Alzheimer’s disease: rare variants with large effect sizes

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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<i>TREM2</i> Variants in Alzheimer's Disease

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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Exome sequencing identifies the cause of a mendelian disorder

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

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Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

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Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

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Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

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Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

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Rare-Variant Association Analysis: Study Designs and Statistical Tests

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Plasma phospholipids identify antecedent memory impairment in older adults

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Rare Variants of <i>IFIH1</i> , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Pooled Association Tests for Rare Variants in Exon-Resequencing Studies

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Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease

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Testing for an Unusual Distribution of Rare Variants

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

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Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

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Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

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Alzheimer’s Disease Genetics: From the Bench to the Clinic

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Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

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TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

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Mutation of an A-kinase-anchoring protein causes long-QT syndrome

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Coding variants in TREM2 increase risk for Alzheimer's disease

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Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

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Yotiao, a Novel Protein of Neuromuscular Junction and Brain That Interacts with Specific Splice Variants of NMDA Receptor Subunit NR1

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

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Blockade of TREM‐2 exacerbates experimental autoimmune encephalomyelitis

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The genetic causes of basal ganglia calcification, dementia, and bone cysts: <i>DAP12</i> and <i>TREM2</i>

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Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

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Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

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Comparison of statistical tests for disease association with rare variants

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Full-Exon Resequencing Reveals Toll-Like Receptor Variants Contribute to Human Susceptibility to Tuberculosis Disease

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Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

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Insights into TREM2 biology by network analysis of human brain gene expression data

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Variant <i>TREM2</i> as Risk Factor for Alzheimer's Disease

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Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

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TREM2 is associated with the risk of Alzheimer's disease in Spanish population

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TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease

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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

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TREM2 is associated with increased risk for Alzheimer’s disease in African Americans

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CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer’s disease susceptibility

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Two rare <i>AKAP9</i> variants are associated with Alzheimer's disease in African Americans

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The epigenetic landscape of Alzheimer's disease

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Missense variant in TREML2 protects against Alzheimer's disease

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Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

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Genetics of Alzheimer disease in the pre- and post-GWAS era

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Multiple Rare Nonsynonymous Variants in the Adenomatous Polyposis Coli Gene Predispose to Colorectal Adenomas

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Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China

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The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer’s disease

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PLD3 variants in population studies

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Expression of a Novel Murine Phospholipase D Homolog Coincides with Late Neuronal Development in the Forebrain

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A Role for Phospholipase D3 in Myotube Formation

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PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains

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A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease

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Cloning and Mapping of theUNC5CGene to Human Chromosome 4q21–q23

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Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration

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Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer’s disease

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A familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma

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Cruchaga & Goate reply

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[Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts].

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P4‐282: PLD3 ASSOCIATES TO PROLINE A PROPOSED BIOMARKER IN MAPSTONE ET AL

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

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Opportunities and challenges in modeling human brain disorders in transgenic primates

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Genetic architecture of Alzheimer's disease

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Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants

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Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

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Alzheimer Disease Overview

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Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout

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Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

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State of Play in Alzheimer’s Disease Genetics

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Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

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Examination of the Effect of Rare Variants in <i>TREM2</i> , <i>ABI3</i> , and <i>PLCG2</i> in LOAD Through Multiple Phenotypes

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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

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Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice

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The role of UNC5C in Alzheimer’s disease

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Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

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A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data

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SORL1 variants across Alzheimer’s disease European American cohorts

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Analysis of population-specific pharmacogenomic variants using next-generation sequencing data

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γ‐Secretase in microglia – implications for neurodegeneration and neuroinflammation

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The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data

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Systems biology and gene networks in Alzheimer’s disease

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The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data

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Association of Acquired and Heritable Factors With Intergenerational Differences in Age at Symptomatic Onset of Alzheimer Disease Between Offspring and Parents With Dementia

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Novel Benzoxazole Derivatives as Potential Acetylcholinesterase (AChE) Inhibitors in Alzheimer's Disease: Molecular Docking and Pharmacokinetics Analysis

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What is Your Risk of Contracting Alzheimer’s Disease? A Telematics Tool Helps you to Predict it

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Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy

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The genetic architecture of molecular traits

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Cheminformatics and Bioinformatics at the Interface with Systems Biology

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Study of Alzheimer's disease- and frontotemporal dementia-associated genes in the Cretan Aging Cohort

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Studi In Silico Senyawa dalam Daun Sirih (Piper betle L.) sebagai Inhibitor Enzim Asetilkolinesterase (AChE) pada Penyakit Alzheimer

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G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework

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Genetics in Vascular Dementia

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Detrimental and synergistic role of epilepsy – Alzheimer’s disease risk factors

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Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer’s disease in a Tunisian population

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Molecular Investigation of Protein–Protein Interaction Candidates Related to the Mammalian Brain

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Representation of family communication patterns in the film Pelangi Tanpa Warna (Indra Gunawan, 2022)

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Molecular docking of capsaicin and its derivatives as acetylcholinesterase (AChE) inhibitors in Alzheimer disease

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Analysis of Memory and Alzheimer's Disease in the Contemporary Context

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Identification of rare variants in Alzheimer’s disease

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Identification of Functional Variants in Alzheimer's Disease-Associated Genes

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[P1–516]: TARGET SEQUENCING ASSOCIATED WITH MULTIPLEX SNP GENOTYPING REVEALED NOVEL CAUSAL AND RISK RARE CODING VARIANTS OF ALZHEIMER's DISEASE

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