Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins
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Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. The findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins (Sirt1 and Sirt2)-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug.
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Acute and chronic drug exposures (stimulants, opioids, alcohol, nicotine) increase total cellular levels of acetylation of histones H3 and H4, apparently by unbalancing HAT and HDAC function.
“These studies have shown that acute and chronic drug exposures (stimulants, opioids, alcohol, nicotine) increase total cellular levels of acetylation of histones H3 and H4 105- 110 , apparently by unbalancing HAT and HDAC function.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [108]
The Results section on histone acetylation in the nucleus accumbens reports that chronic cocaine increased H3 and H4 acetylation at many gene promoters. It does not establish increased total cellular acetylation, effects of acute exposure or of opioids, alcohol, and nicotine, or a HAT–HDAC imbalance as the cause. Page numbers are not available in our copy. (LLM, conf=0.88)
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503 · see citing works
Bioinformatics and Computational Biology Solutions Using R and Bioconductor
Gentleman, R. C., Carey, V. J., Huber, W. K., Irizarry, R. A., & Dudoit, S. (2005) · Statistics in the health sciences · doi:10.1007/0-387-29362-0 · Cited by 3,470 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Self-citationTranscriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Self-citationSirtuins in mammals: insights into their biological function
Michán, S., & Sinclair, D. A. (2007) · Biochemical Journal · doi:10.1042/bj20070140 · Cited by 1,719 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Self-citationA high-resolution map of active promoters in the human genome
Kim, T. H., Barrera, L., Zheng, M., Qu, C.-X., Singer, M. A., Richmond, T., Wu, Y. N., Green, R. D., & Ren, B. (2005) · Nature · doi:10.1038/nature03877 · Cited by 1,019 · see citing works
Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501076102 · Cited by 992 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Self-citationChromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum
Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764 · see citing works
Self-citationImpey, S., McCorkle, S., Cha‐Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., McWeeney, S. K., Dunn, J. J., Mandel, G., & Goodman, R. H. (2004) · Cell · doi:10.1016/j.cell.2004.10.032 · Cited by 695 · see citing works
Empirical Bayes methods and false discovery rates for microarrays
Efron, B., & Tibshirani, R. (2002) · Genetic Epidemiology · doi:10.1002/gepi.1124 · Cited by 684 · see citing works
Mapping Global Histone Acetylation Patterns to Gene Expression
Kurdistani, S. K., Tavazoie, S., & Grunstein, M. R. (2004) · Cell · doi:10.1016/j.cell.2004.05.023 · Cited by 647 · see citing works
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641 · see citing works
Self-citationRegulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625 · see citing works
Self-citationHistone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works
Self-citationGrimm, J. W., Lü, L., Hayashi, T., Hope, B. T., Su, T., & Shaham, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00742.2003 · Cited by 551 · see citing works
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
Bibb, J. A., Chen, J., Taylor, J. R., Svenningsson, P., Nishi, A., Snyder, G. L., Yan, Z., Sagawa, Z. K., Ouimet, C. C., Nairn, A. C., et al. (2001) · Nature · doi:10.1038/35066591 · Cited by 480 · see citing works
Self-citationPounds, S. B., & Morris, S. W. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg148 · Cited by 426 · see citing works
Graham, D. L., Edwards, S., Bachtell, R. K., Dileone, R., Rios, M., & Self, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1929 · Cited by 401 · see citing works
Transcriptional mechanisms of addiction: role of ΔFosB
Nestler, E. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0067 · Cited by 392 · see citing works
Self-citationEpigenetic mechanisms in drug addiction
Renthal, W. R., & Nestler, E. J. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.06.004 · Cited by 383 · see citing works
Self-citationIdentification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 380 · see citing works
Piazza, P. V., Deroche-Gamonent, V., Rougé‐Pont, F., & Moal, M. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04226.2000 · Cited by 353 · see citing works
Glutamate systems in cocaine addiction
Kalivas, P. W. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.11.002 · Cited by 349 · see citing works
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
Li, Y., Xu, W., McBurney, M. W., & Longo, V. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.004 · Cited by 331 · see citing works
The Sir2 family of protein deacetylases
Denu, J. M. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.08.010 · Cited by 325 · see citing works
Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase
Pak, D. T. S., & Sheng, M. (2003) · Science · doi:10.1126/science.1082475 · Cited by 299 · see citing works
Hiroi, N., Brown, J. R., Haile, C. N., Ye, H., Greenberg, M. E., & Nestler, E. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10397 · Cited by 285 · see citing works
Self-citationCocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
Pulipparacharuvil, S., Renthal, W., Hale, C. F., Taniguchi, M., Xiao, G., Kumar, A., Russo, S. J., Sikder, D., Dewey, C. M., Davis, M. M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.020 · Cited by 281 · see citing works
Self-citationRGS9 Modulates Dopamine Signaling in the Basal Ganglia
Rahman, Z. U., Schwarz, J., Gold, S. J., Zachariou, V., Wein, M. N., Choi, K.-H., Kovoor, A., Chen, C.-K., Dileone, R., Schwarz, S. C., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00321-0 · Cited by 265 · see citing works
Self-citationLevine, A. A., Guan, Z., Barco, Á., Xu, S., Kandel, E. R., & Schwartz, J. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509735102 · Cited by 249 · see citing works
Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward
Russo, S. J., Wilkinson, M. B., Mazei‐Robison, M. S., Dietz, D., Maze, I. S., Krishnan, V., Renthal, W. R., Graham, A., Birnbaum, S. G., Green, T. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6173-08.2009 · Cited by 248 · see citing works
Self-citationActivator of G Protein Signaling 3
Bowers, M. S., McFarland, K., LAKE, R. W., Peterson, Y. K., Lapish, C. C., Gregory, M. L., Lanier, S. M., & Kalivas, P. W. (2004) · Neuron · doi:10.1016/s0896-6273(04)00159-x · Cited by 236 · see citing works
ΔFosB Mediates Epigenetic Desensitization of the c-fosGene After Chronic Amphetamine Exposure
Renthal, W. R., Carle, T. L., Maze, I. S., Covington, H. E., Truong, H.-T., Alibhai, I. N., Kumar, A., Montgomery, R. L., Olson, E. N., & Nestler, E. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1043-08.2008 · Cited by 234 · see citing works
Self-citationStriatal Cell Type-Specific Overexpression of ΔFosB Enhances Incentive for Cocaine
Colby, C. R., Whisler, K., Steffen, C., Nestler, E. J., & Self, D. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02488.2003 · Cited by 217 · see citing works
Self-citationAlbertson, D. N., Pruetz, B., Schmidt, C. J., Kuhn, D. M., Kapatos, G., & Bannon, M. J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02247.x · Cited by 190 · see citing works
Foll, B. L., Díaz, J., & Sokoloff, P. (2005) · Neuroreport · doi:10.1097/00001756-200502080-00022 · Cited by 178 · see citing works
Cocaine selectively increases striatonigral dynorphin levels by a dopaminergic mechanism.
Sivam, S. P. (1989) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22808-7 · Cited by 167 · see citing works
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data
Buck, M. J., Nobel, A. B., & Lieb, J. D. (2005) · Genome biology · doi:10.1186/gb-2005-6-11-r97 · Cited by 161 · see citing works
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
Cha‐Molstad, H., Keller, D. M., Yochum, G. S., Impey, S., & Goodman, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405587101 · Cited by 148 · see citing works
Induction of nuclear factor‐κB in nucleus accumbens by chronic cocaine administration
Ang, E. S. B. C., Chen, J., Zagouras, P., Magna, H. A., Holland, J., Schaeffer, E., & Nestler, E. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00563.x · Cited by 146 · see citing works
Self-citationc-Fos Facilitates the Acquisition and Extinction of Cocaine-Induced Persistent Changes
Zhang, J., Zhang, L., Jiao, H., Zhang, Q., Zhang, D., Lou, D., Katz, J. L., & Xu, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3795-06.2006 · Cited by 146 · see citing works
Activation of arc, a Putative “Effector” Immediate Early Gene, by Cocaine in Rat Brain
Fosnaugh, J. S., Bhat, R. V., Yamagata, K., Worley, P. F., & Baraban, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052377.x · Cited by 131 · see citing works
Self, D. W., Choi, K.-H., Simmons, D. L., Walker, J. R., & Smagula, C. S. (2004) · Learning & Memory · doi:10.1101/lm.81404 · Cited by 125 · see citing works
Chronic cocaine‐mediated changes in non‐human primate nucleus accumbens gene expression
Freeman, W. M., Nader, M. A., Nader, S. H., Robertson, D. J., Gioia, L., Mitchell, S. M., Daunais, J. B., Porrino, L. J., Friedman, D. P., & Vrana, K. E. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00252.x · Cited by 122 · see citing works
Romieu, P. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00391-8 · Cited by 119 · see citing works
Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration
Bowers, M. S., & Kalivas, P. W. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02537.x · Cited by 90 · see citing works
Repeated Cocaine Administration Induces Gene Expression Changes through the Dopamine D1 Receptors
Zhang, D., Zhang, L., Tang, Y., Zhang, Q., Lou, D., Sharp, F. R., Zhang, J., & Xu, M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300680 · Cited by 89 · see citing works
ChIP‐chip: Data, Model, and Analysis
