The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
Open accessAbstract
Astrocytes contribute to the formation and function of synapses and are found throughout the brain, where they show intracellular store–mediated Ca2+ signals. Here, using a membrane-tethered, genetically encoded calcium indicator (Lck-GCaMP3), we report the serendipitous discovery of a new type of Ca2+ signal in rat hippocampal astrocyte-neuron cocultures. We found that Ca2+ fluxes mediated by transient receptor potential A1 (TRPA1) channels gave rise to frequent and highly localized 'spotty' Ca2+ microdomains near the membrane that contributed appreciably to resting Ca2+ in astrocytes. Mechanistic evaluations in brain slices showed that decreases in astrocyte resting Ca2+ concentrations mediated by TRPA1 channels decreased interneuron inhibitory synapse efficacy by reducing GABA transport by GAT-3, thus elevating extracellular GABA. Our data show how a transmembrane Ca2+ source (TRPA1) targets a transporter (GAT-3) in astrocytes to regulate inhibitory synapses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
Ortinski, P. I., Dong, J., Mungenast, A., Yue, C., Takano, H., Watson, D. J., Haydon, P. G., & Coulter, D. A. (2010) · Nature Neuroscience · doi:10.1038/nn.2535 · Cited by 495
Activation of GABAA Receptors: Views from Outside the Synaptic Cleft
Glykys, J., & Mody, I. (2007) · Neuron · doi:10.1016/j.neuron.2007.11.002 · Cited by 358
Moss, F. J., Imoukhuede, P. I., Scott, K., Hu, J., Jankowsky, J. L., Quick, M. W., & Lester, H. A. (2009) · Journal of General Physiology · doi:10.1085/jgp.200910314 · Cited by 45
Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Diversity of astrocyte functions and phenotypes in neural circuits
Khakh, B. S., & Sofroniew, M. V. (2015) · Nature Neuroscience · doi:10.1038/nn.4043 · Cited by 1,239
Self-citationTong, X., Ao, Y., Faas, G. C., Nwaobi, S. E., Xu, J., Haustein, M. D., Anderson, M. A., Mody, I., Olsen, M. L., Sofroniew, M. V., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3691 · Cited by 592
Self-citationThe Emerging Nature of Astrocyte Diversity
Khakh, B. S., & Deneen, B. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050443 · Cited by 482
Self-citation
Metadata
- Authors
- Shigetomi, E., Tong, X., Kwan, K. Y., Corey, D. P., & Khakh, B. S.
- Venue
- Nature Neuroscience
- Published
- 2011-12-11
- Volume
- 15
- Issue
- 1
- Pages
- 70-80
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2113679292
- Cited by
- 472
- References
- 6
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. https://app.cochat.ai/papers/10.1038/nn.3000
- The paper
- Shigetomi, E., Tong, X., Kwan, K. Y., Corey, D. P., & Khakh, B. S. (2012). TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nature Neuroscience. https://doi.org/10.1038/nn.3000
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
