Characterization of Placental MicroRNAs in Maternal Plasma
Chim, S. S. C., Shing, T. K. F., Hung, E. C. W., Leung, T.-Y., Lau, T. K., Chiu, R. W. K., & Lo, Y. M. D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097972 · Cited by 850 · see citing works
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2005) · Diabetes Care · doi:10.2337/diacare.28.suppl_1.s37 · Cited by 830 · see citing works
Regression of Microalbuminuria in Type 1 Diabetes
Perkins, B. A., Ficociello, L., Silva, K. H., Finkelstein, D. M., Warram, J. H., & Królewski, A. S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021835 · Cited by 799 · see citing works
Biological principles of microRNA-mediated regulation: shared themes amid diversity
Flynt, A. S., & Lai, E. C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2455 · Cited by 778 · see citing works
<i>miR-375</i> maintains normal pancreatic α- and β-cell mass
Poy, M. N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M., & Stoffel, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810550106 · Cited by 740 · see citing works
Changes in circulating microRNA levels associated with prostate cancer
Bryant, R. J., Pawlowski, T. L., Catto, J. W. F., Marsden, G. L., Vessella, R. L., Rhees, B. K., Kuslich, C. D., Visakorpi, T., & Hamdy, F. C. (2012) · British Journal of Cancer · doi:10.1038/bjc.2011.595 · Cited by 716 · see citing works
Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges
McDonald, J. S., Milosevic, D., Reddi, H. V., Grebe, S. K., & Algeciras‐Schimnich, A. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.157198 · Cited by 684 · see citing works
Orban, T., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Gottlieb, P. A., Greenbaum, C. J., Marks, J. B., Monzavi, R., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60886-6 · Cited by 612 · see citing works
Kong, L., Zhu, J., Han, W., Jiang, X., Xu, M., Zhao, Y., Dong, Q., Pang, Z., Guan, Q., Gao, L., et al. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0226-0 · Cited by 529 · see citing works
Parving, H., Lewis, J., Ravid, M., Remuzzi, G., & Hunsicker, L. (2006) · Kidney International · doi:10.1038/sj.ki.5000377 · Cited by 527 · see citing works
Jordan, S. D., Krüger, M., Willmes, D. M., Redemann, N., Wunderlich, F. T., Brönneke, H. S., Merkwirth, C., Kashkar, H., Olkkonen, V. M., Böttger, T., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2211 · Cited by 522 · see citing works
The 30-Year Natural History of Type 1 Diabetes Complications
Pambianco, G., Costacou, T., Ellis, D., Becker, D. J., Klein, R., & Orchard, T. J. (2006) · Diabetes · doi:10.2337/db05-1423 · Cited by 493 · see citing works
Sherry, N., Hagopian, W., Ludvigsson, J., Jain, S. M., Wahlen, J., Ferry, R. J., Bode, B., Aronoff, S., Holland, C., Carlin, D., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60931-8 · Cited by 493 · see citing works
Cost-Effectiveness of Interventions to Prevent and Control Diabetes Mellitus: A Systematic Review
Li, R., Zhang, P., Barker, L. E., Chowdhury, F. M., & Zhang, X. (2010) · Diabetes Care · doi:10.2337/dc10-0843 · Cited by 491 · see citing works
Li, L., Hu, Z., Zhou, Z., Chen, X., Liu, F.-Y., Zhang, J., Shen, H., Zhang, C., & Zen, K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1001 · Cited by 452 · see citing works
Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
Miranda, K. C., Bond, D. T., McKee, M. L., Skog, J., Păunescu, T. G., Silva, N. D., Brown, D., & Russo, L. M. (2010) · Kidney International · doi:10.1038/ki.2010.106 · Cited by 409 · see citing works
Circulating miRNA Profiles in Patients with Metabolic Syndrome
Karolina, D. S., Subramaniam, T., Armugam, A., Sepramaniam, S., Pek, S. L. T., Wong, M. T. K., Lim, S. C., Sum, C. F., & Jeyaseelan, K. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1996 · Cited by 409 · see citing works
Caporali, A., Meloni, M., Völlenkle, C., Bonci, D., Sala-Newby, G. B., Addis, R., Spinetti, G., Losa, S., Masson, R., Baker, A. H., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.952325 · Cited by 397 · see citing works
Microalbuminuria and the Risk for Early Progressive Renal Function Decline in Type 1 Diabetes
Perkins, B. A., Ficociello, L., Ostrander, B., Silva, K. H., Weinberg, J., Warram, J. H., & Królewski, A. S. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080872 · Cited by 369 · see citing works
Toward the blood-borne miRNome of human diseases
Keller, A., Leidinger, P., Bauer, A. S., ElSharawy, A., Haas, J., Backes, C., Wendschlag, A., Giese, N. A., Tjaden, C., Ott, K., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1682 · Cited by 358 · see citing works
Serum miR-146a and miR-223 as potential new biomarkers for sepsis
Wang, J., Yu, M., Yu, G., Bian, J., Deng, X., Wan, X., & Zhu, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.145 · Cited by 352 · see citing works
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
Kornfeld, J., Baitzel, C., Könner, A. C., Nicholls, H. T., Vogt, M. C., Herrmanns, K., Scheja, L., Haumaître, C., Wolf, A. M., Knippschild, U., et al. (2013) · Nature · doi:10.1038/nature11793 · Cited by 349 · see citing works
Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
Lovis, P., Roggli, E., Laybutt, D. R., Gattesco, S., Yang, J.-Y., Widmann, C., Abderrahmani, A., & Regazzi, R. (2008) · Diabetes · doi:10.2337/db07-1252 · Cited by 346 · see citing works
Self-citationRoggli, E., Britan, A., Gattesco, S., Lin-Marq, N., Abderrahmani, A., Meda, P., & Regazzi, R. (2010) · Diabetes · doi:10.2337/db09-0881 · Cited by 320 · see citing works
Self-citationDiabetes mellitus, a microRNA-related disease?
