CIRCLE-Seq: A highly sensitive in vitro screen for genome-wide CRISPR-cas9 nuclease off-targets

Tsai, Shengdar Q, Nguyen, Nhu T, Malagon-Lopez, Jose, Topkar, Ved V, Aryee, Martin J, Joung, J Keith·2017·Nature Methods

Cited by (816)

Items 501–600 of 816

  1. Discovering CRISPR–Cas off-target breaks
    Carlos Jiménez, Nicola Crosetto · 2023 · Nature Methods
  2. Genome-wide CRISPR off-target DNA break detection by the BLISS method
    Ballarino, Roberto, Bouwman, Britta A. M., Crosetto, Nicola · 2021 · Methods in molecular biology
  3. Regulatory Considerations for Genome-Edited T-cell Therapies
    Julie K. Jadlowsky, Ju-Fang Chang, David H. Spencer, John M. Warrington, Bruce L. Levine, Carl H. June, Joseph A. Fraietta, Nathan Singh · 2024 · Cancer Immunology Research
  4. Base editors in zebrafish: a new era for functional genomics and disease modeling
    Yuwen Liu, Chao Li, Yiren Qiu, Sihong Chen, Yijun Luo, D Xiong, Jun Zhao, Jianmin Ye, Xuegeng Wang, Wei Qin et al. · 2025 · Frontiers in Genome Editing
  5. Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
    Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Liu Ls, Y Huang, Ningyun Zhang, Lei Sun et al. · 2026 · iMetaOmics.
  6. ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing
    Oscar Enrique Torres Montaguth, Stephen Cross, Kincaid W.A. Ingram, Laura J. Lee, Fiona M. Diffin, Mark D. Szczelkun · 2021 · Nucleic Acids Research
  7. Genetics of Dravet Syndrome and its Targeted Therapy by Nanomedicine: A Roadmap for Future Treatment of Drug Resistant Seizures
    Muhammad Danish Ikram, Sufian Rasheed · 2022 · Current Molecular Pharmacology
  8. Animal Transgenesis and Cloning: Combined Development and Future Perspectives
    M. Yamashita, Eduardo O. Melo · 2023 · Methods in molecular biology
  9. A massively parallel approach for assessing CRISPR off-targets in vitro
    Shisheng Huang, Xingxu Huang · 2023 · Cell Reports Methods
  10. Recent advances in genome engineering by CRISPR technology
    Youngsik Lee, Yeounsun Oh, Seung Hwan Lee · 2024 · BMB Reports
  11. Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
    Juan A. Pérez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia et al. · 2024 · Nature Communications
  12. Developmental progression of DNA double-strand break repair deciphered by a single-allele resolution mutation classifier
    Zhiqian Li, Lang You, Anita Hermann, Ethan Bier · 2024 · Nature Communications
  13. Base editing rescues acid α-glucosidase function in infantile-onset Pompe disease patient-derived cells
    Chloe L. Christensen, Shih‐hsin Kan, Perla Andrade-Heckman, Allisandra K. Rha, Jerry F. Harb, Raymond Wang · 2024 · Molecular Therapy — Nucleic Acids
  14. CRISPR-based genetic screens advance cancer immunology
    Yuanfang Cao, Xueting Li, Yumu Pan, Huahe Wang, Siyu Yang, Lingjuan Hong, Lupeng Ye · 2024 · Science China Life Sciences
  15. Strategic base modifications refine RNA function and reduce CRISPR–Cas9 off-targets
    Kaisong Zhang, Wei Hua Shen, Yunting Zhao, Xinyan Xu, Xingyu Liu, Qianqian Qi, Siqi Huang, Tian Tian, Xiang Zhou · 2025 · Nucleic Acids Research
  16. Parameters affecting successful stem cell collections for genetic therapies in sickle cell disease
    David G. Justus, John P. Manis · 2021 · Transfusion and Apheresis Science
  17. Recognition of CRISPR Off-Target Cleavage Sites with SeqGAN
    Wen Li, Xiaobo Wang, Yan Xu · 2021 · Current Bioinformatics
