Nonblinking and long-lasting single-molecule fluorescence imaging

Spatially resolved, highly multiplexed RNA profiling in single cells

Chen, K. H., Boettiger, A. N., Moffitt, J. R., Wang, S., & Zhuang, X. (2015) · Science · doi:10.1126/science.aaa6090 · Cited by 2,969

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365

Super-resolution microscopy with DNA-PAINT

Schnitzbauer, J., Strauss, M. T., Schlichthaerle, T., Schueder, F., & Jungmann, R. (2017) · Nature Protocols · doi:10.1038/nprot.2017.024 · Cited by 1,047

Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells

Bintu, B., Mateo, L. J., Su, J.-H., Sinnott-Armstrong, N. A., Parker, M., Kinrot, S., Yamaya, K., Boettiger, A. N., & Zhuang, X. (2018) · Science · doi:10.1126/science.aau1783 · Cited by 976

Extreme disorder in an ultrahigh-affinity protein complex

Borgia, A., Borgia, M. B., Bugge, K., Kissling, V. M., Heidarsson, P. O., Fernandes, C. B., Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., et al. (2018) · Nature · doi:10.1038/nature25762 · Cited by 653

Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin

Su, J.-H., Zheng, P., Kinrot, S. S., Bintu, B., & Zhuang, X. (2020) · Cell · doi:10.1016/j.cell.2020.07.032 · Cited by 562

Fast, single-molecule localization that achieves theoretically minimum uncertainty

Smith, C. S., Joseph, N., Rieger, B., & Lidke, K. A. (2010) · Nature Methods · doi:10.1038/nmeth.1449 · Cited by 522

Ultra-stable organic fluorophores for single-molecule research

Zheng, Q., Juette, M. F., Jockusch, S., Wasserman, M. R., Zhou, Z., Altman, R. B., & Blanchard, S. C. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60237k · Cited by 406

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Gong, F., Yang, N., Wang, X., Zhao, Q., Chen, Q., Liu, Z., & Cheng, L. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100851 · Cited by 359

Subnanometre single-molecule localization, registration and distance measurements

Pertsinidis, A., Zhang, Y., & Chu, S. (2010) · Nature · doi:10.1038/nature09163 · Cited by 342

High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing

Moffitt, J. R., Hao, J., Bambah-Mukku, D., Lu, T., Dulac, C., & Zhuang, X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617699113 · Cited by 308

Photophysical processes in single molecule organic fluorescent probes

Stennett, E. M. S., Ciuba, M. A., & Levitus, M. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60211g · Cited by 323

Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

Jeon, Y., Choi, Y. H., Jang, Y., Yu, J., Goo, J., Lee, G., Jeong, Y. K., Lee, S. H., Kim, I.-S., Kim, J.-S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05245-x · Cited by 239

Can DyeCycling break the photobleaching limit in single-molecule FRET?

Vermeer, B., & Schmid, S. (2022) · Nano Research · doi:10.1007/s12274-022-4420-5 · Cited by 25

Functional characterization of dynamic nascent RNA folding ensembles in real time

Gor, K., Geissen, E. M., & Duss, O. (2026) · Science Advances · doi:10.1126/sciadv.aec4037 · Cited by 4