Chemically defined generation of human cardiomyocytes

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947 · see citing works

Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1327 · Cited by 2,207 · see citing works

A more efficient method to generate integration-free human iPS cells

Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K.-I., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1591 · Cited by 2,061 · see citing works

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L. B., Azarin, S. M., Raval, K. K., Zhang, J., Kamp, T. J., & Palecek, S. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200250109 · Cited by 1,717 · see citing works

Chemically defined conditions for human iPSC derivation and culture

Chen, G., Gulbranson, D. R., Hou, Z., Bolin, J. M., Ruotti, V., Probasco, M. D., Smuga-Otto, K., Howden, S. E., Diol, N. R., Propson, N. E., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1593 · Cited by 1,447 · see citing works

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

FUSAKI, N., BAN, H., NISHIYAMA, A., SAEKI, K., & HASEGAWA, M. (2009) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.85.348 · Cited by 1,411 · see citing works

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008) · Nature · doi:10.1038/nature06894 · Cited by 1,389 · see citing works

Heart regeneration

Laflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,231 · see citing works

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., & Keller, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.008 · Cited by 1,159 · see citing works

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.09.013 · Cited by 1,045 · see citing works

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

Blaschke, K., Ebata, K. T., Karimi, M. M., Zepeda-Martínez, J. A., Goyal, P., Mahapatra, S., Tam, A., Laird, D. J., Hirst, M., Rao, A., et al. (2013) · Nature · doi:10.1038/nature12362 · Cited by 865 · see citing works

Culture of Normal Human Leukocytes

Moore, G. E. (1967) · JAMA · doi:10.1001/jama.1967.03120080053007 · Cited by 777 · see citing works

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming

Burridge, P. W., Keller, G., Gold, J. D., & Wu, J. C. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.12.013 · Cited by 670 · see citing works

Intracellular recording of action potentials by nanopillar electroporation

Xie, C., Lin, Z. C., Hanson, L., Cui, Y., & Cui, B. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.8 · Cited by 592 · see citing works

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

Rodin, S., Domogatskaya, A., Ström, S., Hansson, E. M., Chien, K. R., Inzunza, J., Hovatta, O., & Tryggvason, K. (2010) · Nature Biotechnology · doi:10.1038/nbt.1620 · Cited by 554 · see citing works

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

Chou, B.-K., Mali, P., Huang, X., Ye, Z., Dowey, S. N., Resar, L. M. S., Zou, C., Zhang, Y. A., Tong, J., & Cheng, L. (2011) · Cell Research · doi:10.1038/cr.2011.12 · Cited by 482 · see citing works

Ascorbic Acid Enhances Differentiation of Embryonic Stem Cells Into Cardiac Myocytes

Takahashi, T., Lord, B., Schulze, P. C., Fryer, R. M., Sarang, S. S., Gullans, S. R., & Lee, R. T. (2003) · Circulation · doi:10.1161/01.cir.0000064899.53876.a3 · Cited by 478 · see citing works

Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells

Melkoumian, Z. K., Weber, J. L., Weber, D. M., Fadeev, A. G., Zhou, Y., Dolley-Sonneville, P., Yang, J., Qiu, L., Priest, C. A., Shogbon, C., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1629 · Cited by 446 · see citing works

Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells

Zhang, J., Klos, M., Wilson, G. F., Herman, A. M., Lian, X. L., Raval, K. K., Barron, M., Hou, L., Soerens, A. G., Yu, J., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.273144 · Cited by 445 · see citing works

Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin

Braam, S. R., Zeinstra, L. M., Litjens, S. H. M., Oostwaard, D. W., van den Brink, S., Laake, L. W. V., Lebrin, F., Kats, P., Hochstenbach, R., Passier, R. C., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0291 · Cited by 433 · see citing works

NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes

Elliott, D. A., Braam, S. R., Koutsis, K., Ng, E. S., Jenny, R., Lagerqvist, E. L., Biben, C., Hatzistavrou, T., Hirst, C. E., Yu, Q. C., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1740 · Cited by 426 · see citing works

A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability

Burridge, P. W., Thompson, S. A., Millrod, M. A., Weinberg, S. H., Yuan, X., Peters, A., Mahairaki, V., Koliatsos, V. E., Tung, L., & Zambidis, E. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018293 · Cited by 420 · see citing works

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

Mali, P., Chou, B.-K., Yen, J., Ye, Z., Zou, J., Dowey, S., Brodsky, R. A., Ohm, J. E., Yu, W., Baylin, S. B., et al. (2010) · Stem Cells · doi:10.1002/stem.402 · Cited by 417 · see citing works