  18. Chemical and Biological Approaches to Interrogate off-Target Effects of Genome Editing Tools
    Zhixin Lei, Haowei Meng, Yuan Zhuang, Qingguo Zhu, Chengqi Yi · 2023 · ACS Chemical Biology
  19. Development of Toolboxes for Precision Genome/Epigenome Editing and Imaging of Epigenetics
    Wataru Nomura · 2018 · The Chemical Record
  20. Analysis of CRISPR/Cas9 Guide RNA Efficiency and Specificity Against Genetically Diverse HIV-1 Isolates
    Katherine J. Sessions, Yun Yue Chen, Christine A. Hodge, Taylor R. Hudson, Susan K. Eszterhas, Matthew S. Hayden, Alexandra L. Howell · 2020 · AIDS Research and Human Retroviruses
  21. Immunotherapy to get on point with base editing
    Jennifer A. Harbottle · 2021 · Drug Discovery Today
  22. Challenges and advances of CRISPR-Cas9 genome editing in therapeutics
    Konstantinos Stellos, Kiran Musunuru · 2018 · Cardiovascular Research
  23. Genome Editing: Insights from Chemical Biology to Support Safe and Transformative Therapeutic Applications
    Renee D. Wegrzyn, Andrew H. Lee, Amy L. Jenkins, Colby D. Stoddard, Anne E. Cheever · 2017 · ACS Chemical Biology
  24. Inconclusive studies on possible CRISPR-Cas off-targets should moderate expectations about enzymes that have evolved to be non-specific
    Sandeep Chakraborty · 2018 · Journal of Biosciences
  25. CRISPR-Based Gene Editing Techniques in Pediatric Neurologic Disorders
    Stephen Mark Chrzanowski, Ranjan Batra · 2022 · Pediatric Neurology
  26. DNA shape features improve prediction of CRISPR/Cas9 activity
    Dhvani Sandip Vora, Sakshi Manoj Bhandari, Durai Sundar · 2024 · Methods
  27. CRISPR technology in human diseases
    Qiang Feng, Qirong Li, Hengzong Zhou, Zhan Wang, Chao Lin, Ziping Jiang, Tianjia Liu, Dongxu Wang · 2024 · MedComm
  28. CRISPR/ Cas9 Off-targets: Computational Analysis of Causes, Prediction, Detection, and Overcoming Strategies
    Roshan Kumar Roy, Ipsita Debashree, Sonal Srivastava, Narayan Rishi, Ashish Srivastava · 2021 · Current Bioinformatics
  29. Modulating Cas9 activity for precision gene editing
    Merve Uslu, Pınar Si̇yah, Andrew John Harvey, Fatih Kocabaş · 2021 · Progress in molecular biology and translational science
  30. A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients
    Pu‐Yu Li, Sanqiang Li, Shegan Gao, Dao-Yin Dong · 2022 · Medical Hypotheses
  31. Crispr2vec: Machine Learning Model Predicts Off-Target Cuts of CRISPR systems
    Tara Basu Trivedi, Ron S. Boger, Govinda M. Kamath, Georgios Evangelopoulos, Jamie H. D. Cate, Jennifer A. Doudna, Jack D. Hidary · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  32. CNS-targeted base editing of the major late-onset Tay-Sachs mutation alleviates disease in mice
    María L. Allende, Mari Kono, Y Terry Lee, Samantha M Olmsted, Vienna L. Huso, Jenna Y. Bakir, Florencia Pratto, Cuiling Li, Colleen Byrnes, Galina Tuymetova et al. · 2025 · Journal of Clinical Investigation
  33. Extrachromosomal DNA in cancer: Molecular mechanisms underlying oncogene amplification and tumor heterogeneity
    Hangbang Li, Jialin Lu, Yan Bian, Ye Gao, Luo‐Wei Wang · 2025 · Critical Reviews in Oncology/Hematology
  34. Guarding the genome: strategies for off-target detection and minimization in CRISPR/Cas9 system
    Malihe Lotfi, Zahra Farshchian Yazdi, Mohammad Reza Hashemi, Mohammad Reza Abbaszadegan, Samaneh Sharif · 2025 · Expert Review of Molecular Diagnostics
