Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

Thakore, Pratiksha I, D'Ippolito, Anthony M, Song, Lingyun, Safi, Alexias, Shivakumar, Nishkala K, Kabadi, Ami M, Reddy, Timothy E, Crawford, Gregory E +1 more·2015·Nature Methods

DOI 10.1038/nmeth.3630

Cited by (1,000)

Items 201–300 of 1,000

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Vijay Ramani, Jay Shendure, Zhijun Duan · 2016 · Genomics Proteomics & Bioinformatics
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Shaunak Sanjay Adkar, Jonathan M. Brunger, Vincent P. Willard, Chia‐Lung Wu, Charles A. Gersbach, Farshid Guilak · 2017 · Trends in Molecular Medicine
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Neelam Soda, Lokesh Verma, Jitender Giri · 2017 · Plant Physiology and Biochemistry
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Hui He, Zhiping Hu, Xiao Han, Fangfang Zhou, Binbin Yang · 2018 · Human Genomics
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Daniel Aldea, Yuji Atsuta, Blerina Kokalari, Stephen F. Schaffner, Rexxi D. Prasasya, Adam Aharoni, Heather L. Dingwall, Bailey N. Warder, Yana G. Kamberov · 2021 · Proceedings of the National Academy of Sciences
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Tycko, Josh, Van, Mike V., Aradhana, DelRosso, Nicole, Ye, Hanrong, Yao, David, Valbuena, Raeline, Vaughan-Jackson, Alun, Xu, Xiaoshu, Ludwig, Connor et al. · 2025 · Nature Biotechnology
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Fabian Erdel, Eric C. Greene · 2016 · Proceedings of the National Academy of Sciences
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Suhn K. Rhie, Yu Guo, Yu Gyoung Tak, Lijing Yao, Hui Shen, Gerhard A. Coetzee, Peter W. Laird, Peggy Farnham · 2016 · Epigenetics & Chromatin
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Priscilla Y. Hwang, Liufang Jing, Jun Chen, Foon-Lian Lim, Ruhang Tang, Hyowon Choi, Kmc Cheung, Makarand V. Risbud, Charles A. Gersbach, Farshid Guilak et al. · 2016 · Scientific Reports
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Zachary WareJoncas, Jarryd M. Campbell, Gabriel Martínez‐Gálvez, William A.C. Gendron, Michael A. Barry, Peter C. Harris, Caroline R. Sussman, Stephen Carl Ekker · 2018 · Nature Reviews Nephrology
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Connor Ludwig, Lacramioara Bintu · 2019 · Development
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Mu‐Nung Hsu, Fu-Jen Yu, Yu‐Han Chang, Kai-Lun Huang, Nam Ngoc Pham, Vu Anh Truong, Mei‐Wei Lin, Nuong Thi Kieu Nguyen, Shiaw‐Min Hwang, Yu‐Chen Hu · 2020 · Biomaterials
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Stoll, Guido A, Pandiloski, Ninoslav, Douse, Christopher H, Modis, Yorgo · 2022 · The EMBO Journal
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Minhee Park, Albert J. Keung, Ahmad S. Khalil · 2016 · Genome biology
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Qian Cong, Yuchen Liu, Taifeng Zhou, Yaxing Zhou, Ruoshi Xu, Caiqi Cheng, Hye Soo Chung, Meijun Yan, Hang Zhou, Zhiheng Liao et al. · 2021 · Science Translational Medicine
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David Yao, Josh Tycko, Jin Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt et al. · 2024 · Nature Methods
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Chris C.‐S. Hsiung, Caroline M. Wilson, Nicholas A. Sambold, R. Dai, Q. Chen, Noam Teyssier, Sara Misiukiewicz, Abolfazl Arab, Thomas A. O’Loughlin, Joshua C. Cofsky et al. · 2024 · Nature Biotechnology
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Muhammad Abu Bakr Shabbir, Haihong Hao, Muhammad Zubair Shabbir, Hafiz Iftikhar Hussain, Iqbal Zahid, Saeed Ahmed, Adeel Sattar, Mujahid Iqbal, Jun Li, Zonghui Yuan · 2016 · Frontiers in Immunology
Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Chang Liao, Ross C. Hardison, Mary J. Kennett, Bradley Allen Carlson, Robert F. Paulson, K. Sandeep Prabhu · 2018 · Blood
CRISPR interference and its applications
Seyedkhashayar Ghavami, Amir Pandi · 2021 · Progress in molecular biology and translational science
A single-cell multiomic analysis of kidney organoid differentiation
