Chemically defined generation of human cardiomyocytes

Burridge, Paul W, Matsa, Elena, Shukla, Praveen, Lin, Ziliang C, Churko, Jared M, Ebert, Antje D, Lan, Feng, Diecke, Sebastian +7 more·2014·Nature Methods

DOI 10.1038/nmeth.2999

Cited by (1,001)

Items 801–900 of 1,001

Heart in a Dish: From Traditional 2D Differentiation Protocols to Cardiac Organoids
Gustavo Ramírez-Calderón, Giovanni Colombo, Carlos Alberto Hernandez-Bautista, Veronica Astro, Antonio Adamo · 2022 · Frontiers in Cell and Developmental Biology
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy
Tingcai Pan, Ning Wang, Jiaye Zhang, Fan Yang, Yan Chen, Yuanqi Zhuang, Yingying Xu, Fang Ji, Kai You, Xian-Hua Lin et al. · 2022 · Stem Cell Research & Therapy
Cellular reprogramming of fibroblasts in heart regeneration
Congwu Chi, Kunhua Song · 2023 · Journal of Molecular and Cellular Cardiology
Utilizing human induced pluripotent stem cells to study atrial arrhythmias in the short QT syndrome
Assad Shiti, Gil Arbil, Naim Shaheen, Irit Huber, Noga Setter, Lior Gepstein · 2023 · Journal of Molecular and Cellular Cardiology
Hypertrophy of human embryonic stem cell–derived cardiomyocytes supported by positive feedback between Ca2+ and diacylglycerol signals
Christine Deisl, Michael Fine, Orson W. Moe, Donald W. Hilgemann · 2019 · Pflügers Archiv - European Journal of Physiology
Vismione B Interferes with Trypanosoma cruzi Infection of Vero Cells and Human Stem Cell–Derived Cardiomyocytes
Gabriele Sass, Armelle Tontsa Tsamo, Gwladys A. M. Chounda, Pamela Kemda Nangmo, Nazish Sayed, Adriana Bozzi, Joseph C. Wu, Augustin Ephrem Nkengfack, David A. Stevens · 2019 · American Journal of Tropical Medicine and Hygiene
Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes
Markos Athanasiadis, Dzmitry Afanasenkau, Wouter J. A. Derks, Christoph Tondera, Francesca Murganti, Volker Busskamp, Olaf Bergmann, Ivan Rusev Minev · 2020 · npj Flexible Electronics
RAD-Deficient Human Cardiomyocytes Develop Hypertrophic Cardiomyopathy Phenotypes Due to Calcium Dysregulation
Yanan Li, Yun Chang, Xiaolei Li, Xiaowei Li, Jian Gao, Yafei Zhou, Fujian Wu, Rui Bai, Tao Dong, Shuhong Ma et al. · 2020 · Frontiers in Cell and Developmental Biology
Cardiac specification during gastrulation – The Yellow Brick Road leading to Tinman
Nathan Stutt, Mengyi Song, Michael D. Wilson, Ian C. Scott · 2021 · Seminars in Cell and Developmental Biology
FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes
Francesca Murganti, Wouter J. A. Derks, Marion Baniol, Irina Simonova, Palina Trus, Katrin Neumann, Shahryar Khattak, Kaomei Guan, Olaf Bergmann · 2022 · Frontiers in Cardiovascular Medicine
Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization
Oscar John Abilez, Huaxiao Yang, Lei Tian, Kitchener D. Wilson, Evan H. Lyall, Mengcheng Shen, Rahulkumar Bhoi, Yan Zhuge, Fangjun Jia, Hung-Ta Wo et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Experimental Models of Hypertrophic Cardiomyopathy
Floor W. van den Dolder, Rafeeh Dinani, Vincent A J Warnaar, Sofija Vuckovic, Adriana S Passadouro, Ali A. Nassar, Azhaar X Ramsaroep, George B Burchell, Linda Jeanne Schoonmade, Jolanda van der Velden et al. · 2025 · JACC Basic to Translational Science
Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases
Sai Zhang, Hantao Shu, Jingtian Zhou, Jasper Rubin-Sigler, Xiaoyu Jenny Yang, Yuxi Liu, Johnathan Cooper‐Knock, Emma Monte, Chenchen Zhu, Sharon Tu et al. · 2025 · Nature Biotechnology
Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes
Daniel J. Clemens, Dan Ye, Lili Wang, C.S. John Kim, Wei Zhou, Steven Michael Dotzler, David J. Tester, Isabelle Marty, Björn C. Knollmann, Michael John Ackerman · 2023 · Stem Cell Reports
An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes
Yuanyuan Dai, Nadezda Ignatyeva, Hang Xu, Ruheen Wali, Karl Toischer, Sören Brandenburg, Christof Lenz, Julius Ryan D. Pronto, Funsho E. Fakuade, Samuel Tobias Sossalla et al. · 2023 · Circulation Research
The future of personalized cardiovascular medicine demands 3D and 4D printing, stem cells, and artificial intelligence
Monique Bax, Jordan Thorpe, Valentin Romanov · 2023 · Frontiers in Sensors
Probing early heart development to instruct stem cell differentiation strategies
Damelys Calderon, Evan Bardot, Nicole C. Dubois · 2016 · Developmental Dynamics
Pathogenic mechanism and gene correction for LQTS-causing double mutations in KCNQ1 using a pluripotent stem cell model
Zhen Wang, Lipeng Wang, Wenling Liu, Dayi Hu, Yuanfeng Gao, Qing Ge, Xin Liu, Lei Li, Yangming Wang, Shi‐Qiang Wang et al. · 2019 · Stem Cell Research
Advanced Technologies to Target Cardiac Cell Fate Plasticity for Heart Regeneration
Gianluca Testa, Giorgia Di Benedetto, Fabiana Passaro · 2021 · International Journal of Molecular Sciences
Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements
Dinko Mitrečić, Valentina Hribljan, Denis Jagečić, Jasmina Isaković, Federica Lamberto, Alex Horánszky, Melinda Zana, Gábor Földes, Barbara Zavan, Augustas Pivoriūnas et al. · 2022 · International Journal of Molecular Sciences
Genome sequencing in a genetically elusive multigenerational long QT syndrome pedigree identifies a novel LQT2-causative deeply intronic KCNH2 variant
Kathryn E. Tobert, David J. Tester, Wei Zhou, Carla M. Haglund-Turnquist, John R. Giudicessi, Michael John Ackerman · 2022 · Heart Rhythm
Tissue-Engineering for the Study of Cardiac Biomechanics
Stephen P. Ma, Gordana Vunjak‐Novakovic · 2015 · Journal of Biomechanical Engineering
Conservative site-specific and single-copy transgenesis in humanLINE-1elements
Shree Harsha Vijaya Chandra, Harshyaa Makhija, Sabrina Peter, Cho Mar Myint Wai, Jinming Li, Jindong Zhu, Zhonglu Ren, Martina Stagno d’Alcontres, Jia Wei Siau, Sharon Min Qi Chee et al. · 2015 · Nucleic Acids Research
The double life of cardiac mesenchymal cells: Epimetabolic sensors and therapeutic assets for heart regeneration
Chiara Cencioni, Sandra Atlante, Matteo Savoia, Fabio Martelli, Antonella Farsetti, Maurizio Colognesi Capogrossi, Andreas Michael Zeiher, Carlo Gaetano, Francesco Spallotta · 2016 · Pharmacology & Therapeutics
Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells
Maria Grazia Perino, Satoshi Yamanaka, Daniel R. Riordon, Yelena S. Tarasova, Kenneth R. Boheler · 2017 · PLoS ONE
Key Regulators of Cardiovascular Differentiation and Regeneration: Harnessing the Potential of Direct Reprogramming to Treat Heart Failure
Masaki Ieda · 2019 · Journal of Cardiac Failure
RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells
Paula Mueller, Markus Wolfien, Katharina Ekat, Cajetan Immanuel Lang, Dirk Koczan, Olaf Wolkenhauer A, Olga Hahn, Kirsten Peters, Hermann Lang, Robert David et al. · 2020 · Cells
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods
Christina Schmid, Christian T. Wohnhaas, Tobias Hildebrandt, Patrick Baum, Georg F. Rast · 2020 · Journal of Pharmacological and Toxicological Methods
Transferrin improved the generation of cardiomyocyte from human pluripotent stem cells for myocardial infarction repair
Fengzhi Zhang, Hui Qiu, Xiaohui Dong, Chunlan Wang, Jie Na, Jin Zhou, Changyong Wang · 2020 · Journal of Molecular Histology
Defining optimal enzyme and matrix combination for replating of human induced pluripotent stem cell-derived cardiomyocytes at different levels of maturity
Arzuhan Koc, Sevilay Sahoglu Goktas, Tuba Akgül Çağlar, Esra Çağavi · 2021 · Experimental Cell Research
The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes
James W.S. Jahng, Mao Zhang, Joseph C. Wu · 2021 · Seminars in Cell and Developmental Biology
Purification of small molecule‐induced cardiomyocytes from human induced pluripotent stem cells using a reporter system
Geun Hye Hwang, So Mi Park, Ho Jae Han, Joong‐Sun Kim, Seung Pil Yun, Jung Min Ryu, Ho Jin Lee, Woochul Chang, Su‐Jin Lee, Jeong‐Hee Choi et al. · 2017 · Journal of Cellular Physiology
Redefining cellular reprogramming with advanced genomic technologies
Samantha A. Morris · 2025 · Nature Reviews Genetics
MorphoScript: a dedicated analysis to assess the morphology and contractile structures of cardiomyocytes derived from stem cells
Tess Homan, Hélène Delanoë‐Ayari, Albano C. Méli, Olivier Cazorla, Csilla Gergely, Alexandre Méjat, Philippe Chevalier, Adrien Moreau · 2021 · Bioinformatics
STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development
Chikai Zhou, Timm Häneke, Eduarde Rohner, Jesper Sohlmér, Polina Kameneva, Artem V. Artemov, Igor I. Adameyko, Makoto Sahara · 2023 · Cardiovascular Research
Platform-agnostic CellNet enables cross-study analysis of cell fate engineering protocols
Emily K.W. Lo, Jeremy J. Velazquez, Da Peng, Chulan Kwon, Mo R. Ebrahimkhani, Patrick Cahan · 2023 · Stem Cell Reports
Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells
Mohammed Djemai, Michael Cupelli, Mohamed Boutjdir, Mohamed Chahine · 2023 · Cells
Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues
Jasmeet Singh Reyat, Alessandro Di Maio, Beata Grygielska, Jeremy Andrew Pike, Samuel Kemble, Antonio Rodriguez-Romero, Christina Simoglou Karali, Adam P. Croft, Bethan Psaila, Filipa Costa Simões et al. · 2023 · Frontiers in Cardiovascular Medicine
Lactate- and immunomagnetic-purified hiPSC–derived cardiomyocytes generate comparable engineered cardiac tissue constructs
Kalina J. Rossler, Willem J. de Lange, Morgan W. Mann, Timothy J. Aballo, Jake A. Melby, Jianhua Zhang, Gina Kim, Elizabeth F. Bayne, Yanlong Zhu, Emily T. Farrell et al. · 2023 · JCI Insight
Cell Therapy in the Treatment of Coronary Heart Disease
Elena V. Chepeleva · 2023 · International Journal of Molecular Sciences
Three-dimensional co-culturing of stem cell-derived cardiomyocytes and cardiac fibroblasts reveals a role for both cell types in Marfan-related cardiomyopathy
Jeffrey Aalders, Laurens Léger, Louis Van der Meeren, Sanjay Sinha, André G. Skirtach, Julie F A De Backer, Jolanda van Hengel · 2024 · Matrix Biology
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias
Joyce C. Ohiri, Lisa M. Dellefave‐Castillo, Garima Tomar, Lisa D. Wilsbacher, Lubna Choudhury, David Y. Barefield, Dominic E. Fullenkamp, Anthony M. Gacita, Tanner O. Monroe, Lorenzo L. Pesce et al. · 2024 · Journal of the American Heart Association
