Self-generated theta oscillations in the hippocampus

Primary generating mechanisms for theta appear to be located within the hippocampus, i.e., in CA1, although extrahippocampal input, mainly from the septum, contributes.

“Primary generating mechanisms appear to be located within the hippocampus, i.e., in CA1 (472), although extrahippocampal input, mainly from the septum, contributes.”

The CA1 circuit has an intrinsic ability to generate some form of theta waves even without rhythmic external inputs.

“Therefore, the latter studies suggest an intrinsic ability of the CA1 circuit to generate some form of theta waves even without rhythmic external inputs.”

Spontaneous theta-frequency LFP oscillations are present in the isolated whole CA1 preparation in vitro.

“recent reports indicate the presence of spontaneous theta-frequency LFP oscillations even in the isolated whole CA1 preparation in vitro (Goutagny et al., 2009; Amilhon et al., 2015).”

These oscillations emerged from the network model without explicit encoding, rhythmic inputs or purposeful tuning of intra-CA1 parameters.

“Consistent with experimental results (Goutagny et al., 2009; Amilhon et al., 2015), these oscillations emerged from the network model without explicit encoding, rhythmic inputs or purposeful tuning of intra-CA1 parameters (all anatomical connectivity parameters were exactly as previously published in Bezaire and Soltesz (2013)).”

Experimental data on the isolated CA1 preparation were obtained from both rat and mouse.

“the experimental data on the isolated CA1 preparation were obtained from both rat (Goutagny et al., 2009) and mouse (Amilhon et al., 2015)”