The epigenetic landscape of Alzheimer's disease
Open accessAbstract
Two independent epigenome-wide association studies of Alzheimer’s disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer’s disease. These studies also suggest that epigenetic changes contribute more to Alzheimer’s disease than expected.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Differences in overall methylation are observed in AD-affected brain regions.
“differences in overall methylation have been observed in AD-affected brain regions”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [229]
Abnormal DNA methylation patterns are present in several genes associated with AD.
“abnormal DNA methylation patterns have been reported in several genes associated with AD [227,228,229].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [229]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Self-citationForecasting the global burden of Alzheimer's disease
Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370 · see citing works
Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997 · see citing works
Self-citationAlzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
De Jager, P. L., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, L. C., Yu, L., Eaton, M. L., Keenan, B. T., Ernst, J., McCabe, C., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3786 · Cited by 956 · see citing works
Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630 · see citing works
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3782 · Cited by 574 · see citing works
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M., Traynor, B. J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq561 · Cited by 376 · see citing works
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
Coppieters, N., Dieriks, B. V., Lill, C. L., Faull, R. L. M., Curtis, M. A., & Dragunow, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.031 · Cited by 350 · see citing works
From promises to practical strategies in epigenetic epidemiology
Mill, J. S., & Heijmans, B. T. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3405 · Cited by 347 · see citing works
Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions
Jayaraman, A., & Pike, C. J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0476-2 · Cited by 181 · see citing works
Epigenomics of Alzheimer's disease
Bennett, D. A., Yu, L., Yang, J., Srivastava, G. P., Aubin, C., & Jager, P. L. D. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.006 · Cited by 124 · see citing works
Genetics of Alzheimer disease in the pre- and post-GWAS era
Ertekin‐Taner, N. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt26 · Cited by 107 · see citing works
Independent component analysis of Alzheimer's DNA microarray gene expression data
Kong, W., Mou, X., Liu, Q., Chen, Z., Vanderburg, C. R., Rogers, J. T., & Huang, X. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-5 · Cited by 79 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [6]Mazzio EA Soliman KF Basic concepts of epigenetics: impact of environmental signals on gene expression Epigenetics: official journal of the DNA Methylation Society 7 119 130 10.4161/epi.7.2.18764 2012 PMC3335905 22395460 · DOI
- [13]Seshadri S Genome-wide analysis of genetic loci associated with Alzheimer disease Jama 303 1832 1840 doi:303/18/1832 [pii] 10.1001/jama.2010574 2010 20460622 PMC2989531 · DOI
Cited by
Sorted by citations
Ageing, neurodegeneration and brain rejuvenation
Wyss-Coray, T. (2016) · Nature · doi:10.1038/nature20411 · Cited by 1,147 · see citing works
Ageing, Cellular Senescence and Neurodegenerative Disease
Kritsilis, M., V. Rizou, S., Koutsoudaki, P. N., Evangelou, K., Gorgoulis, V. G., & Papadopoulos, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102937 · Cited by 448 · see citing works
Smith, R. G., Hannon, E., De Jager, P. L., Chibnik, L., Lott, S. J., Condliffe, D., Smith, A. R., Haroutunian, V., Troakes, C., Al‐Sarraj, S., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.01.017 · Cited by 184 · see citing works
Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease
Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. E. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9647-6 · Cited by 121 · see citing works
Sibbett, R. A., Altschul, D. M., Marioni, R. E., Deary, I. J., Starr, J. M., & Russ, T. C. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-2469-9 · Cited by 41 · see citing works
Alzheimer’s disease: rare variants with large effect sizes
Del-Aguila, J. L., Koboldt, D. C., Black, K., Chasse, R., Norton, J., Wilson, R. K., & Cruchaga, C. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.07.008 · Cited by 41 · see citing works
Mitsumori, R., Sakaguchi, K., Shigemizu, D., Mori, T., Akiyama, S., Ozaki, K., Niida, S., & Shimoda, N. (2020) · PLOS ONE · doi:10.1371/journal.pone.0239196 · Cited by 34 · see citing works
- Authors
- Lord, J., & Cruchaga, C.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Cruchaga, Carlos
- Venue
- Nature Neuroscience
- Published
- 2014-08-26
- Volume
- 17
- Issue
- 9
- Pages
- 1138-1140
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5472058
- OpenAlex
- W2009169574
- Cited by
- 122
- References
- 13
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 16 · 2020: 13 · 2019: 9 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 10 · 2014: 1
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (RF1AG044546, RF1AG053303, R01AG044546)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, DNA methylation, epigenetics, epigenome-wide association study, ANK1, RPL13, RHBDF2, CDH23, genetic loci
- MeSH terms
- Alzheimer Disease, Carrier Proteins, Cerebral Cortex, Female, Humans, Male, Nuclear Proteins, Ankyrins, DNA Methylation, Tumor Suppressor Proteins, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
