The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Circuit Mechanisms of Parkinson’s Disease
Open accessAbstract
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The second most common neurodegenerative disorder after Alzheimer's disease, it affects approximately 1% of adults over age 60. Diagnosis follows the development of one or more of the core motor features of the disease, including tremor, slowing of movement (bradykinesia), and rigidity. However, there are numerous other motor and nonmotor disease manifestations. Many PD symptoms result directly from neurodegeneration; others are driven by aberrant activity patterns in surviving neurons. This latter phenomenon, PD circuit dysfunction, is an area of intense study, as it likely underlies our ability to treat many disease symptoms in the face of (currently) irreversible neurodegeneration. This Review will discuss key clinical features of PD and their basis in neural circuit dysfunction. We will first review important disease symptoms and some of the responsible neuropathology. We will then describe the basal ganglia-thalamocortical circuit, the major locus of PD-related circuit dysfunction, and some of the models that have influenced its study. We will review PD-related changes in network activity, subdividing findings into those that touch on the rate, rhythm, or synchronization of neurons. Finally, we suggest some critical remaining questions for the field and areas for new developments.
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Cites
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Cited by
Parkinson disease and the gut: new insights into pathogenesis and clinical relevance
Travagli, R. A., Browning, K. N., & Camilleri, M. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0339-z · Cited by 181
Deep brain stimulation of symptom-specific networks in Parkinson’s disease
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Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy
Lee, J. Y., Jin, H. K., & Bae, J.-S. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.278 · Cited by 80
Parkinson’s disease as a somato-cognitive action network disorder
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Basal ganglia-spinal cord pathway that commands locomotor gait asymmetries in mice
Cregg, J. M., Sidhu, S. K., Leiras, R., & Kiehn, O. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01569-8 · Cited by 48
Metadata
- Authors
- McGregor, M. M., & Nelson, A. B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 101
- Issue
- 6
- Pages
- 1042-1056
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2922876238
- Cited by
- 624
- References
- 13
- FWCI
- 26.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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