Yasuhiro Yoshimura, Yoshiharu Muto, Nicolas Ledru, Hao Wu, Kohei Omachi, Jeffrey H. Miner, Benjamin D. Humphreys · 2023 · Proceedings of the National Academy of Sciences
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Goldie V. Roth, Isabella R. Gengaro, Lei S. Qi · 2024 · Cell chemical biology
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J. Halmai, P. Deng, Casiana E. Gonzalez, Nicole B. Coggins, D. Cameron, Jasmine L. Carter, Fiona K. B. Buchanan, J. Waldo, Samantha Lock, Johnathon D. Anderson et al. · 2020 · Nucleic Acids Research
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Charis L. Himeda, Takako Iida Jones, Peter L. Jones · 2020 · Molecular Therapy — Methods & Clinical Development
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Kaya, Cengiz, Uğurlar, Ferhat, Adamakis, Ioannis-Dimosthenis S. · 2024 · International Journal of Molecular Sciences
Prediction of activity and specificity of CRISPR-Cpf1 using convolutional deep learning neural networks
Jiesi Luo, Wei Chen, Li Xue, Bin Tang · 2019 · BMC Bioinformatics
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Angelika Lampert, David Bennett, Lucy McDermott, Anika Neureiter, Esther Eberhardt, Beate Winner, Martin Zenke · 2020 · Neurobiology of Pain
AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency
Glenn J. Markov, Thach Mai, Surag Nair, Anna Shcherbina, Yu Xin Wang, David M. Burns, Anshul Bharat Kundaje, Helen M. Blau · 2021 · Proceedings of the National Academy of Sciences
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Alejandra Fernandez, Connor Gerard O’Leary, Kenneth John O'Byrne, Joshua T. Burgess, Derek J. Richard, Amila Suraweera · 2021 · Frontiers in Molecular Biosciences
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Galina Yurevna Zheleznyakova, Eliane Piket, Francesco Marabita, Majid Pahlevan Kakhki, Ewoud Ewing, Sabrina Ruhrmann, Maria Needhamsen, Maja Jagodic, Lara Kular · 2017 · Physiological Genomics
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells
Alireza Delfarah, Sydney Parrish, Jason A. Junge, Jesse Yang, Frances Seo, Si Li, John Mac, Pin Wang, Scott E. Fraser, Nicholas Alexander Graham · 2019 · Journal of Biological Chemistry
CRISPR/Cas9 treatment causes extended TP53-dependent cell cycle arrest in human cells
Jonathan M. Geisinger, Tim Stearns · 2020 · Nucleic Acids Research
Translating cancer epigenomics into the clinic: focus on lung cancer
Josep Marí‐Alexandre, Ángel Díaz‐Lagares, María Villalba-Esparza, Óscar Juan, Ana Belen Crujeiras, Alfonso Calvo, Juan Sandoval · 2017 · Translational research
In vivo epigenome editing and transcriptional modulation using CRISPR technology
Cia‐Hin Lau, Yousin Suh · 2018 · Transgenic Research
Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus
Rutger A. F. Gjaltema, Till Schwämmle, Pauline Kautz, Michael I. Robson, Robert Schöpflin, Liat Ravid Lustig, Lennart Brandenburg, Ilona Dunkel, Carolina Vechiatto, Evgenia Ntini et al. · 2021 · Molecular Cell
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Yuan Tao Hao, Samuel Bates, Hongmei Mou, Jeong Hyun Yun, Betty Pham, Jiangyuan Liu, Weiliang Qiu, Feng Guo, Jarrett D. Morrow, Craig P. Hersh et al. · 2020 · American Journal of Respiratory and Critical Care Medicine
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Renhe Luo, Jielin Yan, Jin Woo Oh, Xi Wang, Dustin Shigaki, Wilfred Wong, Hyunwoo Cho, Dylan Murphy, Ronald R. Cutler, Bess P. Rosen et al. · 2023 · Nature Genetics
TRIM28 and the control of transposable elements in the brain
Daniela A. Grassi, Marie E. Jönsson, Per Ludvik Brattås, Johan Jakobsson · 2018 · Brain Research
Modeling the complex genetic architectures of brain disease
Michael B. Fernando, Tim Ahfeldt, Kristen Brennand · 2020 · Nature Genetics
Emerging Roles of SKP2 in Cancer Drug Resistance
Ting Wu, Xinsheng Gu, Hongmei Cui · 2021 · Cells
Progress and Perspective of CRISPR‐Cas9 Technology in Translational Medicine
Ruixuan Zheng, Lexiang Zhang, Rokshana Parvin, Lihuang Su, Junjie Chi, Keqing Shi, Fangfu Ye, Xiaoying Huang · 2023 · Advanced Science
Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor
Benjamin Ducarouge, Anna Rita Redavid, Camille Victoor, Ruxanda Chira, Aurélien Fonseca, Maëva Hervieu, Roméo Bergé, Justine Lengrand, Pauline Vieugué, David Neves et al. · 2023 · Cell Death and Differentiation