  35. Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair
    Dongzhen Zhu, JianJun Li, Bingyang Yu, Nanbo Liu, Xu Ming Guo, Yanlin Su, Yuzhen Wang, Yuyan Huang, Liting Liang, Linhao Hou et al. · 2026 · Burns & Trauma
  36. Beyond CRISPR: next-gen precision engineering of CAR-NK cells for enhanced persistence, trafficking, and tumor eradication
    Aiyun Dong, Hamed Soleimani Samarkhazan, Farzaneh Tavakoli · 2026 · Cancer Cell International
  37. Precise DNA base editing using AlphaFold3-based contact modelling
    Haowei Meng, Zhi‐Xin Lei, Yongchang Yan, Liren Wang, Sihan Zhang, Xichen Rao, Chuyun Shao, Xiaoting Zhang, Ke Chen, Lei Yang et al. · 2026 · Nature
  38. Efficient and sustained FOXP3 locus editing in hematopoietic stem cells as a therapeutic approach for IPEX syndrome
    Swati Singh, Cole M. Pugliano, Yuchi Honaker, Aidan Laird, M. Quinn DeGottardi, Ezra Lopez, Stefan Lachkar, Claire M. Stoffers, Karen Sommer, Iram Khan et al. · 2023 · Molecular Therapy — Methods & Clinical Development
  39. Novel off-Targeting Events Identified after Genome Wide Analysis of CRISPR-Cas Edited Pigs
    Bethany K. Redel, Junchul David Yoon, Emily D. Reese, Hong An, Kyungjun Uh, Paula R. Chen, Randall S. Prather, Kiho Lee · 2024 · The CRISPR Journal
  40. RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors
    A. Kuzin, Brendan Redler, Jaya Onuska, Alexei I. Slesarev · 2021 · Scientific Reports
  41. Genome Engineering of Hematopoietic Stem Cells Using CRISPR/Cas9 System
    Nivedhitha Devaraju, Vignesh Rajendiran, Nithin Sam Ravi, Kumarasamypet Murugesan Mohankumar · 2022 · Methods in molecular biology
  42. Prime Editing in Mammals: The Next Generation of Precision Genome Editing
    Dawei Wang, Xiude Fan, Mengzhu Li, Tianbo Liu, Peng Lü, Guangxin Wang, Yuan Li, Junming Han, Jiajun Zhao · 2022 · The CRISPR Journal
  43. Production of Duchenne muscular dystrophy cellular model using CRISPR-Cas9 exon deletion strategy
    Farzaneh Lal Alizadeh, Yousef Jafari Abraghan, Shima Farrokhi, Yasamin Yousefi, Yeganeh Mirahmadi, Atieh Eslahi, Majid Mojarrad · 2023 · Molecular and Cellular Biochemistry
  44. Methods for Measuring CRISPR/Cas9 DNA Cleavage in Cells
    Christopher R. Cromwell, Juan Jovel, Basil P. Hubbard · 2020 · Methods in molecular biology
  45. Single molecule methods for studying CRISPR Cas9-induced DNA unwinding
    Ikenna C. Okafor, Janice Choi, Taekjip Ha · 2021 · Methods
  46. A Highly Sensitive GFP Activation Assay for Detection of DNA Cleavage in Cells
    Ziying Hu, Chengdong Zhang, Daqi Wang, Siqi Gao, Sang‐Ging Ong, Yongming Wang, Wei Zheng · 2021 · Frontiers in Cell and Developmental Biology
  47. The effect of sequence mismatches on binding affinity and endonuclease activity are decoupled throughout the Cas9 binding site
    Liyang Zhang, H. Tomas Rube, Harmen J. Bussemaker, Miles A. Pufall · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  48. AI-generated small binder improves prime editing
    Ju-Chan Park, Heesoo Uhm, Yong Woo Kim, Ye Eun Oh, Sangsu Bae · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Improved CRISPR/Cas9 off-target prediction with DNABERT and epigenetic features
    Kai Kimata, Kenji Satou · 2025 · PLoS ONE
  50. Programmable spatiotemporal control of CRISPR-Cas12a: Engineering precision for next-generation gene editing and diagnostics
