The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination
Chen, Ying, Wu, Heng, Wang, Shuzong, Koito, Hisami, Li, Jianrong, Ye, Feng, Hoang, Jenny, Escobar, Sabine S +6 more·2009·Nature Neuroscience
DOI 10.1038/nn.2410
Cited by (351)
Items 301–351 of 351
- Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid PathologyIsabel Castanho, Tracey K. Murray, Eilis J. Hannon, Aaron R. Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Andrew D. Randall, Karen Moore et al. · 2019 · SSRN Electronic Journal
- [G protein-coupled receptor 17 is involved in CoCl2-induced hypoxic injury in RGC-5 cells].Ka-Na Lin, Meili Lin, Yingfen Gu, Shunguo Zhang, Shiying Huang · 2018 · PubMed Central
- The white matter is a pro-differentiative microenvironment for glioblastomaLucy J. Brooks, Melanie Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Megan Woodberry, Michael J. Ellis, Leila Zakka, Zane Jaunmuktane et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse BrainMing Zhang, Jian Wang, Kaixiang Zhang, Guozhen Lu, Yuming Liu, Keke Ren, Wenting Wang, Dazhuan Xin, Lingli Xu, Honghui Mao et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Targeting G protein-coupled receptor-17 (GPR17) upregulation in paediatric diffuse midbrain gliomas leads to altered phenotype and susceptibility to therapiesKatie F. Loveson, Helen L. Fillmore · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Pluripotent stem-cell-derived oligodendrocyte progenitors to model demyelination caused by Theiler’s murine encephalomyelitis virus and other virusesEric C. Freundt, Pavan Rajanahalli · 2021 · Elsevier eBooks
- Investigating age and differentiation stage differences in human oligodendrocyte lineage cells via single-cell and bulk RNA sequencing analysisJulia Xiao Xuan Luo · 2021 · eScholarship@McGill (McGill)
- Post-transcriptional Regulation of Myelin Basic Protein ExpressionAnthony Giampetruzzi · 2014 · OpenCommons at University of Connecticut (University of Connecticut)
- Role of miRNAs in Oligodendrocyte DevelopmentHolger Budde · 2010 · eDiss (Georg-August-Universität Göttingen)
- Faculty Opinions recommendation of YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.Jonathan Chernoff · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Physiology of GPCRs in the nervous system and the contribution of orphan GPCRsNecla Birgül İyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Dogan Soner, Zafiroula Georgoussi, Jesús Giraldo, Anemarie Horvat et al. · 2023
- Molecular Logic of Neuromodulatory Systems in the Zebrafish TelencephalonLukas Anneser, Chie Satou, Hans-Rudolf Hotz, Rainer W. Friedrich · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Cluster decomposition-based anomaly detection for rare cell identification in single-cell expression dataYunpei Xu, Shaokai Wang, Hong‐Dong Li, Qilong Feng, Yaohang Li, Jianxin Wang · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Orchestrating the neuroglial compartment: Ontogeny and developmental interaction of astrocytes, oligodendrocytes, and microgliaImke M. E. Schuurmans, Annika Mordelt, Lot D. de Witte · 2025 · Handbook of clinical neurology
