The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

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  10. Drug discovery for remyelination and treatment of MS
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  11. Tracking cell-type-specific temporal dynamics in human and mouse brains
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  12. Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives
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  13. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model
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  14. Advances in myelinating glial cell development
    Amy L Herbert, Kelly R. Monk · 2016 · Current Opinion in Neurobiology
  15. G Protein-Coupled Receptors in Myelinating Glia
    Amit Mogha, Mitchell D’Rozario, Kelly R. Monk · 2016 · Trends in Pharmacological Sciences
  16. The G Protein‐Coupled Receptor GPR17: Overview and Update
    Gabriella Marucci, Diego Dal Ben, Catia Lambertucci, Claudia Santinelli, Andrea Spinaci, Ajiroghene Thomas, Rosaria Volpini, Michela Buccioni · 2016 · ChemMedChem
  17. G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models
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  18. Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation
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  19. G protein‐coupled receptor 30 contributes to improved remyelination after cuprizone‐induced demyelination
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  20. Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signaling
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  21. The Regulated Expression, Intracellular Trafficking, and Membrane Recycling of the P2Y-like Receptor GPR17 in Oli-neu Oligodendroglial Cells
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  23. Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?
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  25. Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands
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  27. On the resemblance of synapse formation and CNS myelination
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  29. A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
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  31. The GPR17 receptor-A promising goal for therapy and a potential marker of the neurodegenerative process in multiple sclerosis
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  32. TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum
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  33. Inhibition of Leukotriene Receptors Boosts Neural Progenitor Proliferation
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  34. Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination
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  37. Ulk4 deficiency leads to hypomyelination in mice
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  38. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen
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  39. Sustained Expression of Negative Regulators of Myelination Protects Schwann Cells from Dysmyelination in a Charcot–Marie–Tooth 1B Mouse Model
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  40. Reappraisal of Human HOG and MO3.13 Cell Lines as a Model to Study Oligodendrocyte Functioning
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  43. G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production
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  45. Multipotency and therapeutic potential of NG2 cells
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  46. Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis
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    Pauline E. M. van Schaik, Inge S. Zuhorn, Wia Baron · 2022 · International Journal of Molecular Sciences
  49. GAT‐1 mediated GABA uptake in rat oligodendrocytes
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    Joana Murad, Chelsea S. Place, Cong Ran, S. K. Hekmatyar, Nathan P. Watson, Risto A. Kauppinen, Mark A. Israel · 2010 · Journal of Biological Chemistry
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  53. GPR17 mediates ischemia-like neuronal injury via microglial activation
    Bing Zhao, Hao Wang, Caixia Li, Shengwen Song, San‐Hua Fang, Er‐Qing Wei, Qiaojuan Shi · 2018 · International Journal of Molecular Medicine
  54. DHHC5 facilitates oligodendrocyte development by palmitoylating and activating STAT3
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  56. 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17
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  57. DBZ, a CNS‐specific DISC1 binding protein, positively regulates oligodendrocyte differentiation
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  58. Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion
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  59. A Glance at the Molecules That Regulate Oligodendrocyte Myelination
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  60. Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin
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  61. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis
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