Guay, C., Roggli, E., Nesca, V., Jacovetti, C., & Regazzi, R. (2011) · Translational Research: The Journal of Laboratory and Clinical Medicine · doi:10.1016/j.trsl.2011.01.009 · Cited by 313 · see citing works
Self-citationGallagher, I. J., Schéele, C., Keller, P., Nielsen, A. R., Reményi, J., Fischer, C. P., Roder, K., Babraj, J., Wahlestedt, C., Hutvágner, G., et al. (2010) · Genome Medicine · doi:10.1186/gm130 · Cited by 291 · see citing works
Nielsen, L. B., Wang, C., Sørensen, K., Bang‐Berthelsen, C. H., Hansen, L. B., Andersen, M.-L. M., Hougaard, P., Juul, A., Zhang, C., Pociot, F., et al. (2012) · Experimental Diabetes Research · doi:10.1155/2012/896362 · Cited by 289 · see citing works
Diabetes Complications: The MicroRNA Perspective
Kantharidis, P., Wang, B., Carew, R. M., & Lan, H. Y. (2011) · Diabetes · doi:10.2337/db11-0082 · Cited by 288 · see citing works
Herrera, B. M., Lockstone, H. E., Taylor, J. M., Ria, M., Barrett, A., Collins, S. C., Kaisaki, P. J., Argoud, K., Fernández, C., Travers, M. E., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1667-2 · Cited by 287 · see citing works
Role of microRNAs in diabetes and its cardiovascular complications
Shantikumar, S., Caporali, A., & Emanueli, C. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvr300 · Cited by 263 · see citing works
Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma
Komatsu, S., Ichikawa, D., Takeshita, H., Tsujiura, M., Morimura, R., Nagata, H., Kosuga, T., Iitaka, D., Konishi, H., Shiozaki, A., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.198 · Cited by 255 · see citing works
Madhavan, D., Zucknick, M., Wallwiener, M., Ćuk, K., Modugno, C., Scharpff, M., Schott, S., Heil, J., Turchinovich, A. A., Yang, R., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1407 · Cited by 248 · see citing works
MicroRNAs as biomarkers in rheumatic diseases
Alevizos, I., & Illei, G. G. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.81 · Cited by 231 · see citing works
Early Second-Trimester Serum MiRNA Profiling Predicts Gestational Diabetes Mellitus
Zhao, C., Dong, J., Jiang, T., Shi, Z., Yu, B., Zhu, Y., Chen, D., Xu, J., Huo, R., Dai, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023925 · Cited by 230 · see citing works
MicroRNA isolation and stability in stored RNA samples
Mráz, M., Malinová, K., Mayer, J., & Pospı́šilová, Š. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.061 · Cited by 229 · see citing works
Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice
Roggli, E., Gattesco, S., Caille, D., Briet, C., Boîtard, C., Meda, P., & Regazzi, R. (2012) · Diabetes · doi:10.2337/db11-1086 · Cited by 227 · see citing works
Self-citationWiner, N., & Sowers, J. R. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004263017 · Cited by 224 · see citing works
Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases
van Balkom, B. W. M., Pisitkun, T., Verhaar, M. C., & Knepper, M. A. (2011) · Kidney International · doi:10.1038/ki.2011.292 · Cited by 222 · see citing works
Circulating microRNA expression is reduced in chronic kidney disease
Neal, C. S., Michael, M., Pimlott, L. K., Yong, T. Y., Li, J. Y. Z., & Gleadle, J. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr485 · Cited by 215 · see citing works
Diabetic kidney disease with and without albuminuria
MacIsaac, R. J., & Jerums, G. (2011) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283456546 · Cited by 189 · see citing works
Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice
Erener, S., Mojibian, M., Fox, J. K., Denroche, H. C., & Kieffer, T. J. (2013) · Endocrinology · doi:10.1210/en.2012-1744 · Cited by 182 · see citing works
Microvesicles/exosomes as potential novel biomarkers of metabolic diseases
ller, G. M. A. U. (2012) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s32923 · Cited by 169 · see citing works
Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort
Kolberg, J. A., Jørgensen, T., Gerwien, R. W., Hamren, S., McKenna, M. P., Moler, E. J., Rowe, M. W., Urdea, M. S., Xu, X. M., Hansen, T. F., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1935 · Cited by 164 · see citing works
Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes
Argyropoulos, C., Wang, K., McClarty, S., Huang, D. Y. C., Bernardo, J., Ellis, D., Orchard, T. J., Galas, D. J., & Johnson, J. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054662 · Cited by 157 · see citing works
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
Pirot, P., Cardozo, A. K., & Eizirik, D. L. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000200003 · Cited by 154 · see citing works
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice
Zhao, E., Keller, M. P., Rabaglia, M. E., Oler, A. T., Stapleton, D. S., Schueler, K. L., Neto, E. C., Moon, J., Wang, P., Wang, I., et al. (2009) · Mammalian Genome · doi:10.1007/s00335-009-9217-2 · Cited by 148 · see citing works
Granjon, A., Gustin, M., Rieusset, J., Lefai, É., Meugnier, E., Güller, I., Cerutti, C., Paultre, C. Z., Disse, E., RABASA-LHORET, R. P. R., et al. (2009) · Diabetes · doi:10.2337/db09-0165 · Cited by 142 · see citing works
Palmisano, G., Jensen, S. S., Bihan, M. L., Lainé, J., McGuire, J. N., Pociot, F., & Larsen, M. R. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.012732 · Cited by 142 · see citing works
Schulze, M. B., Weikert, C., Pischon, T., Bergmann, M. M., Al‐Hasani, H., Schleicher, E. D., Fritsche, A., Häring, H., Boeing, H., & Joost, H. (2009) · Diabetes Care · doi:10.2337/dc09-0197 · Cited by 141 · see citing works
Wang, G., Kwan, B. C., Lai, F. M., Chow, K. M., Li, P. K., & Szeto, C. (2011) · Disease Markers · doi:10.1155/2011/304852 · Cited by 140 · see citing works
Increased expression of microRNA miR‐326 in type 1 diabetic patients with ongoing islet autoimmunity
Sebastiani, G., Grieco, F. A., Spagnuolo, I., Galleri, L., Cataldo, D., & Dotta, F. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1262 · Cited by 131 · see citing works
Wang, G., Kwan, B. C., Lai, F. M., et al. (2011) · PubMed · doi:10.3233/dma-2011-0766 · Cited by 122 · see citing works
Alvarez, M. L., & DiStefano, J. K. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.10.010 · Cited by 110 · see citing works
Salas‐Pérez, F., Ethel Codner, D., Valencia, E., Pizarro, C., Carrasco, E., & Pérez‐Bravo, F. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.08.276 · Cited by 104 · see citing works
Sheng, H., Hassanali, S., Nugent, C., Li, W., Hamilton‐Williams, E. E., Dias, P. B., & Dai, Y. D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100231 · Cited by 102 · see citing works
Wang, N., Zhou, Y., Jiang, L., Li, D., Yang, J., Zhang, C., & Zen, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051140 · Cited by 99 · see citing works
MicroRNAs and Diabetic Complications
Natarajan, R. D., Putta, S., & Kato, M. V. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9368-5 · Cited by 99 · see citing works
Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?