Functional Diversity of Laminins

Domogatskaya, A., Rodin, S., & Tryggvason, K. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155750 · Cited by 396 · see citing works

Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen

Brewer, G. J., & Cotman, C. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)90144-3 · Cited by 376 · see citing works

Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells

Miyazaki, T., Futaki, S., Suemori, H., Taniguchi, Y., Yamada, M., Kawasaki, M., Hayashi, M., Kumagai, H., Nakatsuji, N., Sekiguchi, K., et al. (2012) · Nature Communications · doi:10.1038/ncomms2231 · Cited by 368 · see citing works

Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals

Zhang, Q., Jiang, J., Han, P., Yuan, Q., Zhang, J., Zhang, X., Xu, Y., Cao, H., Meng, Q., Chen, L., et al. (2010) · Cell Research · doi:10.1038/cr.2010.163 · Cited by 368 · see citing works

Albumin and Mammalian cell culture: implications for biotechnology applications

Francis, G. L. (2010) · Cytotechnology · doi:10.1007/s10616-010-9263-3 · Cited by 330 · see citing works

A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies

Ng, E. S., Davis, R. P., Stanley, E. G., & Elefanty, A. G. (2008) · Nature Protocols · doi:10.1038/nprot.2008.42 · Cited by 327 · see citing works

Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V-96 Plate Aggregation System Highlights Interline Variability

Burridge, P. W., Anderson, D., Priddle, H., Muñoz, M. D. B., Chamberlain, S. R., Allegrucci, C., Young, L. E., & Denning, C. N. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0598 · Cited by 301 · see citing works

Efficient and Scalable Purification of Cardiomyocytes from Human Embryonic and Induced Pluripotent Stem Cells by VCAM1 Surface Expression

Uosaki, H., Fukushima, H., Takeuchi, A., Matsuoka, S., Nakatsuji, N., Yamanaka, S., & Yamashita, J. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023657 · Cited by 299 · see citing works

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment

Rodin, S., Antonsson, L., Niaudet, C., Simonson, O. E., Salmela, E., Hansson, E. M., Domogatskaya, A., Xiao, Z., Damdimopoulou, P., Sheikhi, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4195 · Cited by 293 · see citing works

Endogenous Wnt/β-Catenin Signaling Is Required for Cardiac Differentiation in Human Embryonic Stem Cells

Paige, S. L., Osugi, T., Afanasiev, O. K., Pabon, L., Reinecke, H., & Murry, C. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011134 · Cited by 274 · see citing works

Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials

Lin, Z. C., Xie, C., Osakada, Y., Cui, Y., & Cui, B. (2014) · Nature Communications · doi:10.1038/ncomms4206 · Cited by 249 · see citing works

A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions

Minami, I., Yamada, K., Otsuji, T. G., Yamamoto, T., Shen, Y., Otsuka, S., Kadota, S., Morone, N., Barve, M. P., Asai, Y., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.015 · Cited by 248 · see citing works

Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK

Graichen, R., Xu, X., Braam, S. R., Balakrishnan, T., Rahmat, S. N. B., Sieh, S., Soo, S. Y., Tham, S. C., Mummery, C. L., Colman, A., et al. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00236.x · Cited by 245 · see citing works

Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells

Cao, N., Liu, Z., Chen, Z., Wang, J., Chen, T., Zhao, X., Ma, Y., Qin, L., Kang, J., Wei, B. K., et al. (2011) · Cell Research · doi:10.1038/cr.2011.195 · Cited by 240 · see citing works

Human Stem Cells for Modeling Heart Disease and for Drug Discovery

Matsa, E., Burridge, P. W., & Wu, J. C. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008921 · Cited by 210 · see citing works

Culture of human pluripotent stem cells using completely defined conditions on a recombinant E-cadherin substratum

Nagaoka, M., Si‐Tayeb, K., Akaike, T., & Duncan, S. A. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-60 · Cited by 192 · see citing works

The human adult cardiomyocyte phenotype

Bird, S. D. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00253-0 · Cited by 190 · see citing works

Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I.

