The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
The Success and Failure of the Schwann Cell Response to Nerve Injury
Open accessAbstract
The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin) and myelin phenotypes, which are specialized to meet the needs of small and large diameter axons, and differ markedly from each other. It also enables Schwann cells initially to mount a strikingly adaptive response to nerve injury and to promote regeneration by converting to a repair-promoting phenotype. These repair cells activate a sequence of supportive functions that engineer myelin clearance, prevent neuronal death, and help axon growth and guidance. Eventually, this response runs out of steam, however, because in the long run the phenotype of repair cells is unstable and their survival is compromised. The re-programming of Remak and myelin cells to repair cells, together with the injury-induced switch of peripheral neurons to a growth mode, gives peripheral nerves their strong regenerative potential. But it remains a challenge to harness this potential and devise effective treatments that maintain the initial repair capacity of peripheral nerves for the extended periods typically required for nerve repair in humans.
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Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
The origin and development of glial cells in peripheral nerves
Jessen, K. R., & Mirsky, R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1746 · Cited by 1,354
Self-citationThe cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
The repair Schwann cell and its function in regenerating nerves
Jessen, K. R., & Mirsky, R. (2016) · The Journal of Physiology · doi:10.1113/jp270874 · Cited by 1,176
Self-citationMacrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
Cattin, A.-L., Burden, J. J., Van Emmenis, L., Mackenzie, F. E., Hoving, J. J. A., Garcia Calavia, N., Guo, Y., McLaughlin, M., Rosenberg, L. H., Quereda, V., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.021 · Cited by 936
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Self-citationInfluence of aging on peripheral nerve function and regeneration
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Cited by
Peripheral nerve Single-cell analysis identifies Mesenchymal Ligands that promote axonal growth
Toma, J. S., Karamboulas, K., Carr, M. J., Kolaj, A., Yuzwa, S. A., Mahmud, N., Storer, M. A., Kaplan, D. R., & Miller, F. D. (2020) · eneuro · doi:10.1523/eneuro.0066-20.2020 · Cited by 82
Metadata
- Authors
- Jessen, K. R., & Mirsky, R.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-02-11
- Volume
- 13
- Pages
- 33-33
- ISSN
- 1662-5102 (ISSN-L)
- OpenAlex
- W2911366120
- Cited by
- 466
- References
- 116
- FWCI
- 24.05
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
