NEUROTROPHINS AND SYNAPTIC PLASTICITY

McAllister, A. Kimberley; Katz, Lawrence C.; Lo, Donald C.

doi:10.1146/annurev.neuro.22.1.295

Cited by 1,337Nerve injury and regenerationNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

NEUROTROPHINS AND SYNAPTIC PLASTICITY

McAllister, A. Kimberley, Katz, Lawrence C., Lo, Donald C.·1999·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.22.1.295

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Abstract

▪ Abstract Despite considerable evidence that neuronal activity influences the organization and function of circuits in the developing and adult brain, the molecular signals that translate activity into structural and functional changes in connections remain largely obscure. This review discusses the evidence implicating neurotrophins as molecular mediators of synaptic and morphological plasticity. Neurotrophins are attractive candidates for these roles because they and their receptors are expressed in areas of the brain that undergo plasticity, activity can regulate their levels and secretion, and they regulate both synaptic transmission and neuronal growth. Although numerous experiments show demonstrable effects of neurotrophins on synaptic plasticity, the rules and mechanisms by which they exert their effects remain intriguingly elusive.

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For neurotrophins to mediate activity-dependent plasticity in the CNS, they must be released and act in an activity-dependent manner.
“To act as a mediator of activity-dependent plasticity in the central nervous system (CNS), neurotrophins need to be released and to act in an activity-dependent manner10,35,36.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [36]

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Brain‐derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
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Authors: McAllister, A. K., Katz, L. C., & Lo, D. C.
Affiliations: Salk Institute for Biological Studies (US)
Howard Hughes Medical Institute (US)
ORCID: McAllister, A. Kimberley
Lo, Donald C.
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 1999-03
Volume: 22
Issue: 1
Pages: 295-318
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.22.1.295
OpenAlex: W2163639252
Cited by: 1,337
References: 228
Citations by year: 2026: 8 · 2025: 12 · 2024: 15 · 2023: 24 · 2022: 18 · 2021: 26 · 2020: 21 · 2019: 28 · 2018: 33 · 2017: 35 · 2016: 49 · 2015: 44 · 2014: 53 · 2013: 51 · 2012: 52
FWCI: 9.55
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophins, synaptic plasticity, activity-dependent plasticity, neurotrophin receptors, neuronal growth, synaptic transmission, morphological plasticity
MeSH terms: Animals, Central Nervous System, Nerve Growth Factors, Neuronal Plasticity, Synapses, Receptors, Nerve Growth Factor

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NEUROTROPHINS AND SYNAPTIC PLASTICITY

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