Martin, A. F. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70073-8 · Cited by 151 · see citing works

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

Willems, E., Cabral-Teixeira, J., Schade, D., Cai, W., Reeves, P. M., Bushway, P., Lanier, M. C., Walsh, C., Kirchhausen, T. L., Belmonte, J. C. I., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.025 · Cited by 139 · see citing works

Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies

Ng, S. Y., Wong, C. K., & Tsang, S. Y. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00402.2009 · Cited by 125 · see citing works

Efficient Differentiation of Human Induced Pluripotent Stem Cells Generates Cardiac Cells That Provide Protection Following Myocardial Infarction in the Rat

Carpenter, L., Carr, C. A., Yang, C. T., Stuckey, D. J., Clarke, K. J., & Watt, S. M. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0075 · Cited by 94 · see citing works

Patterning the heart, a template for human cardiomyocyte development

Lopes, S. M. C. D. S., Hassink, R. J., Feijen, A., van Rooijen, M. A., Doevendans, P. A., Tertoolen, L. G. J., de la Rivière, A. B., & Mummery, C. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20830 · Cited by 71 · see citing works

Defining a Threshold Surface Density of Vitronectin for the Stable Expansion of Human Embryonic Stem Cells

Yap, L., Li, J., Phang, I. Y., Ong, L. T., Ow, J. Z.-E., Goh, J., Nurcombe, V., Hobley, J., Choo, A. B. H., Oh, S. K. W., et al. (2010) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2010.0328 · Cited by 51 · see citing works

Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation

Titmarsh, D. M., Hudson, J. E., Hidalgo, A., Elefanty, A. G., Stanley, E. G., Wolvetang, E. J., & Cooper-White, J. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052405 · Cited by 48 · see citing works

Enhanced Connexin-43 and α-Sarcomeric Actin Expression in Cultured Heart Myocytes Exposed to Triiodo-l-thyronine

Tribulová, N., Shneyvays, V., Mamedova, L. K., Moshel, S., Zinman, T., Shainberg, A., Manoach, M., Weismann, P., & Sawa Kostin, D. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000045945.16046.b5 · Cited by 29 · see citing works

Human Embryonic Stem Cell-Derived Cardiomyocytes Migrate in Response to Gradients of Fibronectin and Wnt5a

Moyes, K. W., Sip, C. G., Obenza, W., Yang, E., Horst, C., Welikson, R. E., Hauschka, S. D., Folch, A., & Laflamme, M. A. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0586 · Cited by 29 · see citing works

Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased β-myosin heavy chain gene expression

Wang, B., Ouyang, J., & Xia, Z. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-043 · Cited by 28 · see citing works

3D bioprinting of collagen to rebuild components of the human heart

Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G., & Feinberg, A. W. (2019) · Science · doi:10.1126/science.aav9051 · Cited by 1,782 · see citing works

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

Burridge, P. W., Li, Y. F., Matsa, E., Wu, H., Ong, S., Sharma, A., Holmström, A., Chang, A. C. Y., Coronado, M. J., Ebert, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4087 · Cited by 746 · see citing works

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

Tiburcy, M., Hudson, J. E., Balfanz, P., Schlick, S. F., Meyer, T., Liao, M.-L. C., Levent, E., Raad, F. S., Zeidler, S., Wingender, E., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024145 · Cited by 650 · see citing works

The Translational Landscape of the Human Heart

van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J. F., Adami, E., Faber, A. B., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.-L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.010 · Cited by 619 · see citing works

Cardioids reveal self-organizing principles of human cardiogenesis

Hofbauer, P., Jahnel, S. M., Papai, N., Giesshammer, M., Deyett, A., Schmidt, C., Penc, M., Tavernini, K., Grdseloff, N., Meledeth, C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.034 · Cited by 588 · see citing works

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Lewis-Israeli, Y. R., Wasserman, A. H., Gabalski, M. A., Volmert, B. D., Ming, Y., Ball, K. A., Yang, W., Zou, J., Ni, G., Pajares, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25329-5 · Cited by 536 · see citing works

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research · doi:10.1161/circresaha.117.305365 · Cited by 478 · see citing works

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

Loh, K. M., Chen, A. C., Koh, P. W., Deng, T. Z., Sinha, R., Tsai, J. M., Barkal, A. A., Shen, K., Jain, R., Morganti, R. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.011 · Cited by 493 · see citing works

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, R. J., Titmarsh, D. M., Koenig, X., Parker, B. L., Ryall, J. G., Quaife-Ryan, G. A., Voges, H. K., Hodson, M. P., Ferguson, C., Drowley, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707316114 · Cited by 478 · see citing works

Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine

Gao, L., Gregorich, Z. R., Zhu, W., Mattapally, S., Oduk, Y., Lou, X., Kannappan, R., Borovjagin, A. V., Walcott, G. P., Pollard, A. E., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.030785 · Cited by 465 · see citing works

Human heart-forming organoids recapitulate early heart and foregut development

Drakhlis, L., Biswanath, S., Farr, C.-M., Lupanow, V., Teske, J., Ritzenhoff, K., Franke, A., Manstein, F., Bolesani, E., Kempf, H., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00815-9 · Cited by 452 · see citing works

