Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

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Items 401–500 of 999

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2. CRISPR/dCas system as the modulator of gene expression
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3. Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants
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4. CRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung
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5. Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems
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6. Improving isoprenol production via systematic CRISPRi screening in engineered Escherichia coli
   Jian Wang, Tian Jiang, Sierra Milligan, Jianli Zhang, Chenyi Li, Yajun Yan · 2022 · Green Chemistry
7. A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer
   Yongheng Chen, Ying Ying, Maolin Wang, Canjie Ma, Min Jia, Liang Shi, Shilan Wang, Xiangyi Zheng, Wei Chen, Xing‐sheng Shu · 2023 · Cell Death and Disease
8. What is an enhancer?
   Henry Thomas, Christa Buecker · 2023 · BioEssays
9. Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen
   Song, Qingkai, Ni, Ke, Liu, Min, Li, Yini, Wang, Lixia, Wang, Yingying, Liu, Yingzheng, Yu, Zhenxing, Qi, Yinyao, Lu, Zhike et al. · 2020 · Genome Biology
10. Neuroepigenetic Editing
    Hamilton, Peter J., Lim, Carissa J., Nestler, Eric J., Heller, Elizabeth A. · 2018 · Methods in Molecular Biology
11. Applications of CRISPR-Cas for synthetic biology and genetic recording
    Florian Schmidt, Randall J. Platt · 2017 · Current Opinion in Systems Biology
12. Epigenetic Control of a Local Chromatin Landscape
    Anna M. Chiarella, Dongbo Lu, Nathaniel A. Hathaway · 2020 · International Journal of Molecular Sciences
13. Innovative Precision Gene‐Editing Tools in Personalized Cancer Medicine
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14. Back to the Future: Rethinking the Great Potential of lncRNAS for Optimizing Chemotherapeutic Response in Ovarian Cancer
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15. FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma
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16. Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis
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17. Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures
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18. How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances
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19. CTCF mediates CD8+ effector differentiation through dynamic redistribution and genomic reorganization
    Jia Liu, Shaoqi Zhu, Wei Hu, Xin Zhao, Qiang Shan, Weiqun Peng, Hai‐Hui Xue · 2023 · The Journal of Experimental Medicine
20. Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer
    Charlene Babra Waryah, Joseph Cursons, Momeneh Foroutan, Christian Pflueger, Edina Wang, Ramyar Molania, Eleanor Woodward, Anabel Sorolla, Christopher J. D. Wallis, Colette Moses et al. · 2023 · Advanced Science
21. Novel epigenetic molecular therapies for imprinting disorders
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22. Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1
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23. Neuro-Immuno-Gene- and Genome-Editing-Therapy for Alzheimer’s Disease: Are We There Yet?
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24. Construction and validation of the CRISPR/dCas9-EZH2 system for targeted H3K27Me3 modification
    Xutao Chen, Mengying Wei, Xiangwei Liu, Shuang Song, Lei Wang, Xuekang Yang, Yingliang Song · 2019 · Biochemical and Biophysical Research Communications
25. Exploring CRISPR-Cas: The transformative impact of gene editing in molecular biology
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26. Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons
    John Peyton Bohnsack, Vraj Patel, A. Leslie Morrow · 2017 · Journal of Pharmacology and Experimental Therapeutics
27. Towards Quantitative Analysis of Gene Regulation by Enhancers
    Ekaterina V. Nizovtseva, Stefjord Todolli, Wilma K. Olson, Vasily M. Studitsky · 2017 · Epigenomics
28. Engineering in Hairy Roots Using CRISPR/Cas9-Mediated Editing
    Anshu Alok, Jitesh Kumar, Santosh Kumar Upadhyay · 2018 · Springer eBooks
29. Recent trends in CRISPR-Cas system: genome, epigenome, and transcriptome editing and CRISPR delivery systems
    Taegeun Bae, Junseok W. Hur, Dokyoung Kim, Junho K. Hur · 2019 · Genes & Genomics
30. Epigenetics in Multiple Sclerosis
    Vera S. F. Chan · 2020 · Advances in experimental medicine and biology
31. Synergistic CRISPRa-Regulated Chondrogenic Extracellular Matrix Deposition Without Exogenous Growth Factors
    Niloofar Farhang, Bryton J. Davis, Jacob D. Weston, Matthew Ginley-Hidinger, Jason Gertz, Robby D. Bowles · 2020 · Tissue Engineering Part A
32. Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications
    Lifang Zhou, Shaohua Yao · 2023 · Molecular Biomedicine
33. Genome editing: the end of the beginning
    Jennifer A. Doudna, Charles A. Gersbach · 2015 · Genome biology
34. In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?
    Pablo Lubroth, Gaia Colasante, Gabriele Lignani · 2021 · Frontiers in Neuroscience
35. Synthetic transcription factors for cell fate reprogramming
    Joshua B. Black, Charles A. Gersbach · 2018 · Current Opinion in Genetics & Development
36. CRISPR Tools for Physiology and Cell State Changes: Potential of Transcriptional Engineering and Epigenome Editing
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37. Double-Barreled CRISPR Technology as a Novel Treatment Strategy For COVID-19
    Dhanusha A. Nalawansha, Kusal T. G. Samarasinghe · 2020 · ACS Pharmacology & Translational Science
38. A guide to the design of synthetic gene networks in mammalian cells
    Anže Verbič, Arne Praznik, Roman Jerala · 2020 · FEBS Journal
39. A universal strategy for AAV delivery of base editors to correct genetic point mutations in neonatal PKU mice
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40. Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells
    Mario Escobar, Jing Li, Aditi Patel, Shizhe Liu, Qi Xu, Isaac B. Hilton · 2022 · ACS Synthetic Biology
41. Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling
    Yonggang Zhang, Gustavo Arango, Fang Li, Xiao Xiao, Raj Putatunda, Jun Yu, Xiao Feng Yang, Hong Wang, Layne T. Watson, Liqing Zhang et al. · 2018 · BMC Medical Genomics
42. C/EBPβ is a critical mediator of IFN-α–induced exhaustion of chronic myeloid leukemia stem cells
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43. Therapeutic application of the CRISPR system: current issues and new prospects
    Minyoung Lee, Seokjoong Kim · 2019 · Human Genetics
44. New insights on CRISPR/Cas9-based therapy for breast Cancer
    Hussein Sabit, Shaimaa E. Abdel-Ghany, Hüseyin Tombuloğlu, Emre Çevik, Amany I. Alqosaibi, Fatma A. Al-Mulhim, Afnan Al Muhanna · 2021 · Genes and Environment
45. CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network
    Eugenio Morelli, Annamaria Gullà, Nicola Amodio, Elisa Taìana, Antonino Neri, Mariateresa Fulciniti, Nikhil C. Munshi · 2021 · Methods in molecular biology
46. Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma
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47. Zebrafish: A Model to Study and Understand the Diabetic Nephropathy and Other Microvascular Complications of Type 2 Diabetes Mellitus
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48. 7SK methylation by METTL3 promotes transcriptional activity
    Marcelo Pérez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón · 2023 · Science Advances
49. Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing
    Inna Zukher, Gwendal Dujardin, Rui Sousa‐Luís, Nicholas J. Proudfoot · 2023 · Nature Structural & Molecular Biology
50. Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine
    Shahab Ur Rehman, Numan Ullah, Zhenbin Zhang, Yongkang Zhen, Aziz Ud-Din, Hengmi Cui, Mengzhi Wang · 2024 · Frontiers in Chemistry
51. Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis
    Jens Langstein, Michael D. Milsom, Daniel B. Lipka · 2017 · Seminars in Cancer Biology
52. Applications of CRISPR-Cas in Bioengineering, Biotechnology, and Translational Research
    Cia‐Hin Lau · 2018 · The CRISPR Journal
53. Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer
    Jae‐Ryeon Ryu, Suchit Ahuja, Corey R. Arnold, Kyle G. Potts, Aniket Mishra, Qiong Yang, Muralidharan Sargurupremraj, Douglas J. Mahoney, Sudha S. Seshadri, Stéphanie Debette et al. · 2022 · Proceedings of the National Academy of Sciences
54. Foundations and Emerging Paradigms for Computing in Living Cells
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55. CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish
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56. Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity
    Yan Sun, Ambroise Manceau, Lisa Frydman, Lucie Cappuccio, David Neves, Valéria Basso, Hong Wang, Joanna Fombonne, Carine Maisse, Patrick Mehlen et al. · 2021 · Proceedings of the National Academy of Sciences
57. Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
    Qu Deng, Ramakrishnan Natesan, Florencia Cidre‐Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca et al. · 2022 · Cell Reports
58. PHF20 is crucial for epigenetic control of starvation-induced autophagy through enhancer activation
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59. Epigenetic Regulation of β-Globin Genes and the Potential to Treat Hemoglobinopathies through Epigenome Editing
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60. Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation
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61. CRISPR‐Cas9: A cornerstone for the evolution of precision medicine
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62. CRISPR/dCas9 as a Therapeutic Approach for Neurodevelopmental Disorders: Innovations and Limitations Compared to Traditional Strategies
