The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog
Open accessAbstract
The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant worms, we found that phototransduction in ASJ is a G protein–mediated process and requires membrane-associated guanylate cyclases, but not typical phosphodiesterases. In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photoreceptor protein known to be a member of the invertebrate taste receptor family. Our genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptor cells. Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Active Currents Regulate Sensitivity and Dynamic Range in C. elegans Neurons
Goodman, M. B., Hall, D. H., Avery, L., & Lockery, S. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)81014-4 · Cited by 370
Cited by
Liman, E. R., Zhang, Y. V., & Montell, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.022 · Cited by 473
Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall
Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y., & Jan, Y. N. (2010) · Nature · doi:10.1038/nature09576 · Cited by 462
The neuronal genome of Caenorhabditis elegans
Hobert, O. (2013) · WormBook · doi:10.1895/wormbook.1.161.1 · Cited by 279
A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila
Ni, L., Bronk, P., Chang, E. C., Lowell, A. M., Flam, J. O., Panzano, V. C., Theobald, D. L., Griffith, L. C., & Garrity, P. A. (2013) · Nature · doi:10.1038/nature12390 · Cited by 254
Garrity, P. A., Goodman, M. B., Samuel, A. D., & Sengupta, P. (2010) · Genes & Development · doi:10.1101/gad.1953710 · Cited by 197
Metadata
- Authors
- Liu, J., Ward, A., Gao, J., Dong, Y., Nishio, N., Inada, H., Kang, L., Yu, Y., Ma, D., Xu, T., Mori, I., Xie, Z., & Xu, X. Z. S.
- Venue
- Nature Neuroscience
- Published
- 2010-05-02
- Volume
- 13
- Issue
- 6
- Pages
- 715-722
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2123624203
- Cited by
- 200
- References
- 1
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog. https://app.cochat.ai/papers/10.1038/nn.2540
- The paper
- Liu, J., Ward, A., Gao, J., Dong, Y., Nishio, N., Inada, H., Kang, L., Yu, Y., Ma, D., Xu, T., Mori, I., Xie, Z., & Xu, X. Z. S. (2010). C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog. Nature Neuroscience. https://doi.org/10.1038/nn.2540
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
