The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Canceling actions involves a race between basal ganglia pathways
Open accessAbstract
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested this by comparing activity in multiple rat basal ganglia structures during performance of a stop-signal task. Subthalamic nucleus (STN) neurons exhibited low-latency responses to 'Stop' cues, irrespective of whether actions were canceled or not. By contrast, neurons downstream in the substantia nigra pars reticulata (SNr) only responded to Stop cues in trials with successful cancellation. Recordings and simulations together indicate that this sensorimotor gating arises from the relative timing of two distinct inputs to neurons in the SNr dorsolateral 'core' subregion: cue-related excitation from STN and movement-related inhibition from striatum. Our results support race models of action cancellation, with stopping requiring Stop-cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.
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Cites
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885
On the ability to inhibit simple and choice reaction time responses: A model and a method.
Logan, G. D., Cowan, W. B., & Davis, K. A. (1984) · Journal of Experimental Psychology: Human Perception and Performance · doi:10.1037/0096-1523.10.2.276 · Cited by 1,542
Cortico–basal ganglia circuit mechanism for a decision threshold in reaction time tasks
Lo, C.-C., & Wang, X.-J. (2006) · Nature Neuroscience · doi:10.1038/nn1722 · Cited by 505
Inhibitory control in mind and brain: An interactive race model of countermanding saccades.
Boucher, L., Palmeri, T. J., Logan, G. D., & Schall, J. D. (2007) · Psychological Review · doi:10.1037/0033-295x.114.2.376 · Cited by 485
Jahfari, S., Waldorp, L., van den Wildenberg, W. P. M., Scholte, H. S., Ridderinkhof, K. R., & Forstmann, B. U. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5253-10.2011 · Cited by 308
Cited by
Inhibition and the right inferior frontal cortex: one decade on
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.12.003 · Cited by 2,166
Neuronal Reward and Decision Signals: From Theories to Data
Schultz, W. (2015) · Physiological Reviews · doi:10.1152/physrev.00023.2014 · Cited by 1,126
Circuit Mechanisms of Parkinson’s Disease
McGregor, M. M., & Nelson, A. B. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.004 · Cited by 624
A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
Jahanshahi, M., Obeso, I., Rothwell, J. C., & Obeso, J. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4038 · Cited by 521
Wessel, J. R., & Aron, A. R. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.013 · Cited by 409
Metadata
- Authors
- Schmidt, R., Leventhal, D. K., Mallet, N., Chen, F., & Berke, J. D.
- Venue
- Nature Neuroscience
- Published
- 2013-07-14
- Volume
- 16
- Issue
- 8
- Pages
- 1118-1124
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2116257195
- Cited by
- 407
- References
- 5
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- green
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