The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A genetically targetable near-infrared photosensitizer
Open accessAbstract
Upon illumination, photosensitizer molecules produce reactive oxygen species that can be used for functional manipulation of living cells, including protein inactivation, targeted-damage introduction and cellular ablation. Photosensitizers used to date have been either exogenous, resulting in delivery and removal challenges, or genetically encoded proteins that form or bind a native photosensitizing molecule, resulting in a constitutively active photosensitizer inside the cell. We describe a genetically encoded fluorogen-activating protein (FAP) that binds a heavy atom−substituted fluorogenic dye, forming an 'on-demand' activated photosensitizer that produces singlet oxygen and fluorescence when activated with near-infrared light. This targeted and activated photosensitizer (TAPs) approach enables protein inactivation, targeted cell killing and rapid targeted lineage ablation in living larval and adult zebrafish. The near-infrared excitation and emission of this FAP-TAPs provides a new spectral range for photosensitizer proteins that could be useful for imaging, manipulation and cellular ablation deep within living organisms.
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Citations
Cites
Role of reactive oxygen species (ROS) in apoptosis induction
Simon, H.-U., Haj-Yehia, A., & Levi-Schaffer, F. (2000) · Apoptosis · doi:10.1023/a:1009616228304 · Cited by 2,774
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333
Cited by
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,098
Cell-cell communication: New insights and clinical implications
Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433
Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy
Deng, H., Zhou, Z., Yang, W., Lin, L.-S., Wang, S., Niu, G., Song, J., & Chen, X. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b05210 · Cited by 363
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis
Fouquerel, E., Barnes, R. P., Uttam, S., Watkins, S. C., Bruchez, M. P., & Opresko, P. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.024 · Cited by 275
“We observed significant XRCC1 enrichment at telomeres after dye + light, which was reduced by pre-treatment with the (1)O2 quencher sodium azide (He et al., 2016) or by PARP1 inhibition or depletion (Figures 2E–2G, S2G, and S2I).”
BackgroundSelf-citationSinglet Oxygen “Afterglow” Therapy with NIR‐II Fluorescent Molecules
Zou, J., Li, L., Zhu, J., Li, X., Yang, Z., Huang, W., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202103627 · Cited by 155
Metadata
- Authors
- He, J., Wang, Y., Missinato, M. A., Onuoha, E., Perkins, L. A., Watkins, S. C., St Croix, C. M., Tsang, M., & Bruchez, M. P.
- Venue
- Nature Methods
- Published
- 2016-01-25
- Volume
- 13
- Issue
- 3
- Pages
- 263-268
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2263056748
- Cited by
- 181
- References
- 3
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- green
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