Generation and Characterization of hiPSC‐Derived Vascularized‐, Perfusable Cardiac Microtissues‐on‐Chip
Ulgu Arslan, Francijna E. van den Hil, Christine L. Mummery, Valeria V. Orlova · 2024 · Current Protocols
Hydrogel microsphere stem cell encapsulation enhances cardiomyocyte differentiation and functionality in scalable suspension system
Mohammadjafar Hashemi, Ferdous B. Finklea, Hanna Hammons, Yuan Tian, Nathan Young, E. Kim, Caroline Halloin, Wiebke Triebert, Robert Zweigerdt, Amit Mitra et al. · 2024 · Bioactive Materials
N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes
Yi-Wei Tsai, Yi-Shuan Tseng, Yu‐Shuo Wu, Wei Song, Min-Yi You, Yun-Chia Hsu, Wen‐Pin Chen, Wei‐Han Huang, Jia-Ci Chng, Chai-Ling Lim et al. · 2025 · Nature Communications
Mechanical Characterization of hiPSC‐Derived Cardiac Tissues for Quality Control
Seungman Park, Cecillia Lui, Wei‐Hung Jung, Debonil Maity, Chin Siang Ong, Joshua R. Bush, Venkat Maruthamuthu, Narutoshi Hibino, Yun Chen · 2018 · Advanced Biosystems
Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration
Yike Huang, Ting Wang, Maria Elizabeth Urbina Lopez, Minoru Hirano, Anwarul Hasan, Su Ryon Shin · 2020 · Microphysiological Systems
Involvement of kallikrein‐PAR2 ‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity
Ritsuko Sasaki, Nagomi Kurebayashi, Hidetaka Eguchi, Yoshiya Horimoto, Takahiro Shiga, Sakiko Miyazaki, Taku Kashiyama, Wado Akamatsu, Mitsue Saito · 2022 · Cancer Science
Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review
Afshin Zare, Aria Salehpour, Arezoo Khoradmehr, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Sahar Almasi-turk, Mahdi Mahdipour, Reza Shirazi, Amin Tamadon · 2023 · Life
De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges
Veronique Hamel, Kang Cheng, Shudan Liao, Aizhu Lu, Yong Zheng, Ya‐Wen Chen, Yucai Xie, Wenbin Liang · 2017 · Stem Cells International
Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes
Adrian Gabriel Cadar, Tromondae K. Feaster, Kevin Richard Bersell, Lili Wang, TingTing Hong, Joseph A. Balsamo, Zhentao Zhang, Young Wook Chun, Young‐Jae Nam, Michael Gotthardt et al. · 2019 · American Journal of Physiology-Cell Physiology
Guided vascularization in the rat heart leads to transient vessel patterning
Eileen L. Brady, Mitchell A. Kirby, Emily Olszewski, Parker Grosjean, Fredrik Johansson, Jennifer Davis, Ruikang K. Wang, Kelly R. Stevens · 2020 · APL Bioengineering
Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering
Ana Catarina Santos, Yongjun Jang, Inwoo Son, Jongseong Kim, Yongdoo Park · 2021 · Micromachines
An Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach
Uwe Marx, Enrico Accastelli, Rhiannon M. David, Hendrik Erfurth, Leopold Koenig, Roland Lauster, Anja Patricia Ramme, Petra Reinke, Hans‐Dieter Volk, Annika Winter et al. · 2021 · Frontiers in Medicine
Scalable manufacturing of clinical‐grade differentiated cardiomyocytes derived from human‐induced pluripotent stem cells for regenerative therapy
Yuika Morita, Yoshikazu Kishino, Keiichi Fukuda, Shugo Tohyama · 2022 · Cell Proliferation
Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy
Takumi Kondo, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Satoki Nakamura et al. · 2022 · Circulation Genomic and Precision Medicine
BMP-SMAD signaling: From pluripotent stem cells to cardiovascular commitment
Valeria V. Orlova, Susana M. Chuva de Sousa Lopes, Guðrún Valdimarsdóttir · 2015 · Cytokine & Growth Factor Reviews