van Empel, V. P. M., Windt, L. J. D., & Martins, P. A. D. C. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0310-7 · Cited by 87 · see citing works
MicroRNAs: a new ray of hope for diabetes mellitus
Kumar, M., Nath, S., Prasad, H. K., Sharma, G., & Li, Y. (2012) · Protein & Cell · doi:10.1007/s13238-012-2055-0 · Cited by 67 · see citing works
Characterization of Vesicles Secreted from Insulinoma NIT-1 Cells
Lee, H. S., Jeong, J., & Lee, K. (2009) · Journal of Proteome Research · doi:10.1021/pr900009y · Cited by 58 · see citing works
Towards understanding the inherited susceptibility for nephropathy in diabetes
Thomas, M. C., Groop, P., & Tryggvason, K. (2012) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328350313e · Cited by 57 · see citing works
Circulating MicroRNAs Are Not Eliminated by Hemodialysis
Martino, F., Lorenzen, J. M., Schmidt, J. J., Schmidt, M., Broll, M., Görzig, Y., Kielstein, J. T., & Thum, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038269 · Cited by 52 · see citing works
Type 1 Diabetes Islet Autoantibody Markers
Winter, W. E., Harris, N., & Schatz, D. (2002) · Diabetes Technology & Therapeutics · doi:10.1089/152091502321118838 · Cited by 51 · see citing works
Biomarkers for type 1 diabetes.
Purohit, S. B., & She, J. (2008) · PubMed Central · Cited by 44 · see citing works
Analysis of urinary microRNAs in chronic kidney disease
Beltrami, C., Clayton, A., Phillips, A. O., Fraser, D. J., & Bowen, T. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120090 · Cited by 44 · see citing works
microRNA expression fingerprint in serum of type 1 diabetic patients
Sebastiani, G., Spagnuolo, I., Patti, A., Grieco, F. A., Cataldo, D., Ferretti, E., Tiberti, C., & Dotta, F. (2012) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 16 · see citing works
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- [84]84. Guay, C., Menoud, V., Gattesco, S. & Regazzi, R. MicroRNA transfer as a new cell-to-cell communication mode between pancreatic beta cells. Diabetologia 55, S95 (2012).
Cited by
Sorted by citations
Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.035 · Cited by 1,191 · see citing works
Aptamer-Based Detection of Circulating Targets for Precision Medicine
Wu, L., Wang, Y., Xu, X., Liu, Y., Lin, B., Zhang, M., Zhang, J., Wan, S., Yang, C. J., & Tan, W. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01140 · Cited by 704 · see citing works
Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics
Singh, S., Pal, N., Shubham, S., Sarma, D. K., Verma, V., Marotta, F., & Kumar, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041454 · Cited by 521 · see citing works
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · Diabetes Care · doi:10.2337/dc14-0396 · Cited by 460 · see citing works
“It has been suggested that altered miRNA expression may contribute toward b-cell failure in T2D and that these molecules may serve as biomarkers for the disease (30).”
BackgroundMicroRNA regulatory networks in human adipose tissue and obesity
Arner, P., & Kulyté, A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.25 · Cited by 456 · see citing works
Interplay between miRNAs and human diseases
Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420 · see citing works
Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers
Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M. S., Zaher, W., Alfayez, M. A., Aldahmash, A. M., & Alajez, N. M. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.440 · Cited by 370 · see citing works
Ortega, F. J., Mercader, J. M., Moreno‐Navarrete, J. M., Rovira, O., Guerra, E., Esteve, E., Xifra, G., Martínez, C., Ricart, W., Rieusset, J., et al. (2014) · Diabetes Care · doi:10.2337/dc13-1847 · Cited by 362 · see citing works
Determining the role of microRNAs in psychiatric disorders
Issler, O., & Chen, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3879 · Cited by 309 · see citing works
Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome
Rysz, J., Gluba-Brzózka, A., Franczyk, B., Jabłonowski, Z., & Ciałkowska-Rysz, A. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081702 · Cited by 278 · see citing works
Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR
Marabita, F., de Candia, P., Torri, A., Tegner, J. N., Abrignani, S., & Rossi, R. L. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv056 · Cited by 268 · see citing works
Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms
Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262 · see citing works
The clinical potential of circulating microRNAs in obesity
Ji, C., & Guo, X. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0260-0 · Cited by 260 · see citing works
