The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity
Open accessAbstract
Notch signaling is central to vertebrate development, and analysis of Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissues. However, surprisingly little is known about the role of Notch in the development and pathology of Schwann cells and peripheral nerves. Using transgenic mice and cell cultures, we found that Notch has complex and extensive regulatory functions in Schwann cells. Notch promoted the generation of Schwann cells from Schwann cell precursors and regulated the size of the Schwann cell pool by controlling proliferation. Notch inhibited myelination, establishing that myelination is subject to negative transcriptional regulation that opposes forward drives such as Krox20. Notably, in the adult, Notch dysregulation resulted in demyelination; this finding identifies a signaling pathway that induces myelin breakdown in vivo. These findings are relevant for understanding the molecular mechanisms that control Schwann cell plasticity and underlie nerve pathology, including demyelinating neuropathies and tumorigenesis.
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Cites
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Cited by
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Advances in peripheral nerve regeneration
Scheib, J., & Höke, A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.227 · Cited by 758
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
Jopling, C., Boue, S., & Belmonte, J. C. I. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3043 · Cited by 730
The Success and Failure of the Schwann Cell Response to Nerve Injury
Jessen, K. R., & Mirsky, R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00033 · Cited by 466
Self-citationSchwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Gomez-Sanchez, J. A., Carty, L., Iruarrizaga-Lejarreta, M., Palomo-Irigoyen, M., Varela-Rey, M., Griffith, M., Hantke, J., Macias-Camara, N., Azkargorta, M., Aurrekoetxea, I., et al. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201503019 · Cited by 453
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Metadata
- Authors
- Woodhoo, A., Alonso, M. B. D., Droggiti, A., Turmaine, M., D'Antonio, M., Parkinson, D. B., Wilton, D. K., Al-Shawi, R., Simons, P., Shen, J., Guillemot, F., Radtke, F., Meijer, D., Feltri, M. L., Wrabetz, L., Mirsky, R., & Jessen, K. R.
- Venue
- Nature Neuroscience
- Published
- 2009-06-14
- Volume
- 12
- Issue
- 7
- Pages
- 839-847
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2120442017
- Cited by
- 347
- References
- 1
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Woodhoo, A., Alonso, M. B. D., Droggiti, A., Turmaine, M., D'Antonio, M., Parkinson, D. B., Wilton, D. K., Al-Shawi, R., Simons, P., Shen, J., Guillemot, F., Radtke, F., Meijer, D., Feltri, M. L., Wrabetz, L., Mirsky, R., & Jessen, K. R. (2009). Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nature Neuroscience. https://doi.org/10.1038/nn.2323
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