CIRCLE-Seq: A highly sensitive in vitro screen for genome-wide CRISPR-cas9 nuclease off-targets
Tsai, Shengdar Q, Nguyen, Nhu T, Malagon-Lopez, Jose, Topkar, Ved V, Aryee, Martin J, Joung, J Keith·2017·Nature Methods
Cited by (816)
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- Ultra-deep sequencing reveals no evidence of oncogenic mutations or enrichment by ex vivo CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cellsM. Kyle Cromer, Valentin V. Barsan, Erich B. Jaeger, Mengchi Wang, Jessica P. Hampton, Feng Chen, Drew Kennedy, Irina Khrebtukova, Ana Granat, Tiffany Truong et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
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- Crispr-Embedding: CRISPR/Cas9 Off-Target Activity Prediction Using DNA k-Mer EmbeddingSwakkhar Shatabda, Anika Tahsin, Zarin Tasnim, Muneera Chowdhury, Kangkhita Hassin, Galib Hossain Meraz, Kazi Farzana Aziz · 2022 · SSRN Electronic Journal
- Diminished adherence of Biomphalaria glabrata embryonic cell line to sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factorFernanda Sales Coelho, Rutchanee Rodpai, André Miller, Shannon E. Karinshak, Victoria H. Mann, Omar dos Santos Carvalho, Roberta Lima Cladeira, Marina de Moraes Mourão, Paul J. Brindley, Wannaporn Ittiprasert · 2020 · Research Square
- Diminished Adherence of Biomphalaria Glabrata Embryonic Cell Line to Sporocysts of Schistosoma Mansoni Following Programmed Knockout of the Allograft Inflammatory FactorFernanda Sales Coelho, Rutchanee Rodpai, André Miller, Shannon E. Karinshak, Victoria H. Mann, Omar dos Santos Carvalho, Roberta Lima Cladeira, Marina de Moraes Mourão, Paul J. Brindley, Wannaporn Ittiprasert · 2020 · Research Square
- Faculty Opinions recommendation of In vivo CRISPR editing with no detectable genome-wide off-target mutations.Kevin Yuk-Lap Yip · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Review of Cell and Molecular BiologyKay T. Elder, Brian Dale · 2019 · Cambridge University Press eBooks
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- Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed RepairJuan A. Pérez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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- Characterizing Nucleic Acid‐, Gene‐, and Cell‐Based Therapeutics with Sequencing TechnologiesHayley M. Bennett, Ashley Byrne, William Stephenson, Zora D. Modrusan · 2025 · Wiley eBooks
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- Development of new increased fidelity SpCas9 variantsPéter István Kulcsár · 2019
- CRISPR Therapies for Alzheimer’s DiseaseJichao Sun, Subhojit Roy · 2025 · Springer eBooks
- Off-target sequence variations driven by the intrinsic properties of the Cas–sgRNA–DNA complex in genome editingCeline Kurniawan, Takeshi Itoh · 2025 · PLoS ONE
- 3′-end ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editorsJacob Stewart-Ornstein, Matthew J. Irby, Marina Korinne Lilieholm, Dylan Laprise, Maria Donaldson Collier, Thomas R. Aunins, Dewi Harjanto, Aaron N. Chang, Deepak Reyon, Jeremy S. Duffield · 2025 · Genome Research
- Weighted Off-target and Efficiency Scoring Reveal Genome Composition-Dependent Optimal CRISPR/Cas9 Guide DesignY K Yathu Krishna · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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- Additional file 13 of Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activityIda Höijer, Josefin Johansson, Sanna Gudmundsson, Chin, Chen-Shan, Ignas Bunikis, Susana Häggqvist, Anastasia Emmanouilidou, Maria Wilbe, Marcel den Hoed, Bondeson, Marie-Louise et al. · 2020 · Figshare
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