    Raffaele Ricci, Gaia Colasante · 2021 · Developmental Neuroscience
63. Transcriptional activation with Cas9 activator nanocomplexes rescues Alzheimer's disease pathology
    Hanseul Park, Yerim Hwang, Jongpil Kim · 2021 · Biomaterials
64. CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
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65. CRISPR-Based Approaches for the High-Throughput Characterization of Long Non-Coding RNAs
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66. Engineering CRISPR/Cas9 therapeutics for cancer precision medicine
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67. Implementation and validation of single-cell genomics experiments in neuroscience
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68. Molecular structures guide the engineering of chromatin
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69. A principled strategy for mapping enhancers to genes
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70. Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations
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71. ANO6-mediated trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer cell growth and immune suppression
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72. Transcriptional enhancers: from prediction to functional assessment on a genome-wide scale
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73. Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma
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74. PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA
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75. Molecular basis of FAAH-OUT -associated human pain insensitivity
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76. Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture
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77. Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment
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78. Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease
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79. What rheumatologists need to know about CRISPR/Cas9
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80. A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins
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81. Deciphering the Design Rules of Toehold-Gated sgRNA for Conditional Activation of Gene Expression and Protein Degradation in Mammalian Cells
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82. CD44 3'-Untranslated Region Functions as a Competing Endogenous RNA to Enhance NK Sensitivity of Liver Cancer Stem Cell by Regulating ULBP2 Expression
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83. Liver sinusoidal endothelial cells contribute to portal hypertension through collagen type IV–driven sinusoidal remodeling
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84. Catabolism of extracellular glutathione supplies cysteine to support tumours
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85. CRISPR Double Cutting through the Labyrinthine Architecture of 3D Genomes
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86. Optogenetics and CRISPR: A New Relationship Built to Last
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87. Reactive Oxygen Species and Long Non-Coding RNAs, an Unexpected Crossroad in Cancer Cells
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88. A Myb enhancer-guided analysis of basophil and mast cell differentiation
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89. CRISPR for neuroscientists
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90. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells
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91. Shared Gene Targets of the ATF4 and p53 Transcriptional Networks
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92. Viral Expression of Epigenome Editing Tools in Rodent Brain Using Stereotaxic Surgery Techniques
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93. Implications of human induced pluripotent stem cells in metabolic disorders: from drug discovery toward precision medicine
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94. Blossom of CRISPR technologies and applications in disease treatment
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95. Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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96. Functional Screening Techniques to Identify Long Non-Coding RNAs as Therapeutic Targets in Cancer
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97. CRISPR genome engineering for retinal diseases
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98. Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor
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99. Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy
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100. DNA end-resection in highly accessible chromatin produces a toxic break
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