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Sharma, A., Burridge, P. W., McKeithan, W. L., Serrano, R., Shukla, P., Sayed, N., Churko, J. M., Kitani, T., Wu, H., Holmström, A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2584 · Cited by 404 · see citing works

Spatially resolved multiomics of human cardiac niches

Kanemaru, K., Cranley, J., Muraro, D., Miranda, A. M. A., Ho, S. Y., Wilbrey-Clark, A., Patrick Pett, J., Polanski, K., Richardson, L., Litvinukova, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06311-1 · Cited by 425 · see citing works

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

Shadrin, I. Y., Allen, B. W., Qian, Y., Jackman, C. P., Carlson, A. L., Juhas, M. E., & Bursac, N. (2017) · Nature Communications · doi:10.1038/s41467-017-01946-x · Cited by 420 · see citing works

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations

Lee, J. H., Protze, S. I., Laksman, Z., Backx, P. H., & Keller, G. M. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.003 · Cited by 404 · see citing works

Organ-on-a-chip devices advance to market

Zhang, B., & Radisic, M. (2017) · Lab on a Chip · doi:10.1039/c6lc01554a · Cited by 437 · see citing works

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

Protze, S. I., Liu, J., Nussinovitch, U., Ohana, L., Backx, P. H., Gepstein, L., & Keller, G. M. (2017) · Nature Biotechnology · doi:10.1038/nbt.3745 · Cited by 366 · see citing works

Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

Hoes, M. F., Grote Beverborg, N., Kijlstra, J. D., Kuipers, J., Swinkels, D. W., Giepmans, B. N. G., Rodenburg, R. J., van Veldhuisen, D. J., de Boer, R. A., & van der Meer, P. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1154 · Cited by 333 · see citing works

Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform

Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S. A., George, V., Kalra, S., Kondrashov, A., Hoang, M. D., Mosqueira, D., Patel, A., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.014 · Cited by 293 · see citing works

Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes

Cyganek, L., Tiburcy, M., Sekeres, K., Gerstenberg, K., Bohnenberger, H., Lenz, C., Henze, S., Stauske, M., Salinas, G., Zimmermann, W., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99941 · Cited by 295 · see citing works

Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery

Sharma, A., Sances, S., Workman, M. J., & Svendsen, C. N. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.011 · Cited by 296 · see citing works

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295 · see citing works

Differentiation of cardiomyocytes and generation of human engineered heart tissue

Breckwoldt, K., Letuffe-Brenière, D., Mannhardt, I., Schulze, T., Ulmer, B., Werner, T., Benzin, A., Klampe, B., Reinsch, M. C., Laufer, S., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.033 · Cited by 272 · see citing works

Translation of Human iPSCs: From Clinical Trial in a Dish to Precision Medicine

Sayed, N., Liu, C., & Wu, J. C. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.083 · Cited by 263 · see citing works

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation

Friedman, C. E., Nguyen, Q., Lukowski, S. W., Helfer, A., Chiu, H. S., Miklas, J., Levy, S., Suo, S., Han, J.-D. J., Osteil, P., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.09.009 · Cited by 258 · see citing works

Induced Pluripotent Stem Cells 10 Years Later

Yoshida, Y., & Yamanaka, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.311080 · Cited by 266 · see citing works

Molecular mechanisms of arrhythmogenic cardiomyopathy

Austin, K. M., Trembley, M. A., Chandler, S. F., Sanders, S. P., Saffitz, J. E., Abrams, D. J., & Pu, W. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0200-7 · Cited by 265 · see citing works

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

Goldfracht, I., Protze, S. I., Shiti, A., Setter, N., Gruber, A., Shaheen, N., Nartiss, Y., Keller, G. M., & Gepstein, L. (2020) · Nature Communications · doi:10.1038/s41467-019-13868-x · Cited by 260 · see citing works

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs

Broto, M., Kaminski, M. M., Adrianus, C., Kim, N., Greensmith, R., Dissanayake-Perera, S., Schubert, A. J., Tan, X., Kim, H., Dighe, A. S., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01179-0 · Cited by 254 · see citing works

Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues

Feric, N. T., & Radisic, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.019 · Cited by 247 · see citing works

A Brief Review of Current Maturation Methods for Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes

Ahmed, R. E., Anzai, T., Chanthra, N., & Uosaki, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00178 · Cited by 245 · see citing works

Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing

Chemello, F., Chai, A. C., Li, H. Z., Rodríguez-Caycedo, C., Sanchez‐Ortiz, E., Atmanli, A., Mireault, A. A., Liu, N., Bassel‐Duby, R., & Olson, E. N. (2021) · Science Advances · doi:10.1126/sciadv.abg4910 · Cited by 250 · see citing works

