The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Parvalbumin interneurons provide grid cell–driven recurrent inhibition in the medial entorhinal cortex
Abstract
Grid cells in the medial entorhinal cortex (MEC) generate metric spatial representations. Recent attractor-network models suggest an essential role for GABAergic interneurons in the emergence of the grid-cell firing pattern through recurrent inhibition dependent on grid-cell phase. To test this hypothesis, we studied identified parvalbumin-expressing (PV(+)) interneurons that are the most likely candidate for providing this recurrent inhibition onto grid cells. Using optogenetics and tetrode recordings in mice, we found that PV(+) interneurons exhibited high firing rates, low spatial sparsity and no spatial periodicity. PV(+) interneurons inhibited all functionally defined cell types in the MEC and were in turn recruited preferentially by grid cells. To our surprise, we found that individual PV(+) interneurons received input from grid cells with various phases, which most likely accounts for the broadly tuned spatial firing activity of PV(+) interneurons. Our data argue against the notion that PV(+) interneurons provide phase-dependent recurrent inhibition and challenge recent attractor-network models of grid cells.
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“Spike downsampling was implemented by randomly removing spikes during immobility periods from behaviorally-modulated units to match the median firing rate of non-modulated units (Supplementary Figs. 6b and 3g)135,136.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [135]
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Optogenetics: 10 years of microbial opsins in neuroscience
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Hippocampal GABAergic Inhibitory Interneurons
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Metadata
- Authors
- Buetfering, C., Allen, K., & Monyer, H.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Monyer, Hannah
- Venue
- Nature Neuroscience
- Published
- 2014-04-06
- Volume
- 17
- Issue
- 5
- Pages
- 710-718
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2068578235
- Cited by
- 160
- References
- 46
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 17 · 2023: 11 · 2022: 9 · 2021: 16 · 2020: 12 · 2019: 6 · 2018: 17 · 2017: 20 · 2016: 15 · 2015: 17 · 2014: 8
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- parvalbumin interneurons, medial entorhinal cortex, grid cells, recurrent inhibition, spatial tuning, head direction cells, GABAergic interneurons, spatial representation, optogenetic stimulation
- MeSH terms
- Channelrhodopsins, Red Fluorescent Protein, Action Potentials, Dependovirus, Animals, Humans, Interneurons, Lasers, Luminescent Proteins, Microinjections, Models, Neurological, Nerve Net, Neural Inhibition, Parvalbumins, Theta Rhythm, Transduction, Genetic, Statistics, Nonparametric, Entorhinal Cortex, Maze Learning, Mice
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