Emerging roles of exosomal miRNAs in diabetes mellitus
He, X., Kuang, G., Wu, Y., & Ou, C. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.468 · Cited by 232 · see citing works
Role of microRNAs in obesity and obesity-related diseases
Iacomino, G., & Siani, A. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0577-z · Cited by 225 · see citing works
Testa, R., Bonfigli, A. R., Prattichizzo, F., Sala, L. L., Nigris, V. D., & Ceriello, A. (2017) · Nutrients · doi:10.3390/nu9050437 · Cited by 230 · see citing works
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1425 · Cited by 227 · see citing works
MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases
Kumar, S., Vijayan, M., Bhatti, J. S., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.013 · Cited by 216 · see citing works
Bioinformatic tools for microRNA dissection
Akhtar, M. M., Micolucci, L., Islam, M. S., Olivieri, F., & Procopio, A. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1221 · Cited by 216 · see citing works
Emerging Biosensing Approaches for microRNA Analysis
Graybill, R. M., & Bailey, R. C. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04679 · Cited by 206 · see citing works
Seyhan, A. A., López, Y. O. N., Xie, H., Yi, F., Mathews, C. E., Pasarica, M., & Pratley, R. E. (2016) · Scientific Reports · doi:10.1038/srep31479 · Cited by 174 · see citing works
Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes
Higuchi, C., Nakatsuka, A., Eguchi, J., Teshigawara, S., Kanzaki, M., Katayama, A., Yamaguchi, S., Takahashi, N., Murakami, K., Ogawa, D., et al. (2014) · Metabolism · doi:10.1016/j.metabol.2014.12.003 · Cited by 173 · see citing works
Katayama, M., Wiklander, O. P. B., Fritz, T., Caidahl, K., Andaloussi, S. E., Zierath, J. R., & Krook, A. (2018) · Diabetes · doi:10.2337/db18-0470 · Cited by 166 · see citing works
MicroRNAs as stress regulators in pancreatic beta cells and diabetes
LaPierre, M. P., & Stoffel, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.020 · Cited by 154 · see citing works
Simultaneous and multiplexed detection of exosome microRNAs using molecular beacons
Lee, J. H., Kim, J. A., Jeong, S.-A., & Rhee, W. J. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.06.058 · Cited by 157 · see citing works
Ntoumou, E., Tzetis, M., Braoudaki, M., Lambrou, G. Ι., Poulou, M., Malizos, Κ. Ν., Stefanou, N., Anastasopoulou, L., & Tsezou, A. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0428-1 · Cited by 156 · see citing works
Zhang, T., Lv, C., Li, L., Chen, S., Liu, S., Wang, C., & Su, B. (2013) · BioMed Research International · doi:10.1155/2013/761617 · Cited by 155 · see citing works
Assmann, T. S., Recamonde‐Mendoza, M., de Souza, B. M., & Crispim, D. (2017) · Endocrine Connections · doi:10.1530/ec-17-0248 · Cited by 154 · see citing works
The Role of microRNAs in Mitochondria: Small Players Acting Wide
Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2014) · Genes · doi:10.3390/genes5040865 · Cited by 151 · see citing works
Niculescu, L. S., Simionescu, N., Sanda, G. M., Carnuta, M. G., Stancu, C. S., Popescu, A. C., Popescu, M. R., Vlad, A., Dimulescu, D. R., Simionescu, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140958 · Cited by 151 · see citing works
Early life adversity, genomic plasticity, and psychopathology
Turecki, G., Ota, V., Belangero, S. I., Jackowski, A. P., & Kaufman, J. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00022-4 · Cited by 149 · see citing works
Jiménez-Lucena, R., Camargo, A., Alcala-Diaz, J. F., Romero-Baldonado, C., Luque, R. M., van Ommen, B., Delgado‐Lista, J., Ordovás, J. M., Pérez‐Martínez, P., Rangel-Zúñiga, O. A., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0194-y · Cited by 130 · see citing works
Olivieri, F., Spazzafumo, L., Bonafè, M., Recchioni, R., Prattichizzo, F., Marcheselli, F., Micolucci, L., Mensa’, E., Giuliani, A., Santini, G., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6164 · Cited by 130 · see citing works
Heilmeier, U., Hackl, M., Skalicky, S., Weilner, S., Schroeder, F., Vierlinger, K., Patsch, J., Baum, T. H., Priglinger, E., Lobach, I. V., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2897 · Cited by 127 · see citing works
Nigi, L., Grieco, G. E., Ventriglia, G., Brusco, N., Mancarella, F., Formichi, C., Dotta, F., & Sebastiani, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123705 · Cited by 126 · see citing works
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing
Moura, J., Børsheim, E., & Carvalho, E. (2014) · Genes · doi:10.3390/genes5040926 · Cited by 125 · see citing works
Wang, X., Sundquist, J., Zöller, B., Memon, A. A., Palmér, K., Sundquist, K., & Bennet, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086792 · Cited by 125 · see citing works