    Anmol Seelan, Labdhi Shah, Samer Shamshad, Milan Khanda, Darsh Vira, Harpreet Singh, Hitesh Chopra, Nigel H. Greig · 2026 · Synthetic and Systems Biotechnology
  51. CRISPR–Cas9 Therapeutics in Early Clinical Development: Delivery and Molecular Diagnostics
    Adrianna Rutkowska, Tadeusz Strózik, Tomasz Wasiak, Damian Ciunowicz, Natalia Kapelan, Natalia Szczepaniak, Juliusz Sosnowski, Weronika Goślińska, Jakub Bartkowiak, Agata Budny-Lewandowska et al. · 2026 · Cells
  52. Precision genome editing with DNA base editors
    S J Mawson, Kara Dunne-Dombrink, Benjamin R. Pollak, Alexis C. Komor · 2026 · Nature Reviews Methods Primers
  53. A primer on prime: A prime editing update from advances to first-in-human trial
    Caleb Lushington, Paul Quinton Thomas, Fatwa Adikusuma · 2026 · Molecular Therapy
  54. Advancing CRISPR base editing technology through innovative strategies and ideas
    Xiongwei Fan, Yang Lei, Liren Wang, Xiushan Wu, Dali Li · 2024 · Science China Life Sciences
  55. Beyond precision: evaluation of off-target clustered regularly interspaced short palindromic repeats/Cas9–mediated genome editing
    Irene Peña-Gutiérrez, Beatriz Olalla-Sastre, Paula Rı́o, Juan R. Rodríguez-Madoz · 2024 · Cytotherapy
  56. CRISPR-Embedding: CRISPR/Cas9 off-target activity prediction using DNA k-mer embedding
    Anika Tahsin, Zarin Tasnim, Muneera Chowdhury, Kangkhita Hassin, Galib Hossain Meraz, Kazi Farzana Aziz, Swakkhar Shatabda · 2025 · Computational and Structural Biotechnology Reports
  57. UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems
    Kyle J. Kinney, Kun Jia, He Zhang, Ellen Schmaljohn, Thomas Osborne, Bernice Thommandru, Karthik Murugan, Andrea Sánchez Peña, Sean C. West, Shengyao Chen et al. · 2026 · Nature Communications
  58. Regulations and safety assessment of genome editing technologies for human gene therapy
    Eriko Uchida · 2020 · Translational and Regulatory Sciences
  59. Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells
    Christopher W. Peterson, Rasika Venkataraman, Sowmya Somashekar Reddy, Dnyanada Pande, Mark Enstrom, Stefan Radtke, Olivier Humbert, Hans‐Peter Kiem · 2021 · Molecular Therapy — Methods & Clinical Development
  60. Target-Seq: Single Workflow for Detection of Genome Integration Site, DNA Translocation and Off-Target Events
    Pei‐Zhong Tang, Ding Bo, Christopher Reyes, David Papp, Jason Potter · 2023 · BioTechniques
  61. Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering
    Paul E. Abraham, Jessy Labbé, Amber A. McBride · 2020 · BioDesign Research
  62. Therapeutic Gene Editing with CRISPR
    Elan Hahn, Matthew Hiemenz · 2020 · Clinics in Laboratory Medicine
  63. CRISPR-Cas off-target detection using Oxford Nanopore sequencing - is the mitochondrial genome more vulnerable to off-targets?
    Sandeep Chakraborty · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective
    Wei Li · 2020 · Preprints.org
  65. Enhanced HDR-mediated correction of heterozygous COL7A1 mutations for recessive dystrophic epidermolysis bullosa
    John Hunt, Alex du Rand, Daniel J. Verdon, Leah Clemance, Evert Jan Loef, Chloe Malhi, Ben Buttle, David J. H. F. Knapp, Yale S. Michaels, Jonathan A. Garlick et al. · 2025 · Molecular Therapy — Nucleic Acids
  66. RNA modification-mediated aberrant alternative splicing: An underlying driver of disease pathogenesis
    Jin Zeng, Li‐Ting Diao, Shu‐Juan Xie, Zhen‐Dong Xiao · 2025 · Cell investigation.