Cardiac Cell Cycle Activation as a Strategy to Improve iPSC-Derived Cardiomyocyte Therapy
June‐Wha Rhee, Joseph C. Wu · 2018 · Circulation Research
Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes
Cashman, John R., Ryan, Daniel, McKeithan, Wesley L., Okolotowicz, Karl, Gomez-Galeno, Jorge, Johnson, Mark, Sampson, Kevin J., Kass, Robert S., Pezhouman, Arash, Karagueuzian, Hrayr S. et al. · 2021 · Journal of Medicinal Chemistry
Engineering Cardiovascular Tissue Chips for Disease Modeling and Drug Screening Applications
Alex Chan, Ngan Fong Huang · 2021 · Frontiers in Bioengineering and Biotechnology
Non‐negative blind deconvolution for signal processing in a CRISPR‐edited iPSC‐cardiomyocyte model of dilated cardiomyopathy
Hang Xu, Ruheen Wali, Cleophas Cheruiyot, Jonathan F. E. Bodenschatz, Gerd P Hasenfuss, Andreas Janshoff, Michael Habeck, Antje Ebert · 2021 · FEBS Letters
shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele
Lucía Cócera Ortega, Ronald Wilders, Selina C. Kamps, Benedetta Fabrizi, Irit Huber, Ingeborg van der Made, Anouk van den Bout, Dylan K. de Vries, Lior Gepstein, Arie O. Verkerk et al. · 2022 · International Journal of Molecular Sciences
Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome
Yuejun Jessie Wang, Xicheng Zhang, Chi Keung Lam, Hongchao Guo, Cheng Wang, Sai Zhang, Joseph C. Wu, Michael P. Snyder, Jingjing Li · 2022 · Cell Systems
Engineering Alignment Has Mixed Effects on Human Induced Pluripotent Stem Cell Differentiated Cardiomyocyte Maturation
Nikhith Kalkunte, Talia Delambre, Sogu Sohn, Madison Pickett, Sapun H. Parekh, Janet Zoldan · 2023 · Tissue Engineering Part A
Genetic and Pharmacological YAP Activation Induces Proliferation and Improves Survival in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Thuỳ Anh Bùi, Nicholas Stafford, Delvac Oceandy · 2023 · Cells
Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays
Laura Paz-Artigas, Sandra González‐Lana, Nicolás Polo, Pedro Vicente, Pilar Montero‐Calle, M.Á. Martínez, Gregorio Rábago, Margarida Serra, Felipe Prósper, Manuel M. Mazo et al. · 2024 · ACS Biomaterials Science & Engineering
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development
Bettina Lickiss, Jan Hunker, Jamie R. Bhagwan, Peter Linder, Ulrich Thomas, Hardeep Lotay, Steven D. Broadbent, Elena Dragicevic, Sonja Stoelzle‐Feix, Jan Turner et al. · 2024 · Journal of Pharmacological and Toxicological Methods
Aminated graphene nanosheet stimulates the maturation of hiPSCs‐derived cardiomyocytes in vitro and enhances their survival in vivo
Yin Xu, Xvdong Wang, Zihao Wang, Qi Chen, Donghui Zhang, Nianguo Dong, Jianglin Wang · 2025 · BMEMat
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation
Maj Linea Vestergaard, Søren Grubb, Karen Koefoed, Zoe Anderson-Jenkins, Kristina Grunnet-Lauridsen, Kirstine Calløe, Christian Clausen, Søren T. Christensen, Kjeld Møllgård, Claus Yding Andersen · 2017 · Stem Cells and Development
Yes‐associated protein mediates human embryonic stem cell‐derived cardiomyocyte proliferation: Involvement of epidermal growth factor receptor signaling
Somi Park, Museog Choe, Hancheol Yeo, Ho Jae Han, Joong‐Sun Kim, Woochul Chang, Seungpil Yun, Ho‐Jin Lee, Min Young Lee · 2018 · Journal of Cellular Physiology
Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity
Luis Alberto Gonano, Marisa Sepúlveda, Malena Morell, Tamara Toteff, María Florencia Racioppi, Elena Catalina Lascano, Jorge A. Negroni, María Julieta Fernández Ruocco, Emiliano Horacio Medei, Gabriel Neiman et al. · 2018 · Circulation Journal
Tissue-specific promoter-based reporter system for monitoring cell differentiation from iPSCs to cardiomyocytes
Katarzyna Fiedorowicz, Natalia Rozwadowska, Agnieszka Zimna, Agnieszka Malcher, Katarzyna Tutak, Izabela Szczerbal, Karolina Nowicka-Bauer, Magdalena Nowaczyk, Tomasz Jan Kolanowski, Wojciech Łabędź et al. · 2020 · Scientific Reports
Xenogeneic-Free System for Biomanufacturing of Cardiomyocyte Progeny From Human Pluripotent Stem Cells
Preeti Ashok, Abhirath Parikh, Chuang Du, Emmanuel S. Tzanakakis · 2020 · Frontiers in Bioengineering and Biotechnology
Integrated Ca 2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes
Andrey Victorovich Malkovskiy, Nadezda Ignatyeva, Yuanyuan Dai, Gerd P Hasenfuss, Jayakumar Rajadas, Antje Ebert · 2020 · Biological Chemistry
The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity
Min Zhu, Yangong Liu, Yuanxiu Song, Shiqin Zhang, Chengwen Hang, Fujian Wu, Xianjuan Lin, Zeng‐Hui Huang, Feng Lan, Ming Xu · 2021 · Frontiers in Cardiovascular Medicine
Stimulating Calcium Handling in hiPSC-Derived Engineered Cardiac Tissues Enhances Force Production
Alicia J. Minor, Kareen L. K. Coulombe · 2022 · Stem Cells Translational Medicine
Optogenetic Control of Human Induced Pluripotent Stem Cell‐Derived Cardiac Tissue Models
Amit Gruber, Oded Edri, Shany Glatstein, Idit Goldfracht, Irit Huber, Gil Arbel, Amira Gepstein, Snizhana V. Chorna, Lior Gepstein · 2022 · Journal of the American Heart Association
The Human Induced Pluripotent Stem Cell Test as an Alternative Method for Embryotoxicity Testing
Saskia Galanjuk, Etta Zühr, Arif Dönmez, Deniz Bartsch, Leo Kurian, Julia Tigges, Ellen Fritsche · 2022 · International Journal of Molecular Sciences
Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability
Polakit Teekakirikul, Wenjuan Zhu, Xinxiu Xu, Cullen B. Young, Tuantuan Tan, Amanda M. Smith, Chengdong Wang, Kevin A. Peterson, George C. Gabriel, Sebastian Ho et al. · 2022 · Cell Reports Medicine
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential
Marissa Joy Stutzman, C.S. John Kim, David J. Tester, Samantha K. Hamrick, Steven Michael Dotzler, John R. Giudicessi, Marco Miotto, Jeevan B. GC, Joachim Frank, Andrew R. Marks et al. · 2022 · Stem Cell Reports
Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research
Alexander Goedel, Ilaria My, Daniel Sinnecker, Alessandra Moretti · 2017 · Current Cardiology Reports
Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges
Adrien Moreau, Mohamed Boutjdir, Mohamed Chahine · 2017 · Canadian Journal of Physiology and Pharmacology
Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells
Harshal Nemade, Aviseka Acharya, Umesh Chaudhari, Erastus Nembu Nembo, Filomain Nguemo, Nicole Riet, Hinrich Abken, Jürgen Hescheler, Symeon Papadopoulos, Agapios Sachinidis · 2020 · Cells
Cellular model systems to study cardiovascular injury from chemotherapy
Hananeh Fonoudi, Paul W. Burridge · 2020 · Journal of Thrombosis and Thrombolysis
Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
Shiqiao Ye, Xiaoping Wan, Juan Su, Akshar Patel, Blake S. Justis, Isabelle Deschênes, Mingtao Zhao · 2021 · Journal of Visualized Experiments
Mechanisms underlying diabetic cardiomyopathy: From pathophysiology to novel therapeutic targets.
