The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Building ProteomeTools based on a complete synthetic human proteome
Open accessAbstract
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography–tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.
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Cites
Mass-spectrometry-based draft of the human proteome
Wilhelm, M., Schlegl, J., Hahne, H., Gholami, A. M., Lieberenz, M., Savitski, M. M., Ziegler, E., Butzmann, L., Gessulat, S., Marx, H., et al. (2014) · Nature · doi:10.1038/nature13319 · Cited by 1,820
Self-citationProtein Analysis by Shotgun/Bottom-up Proteomics
Zhang, Y., Fonslow, B. R., Shan, B., Baek, M.-C., & Yates, J. R. (2013) · Chemical Reviews · doi:10.1021/cr3003533 · Cited by 1,491
Guo, T., Kouvonen, P., Koh, C. C., Gillet, L. C., Wolski, W. E., Röst, H. L., Rosenberger, G., Collins, B. C., Blum, L. C., Gillessen, S., et al. (2015) · Nature Medicine · doi:10.1038/nm.3807 · Cited by 376
Self-citationA complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis
Picotti, P., Clément-Ziza, M., Lam, H., Campbell, D. S., Schmidt, A., Deutsch, E. W., Röst, H., Sun, Z., Rinner, O., Reiter, L., et al. (2013) · Nature · doi:10.1038/nature11835 · Cited by 318 · cited 1×
“However, in proteome research the generation or use of such standards is only beginning to be implemented systematically 2–4 .”
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Cited by
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Wang, D., Eraslan, B., Wieland, T., Hallström, B., Hopf, T., Zolg, D. P., Zecha, J., Asplund, A., Li, L., Meng, C., et al. (2019) · Molecular Systems Biology · doi:10.15252/msb.20188503 · Cited by 750
Self-citationTiwary, S., Levy, R., Gutenbrunner, P., Salinas Soto, F., Palaniappan, K. K., Deming, L., Berndl, M., Brant, A., Cimermancic, P., & Cox, J. (2019) · Nature Methods · doi:10.1038/s41592-019-0427-6 · Cited by 256
Assembling the Community-Scale Discoverable Human Proteome
Wang, M., Wang, J., Carver, J., Pullman, B. S., Cha, S. W., & Bandeira, N. (2018) · Cell Systems · doi:10.1016/j.cels.2018.08.004 · Cited by 201
Meyer, J. G., & Schilling, B. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1322904 · Cited by 151
Abdul-Khalek, N., Picciani, M., Shouman, O., Wimmer, R., Overgaard, M. T., Wilhelm, M., & Gregersen Echers, S. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00973 · Cited by 13
Self-citation(2025) · doi:10.1016/j.mcpro.2025.101501 · Cited by 4
Metadata
- Authors
- Zolg, D. P., Wilhelm, M., Schnatbaum, K., Zerweck, J., Knaute, T., Delanghe, B., Bailey, D. J., Gessulat, S., Ehrlich, H.-C., Weininger, M., Yu, P., Schlegl, J., Kramer, K., Schmidt, T., Kusebauch, U., Deutsch, E. W., Aebersold, R., Moritz, R. L., Wenschuh, H., Moehring, T., Aiche, S., Huhmer, A., Reimer, U., & Kuster, B.
- Venue
- Nature Methods
- Published
- 2017-01-30
- Volume
- 14
- Issue
- 3
- Pages
- 259-262
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2580819151
- Cited by
- 249
- References
- 4
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- green
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