  67. CRISPR and gene editing technologies for bleeding disorders
    Thierry VandenDriessche, Mathias Janssens, Marinee Chuah · 2025 · Therapeutic Advances in Hematology
  68. Extrachromosomal circular DNA-related SPOCK1 contributes to development and enzalutamide resistance of prostate cancer by regulating epithelial mesenchymal transition
    Yicong Yao, Qinghua Wang, Wei Jiang, Haopeng Li, Xilei Li, Tong Zi, Xin Qin, Yan Fang Zhao, Denglong Wu, Gang Wu · 2024 · Heliyon
  69. A Practical Guide to Genome Editing Using Targeted Nuclease Technologies
    Shaina N. Porter, Rachel M. Levine, S. Pruett-Miller · 2019 · Comprehensive Physiology
  70. Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy
    King Pan Ng, Michaela Su-Fern Seng, Wing Hang Leung · 2025 · Molecular Therapy — Methods & Clinical Development
  71. Efficacious genome editing in infant mice with glycogen storage disease type Ia
    Benjamin Arnson, Ekaterina Ilich, Troy von Beck, Songtao Li, Elizabeth Drake Brooks, Dorothy Gheorghiu, Gordon He, Matthew Weinrub, Sze Ying Chan, Hye‐Ri Kang et al. · 2025 · JCI Insight
  72. Therapeutic precision gene editing of cholesterol pathways as a gene therapy strategy for cardiovascular disease
    Ezgi Erbasan, Melike Aliciaslan, Fulya Erendor, Ahter Dilşad Şanlioğlu, Salih Şanlıoğlu · 2025 · Gene Therapy
  73. mRNA medicine for cardiovascular disease
    Zhuoming Zhou, Wei Chen, Haojie Yu, Ira A. Tabas, Roger Foo, Wei Tao · 2026 · Nature Cardiovascular Research
  74. CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice
    Masayuki Tanaka, Keiko Yokoyama, Hideki Hayashi, Sanae Isaki, Kanae Kitatani, Ting Wang, Hisako Kawata, Hideyuki Matsuzawa, Channabasavaiah B. Gurumurthy, Hiromi Miura et al. · 2022 · Genome biology
  75. Analysis of Off-target Effects and Risk Assessment Leading from Preclinical to Clinical Trials of Gene-edited Therapeutic Products
    Naoki Yamada, Atsushi Aruga · 2022 · Therapeutic Innovation & Regulatory Science
  76. Advances in Off-Target Detection for CRISPR-Based Genome Editing
    Haozheng Wang, Yangmin Wang, Zhongtao Luo, Xinjian Lin, Meilin Liu, Fenglin Wu, Hongwei Shao, Wenfeng Zhang · 2022 · Human Gene Therapy
  77. Precision medicine advances in cystic fibrosis: Exploring genetic pathways for targeted therapies
    R S Abinesh, R Madhav, K. Trideva Sastri, G S Meghana, Akhila A.R., V. Balamuralidhara · 2024 · Life Sciences
  78. Gene editing based hearing impairment research and therapeutics
    Wen Kang, Zhuoer Sun, Xingle Zhao, Xueling Wang, Yong Tao, Hao Wu · 2019 · Neuroscience Letters
  79. Implementing accelerated dynamics to unravel the effects of high-fidelity Cas9 mutants on target DNA and guide RNA hybrid stability
    Dhvani Sandip Vora, Atul Kumar Jaiswal, Durai Sundar · 2022 · Journal of Biomolecular Structure and Dynamics
  80. Unbiased prediction of off‐target sites in genome‐edited rice using SITE‐Seq analysis on a web‐based platform
    Jumpei Narushima, Shinya Kimata, Yuh Shiwa, Takahiro Gondo, Satoru Akimoto, Keisuke Soga, Satoko Yoshiba, Kôsuke Nakamura, Norihito Shibata, Kazunari Kondo · 2022 · Genes to Cells
  81. CRISPR–Cas9 for Drug Discovery in Oncology
    Sylvie Mireille Guichard · 2017 · Annual reports in medicinal chemistry
  82. In Vitro Validation of Transgene Expression in Gene-Edited Pigs Using CRISPR Transcriptional Activators
    Kathryn M. Polkoff, Jaewook Chung, Sean G. Simpson, Katherine Louise Gleason, Jorge A. Piedrahita · 2020 · The CRISPR Journal
  83. Erratum: Corrigendum: CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
    Shengdar Q. Tsai, Nathalie T. Nguyen, Jose Malagon-Lopez, Ved V. Topkar, Martin J. Aryee, J. Keith Joung · 2018 · Nature Methods
  84. Rescued from the fate of neurological disorder
    Yamin Li, Zachary Glass, Qiaobing Xu · 2018 · Nature Biomedical Engineering
  85. Pervasive off-target and double-stranded DNA nicking by CRISPR-Cas12a
