The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The exon junction complex component Magoh controls brain size by regulating neural stem cell division
Open accessAbstract
Brain structure and size require precise division of neural stem cells (NSCs), which self-renew and generate intermediate neural progenitors (INPs) and neurons. The factors that regulate NSCs remain poorly understood, and mechanistic explanations of how aberrant NSC division causes the reduced brain size seen in microcephaly are lacking. Here we show that Magoh, a component of the exon junction complex (EJC) that binds RNA, controls mouse cerebral cortical size by regulating NSC division. Magoh haploinsufficiency causes microcephaly because of INP depletion and neuronal apoptosis. Defective mitosis underlies these phenotypes, as depletion of EJC components disrupts mitotic spindle orientation and integrity, chromosome number and genomic stability. In utero rescue experiments showed that a key function of Magoh is to control levels of the microcephaly-associated protein Lis1 during neurogenesis. Our results uncover requirements for the EJC in brain development, NSC maintenance and mitosis, thereby implicating this complex in the pathogenesis of microcephaly.
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Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes
Mefford, H. C., Sharp, A. J., Baker, C., Itsara, A., Jiang, Z., Buysse, K., Huang, S., Maloney, V. K., Crolla, J. A., Baralle, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805384 · Cited by 804
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794
Brunetti-Pierri, N., Berg, J. S., Scaglia, F., Belmont, J., Bacino, C. A., Sahoo, T., Lalani, S. R., Graham, B., Lee, B., Shinawi, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.279 · Cited by 625
ASPM is a major determinant of cerebral cortical size
Bond, J., Roberts, E., Mochida, G. H., Hampshire, D. J., Scott, S., Askham, J. M., Springell, K., Mahadevan, M., Crow, Y. J., Markham, A. F., et al. (2002) · Nature Genetics · doi:10.1038/ng995 · Cited by 581
Self-citationGenePaint.org: an atlas of gene expression patterns in the mouse embryo
Visel, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh029 · Cited by 528
Identification of microcephalin, a protein implicated in determining the size of the human brain
Jackson, A. P., Eastwood, H., Bell, S. M., Adu, J., Toomes, C., Carr, I. M., Roberts, E., Hampshire, D. J., Crow, Y. J., Mighell, A. J., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341283 · Cited by 482
Role of Intermediate Progenitor Cells in Cerebral Cortex Development
Pontious, A., Kowalczyk, T., Englund, C., & Hevner, R. F. (2008) · Developmental Neuroscience · doi:10.1159/000109848 · Cited by 378 · cited 1×
“5) 50% (14) 50% (14) NA NA MagohGT0150/+ 89% (321) 11% (40)** NA NA MagohGT027/+ 93% (192) 7% (15)** NA NA Tg-BAC1; MagohMos2/+ 37% (65) 0% 33% (58) 30% (51)** Tg-BAC2; MagohMos2/+ 31% (84) 1% (3) 33% (88) 35% (96)**”
A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy
Matera, I., Watkins-Chow, D. E., Loftus, S. K., Hou, L., Incao, A., Silver, D. L., Rivas, C., Elliott, E. C., Baxter, L. L., & Pavan, W. J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn110 · Cited by 60
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Bershteyn, M., Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Nene, A., Wynshaw-Boris, A., & Kriegstein, A. R. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.12.007 · Cited by 566
Boyd, J. L., Skove, S. L., Rouanet, J. P., Pilaz, L.-J., Bepler, T., Gordân, R., Wray, G. A., & Silver, D. L. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.041 · Cited by 285
Self-citationKraushar, M. L., Thompson, K., Wijeratne, H. R. S., Viljetic, B., Sakers, K., Marson, J. W., Kontoyiannis, D. L., Buyske, S., Hart, R. P., & Rasin, M.-R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408305111 · Cited by 98
Modifier genes and the plasticity of genetic networks in mice
Hamilton, B. A., & Yu, B. D. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002644 · Cited by 78
Globularization and domestication.
Benítez-Burraco, A., Theofanopoulou, C., & Boeckx, C. (2018) · Topoi · doi:10.1007/s11245-016-9399-7 · Cited by 42
Metadata
- Authors
- Silver, D. L., Watkins-Chow, D. E., Schreck, K. C., Pierfelice, T. J., Larson, D. M., Burnetti, A. J., Liaw, H.-J., Myung, K., Walsh, C. A., Gaiano, N., & Pavan, W. J.
- Venue
- Nature Neuroscience
- Published
- 2010-04-04
- Volume
- 13
- Issue
- 5
- Pages
- 551-558
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2133810562
- Cited by
- 181
- References
- 8
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Silver, D. L., Watkins-Chow, D. E., Schreck, K. C., Pierfelice, T. J., Larson, D. M., Burnetti, A. J., Liaw, H.-J., Myung, K., Walsh, C. A., Gaiano, N., & Pavan, W. J. (2010). The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nature Neuroscience. https://doi.org/10.1038/nn.2527
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