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Cited by 301

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior

Open access
Hunt, Robert F, Girskis, Kelly M, Rubenstein, John L, Alvarez-Buylla, Arturo, Baraban, Scott C·2013·Nature Neuroscience
DOI 10.1038/nn.3392
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Abstract

Impaired GABA-mediated neurotransmission has been implicated in many neurologic diseases, including epilepsy, intellectual disability and psychiatric disorders. We found that inhibitory neuron transplantation into the hippocampus of adult mice with confirmed epilepsy at the time of grafting markedly reduced the occurrence of electrographic seizures and restored behavioral deficits in spatial learning, hyperactivity and the aggressive response to handling. In the recipient brain, GABA progenitors migrated up to 1,500 μm from the injection site, expressed genes and proteins characteristic for interneurons, differentiated into functional inhibitory neurons and received excitatory synaptic input. In contrast with hippocampus, cell grafts into basolateral amygdala rescued the hyperactivity deficit, but did not alter seizure activity or other abnormal behaviors. Our results highlight a critical role for interneurons in epilepsy and suggest that interneuron cell transplantation is a powerful approach to halting seizures and rescuing accompanying deficits in severely epileptic mice.

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Research works printed but not linked: 1

  1. Mortazavi, F., Ericson, M., Story, D., Hulce, V.D. & Dunbar, G.L. Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. Epilepsy Behav. 7, 629–638 (2005). · DOI

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Metadata

Authors
Hunt, R. F., Girskis, K. M., Rubenstein, J. L., Alvarez-Buylla, A., & Baraban, S. C.
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2013-05-05
Volume
16
Issue
6
Pages
692-697
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.3392
OpenAlex
W2053358049
Cited by
301
References
42
FWCI
22.97
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. https://app.cochat.ai/papers/10.1038/nn.3392
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Hunt, R. F., Girskis, K. M., Rubenstein, J. L., Alvarez-Buylla, A., & Baraban, S. C. (2013). GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nature Neuroscience. https://doi.org/10.1038/nn.3392

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.