Zheng, M., Barrera, L. O., Ren, B., et al. (2007) · Biometrics · doi:10.1111/j.1541-0420.2007.00768.x · Cited by 83 · see citing works
Mesolimbic gender differences in peptide CART mRNA expression
Fagergren, P., & Hurd, Y. L. (1999) · Neuroreport · doi:10.1097/00001756-199911080-00034 · Cited by 81 · see citing works
Role of Dopamine Receptors in the Nucleus Accumbens in the Rewarding Properties of Cocaine
Robledo, P., Maldonado, R. J., & Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb26015.x · Cited by 80 · see citing works
Widespread, but Non-identical, Association of Proteasomal 19 and 20 S Proteins with Yeast Chromatin*
Sikder, D., Johnston, S. A., & Kodadek, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604706200 · Cited by 71 · see citing works
Self-citationCREB Binding and Activity in Brain: Regional Specificity and Induction by Electroconvulsive Seizure
Tanis, K. Q., Duman, R. S., & Newton, S. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.003 · Cited by 68 · see citing works
Toda, S., Alguacil, L. F., & Kalivas, P. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02121.x · Cited by 68 · see citing works
Toda, S., McGinty, J. F., & Kalivas, P. W. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01083.x · Cited by 67 · see citing works
McCool, K. W., Xu, X., Singer, D. B., Murdoch, F. E., & Fritsch, M. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609519200 · Cited by 65 · see citing works
NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines
Shen, H., Korutla, L., Champtiaux, N., Toda, S., LaLumiere, R. T., Vallone, J., Klugmann, M., Blendy, J. A., Mackler, S. A., & Kalivas, P. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1571-07.2007 · Cited by 58 · see citing works
Hemby, S. E., Horman, B. M., & Tang, W. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.051 · Cited by 56 · see citing works
Crespi, F. (1998) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.1998.20.8.487502 · Cited by 56 · see citing works
Rajadhyaksha, A. M., Husson, I., Satpute, S. S., Kueppenbender, K. D., Ren, J., Guerriero, R. M., Standaert, D. G., & Kosofsky, B. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0612-04.2004 · Cited by 55 · see citing works
Repeated Cocaine Self-Administration Causes Multiple Changes in Rat Frontal Cortex Gene Expression
Freeman, W. M., Brebner, K., Patel, K. M., Lynch, W. J., Roberts, D. C. S., & Vrana, K. E. (2002) · Neurochemical Research · doi:10.1023/a:1020929526688 · Cited by 37 · see citing works
Niwa, M., Nitta, A., Yamada, K., & Nabeshima, T. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cp0070017 · Cited by 34 · see citing works
Regulation of genes involved in dopamine transporter modulation by acute cocaine in rat striatum
Courtin, C., Crété, D., Canestrelli, C., Noble, F., & Cynthia Marie-claire, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.001 · Cited by 15 · see citing works
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Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975 · see citing works
Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665 · see citing works
Self-citationThe addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654 · see citing works
Self-citationDnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works
Self-citationSIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-10.2010 · Cited by 541 · see citing works
Epigenetic mechanisms in cognition
Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Self-citationVolkow, N. D., & Blanco, C. (2023) · World psychiatry · doi:10.1002/wps.21073 · Cited by 503 · see citing works
Common cellular and molecular mechanisms in obesity and drug addiction
Kenny, P. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3105 · Cited by 382 · see citing works
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works
Self-citationWilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
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Abe-Higuchi, N., Uchida, S., Yamagata, H., Higuchi, F., Hobara, T., Hara, K., Kobayashi, A., & Watanabe, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.009 · Cited by 247 · see citing works
Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1875-13.2013 · Cited by 245 · see citing works
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Feng, J., Wilkinson, M., Liu, X., Purushothaman, I., Ferguson, D., Vialou, V., Maze, I., Shao, N., Kennedy, P., Koo, J., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-4-r65 · Cited by 198 · see citing works
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Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
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Savell, K. E., Tuscher, J. J., Zipperly, M. E., Duke, C. G., Phillips, R. A., Bauman, A. J., Thukral, S., Sultan, F. A., Goska, N. A., Ianov, L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba4221 · Cited by 180 · see citing works
Yang, Y. J., Baltus, A. E., Mathew, R. S., Murphy, E. A., Evrony, G. D., Gonzalez, D. M., Wang, E. P., Marshall-Walker, C. A., Barry, B. J., Murn, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.043 · Cited by 176 · see citing works
Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-11.2011 · Cited by 170 · see citing works
Self-citationEpigenetic Signaling in Psychiatric Disorders
Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.03.016 · Cited by 163 · see citing works
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Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works
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Logan, R. W., Williams, W. P., & McClung, C. A. (2014) · Behavioral Neuroscience · doi:10.1037/a0036268 · Cited by 142 · see citing works
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Feng, J., & Nestler, E. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.001 · Cited by 113 · see citing works
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Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L.-J., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8596903 · Cited by 106 · see citing works
Robison, A. J., Vialou, V., Sun, H.-S., Labonte, B., A Golden, S., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.319 · Cited by 105 · see citing works
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Orozco-Solis, R., & Sassone-Corsi, P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.043 · Cited by 94 · see citing works
Serum Response Factor Promotes Resilience to Chronic Social Stress through the Induction of ΔFosB
Vialou, V., Maze, I., Renthal, W., LaPlant, Q. C., Watts, E. L., Mouzon, E., Ghose, S., Tamminga, C. A., & Nestler, E. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2496-10.2010 · Cited by 91 · see citing works
Self-citationIn vivo locus-specific editing of the neuroepigenome
Yim, Y. Y., Teague, C. D., & Nestler, E. J. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0334-y · Cited by 76 · see citing works
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Cheron, J., & Kerchove d’Exaerde, A. D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01542-0 · Cited by 75 · see citing works
Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade
Guha, P., Harraz, M. M., & Snyder, S. H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524860113 · Cited by 70 · see citing works
Jordi, E., Heiman, M., Marion-Poll, L., Guermonprez, P., Cheng, S. K., Nairn, A. C., Greengard, P., & Girault, J.-A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307116110 · Cited by 57 · see citing works
CRACKing the histone code: Cocaine's effects on chromatin structure and function
LaPlant, Q., & Nestler, E. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.015 · Cited by 52 · see citing works
Self-citationLogan, R. W., Parekh, P. K., Kaplan, G. N., Becker-Krail, D. D., Williams, W. P., Yamaguchi, S., Yoshino, J., Shelton, M. A., Zhu, X., Zhang, H., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0061-1 · Cited by 48 · see citing works
Mechanisms of HIV transcriptional regulation by drugs of abuse
Tyagi, M., Bukrinsky, M., & L. Simon, G. (2016) · Current HIV Research · doi:10.2174/1570162x14666160324124736 · Cited by 42 · see citing works
Differential Regulation of MeCP2 Phosphorylation in the CNS by Dopamine and Serotonin
Hutchinson, A. N., Deng, J. V., Aryal, D. K., Wetsel, W. C., & West, A. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.190 · Cited by 31 · see citing works
Epigenomic profiling of mouse nucleus accumbens at single-cell resolution
Bhatia, P., Yang, L., Luo, J. X. J., Xu, M., & Renthal, W. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103857 · Cited by 5 · see citing works
Self-citation
- Authors
- Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H. E., Maze, I., Sikder, D., Robison, A. J., LaPlant, Q., Dietz, D. M., Russo, S. J., Vialou, V., Chakravarty, S., Kodadek, T. J., Stack, A., Kabbaj, M., & Nestler, E. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- Florida State University (US)
- Corresponding author
- Nestler, Eric J.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 62
- Issue
- 3
- Pages
- 335-348
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2779727
- OpenAlex
- W2080585999
- Cited by
- 409
- References
- 68
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 15 · 2023: 19 · 2022: 19 · 2021: 29 · 2020: 16 · 2019: 25 · 2018: 28 · 2017: 25 · 2016: 28 · 2015: 17 · 2014: 35 · 2013: 29 · 2012: 37
- FWCI
- 14.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (P01DA008227, R01DA007359, R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine, chromatin regulation, sirtuins, SIRT1, SIRT2, ΔFosB, CREB, nucleus accumbens, drug addiction, reward systems, transcriptional regulation, gene expression, repeated cocaine administration
- MeSH terms
- Animals, Chromatin, Cocaine, Gene Expression Regulation, Male, Mice, Inbred C57BL, Nucleus Accumbens, Promoter Regions, Genetic, Reinforcement, Psychology, Signal Transduction, Proto-Oncogene Proteins c-fos, Cyclic AMP Response Element-Binding Protein, Dopamine Uptake Inhibitors, Oligonucleotide Array Sequence Analysis, Feedback, Physiological, Sirtuins, Mice, Genome-Wide Association Study
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