Dynamic genetic regulation of gene expression during cellular differentiation

Strober, B. J., Elorbany, R., Rhodes, K., Krishnan, N., Tayeb, K., Battle, A., & Gilad, Y. (2019) · Science · doi:10.1126/science.aaw0040 · Cited by 219 · see citing works

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

Churko, J. M., Garg, P., Treutlein, B., Venkatasubramanian, M., Wu, H., Lee, J., Wessells, Q. N., Chen, S.-Y., Chen, W.-Y., Chetal, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07333-4 · Cited by 207 · see citing works

CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice

Zhang, Y., Long, C., Li, H. Z., McAnally, J., Baskin, K. K., Shelton, J. M., Bassel‐Duby, R., & Olson, E. N. (2017) · Science Advances · doi:10.1126/sciadv.1602814 · Cited by 228 · see citing works

Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association

Musunuru, K., Sheikh, F., Gupta, R. M., Houser, S. R., Maher, K. O., Milan, D. J., Terzic, A., & Wu, J. C. (2018) · Circulation Genomic and Precision Medicine · doi:10.1161/hcg.0000000000000043 · Cited by 230 · see citing works

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., et al. (2019) · Nature · doi:10.1038/s41586-019-1406-x · Cited by 222 · see citing works

Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Park, S., Kim, R. Y., Park, B., Lee, S.-H., Choi, S. W., Park, J.-H., Choi, J. J., Kim, S.-W., Jang, J., Cho, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11091-2 · Cited by 221 · see citing works

Patient and Disease–Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics

Paik, D. T., Chandy, M., & Wu, J. C. (2019) · Pharmacological Reviews · doi:10.1124/pr.116.013003 · Cited by 216 · see citing works

Oligogenic inheritance of a human heart disease involving a genetic modifier

Gifford, C. A., Ranade, S. S., Samarakoon, R., Salunga, H. T., de Soysa, Y., Huang, Y., Zhou, P., Elfenbein, A., Wyman, S. K., Bui, Y. K., et al. (2019) · Science · doi:10.1126/science.aat5056 · Cited by 216 · see citing works

Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers

Gu, M., Shao, N., Sa, S., Li, D., Termglinchan, V., Ameen, M., Karakikes, I., Sosa, G., Grubert, F., Lee, J., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.019 · Cited by 213 · see citing works

Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation

Castilho, M. D., van Mil, A., Maher, M., Metz, C. H. G., Hochleitner, G., Gröll, J., Doevendans, P. A., Ito, K., Sluijter, J. P. G., & Malda, J. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201803151 · Cited by 206 · see citing works

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

Goldfracht, I., Efraim, Y., Shinnawi, R., Kovalev, E., Huber, I., Gepstein, A., Arbel, G., Shaheen, N., Tiburcy, M., Zimmermann, W. H., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.016 · Cited by 222 · see citing works

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease

Hall, C., Gehmlich, K., Denning, C. N., & Pavlović, D. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019338 · Cited by 207 · see citing works

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer

Kitani, T., Ong, S.-G., Lam, C. K., Rhee, J.-W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037357 · Cited by 200 · see citing works

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

Chen, I. Y., Matsa, E., & Wu, J. C. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.36 · Cited by 191 · see citing works

Principles of pharmacology in the eye

Awwad, S., Mohamed Ahmed, A. H. A., Sharma, G., Heng, J. S., Khaw, P. T., Brocchini, S., & Lockwood, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14024 · Cited by 224 · see citing works

Lymphoangiocrine signals promote cardiac growth and repair

Liu, X., de la Cruz, E., Gu, X., Bálint, L., Oxendine, M., Terrones, T. S., Ma, W., Kuo, H., Lantz, C. W., Bansal, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2998-x · Cited by 203 · see citing works

A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

Romero, I. G., Pavlovic, B. J., Hernando-Herraez, I., Zhou, X., Ward, M. C., Banovich, N. E., Kagan, C. L., Burnett, J. E., Huang, C. H., Mitrano, A., et al. (2015) · eLife · doi:10.7554/elife.07103 · Cited by 194 · see citing works

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

Bargehr, J., Ong, L. P., Colzani, M., Davaapil, H., Hofsteen, P., Bhandari, S., Gambardella, L., Le Novère, N., Iyer, D., Sampaziotis, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0197-9 · Cited by 195 · see citing works

