Prophage-mediated defence against viral attack and viral counter-defence

Dedrick, Rebekah M.; Jacobs-Sera, Deborah; Bustamante, Carlos A. Guerrero; Garlena, Rebecca A.; Mavrich, Travis N.; Pope, Welkin H.; Reyes, Juan C. Cervantes; Russell, Daniel A.; Adair, Tamarah; Alvey, Richard; Bonilla, J. Alfred; Bricker, Jerald S.; Brown, Bryony R.; Byrnes, Deanna; Cresawn, Steven G.; Davis, William B.; Dickson, Leon A.; Edgington, Nicholas P.; Findley, Ann M.; Golebiewska, Urszula; Grose, Julianne H.; Hayes, Cory F.; Hughes, Lee E.; Hutchison, Keith W.; Isern, Sharon; Johnson, Allison A.; Kenna, Margaret A.; Klyczek, Karen K.; Mageeney, Catherine M.; Michael, Scott F.; Molloy, Sally D.; Montgomery, Matthew T.; Neitzel, James; Page, Shallee T.; Pizzorno, Marie C.; Poxleitner, Marianne K.; Rinehart, Claire A.; Robinson, Courtney J.; Rubin, Michael R.; Teyim, Joseph N.; Vazquez, Edwin; Ware, Vassie C.; Washington, Jacqueline; Hatfull, Graham F.

doi:10.1038/nmicrobiol.2016.251

Cited by 278

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Prophage-mediated defence against viral attack and viral counter-defence

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Dedrick, Rebekah M., Jacobs-Sera, Deborah, Bustamante, Carlos A. Guerrero, Garlena, Rebecca A., Mavrich, Travis N., Pope, Welkin H., Reyes, Juan C. Cervantes, Russell, Daniel A., Adair, Tamarah, Alvey, Richard, Bonilla, J. Alfred, Bricker, Jerald S., Brown, Bryony R., Byrnes, Deanna, Cresawn, Steven G., Davis, William B., Dickson, Leon A., Edgington, Nicholas P., Findley, Ann M., Golebiewska, Urszula, Grose, Julianne H., Hayes, Cory F., Hughes, Lee E., Hutchison, Keith W., Isern, Sharon, Johnson, Allison A., Kenna, Margaret A., Klyczek, Karen K., Mageeney, Catherine M., Michael, Scott F., Molloy, Sally D., Montgomery, Matthew T., Neitzel, James, Page, Shallee T., Pizzorno, Marie C., Poxleitner, Marianne K., Rinehart, Claire A., Robinson, Courtney J., Rubin, Michael R., Teyim, Joseph N., Vazquez, Edwin, Ware, Vassie C., Washington, Jacqueline, Hatfull, Graham F.·2017·Nature Microbiology

DOI 10.1038/nmicrobiol.2016.251

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Abstract

Temperate phages are common, and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage. Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defence systems include a single-subunit restriction system, a heterotypic exclusion system and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, which acts as a highly effective counter-defence system. Prophage-mediated viral defence offers an efficient mechanism for bacterial success in host–virus dynamics, and counter-defence promotes phage co-evolution.

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Authors: Dedrick, R. M., Jacobs-Sera, D., Bustamante, C. A. G., Garlena, R. A., Mavrich, T. N., Pope, W. H., Reyes, J. C. C., Russell, D. A., Adair, T., Alvey, R., Bonilla, J. A., Bricker, J. S., Brown, B. R., Byrnes, D., Cresawn, S. G., Davis, W. B., Dickson, L. A., Edgington, N. P., Findley, A. M., Golebiewska, U., Grose, J. H., Hayes, C. F., Hughes, L. E., Hutchison, K. W., Isern, S., Johnson, A. A., Kenna, M. A., Klyczek, K. K., Mageeney, C. M., Michael, S. F., Molloy, S. D., Montgomery, M. T., Neitzel, J., Page, S. T., Pizzorno, M. C., Poxleitner, M. K., Rinehart, C. A., Robinson, C. J., Rubin, M. R., Teyim, J. N., Vazquez, E., Ware, V. C., Washington, J., & Hatfull, G. F.
Venue: Nature Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2017-01-09
Volume: 2
Issue: 3
Pages: 16251-16251
ISSN: 2058-5276 (ISSN-L)
DOI: 10.1038/nmicrobiol.2016.251
OpenAlex: W2570615709
Cited by: 278
References: 5
FWCI: 15.43
Type: journal article
Language: en
Open access: green

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This page: CoChat. (2026). Citation check: Prophage-mediated defence against viral attack and viral counter-defence. https://app.cochat.ai/papers/10.1038/nmicrobiol.2016.251
The paper: Dedrick, R. M., Jacobs-Sera, D., Bustamante, C. A. G., Garlena, R. A., Mavrich, T. N., Pope, W. H., Reyes, J. C. C., Russell, D. A., Adair, T., Alvey, R., Bonilla, J. A., Bricker, J. S., Brown, B. R., Byrnes, D., Cresawn, S. G., Davis, W. B., Dickson, L. A., Edgington, N. P., Findley, A. M., . . . Hatfull, G. F. (2017). Prophage-mediated defence against viral attack and viral counter-defence. Nature Microbiology. https://doi.org/10.1038/nmicrobiol.2016.251

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Prophage-mediated defence against viral attack and viral counter-defence

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