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Experience-dependent modification of a central amygdala fear circuit

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Li, Haohong, Penzo, Mario A, Taniguchi, Hiroki, Kopec, Charles D, Huang, Z Josh, Li, Bo·2013·Nature Neuroscience

DOI 10.1038/nn.3322PMC PMC3581751

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Abstract

The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of fear is unclear. We found that fear conditioning in mice induced robust plasticity of excitatory synapses onto inhibitory neurons in the lateral subdivision of the CeA (CeL). This experience-dependent plasticity was cell specific, bidirectional and expressed presynaptically by inputs from the lateral amygdala. In particular, preventing synaptic potentiation onto somatostatin-positive neurons impaired fear memory formation. Furthermore, activation of these neurons was necessary for fear memory recall and was sufficient to drive fear responses. Our findings support a model in which fear conditioning-induced synaptic modifications in CeL favor the activation of somatostatin-positive neurons, which inhibit CeL output, thereby disinhibiting the medial subdivision of CeA and releasing fear expression.

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Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
Self-citation
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Madisen, L., Mao, T., Koch, H., Zhuo, J.-M., Berenyi, A., Fujisawa, S., Hsu, Y.-W. A., Garcia, A. J., Gu, X., Zanella, S., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3078 · Cited by 1,398
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
The amygdala
LeDoux, J. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.005 · Cited by 1,281

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Additional file 9 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 5 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 7 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 6 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 8 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 10 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 2 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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Additional file 3 of CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
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“The CeL integrates emotionally salient information from regions such as the basolateral amygdala [34] and paraventricular nucleus of the thalamus [35].”
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“The CGRP+ terminals mainly target protein kinase C δ (PKCδ+) neurons, one of two major cell types in the CeA (Li et al. 2013; Kim et al. 2017; Wilson et al. 2019; Adke et al. 2021), considered “pronoci-ceptive” because their activation increases pain-related responses (Wilson et al. 2019).”
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He, S., de Almeida, A. P., Feng, C., Petkovic, A., Tamais, A. M., Pospelova, A., Mayer, C., & Klein, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.18.759923

Authors: Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., & Li, B.
Affiliations: Cold Spring Harbor Laboratory (US)
Princeton University (US)
Corresponding author: Li, Bo
ORCID: Li, Haohong
Penzo, Mario A
Kopec, Charles D
Huang, Z Josh
Li, Bo
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2013-01-27
Volume: 16
Issue: 3
Pages: 332-339
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3322
PMC: PMC3581751
OpenAlex: W2003870213
Cited by: 497
References: 49
Citations by year: 2026: 15 · 2025: 25 · 2024: 49 · 2023: 35 · 2022: 42 · 2021: 46 · 2020: 50 · 2019: 40 · 2018: 49 · 2017: 33 · 2016: 34 · 2015: 43 · 2014: 23 · 2013: 13
FWCI: 20.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institute of Mental Health (U01MH078844, R01MH091903)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: central amygdala, fear conditioning, fear memory, inhibitory interneurons, synaptic potentiation, experience-dependent plasticity, lateral amygdala, disinhibition, fear expression
MeSH terms: Amygdala, Animals, Conditioning, Psychological, Fear, Nerve Net, Neuronal Plasticity, Neurons, Somatostatin, Synapses, Mice

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Experience-dependent modification of a central amygdala fear circuit

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