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

Palpant, N. J., Pabon, L., Friedman, C. E., Redd, M. A., Hadland, B., Zaunbrecher, R. J., Bernstein, I. D., Zheng, Y. Y., & Murry, C. E. (2016) · Nature Protocols · doi:10.1038/nprot.2016.153 · Cited by 195 · see citing works

In vitro cardiac tissue models: Current status and future prospects

Mathur, A., Ma, Z., Loskill, P., Jeeawoody, S., & Healy, K. E. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.011 · Cited by 187 · see citing works

Human engineered heart tissue as a model system for drug testing

Eder, A., Vollert, I., Hansen, A., & Eschenhagen, T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.010 · Cited by 190 · see citing works

Understanding the extracellular forces that determine cell fate and maintenance

Kumar, A., Placone, J. K., & Engler, A. J. (2017) · Development · doi:10.1242/dev.158469 · Cited by 175 · see citing works

Dynamic culture yields engineered myocardium with near-adult functional output

Jackman, C. P., Carlson, A. L., & Bursac, N. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.024 · Cited by 188 · see citing works

Regenerating the field of cardiovascular cell therapy

Chien, K. R., Frisén, J., Fritsche‐Danielson, R., Melton, D. A., Murry, C. E., & Weissman, I. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0042-1 · Cited by 185 · see citing works

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model

Choi, I. Y., Lim, H., Estrellas, K. M., Mula, J., Cohen, T. V., Zhang, Y., Donnelly, C. J., Richard, J., Kim, Y. J., Kim, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.016 · Cited by 186 · see citing works

Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells

Burridge, P. W., Holmström, A., & Wu, J. C. (2015) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg2103s87 · Cited by 185 · see citing works

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

Maillet, A., Tan, K. P., Chai, X., Sadananda, S. N., Mehta, A. K., Ooi, J., Hayden, M. R., Pouladi, M. A., Ghosh, S., SHIM, W. S. N., et al. (2016) · Scientific Reports · doi:10.1038/srep25333 · Cited by 184 · see citing works

Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice

Chai, A. C., Cui, M., Chemello, F., Li, H. Z., Chen, K., Tan, W. H., Atmanli, A., McAnally, J., Zhang, Y., Xu, L., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02176-5 · Cited by 187 · see citing works

3D Bioprinting of Engineered Tissue Flaps with Hierarchical Vessel Networks (VesselNet) for Direct Host‐To‐Implant Perfusion

Szklanny, A. A., Machour, M., Redenski, I., Chochola, V., Goldfracht, I., Kaplan, B., Epshtein, M., Yameen, H. S., Merdler, U., Feinberg, A. W., et al. (2021) · Advanced Materials · doi:10.1002/adma.202102661 · Cited by 180 · see citing works

Challenges and opportunities for the next generation of cardiovascular tissue engineering

Cho, S., Discher, D. E., Leong, K. W., Vunjak-Novakovic, G., & Wu, J. C. (2022) · Nature Methods · doi:10.1038/s41592-022-01591-3 · Cited by 176 · see citing works

Matrigel Mattress

Feaster, T. K., Cadar, A. G., Wang, L., Williams, C. H., Chun, Y. W., Hempel, J. E., Bloodworth, N. C., Merryman, W. D., Lim, C. C., Wu, J. C., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.307580 · Cited by 178 · see citing works

Engineering a perfusable 3D human liver platform from iPS cells

Schepers, A. G., Li, C. Y., Chhabra, A., Tschudy-Seney, B., & Bhatia, S. N. (2016) · Lab on a Chip · doi:10.1039/c6lc00598e · Cited by 174 · see citing works

Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells

Chen, V. C., Ye, J., Shukla, P., Hua, G., Chen, D., Lin, Z., Liu, J., Chai, J., Gold, J., Wu, J. C., et al. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.08.002 · Cited by 174 · see citing works

Human Pluripotent Stem Cell-Derived Cardiovascular Cells: From Developmental Biology to Therapeutic Applications

Protze, S. I., Lee, J. H., & Keller, G. M. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.07.010 · Cited by 162 · see citing works

Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome

Miao, Y., Tian, L., Martin, M., Paige, S. L., Galdos, F. X., Li, J., Klein, A., Zhang, H., Ma, N., Wei, Y., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.015 · Cited by 173 · see citing works

Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording

Zhao, Y., You, S. S., Zhang, A., Lee, J., Huang, J., & Lieber, C. M. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0478-y · Cited by 172 · see citing works

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy

Kodo, K., Ong, S., Jahanbani, F., Termglinchan, V., Hirono, K., InanlooRahatloo, K., Ebert, A., Shukla, P., Abilez, O. J., Churko, J. M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3411 · Cited by 171 · see citing works