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
Zhiqiang Huang, Ning Liang, Saioa Goñi, Anastasios E. Damdimopoulos, Cheng Wang, Raphaëlle Ballaire, Jennifer Jager, Henri Niskanen, Hongya Han, Tomas Jakobsson et al. · 2021 · Molecular Cell
Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells
Xuelian Cui, Chao Zhang, Zhifang Xu, Shuaibin Wang, Xin Li, Erica Michelle Stringer-Reasor, Sejong Bae, Leiping Zeng, Dehua Zhao, Runhua Liu et al. · 2022 · Molecular Cancer
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma
Royce W. Zhou, Jia Xu, Tiphaine C. Martin, Alexis L. Zachem, John Cijiang He, Sait Ozturk, Deniz Demircioğlu, Ankita Bansal, Andrew Paul Trotta, Bruno Giotti et al. · 2022 · Nature Communications
Genome editing in the treatment of ocular diseases
Elliot H. Choi, Susie Suh, Avery E. Sears, Rafał Hołubowicz, SANJAY R. KEDHAR, Andrew Browne, Krzysztof Palczewski · 2023 · Experimental & Molecular Medicine
Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer
Carter J. Barger, Linda Chee, Mustafa Albahrani, Catalina Muñoz-Trujillo, Lidia Boghean, Connor Branick, Kunle O. Odunsi, Ronny Drapkin, Lee Zou, Adam R. Karpf · 2021 · eLife
The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation
Tomoya Sakamoto, Kirill Batmanov, Shibiao Wan, Yuanjun Guo, Ling Lai, Rick B. Vega, Daniel P. Kelly · 2022 · Nature Communications
Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa
Cia‐Hin Lau, Jonathan Weng‐Thim Ho, Pik Kwan Lo, Chung Tin · 2019 · Molecular Therapy — Nucleic Acids
A mechanistic view of long noncoding RNAs in cancer
Lauren Winkler, Nadya Dimitrova · 2021 · Wiley Interdisciplinary Reviews - RNA
An oxygen-dependent interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis
Mayank, Adarsh K., Pandey, Vijaya, Vashisht, Ajay A., Barshop, William D., Rayatpisheh, Shima, Sharma, Tanu, Haque, Tisha, Powers, David N., Wohlschlegel, James A. · 2019 · Molecular Cell
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira Al‐Shabeeb Akil, Muzafar Ahmad Macha et al. · 2025 · MedComm
Tuning CRISPR-Cas9 Gene Drives in Saccharomyces cerevisiae
Emily Roggenkamp, Rachael M. Giersch, Madison N. Schrock, Emily Turnquist, Megan Halloran, Gregory C. Finnigan · 2018 · G3 Genes Genomes Genetics
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential
Roberto Di Blasi, Oleg B. Blyuss, John F. Timms, Daniel Conole, Francesca Ceroni, Harry J. Whitwell · 2021 · ACS Chemical Biology
Reversing Post-Infectious Epigenetic-Mediated Immune Suppression
Abhimanyu Abhimanyu, Carlos Oscar Ontiveros, Rosa Selenia Guerra-Resendez, Tomoki Nishiguchi, Malik Ladki, Isaac B. Hilton, Larry S. Schlesinger, Andrew R. DiNardo · 2021 · Frontiers in Immunology
Long Non-Coding RNAs (lncRNAs) in Response and Resistance to Cancer Immunosurveillance and Immunotherapy
Giasemi C. Eptaminitaki, Nora S. Wolff, Dimitris Stellas, Konstantinos Sifakis, Stavroula Baritaki · 2021 · Cells
CRISPR/Cas9: Regulations and challenges for law enforcement to combat its dual-use
Tahir ul Gani Mir, Atif Khurshid Wani, Nahid Akhtar, Saurabh Shukla · 2022 · Forensic Science International
CRISPR-Cas System: The Current and Emerging Translational Landscape
Narendranath Bhokisham, Ethan Laudermilch, Lindsay L. Traeger, Tonya D. Bonilla, Mercedes Ruíz-Estévez, Jordan R. Becker · 2023 · Cells
The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA.
Shijia Bi, Xiao-Yu Jiang, Qian-Zhao Ji, Ze-Hua Wang, Jie Ren, Si Wang, Yang Yu, Ruoqi Wang, Zun-Peng Liu, Junhang Liu et al. · 2024 · Developmental Cell
A Nanozyme-Boosted MOF-CRISPR Platform for Treatment of Alzheimer’s Disease
Jie Yang, Geng Qin, Zhenqi Liu, Haochen Zhang, Xiubo Du, Jinsong Ren, Xiaogang Qu · 2024 · Nano Letters
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Brian D Cosgrove, Lexi R. Bounds, Carson Key Taylor, Alan L. Su, Anthony J Rizzo, Alejandro Barrera, Tongyu Sun, Alexias Safi, Ling-Yun Song, T. Whitlow et al. · 2025 · Science
CRISPR-Mediated Epigenome Editing.
Paul Enríquez · 2016 · Europe PMC (PubMed Central)
The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping
Stephen Eyre, Gisela Orozco, Jane Worthington · 2017 · Nature Reviews Rheumatology