    Karthik Murugan, Arun Somwarpet Seetharam, Andrew Josef Severin, Dipali G. Sashital · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  86. A kinetic model improves off-target predictions and reveals the physical basis of Sp Cas9 fidelity
    Behrouz Eslami-Mossallam, Misha Klein, Constantijn P. van der Smagt, Koen van der Sanden, Stephen K. Jones, John A. Hawkins, Ilya J. Finkelstein, Martin Depken · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  87. Negative DNA Supercoiling Induces Genome Wide Cas9 Off-Target Activity
    Matthew D. Newton, Marialucrezia Losito, Quentin M. Smith, Nishita Parnandi, Benjamin J. Taylor, Pınar Akçakaya, Marcello Maresca, Yi-Fang Wang, Simon J. Boulton, Graeme A. King et al. · 2022 · SSRN Electronic Journal
  88. CHOPOFF: symbolic alignments enable fast and sensitive CRISPR off-target detection
    Kornel Labun, Oline Rio, Håkon Tjeldnes, Michał I. Świrski, Anna Zofia Komisarczuk, Emma Maria Haapaniemi, Eivind Valen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  89. Identification of the <scp>EH CRISPR‐Cas9</scp> system on a metagenome and its application to genome engineering
    Esquerra‐Ruvira, Belen, Baquedano, Ignacio, Ruiz, Raul, Fernandez, Almudena, Montoliu, Lluis, Mojica, Francisco J. M. · 2023 · Microbial Biotechnology
  90. Editing Streptomyces genome using target AID system fused with UGI‐degradation tag
    Pamella Apriliana, Prihardi Kahar, Norimasa Kashiwagi, Akihiko Kondo, Chiaki Ogino · 2024 · Engineering in Life Sciences
  91. Design principle of successful genome editing applications using CRISPR-based toolkits
    Juhi Sharma, Rajesh Kumar Biswas, Prashant S. Khare · 2025 · Journal of Applied Genetics
  92. Off-target interactions in the CRISPR-Cas9 Machinery: mechanisms and outcomes
    Lyubov Yu. Kanazhevskaya, Polina V. Zhdanova, Alexander А. Chernonosov, Vladimir V. Koval · 2025 · Biochemistry and Biophysics Reports
  93. Emerging research insights and future perspectives on the advancement of eccDNA: A comprehensive review
    Kunlong Qi, Zheliang Liu, Felix Kwame Amevor, Dan Xu, Wei Zhu, Tong Li, Yingjie Wang, Liuting Wu, Gang Shu, Xiaoling Zhao · 2025 · Biotechnology Advances
  94. The multiple layers of RNA response in double-strand break repair
    Yilin Lu, Francesca Storici, Youngkyu Jeon · 2025 · Experimental & Molecular Medicine
  95. Upper bound on the mutational burden imposed by a CRISPR-Cas9 gene-drive element
    Michael S. Overton, Sean E. Guy, Xingsen Chen, Alena Martsul, Krypton Carolino, Omar S. Akbari, Justin R. Meyer, Sergey Kryazhimskiy · 2026 · G3 Genes Genomes Genetics
  96. In vitro and in vivo base editing of CCR5 in hematopoietic stem cells confers HIV-1 resistance
    Anna Kate Anderson, Aphrodite Georgakopoulou, Anne-Sophie Kuhlmann, Hongjie Wang, Andrew O. Riker, Karthik V. Karuppusamy, Stefan Radtke, John K. Bui, Hans‐Peter Kiem, André Lieber et al. · 2026 · Molecular Therapy
  97. Feature representation for explainable CRISPR off-target prediction and base editing efficiency
    Faiza Hasin, Michele Minervini, Corrado Mencar, Giuseppe Ventrella, Arianna Consiglio, Alessandro Orro, Tommaso Selmi · 2026 · Frontiers in Bioinformatics
  98. Applications of genome editing technologies in the treatment of human diseases
    Jamal Alshorman, Mohammad Javad Mehran, Kingsley Miyanda Tembo, Niusha Mostafavi, Mansoor Bolideei, Y L Wang · 2026 · Gene Therapy
  99. Cancer Cell-specific Transfection of hCas9 Gene Using Ad5F35 Vector
    Wataru Matsunaga, Katsuyuki Hamada, Masatoshi Tagawa, Takao Morinaga, Akinobu Gotoh · 2021 · Anticancer Research
  100. A bioinformatic analysis of gene editing off‐target loci altered by common polymorphisms, using ‘PopOff’
    Christopher Samson, Alex du Rand, John Hunt, Whitney Whitford, Jessie C. Jacobsen, Hilary M. Sheppard · 2024 · Journal of the Royal Society of New Zealand