The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
Open accessAbstract
Induction of histone acetylation in the nucleus accumbens (NAc), a key brain reward region, promotes cocaine-induced alterations in gene expression. Histone deacetylases (HDACs) tightly regulate the acetylation of histone tails, but little is known about the functional specificity of different HDAC isoforms in the development and maintenance of cocaine-induced plasticity, and previous studies of HDAC inhibitors report conflicting effects on cocaine-elicited behavioral adaptations. Here we demonstrate that specific and prolonged blockade of HDAC1 in NAc of mice increased global levels of histone acetylation, but also induced repressive histone methylation and antagonized cocaine-induced changes in behavior, an effect mediated in part through a chromatin-mediated suppression of GABAA receptor subunit expression and inhibitory tone on NAc neurons. Our findings suggest a new mechanism by which prolonged and selective HDAC inhibition can alter behavioral and molecular adaptations to cocaine and inform the development of therapeutics for cocaine addiction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
Self-citationSynaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641
Self-citationDynamics of Replication-Independent Histone Turnover in Budding Yeast
Dion, M. F., Kaplan, T., Kim, M., Buratowski, S., Friedman, N., & Rando, O. J. (2007) · Science · doi:10.1126/science.1134053 · Cited by 556
Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins
Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H. E., Maze, I., Sikder, D., Robison, A. J., LaPlant, Q., Dietz, D. M., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.026 · Cited by 409
Self-citationA Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289
Self-citationLevine, A., Huang, Y., Drisaldi, B., Griffin, E. A., Pollak, D. D., Xu, S., Yin, D., Schaffran, C., Kandel, D. B., & Kandel, E. R. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003062 · Cited by 280
Schroeder, F. A., Penta, K. L., Matevossian, A., Jones, S. R., Konradi, C., Tapper, A. R., & Akbarian, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.15 · Cited by 139 · cited 3×
“…inhibition on psychostimulant-induced behavioral plasticity have yielded conflicting results, with some studies reporting that systemic or intra-NAc HDAC inhibition enhances the behavioral effects of cocaine or amphetamine, and other studies reporting changes in the opposite direction 1,3–5,10 –”
Cited by
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Self-citationEpigenetic mechanisms of drug addiction
Nestler, E. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.004 · Cited by 454
Self-citationAlterations of the Host Microbiome Affect Behavioral Responses to Cocaine
Kiraly, D. D., Walker, D. M., Calipari, E. S., Labonte, B., Issler, O., Pena, C. J., Ribeiro, E. A., Russo, S. J., & Nestler, E. J. (2016) · Scientific Reports · doi:10.1038/srep35455 · Cited by 264
Self-citationLocus-specific epigenetic remodeling controls addiction- and depression-related behaviors
Heller, E. A., Cates, H. M., Peña, C. J., Sun, H., Shao, N., Feng, J., Golden, S. A., Herman, J. P., Walsh, J. J., Mazei-Robison, M., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3871 · Cited by 227
Self-citationChronic cocaine-regulated epigenomic changes in mouse nucleus accumbens
Feng, J., Wilkinson, M., Liu, X., Purushothaman, I., Ferguson, D., Vialou, V., Maze, I., Shao, N., Kennedy, P., Koo, J., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-4-r65 · Cited by 198
Self-citation
Metadata
- Authors
- Kennedy, P. J., Feng, J., Robison, A. J., Maze, I., Badimon, A., Mouzon, E., Chaudhury, D., Damez-Werno, D. M., Haggarty, S. J., Han, M.-H., Bassel-Duby, R., Olson, E. N., & Nestler, E. J.
- Venue
- Nature Neuroscience
- Published
- 2013-03-10
- Volume
- 16
- Issue
- 4
- Pages
- 434-440
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2117918664
- Cited by
- 170
- References
- 11
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. https://app.cochat.ai/papers/10.1038/nn.3354
- The paper
- Kennedy, P. J., Feng, J., Robison, A. J., Maze, I., Badimon, A., Mouzon, E., Chaudhury, D., Damez-Werno, D. M., Haggarty, S. J., Han, M.-H., Bassel-Duby, R., Olson, E. N., & Nestler, E. J. (2013). Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature Neuroscience. https://doi.org/10.1038/nn.3354
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