Application of microRNAs in diabetes mellitus
Chen, H., Lan, H.-Y., Roukos, D. H., & Cho, W. C. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0544 · Cited by 124 · see citing works
Platania, C. B. M., Maisto, R., Trotta, M. C., D’Amico, M., Rossi, S., Gesualdo, C., D’Amico, G., Baltă, C., Herman, H., Hermenean, A. O., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14665 · Cited by 124 · see citing works
Latreille, M., Herrmanns, K., Renwick, N. M., Tuschl, T., Malecki, M. T., McCarthy, M. I., Owen, K. R., Rülicke, T., & Stoffel, M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1296-9 · Cited by 125 · see citing works
Maffioletti, E., Tardito, D., Gennarelli, M., & Bocchio‐Chiavetto, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00075 · Cited by 121 · see citing works
Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts
Nowak, C., Sundström, J., Gustafsson, S., Giedraitis, V., Lind, L., Ingelsson, E., & Fall, T. (2015) · Diabetes · doi:10.2337/db15-0881 · Cited by 121 · see citing works
Olivieri, F., Capri, M., Bonafè, M., Morsiani, C., Jung, H. J., Spazzafumo, L., Viña, J., & Suh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.004 · Cited by 120 · see citing works
Jiménez-Lucena, R., Rangel-Zúñiga, O. A., Alcala-Diaz, J. F., López-Moreno, J., Roncero‐Ramos, I., Molina‐Abril, H., Yubero‐Serrano, E. M., Caballero‐Villarraso, J., Delgado‐Lista, J., Castano, J. P., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.002 · Cited by 120 · see citing works
Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
Liauchonak, I., Qorri, B., Dawoud, F., Riat, Y., & Szewczuk, M. R. (2019) · Nutrients · doi:10.3390/nu11030644 · Cited by 119 · see citing works
Si, Y., Xu, L. P., Wang, N., Zheng, J., Yang, R., & Li, J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04606 · Cited by 118 · see citing works
Li, B., Xin, Z., Gao, S., Li, Y., Guo, S., Fu, Y., Zhang, P., Wang, D., Cheng, J., Liu, L., et al. (2022) · Theranostics · doi:10.7150/thno.78878 · Cited by 113 · see citing works
Wang, C., Wan, S., Yang, T., Niu, D., Zhang, A., Yang, C., Cai, J., Wu, J., Song, J., Zhang, C., et al. (2016) · Scientific Reports · doi:10.1038/srep20032 · Cited by 112 · see citing works
Zhao, S., Li, T., Li, J., Lu, Q., Han, C., Wang, N., Qiu, Q., Cao, H., Xu, X., Chen, H., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3832-0 · Cited by 111 · see citing works
Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications
Filardi, T., Catanzaro, G., Mardente, S., Zicari, A., Santangelo, C., Lenzi, A., Morano, S., & Ferretti, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114020 · Cited by 112 · see citing works
Black phosphorus nanosheets for rapid microRNA detection
Zhou, J., Li, Z., Ying, M., Liu, M., Wang, X., Wang, X., Cao, L., Zhang, H., & Xu, G. (2018) · Nanoscale · doi:10.1039/c7nr08900g · Cited by 108 · see citing works
Eliasson, L. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.043 · Cited by 88 · see citing works
Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome
Borujeni, M. J. S., Esfandiary, E., Taheripak, G., Codoñer‐Franch, P., Alonso‐Iglesias, E., & Mirzaei, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26271 · Cited by 106 · see citing works
Cytokines and Pancreatic β-Cell Apoptosis
Berchtold, L. A., Prause, M. C. B., Størling, J., & Mandrup-Poulsen, T. R. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.02.001 · Cited by 102 · see citing works
Pordzik, J., Pisarz, K., Rosa, S. D., Jones, A. D., Eyileten, C., Indolfi, C., Małek, Ł. A., & Postula, M. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00074 · Cited by 105 · see citing works
Circulating microRNAs as potential diagnostic biomarkers for osteoporosis
Mandourah, A. Y., Ranganath, L. R., Barraclough, R., Vinjamuri, S., Hof, R. V., Hamill, S., Czanner, G., Dera, A. A., Wang, D., & Barraclough, D. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-26525-y · Cited by 104 · see citing works
Abdulle, L. E., Hao, J., Pant, O. P., Liu, X., Zhou, D., Gao, Y., Suwal, A., & Lu, C. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.30097 · Cited by 104 · see citing works
Modulation of Host miRNAs by Intracellular Bacterial Pathogens
Das, K., Garnica, O., & Dhandayuthapani, S. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00079 · Cited by 104 · see citing works
MicroRNAs and diabetic kidney disease: Systematic review and bioinformatic analysis
Assmann, T. S., Recamonde‐Mendoza, M., de Souza, B. M., Bauer, A. C., & Crispim, D. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.06.005 · Cited by 102 · see citing works
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases
de Lucia, C., Komici, K., Borghetti, G., Femminella, G. D., Bencivenga, L., Cannavò, A., Corbi, G., Ferrara, N., Houser, S. R., Koch, W. J., et al. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00074 · Cited by 101 · see citing works
Si, Y., Xu, L. P., Deng, T., Zheng, J., & Li, J. (2020) · ACS Sensors · doi:10.1021/acssensors.0c01876 · Cited by 101 · see citing works
Zhang, T., Li, L., Shang, Q., Lv, C., Wang, C., & Su, B. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.017 · Cited by 101 · see citing works
Yang, W., Wang, J., Chen, Z., Chen, J., Meng, Y., Chen, L., Chang, Y., Geng, B., Sun, L., Dou, L., et al. (2017) · Diabetes · doi:10.2337/db16-1172 · Cited by 101 · see citing works
Zhou, W., Li, D., Xiong, C., Yuan, R., & Xiang, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b03165 · Cited by 99 · see citing works
Xiang, Y., Cheng, J., Wang, D., Hu, X., Xie, Y., Stitham, J., Atteya, G. A., Du, J., Tang, W. H., Lee, S. H., et al. (2015) · Blood · doi:10.1182/blood-2015-01-620278 · Cited by 99 · see citing works
Profiles of Circulating miRNAs Following Metformin Treatment in Patients with Type 2 Diabetes
Demirsoy, İ. H., Ertural, D. Y., Balcı, Ş., Çınkır, Ü., Sezer, K., Tamer, L., & Aras, N. (2018) · Journal of Medical Biochemistry · doi:10.2478/jomb-2018-0009 · Cited by 98 · see citing works
Diversity and signature of small RNA in different bodily fluids using next generation sequencing
El-Mogy, M., Lam, B., Haj-Ahmad, T. A., McGowan, S., Yu, D. L., Nosal, L., Rghei, N., Roberts, P., & Haj-Ahmad, Y. (2018) · BMC Genomics · doi:10.1186/s12864-018-4785-8 · Cited by 95 · see citing works
Zaiou, M. (2020) · Cells · doi:10.3390/cells9030659 · Cited by 93 · see citing works
Mazzeo, A., Beltramo, E., Lopatina, T., Gai, C., Trento, M., & Porta, M. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.07.003 · Cited by 95 · see citing works
Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk
Duval, M., Cossart, P., & Lebreton, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.016 · Cited by 91 · see citing works
Sathyapalan, T., David, R., Gooderham, N. J., & Atkin, S. L. (2015) · Scientific Reports · doi:10.1038/srep16890 · Cited by 90 · see citing works
Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus
Hashimoto, N., & Tanaka, T. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2016.150 · Cited by 90 · see citing works
Sebastiani, G., Nigi, L., Grieco, G. E., Mancarella, F., Ventriglia, G., & Dotta, F. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0611-4 · Cited by 89 · see citing works
Wang, W. J., Kong, T., Zhang, D., Zhang, J., & Cheng, G. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01930 · Cited by 88 · see citing works
Recent progress toward the use of circulating microRNAs as clinical biomarkers
Ghai, V., & Wang, K. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1828-2 · Cited by 89 · see citing works
Ślusarz, A., & Pulakat, L. (2015) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000246 · Cited by 87 · see citing works
Jia, L., Chopp, M., Wang, L., Lu, X., Szalad, A., & Zhang, Z. G. (2018) · The FASEB Journal · doi:10.1096/fj.201800597r · Cited by 86 · see citing works
MicroRNAs as regulators of beta‐cell function and dysfunction
Osmai, M., Osmai, Y., Bang‐Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, F., & Mandrup-Poulsen, T. R. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2719 · Cited by 84 · see citing works
Expression of microRNA in follicular fluid in women with and without PCOS
Butler, A. E., Ramachandran, V., Hayat, S., Dargham, S. R., Cunningham, T. K., Benurwar, M., Sathyapalan, T., Najafi-Shoushtari, S. H., & Atkin, S. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-52856-5 · Cited by 83 · see citing works
Abdalla, M. A., Deshmukh, H., Atkin, S. L., & Sathyapalan, T. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118174 · Cited by 83 · see citing works
Jin, L., Wang, Y., Zou, Y., Chen, X., Huang, B., Liu, J., Xu, Y., Li, J., Zhang, J., Yang, W., et al. (2016) · Tumor Biology · doi:10.1007/s13277-016-5410-6 · Cited by 82 · see citing works
Bijkerk, R., Duijs, J. M. G. J., Khairoun, M., ter Horst, C. J. H., van der Pol, P., Mallat, M. J. K., Rotmans, J. I., de Vries, A. P. J., de Koning, E. J. P., de Fijter, J. W., et al. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13072 · Cited by 82 · see citing works
Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity
Torri, A., Carpi, D., Bulgheroni, E., Crosti, M., Moro, M., Gruarin, P., Rossi, R. L., Rossetti, G., Vizio, D. D., Hoxha, M., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.769893 · Cited by 82 · see citing works
Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?