- GPR17 modulates oligodendrocyte precursor cell maturation during development but has limited impact on myelin regeneration following demyelinating insultsKristin Puorro-Radzwill, Petti T. Pang, Stefanie Giera, Guoqing Sheng, Jonathan E. Farley, Carrie Garron, Sanjay J. Danthi, Joseph Gans, Dinesh Kumar, Rajiv G. Agrawal et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- PEDIA-BRAIN: A single nuclei multiomic encyclopedia of the human pons provides a resource for normal development and disease vulnerabilityTianli Ding, Gary Schweickart, Kaitlin Kaiser, Adithe Rivaldi, Nicholas Marchal, Cole A. Harrington, Aaron Varghese, Ke Qin, Benjamin Kelly, Benjamin D. Sunkel et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- G Protein: β-Arrestin Bias Confers Differential Regulation of Gα q Signaling by GPR17 AntagonistsJack K. McDonald, Aakanksha Abrol, Chris Lumb, Ben Capuano, Peter J. Scammells, Liam Scott, Natalie A. Diepenhorst, Christopher J. Langmead, Sheng Yu Ang, Gregory D. Stewart · 2025 · ACS Chemical Neuroscience
- GPR17 structure and agonism with small molecules and oxysterolsClaire M. Metrick, Lu Zhang, Maria Hercher, Greg J. Dodge, Dennis Cherry, Jorge Vera Rebollar, Margot Brickelmaier, Jing Wang, Jeffrey G. Martin, Xiaoping L. Hronowski et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve systemXu, Jinghui, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Su, Wenfeng, Chen, Gang, Sun, Hualin, 朱昌来, Gu, Yun · 2024 · Figshare
- Additional file 2 of The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve systemXu, Jinghui, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Su, Wenfeng, Chen, Gang, Sun, Hualin, 朱昌来, Gu, Yun · 2024 · Figshare
- Additional file 3 of The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve systemXu, Jinghui, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Su, Wenfeng, Chen, Gang, Sun, Hualin, 朱昌来, Gu, Yun · 2024 · Figshare
- Adenine nucleotides as potent and selective GPR17 modulatorsDiego Dal Ben, Catia Lambertucci, Michela Buccioni, Beatrice Francucci, Andrea Spinaci, Rosaria Volpini, Gabriella Marucci · 2026 · Bioorganic Chemistry
- Bi-allelic loss-of-function variants in JKAMP cause a neurodevelopmental syndrome associated with dysregulation of GPR37 traffickingPilar Chacon-Millan, Antonella Delicato, Arif Mahmood, Alfonsina Tirozzi, Jlenia Monfregola, Karine Duroure, Malo Serafini, François Kroll, Océane El-Hage, Somaya Salah et al. · 2026 · The American Journal of Human Genetics
- Diverging routes of oligodendrocyte recruitment in adaptive and regenerative myelinationLaura J. Hoodless, Patricia Bispo, Elena MD Collins, Karl Baldacchino, Franziska Auer, Tim Czopka · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Premyelinating Oligodendrocyte Survival Governs CNS RemyelinationMichael E. Stockton, Maureen Wentling, Yessenia I. Mancha Corchado, Abigail J. Kucera, Stephanie Karas, Tania A. Seabrook, Clara Mutschler, Lindsay A. Osso, Kristen H. Schuster, Gustavo Della Flora Nunes et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Rôles des androgènes et de leur récepteur AR dans le dimorphisme et la réparation de la myélineCharly Abi‐Ghanem · 2016 · theses.fr (ABES)
- The role of Chd7 & Chd8 chromatin remodelers in oligodendrogenesis and (re)myelinationCorentine Marie · 2017 · theses.fr (ABES)
- Dynamics of nodes of Ranvier assembly during myelination and remyelination in the central nervous systemMelina Thétiot · 2018
- Etude des foyers d’hétérogénéité tumorale dans les gliomes diffus de bas grade de l’adulte mutés IDH1Nicolas Leventoux · 2018 · theses.fr (ABES)
- Régénération spontanée de la myéline dans le cerveau de souris adulte : interactions entre cellules souches, progéniteurs et microglieBéatrice Brousse · 2019 · theses.fr (ABES)
- Influence de l'activateur tissulaire du plasminogène sur la lignée oligodendrocytaire et dans le processus de myélinisationBarbara Delaunay-Piednoir · 2020
- Le cil primaire : une nouvelle cible pour la remyélinisation ?Giada Delfino · 2020 · theses.fr (ABES)
