The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching
Open accessAbstract
The refinement of neural circuits during development depends on a dynamic process of branching of axons and dendrites that leads to synapse formation and connectivity. The neurotrophin brain-derived neurotrophic factor (BDNF) is essential for the outgrowth and activity-dependent remodeling of axonal arbors in vivo. However, the mechanisms that translate extracellular signals into the formation of axonal branches are incompletely understood. We found that MAP kinase phosphatase-1 (MKP-1) controls axon branching. MKP-1 expression induced by BDNF signaling caused spatiotemporal deactivation of c-jun N-terminal kinase (JNK), which reduced the phosphorylation of JNK substrates that destabilize microtubules. Indeed, neurons from mkp-1 null mice could not produce axon branches in response to BDNF. Our results identify a signaling mechanism that regulates axonal branching and provide a framework for studying the molecular mechanisms of innervation and axonal remodeling under normal and pathological conditions.
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NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
Owens, D. M., & Keyse, S. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210412 · Cited by 777
Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
Cohen-Cory, S., & Fraser, S. E. (1995) · Nature · doi:10.1038/378192a0 · Cited by 580
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559
Self-citationBartkowska, K., Paquin, A., Gauthier, A. S., Kaplan, D. R., & Miller, F. D. (2007) · Development · doi:10.1242/dev.008227 · Cited by 226
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect
Jeanneteau, F., Garabedian, M. J., & Chao, M. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709102105 · Cited by 215
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Cited by
Dual‐specificity MAP kinase phosphatases (MKPs): Shaping the outcome of MAP kinase signalling
Caunt, C. J., & Keyse, S. M. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08716.x · Cited by 535
Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance.
Liston, C., Cichon, J. M., Jeanneteau, F., Jia, Z., Chao, M. V., & Gan, W.-B. (2013) · Nature Neuroscience · doi:10.1038/nn.3387 · Cited by 358
Self-citationCourchet, J., Lewis, T. L., Lee, S., Courchet, V., Liou, D.-Y., Aizawa, S., & Polleux, F. (2013) · Cell · doi:10.1016/j.cell.2013.05.021 · Cited by 349
Nuclear and cytosolic JNK signalling in neurons
Coffey, E. T. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3729 · Cited by 338
Protein tyrosine phosphatases as potential therapeutic targets
He, R.-J., Yu, Z.-H., Zhang, R.-Y., & Zhang, Z.-Y. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.80 · Cited by 327
Metadata
- Authors
- Jeanneteau, F., Deinhardt, K., Miyoshi, G., Bennett, A. M., & Chao, M. V.
- Venue
- Nature Neuroscience
- Published
- 2010-10-10
- Volume
- 13
- Issue
- 11
- Pages
- 1373-1379
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2161050830
- Cited by
- 163
- References
- 6
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Jeanneteau, F., Deinhardt, K., Miyoshi, G., Bennett, A. M., & Chao, M. V. (2010). The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nature Neuroscience. https://doi.org/10.1038/nn.2655
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