The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Endoplasmic reticulum stress in disorders of myelinating cells
Open accessAbstract
Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly susceptible to disruptions of the secretory pathway. Endoplasmic reticulum stress, initiated by the accumulation of unfolded or misfolded proteins, activates the unfolded protein response, which adapts cells to the stress. If this adaptive response is insufficient, the unfolded protein response activates an apoptotic program to eliminate the affected cells. Recent observations suggest that endoplasmic reticulum stress in myelinating cells is important in the pathogenesis of various disorders of myelin, including Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease and Vanishing White Matter Disease, as well as in the most common myelin disorder, multiple sclerosis. A better understanding of endoplasmic reticulum stress in myelinating cells has laid the groundwork for the design of new therapeutic strategies for promoting myelinating cell survival in these disorders.
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Cites
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Cited by
The Unfolded Protein Response and Cell Fate Control
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Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes-Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 728
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
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Neural Stem Cell Engraftment and Myelination in the Human Brain
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Metadata
- Authors
- Lin, W., & Popko, B.
- Venue
- Nature Neuroscience
- Published
- 2009-03-15
- Volume
- 12
- Issue
- 4
- Pages
- 379-385
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1973854653
- Cited by
- 252
- References
- 91
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
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