- Characterization of cellular heterogeneity in Diffuse Low Grade GliomaMeera Augustus · 2020 · theses.fr (ABES)
- Etude des conséquences des altérations de la myéline sur les fonctions cognitives à la suite d’un épisode transitoire de démyélinisation chez la souris adulteOcéane Mercier · 2022 · theses.fr (ABES)
- Pharmacogenomic identification of small molecules promoting oligodendrogenesis and myelin repairJean-Baptiste Huré · 2022 · theses.fr (ABES)
- Rôle de la protéine de densité post-synaptique 95 (PSD-95) dans la myélinisation du système nerveux centralMauricio Lopez Portillo Masson · 2024 · theses.fr (ABES)
- Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A miceStefano Raffaele, Tiziana Bonifacino, Francesca Carolina Mannella, Nhung Nguyen, Carola Torazza, Davide Marangon, Elena Maria Chinosi, Henrik Daa Schrøder, Eva Kildall Hejbøl, Kirsten Madsen et al. · 2026 · Pharmacological Research
- Oligodendrocyte lineage cell–specific GPR17/Gelsolin signaling regulates remyelination and cognitive recovery after subarachnoid hemorrhageSong Tan, Yingwen Wang, Xuesong Li, Yajun Zhu, Zichao Huang, Chunyue Deng, Rui Tang, Jianjun Zhong, Zongduo Guo · 2026 · Experimental Neurology
- Machine learning–driven drug repurposing for GPR17: activity prediction via graph neural networks and multistage computational validationNoushin Agha Babaie, Morteza Farnia, Jahan Bakhsh Ghasemi · 2026 · Journal of Biomolecular Structure and Dynamics
- GPR37 Modulates Remyelination Following Demyelinating InjuryRenana Hajbi Karasik, Anna Vainshtein, Rina Aharoni, Yael Eshed‐Eisenbach, Daniela Marazziti, Elior Peles, Hyun‐Jeong Yang · 2026 · Journal of Neuroscience
- Activation of GPR17 ameliorates neuroinflammation and improves neurological function via NF-κB pathway in an experimental germinal matrix hemorrhage rat modelChenxi Guo, Fengmei Zhou, Chi Qin, Xiaoan Zhang, Hui Chang, Xin Zhao · 2026 · Journal of Cerebral Blood Flow & Metabolism
- Xuefu Zhuyu Decoction Ameliorates Neuroinflammation after Traumatic Brain Injury via tRF-3-Leu-AAG/Gpr17 axisZhaoyu Yang, Zhiqiang Yuan, Jiaqi Hou, Yali Long, Ming Luo, ZiLi Lai, Zixuan Zhong, Xudong Fan, Daiyi Chen, Tao Tang et al. · 2026 · Phytomedicine
- Role of E3 Ubiquitin Ligases in Oligodendrocyte Health and DiseaseAngela M. Mabb, Dhanya N. Pyaram, Jayshree Samanta · 2026 · ASN NEURO
- Selective GPR17 antagonism enhances structural and functional recovery in animal models of demyelinationD. De Herdt, Evy Lefevere, Véronique Brouwers, Line Hartvig, Emiel Geeraerts, Cheng‐Chih Hsiao, J. Q. Alida Chen, Rui Pinto, Guillaume Duvey, Stephen Burbidge et al. · 2026 · PLoS ONE
- Up-Regulation of Anthranilic Acid Formation and Pro-Cognitive Effect of Indoleamine 2,3-Dioxygenase InhibitionGregory F. Oxenkrug, Stefano Comai · 2026 · International Journal of Tryptophan Research
- Design, Synthesis, and Characterization of Novel Small Molecule Antagonists of the GPR17 ReceptorSanju Narayanan, Ann M. Decker, Danni L. Harris, Tiffany L. Langston, E Tonetti, Xuezhao Liu, Qing Richard Lu · 2026 · Journal of Medicinal Chemistry
- Oligodendrocytes in central nervous system health and diseaseLucy J. Ryan, Véronique E. Miron · 2026 · Cell
- BindingDB Entry 50044258: TBABindingDB · 2015 · UC San Diego
- BindingDB Entry 50002464: 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50012636: Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2YBindingDB · 2022 · UC San Diego
- Investigation of myelin membrane adhesion and compaction in the central nervous systemMostafa Bakhti · 2013