Crigna, A. T., Samec, M., Koklesová, L., Líšková, A., Giordano, F. A., Kubatka, P., & Golubnitschaja, O. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00226-x · Cited by 79 · see citing works
Raitoharju, E., Seppälä, I., Oksala, N., Lyytikäinen, L., Raitakari, O. T., Viikari, J. S. A., Ala‐Korpela, M., Soininen, P., Kangas, A. J., Waldenberger, M., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.04.013 · Cited by 81 · see citing works
Kumar, A., Ren, Y., Sundaram, K., Mu, J., Sriwastva, M. K., Dryden, G. W., Lei, C., Zhang, L., Yan, J., Zhang, X., et al. (2021) · Theranostics · doi:10.7150/thno.52558 · Cited by 80 · see citing works
The Role of High-Density Lipoproteins in Diabetes and Its Vascular Complications
Wong, N. K. P., Nicholls, S. J., Tan, J. T. M., & Bursill, C. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061680 · Cited by 77 · see citing works
Denzer, L., Schroten, H., & Schwerk, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103730 · Cited by 77 · see citing works
miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies
Do, D. N., Dudemaine, P.-L., Mathur, M., Suravajhala, P., Zhao, X., & Ibeagha-Awemu, E. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063080 · Cited by 78 · see citing works
The role of beta-cell dysfunction in early type 1 diabetes
Sims, E. K., Mirmira, R. G., & Evans‐Molina, C. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000548 · Cited by 77 · see citing works
Zeinali, F., Zarch, S. M. A., Jahan-Mihan, A., Kalantar, S. M., Mehrjardi, M. Y. V., Fallahzadeh, H., Hosseinzadeh, M., Rahmanian, M., & Mozaffari–Khosravi, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251697 · Cited by 77 · see citing works
Snowhite, I. V., Allende, G., Sosenko, J. M., Pastori, R. L., Messinger, S., & Pugliese, A. (2017) · Diabetologia · doi:10.1007/s00125-017-4294-3 · Cited by 78 · see citing works
Ultrasensitive Detection of MicroRNAs with Morpholino-Functionalized Nanochannel Biosensor
Liao, T., Li, X., Tong, Q., Zou, K., Zhang, H., Tang, L., Sun, Z. J., & Zhang, G. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00487 · Cited by 76 · see citing works
Wang, H., Lo, H.-H., Chiu, Y.-L., Chang, S.-J., Huang, P.-H., Liao, K., Tasi, C.-F., Wu, C., Tsai, T.-N., Cheng, C.-C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098070 · Cited by 74 · see citing works
Miao, X., Ning, X., Li, Z., & Cheng, Z. (2016) · Scientific Reports · doi:10.1038/srep32358 · Cited by 73 · see citing works
Farr, R. J., Januszewski, A. S., Joglekar, M. V., Liang, H. H., McAuley, A. K., Hewitt, A. W., Thomas, H. E., Loudovaris, T., Kay, T. W. H., Jenkins, A. J., et al. (2015) · Scientific Reports · doi:10.1038/srep10375 · Cited by 72 · see citing works
Wan, S., Wang, J., Wang, J., Wu, J., Song, J., Zhang, C., Zhang, C., Wang, C., & Wang, J. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.06.005 · Cited by 70 · see citing works
The role of miR-320 in glucose and lipid metabolism disorder-associated diseases
Du, H., Zhao, Y., Yin, Z., Wang, D. W., & Chen, C. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.53419 · Cited by 70 · see citing works
Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
Prattichizzo, F., Giuliani, A., Nigris, V. D., Pujadas, G., Çeka, A., Sala, L. L., Genovese, S., Testa, R., Procopio, A. D., Olivieri, F., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12688 · Cited by 69 · see citing works
Yin, H., Li, B.-C., Zhou, Y., Wang, H.-Y., Wang, M., & Ai, S. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.04.049 · Cited by 69 · see citing works
- Authors
- Guay, C., & Regazzi, R.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Regazzi, Romano
- Venue
- Nature Reviews Endocrinology
- Published
- 2013-04-30
- Volume
- 9
- Issue
- 9
- Pages
- 513-521
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2061998727
- Cited by
- 563
- References
- 102
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 20 · 2023: 41 · 2022: 28 · 2021: 55 · 2020: 54 · 2019: 57 · 2018: 71 · 2017: 72 · 2016: 49 · 2015: 54 · 2014: 32 · 2013: 3
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- iris.unil.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- European Foundation for the Study of Diabetes
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Société Francophone du Diabète
- Servier
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- circulating microRNAs, diabetes mellitus, type 1 diabetes, type 2 diabetes, biomarkers, early diagnosis, disease complications, pancreatic beta cells, insulin secretion, non-coding RNA
- MeSH terms
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, MicroRNAs
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