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types

Panopoulos, A. D., D’Antonio, M., Benaglio, P., Williams, R. M., Hashem, S. I., Schuldt, B. M., DeBoever, C., Arias, A. D., Garcia, M., Nelson, B., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.012 · Cited by 162 · see citing works

Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

Bertero, A., Fields, P., Ramani, V., Bonora, G., Yardımcı, G. G., Reinecke, H., Pabon, L., Noble, W. S., Shendure, J., & Murry, C. E. (2019) · Nature Communications · doi:10.1038/s41467-019-09483-5 · Cited by 165 · see citing works

Paracrine Effects of the Pluripotent Stem Cell-Derived Cardiac Myocytes Salvage the Injured Myocardium

Tachibana, A., Santoso, M. R., Mahmoudi, M., Shukla, P., Wang, L., Bennett, M. V., Goldstone, A. B., Wang, M., Fukushi, M., Ebert, A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.310803 · Cited by 169 · see citing works

Hurdles to clinical translation of human induced pluripotent stem cells

Neofytou, E. A., O’Brien, C., Couture, L. A., & Wu, J. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80575 · Cited by 166 · see citing works

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders

Calo, E., Gu, B., Bowen, M. E., Aryan, F., Zalc, A., Liang, J., Flynn, R. A., Swigut, T., Chang, H. Y., Attardi, L. D., et al. (2018) · Nature · doi:10.1038/nature25449 · Cited by 167 · see citing works

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories

Hwang, H. S., Kryshtal, D. O., Feaster, T. K., Sánchez-Freire, V., Zhang, J., Kamp, T. J., Hong, C. C., Wu, J. C., & Knollmann, B. C. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.05.003 · Cited by 173 · see citing works

Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies

Tzatzalos, E., Abilez, O. J., Shukla, P., & Wu, J. C. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.010 · Cited by 162 · see citing works

Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells

Hoang, P., Wang, J., Conklin, B. R., Healy, K. E., & Ma, Z. (2018) · Nature Protocols · doi:10.1038/nprot.2018.006 · Cited by 156 · see citing works

Cardiac differentiation of human pluripotent stem cells in scalable suspension culture

Kempf, H., Kropp, C., Olmer, R., Martin, U., & Zweigerdt, R. (2015) · Nature Protocols · doi:10.1038/nprot.2015.089 · Cited by 161 · see citing works

Chemically defined, albumin-free human cardiomyocyte generation

Lian, X., Bao, X., Zilberter, M., Westman, M., Fisahn, A., Hsiao, C., Hazeltine, L. B., Dunn, K. K., Kamp, T. J., & Palecek, S. P. (2015) · Nature Methods · doi:10.1038/nmeth.3448 · Cited by 159 · see citing works

Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association

Gintant, G. A., Burridge, P. W., Gepstein, L., Harding, S. E., Herron, T. J., Hong, C. C., Jalife, J., & Wu, J. C. (2019) · Circulation Research · doi:10.1161/res.0000000000000291 · Cited by 160 · see citing works

Cardiomyocyte renewal in the human heart: insights from the fall-out

Lázár, E., Sadek, H. A., & Bergmann, O. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx343 · Cited by 159 · see citing works

Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling

Abilez, O. J., Tzatzalos, E., Yang, H., Zhao, M., Jung, G., Zöllner, A. M., Tiburcy, M., Riegler, J., Matsa, E., Shukla, P., et al. (2017) · Stem Cells · doi:10.1002/stem.2732 · Cited by 156 · see citing works

Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture

Kuo, H., Gao, X., DeKeyser, J., Fetterman, K. A., Pinheiro, E. A., Weddle, C. J., Fonoudi, H., Orman, M. V., Romero‐Tejeda, M., Jouni, M., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.12.007 · Cited by 154 · see citing works

Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions

Yamakawa, H., Muraoka, N., Miyamoto, K., Sadahiro, T., Isomi, M., Haginiwa, S., Kojima, H., Umei, T. C., Akiyama, M., Kuishi, Y., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.10.019 · Cited by 153 · see citing works

Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening

Smith, A. S. T., Macadangdang, J., Leung, W., Laflamme, M., & Kim, D.-H. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.002 · Cited by 137 · see citing works

Selenium and Outcome in Heart Failure

Bömer, N., Beverborg, N. G., Hoes, M. F., Streng, K. W., Vermeer, M. C. S. C., Dokter, M. M., IJmker, J., Anker, S. D., Cleland, J. G. F., Hillege, H. L., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1644 · Cited by 153 · see citing works

Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring

Cao, Y., Hjort, M., Chen, H., Birey, F., Leal‐Ortiz, S., Han, C. M., Santiago, J. G., Pașca, S. P., Wu, J. C., & Melosh, N. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615375114 · Cited by 151 · see citing works

An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium

Yang, H., Qin, X., Wang, H., Zhao, X., Liu, Y., Wo, H.-T., Liu, C., Nishiga, M., Chen, H., Ge, J., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03343 · Cited by 147 · see citing works

Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes

Lü, S., Liao, Z., Lu, X., Katschinski, D. M., Mercola, M. A., Chen, J., Brown, J. H., Molkentin, J. D., Bossuyt, J., & Bers, D. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.316288 · Cited by 150 · see citing works

A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation

Sakamoto, T., Matsuura, T. R., Wan, S., Ryba, D. M., Kim, J., Won, K., Lai, L., Petucci, C. J., Petrenko, N. B., Musunuru, K., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316100 · Cited by 148 · see citing works

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

Cui, M., Atmanli, A., Morales, M. G., Tan, W. H., Chen, K., Xiao, X., Xu, L., Liu, N., Bassel‐Duby, R., & Olson, E. N. (2021) · Nature Communications · doi:10.1038/s41467-021-25653-w · Cited by 148 · see citing works

Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype

Ronaldson-Bouchard, K., Yeager, K., Teles, D., Chen, T., Ma, S., Song, L., Morikawa, K., Wobma, H. M., Vasciaveo, A., Ruiz, E. C., et al. (2019) · Nature Protocols · doi:10.1038/s41596-019-0189-8 · Cited by 144 · see citing works

A promoter interaction map for cardiovascular disease genetics

Montefiori, L. E., Sobreira, D. R., Sakabe, N. J., Aneas, I., Joslin, A. C., Hansen, G. T., Bozek, G., Moskowitz, I. P., McNally, E. M., & Nóbrega, M. A. (2018) · eLife · doi:10.7554/elife.35788 · Cited by 145 · see citing works

Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity

Sharma, A., McKeithan, W. L., Serrano, R., Kitani, T., Burridge, P. W., del Álamo, J. C., Mercola, M. A., & Wu, J. C. (2018) · Nature Protocols · doi:10.1038/s41596-018-0076-8 · Cited by 141 · see citing works

Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering

Tenreiro, M. F., Louro, A. F., Alves, P. M., & Serra, M. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00140-4 · Cited by 145 · see citing works

Multiscale technologies for treatment of ischemic cardiomyopathy

Mahmoudi, M., Yu, M., Serpooshan, V., Wu, J. C., Langer, R., Lee, R. T., Karp, J. M., & Farokhzad, O. C. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.167 · Cited by 138 · see citing works

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Barc, J., Tadros, R., Glinge, C., Chiang, D. Y.-E., Jouni, M., Simonet, F., Jurgens, S. J., Baudic, M., Nicastro, M., Potet, F., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-01007-6 · Cited by 139 · see citing works

Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair

Hartman, M. E., Dai, D., & Laflamme, M. A. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.004 · Cited by 140 · see citing works

A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming

Lyra‐Leite, D. M., Gutiérrez‐Gutiérrez, Ó., Wang, M., Zhou, Y., Cyganek, L., & Burridge, P. W. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101560 · Cited by 136 · see citing works

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype

Bliley, J. M., Vermeer, M. C. S. C., Duffy, R. M., Batalov, I., Kramer, D., Tashman, J. W., Shiwarski, D. J., Lee, A. R., Teplenin, A. S., Volkers, L., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd1817 · Cited by 134 · see citing works

Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells

Zanella, F., & Sheikh, F. (2014) · Methods in molecular biology · doi:10.1007/7651_2014_172 · Cited by 9 · see citing works

[MDC_Alternative_2D_hiPSC-CM_diff] hiPSC Cardiomyocyte differentiation v2Preprint

Ueda, Y., & Genehr, C. (2025) · doi:10.17504/protocols.io.14egn9p8yl5d/v1

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions

van den Berg, C. W., Elliott, D. A., Braam, S. R., Mummery, C. L., & Davis, R. P. (2014) · Methods in molecular biology · doi:10.1007/7651_2014_178 · Cited by 59 · see citing works

The impact of growth factors on human induced pluripotent stem cells differentiation into cardiomyocytes

Yassa, M. E., Mansour, I., Sewelam, N. I., Hamza, H., & Gaafar, T. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.009 · Cited by 15 · see citing works

Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells in Fully Chemically Defined Conditions

Lin, Y., & Zou, J. (2020) · STAR Protocols · doi:10.1016/j.xpro.2020.100015 · Cited by 43 · see citing works