Shuo Cong, Chrishan J. A. Ramachandra, K.P. Myu Mai Ja, Jonathan Yap, WINSTON S. N. SHIM, Lai Wei, Derek John Hausenloy · 2020 · PubMed
Pluripotent stem cells for skeletal tissue engineering
Miguel J. S. Ferreira, Fabrizio E. Mancini, Paul A. Humphreys, Leona Ogene, Michael Buckley, Marco A.N. Domingos, Susan J. Kimber · 2021 · Critical Reviews in Biotechnology
Characterization of the mechanism by which a nonsense variant in RYR2 leads to disordered calcium handling
Claire Hopton, Anke J. Tijsen, Leonid Maizels, Gil Arbel, Amira Gepstein, Nicola Bates, Benjamin Brown, Irit Huber, Susan J. Kimber, William G. Newman et al. · 2022 · Physiological Reports
Manipulating Cardiomyocyte Plasticity for Heart Regeneration
Toshiyuki Ko, Seitaro Nomura · 2022 · Frontiers in Cell and Developmental Biology
ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells
Chrishan J. A. Ramachandra, Ashish K. Mehta, Chong Hui Lua, Anuja Chitre, K.P. Myu Mai Ja, WINSTON S. N. SHIM · 2016 · Stem Cells
Letter by Murry et al Regarding Article, “Embryonic Stem Cell–Derived Cardiac Myocytes Are Not Ready for Human Trials”
Charles E. Murry, James J.H. Chong, Michael A. Laflamme · 2014 · Circulation Research
Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: piece by piece
David J. Lundy, Desy S. Lee, Patrick C.H. Hsieh · 2017 · Annals of Translational Medicine
Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions
Colin O’Hern, Sammantha Caywood, Shakhlo Aminova, Artem M. Kiselev, Brett D. Volmert, Fei Wang, Merlinda-Loriane Sewavi, Weiheng Cao, Mia Dionise, Priyadharshni Muniyandi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Integrating Hierarchical Vasculature into Engineered Cardiac Tissues
Richard Z. Zhuang, François Chesnais, Gordana Vunjak‐Novakovic · 2025 · Advanced Materials
Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Shanshan Gao, Lingaonan He, Chi Keung Lam, Matthew R.G. Taylor, Luisa Mestroni, Raffaella Lombardi, Suet Nee Chen · 2024 · Cells
Injectable biodegradable microcarriers for iPSC expansion and cardiomyocyte differentiation
Annalisa Bettini, Patrizia Camelliti, Daniel J. Stuckey, Richard M. Day · 2024 · Advanced Science
Protein-free media for cardiac differentiation of hPSCs in 2000 mL suspension culture
Nils Kriedemann, Felix Manstein, Carlos Alberto Hernandez-Bautista, Kevin Ullmann, Wiebke Triebert, Annika Franke, Mira Mertens, Inês Carvalheira Arnaut Pombeiro Stein, Andreas Leffler, Merlin Witte et al. · 2024 · Stem Cell Research & Therapy
Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation
Pedro Vicente, Lara R. Inocêncio, Asier Ullate‐Agote, Ana Filipa Louro, João P. Jacinto, Beatriz Gamelas, Olalla Iglesias‐García, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Gonzalo Ricardo Ríos-Muñoz et al. · 2025 · Advanced Science
Prime editing corrects the dilated cardiomyopathy causing RBM20-P633L-mutation in human cardiomyocytes
Alexandra Roman, Anja Zimmer, Michael Gotthardt, Lars Michael Steinmetz, Ralf Kühn, Tu Dang · 2025 · Molecular Therapy — Nucleic Acids
Cardiac differentiation at an initial low density of human-induced pluripotent stem cells
Minh Nguyen Tuyet Le, Mika Takahi, Kenshiro Maruyama, Akira Kurisaki, Kiyoshi Ohnuma · 2018 · In Vitro Cellular & Developmental Biology - Animal