The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
A neural basis for melanocortin-4 receptor–regulated appetite
Open accessAbstract
Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and coordinately stimulate and inhibit homeostatic satiety, respectively. This bimodality is principally underscored by the antagonistic actions of these ligands at downstream melanocortin-4 receptors (MC4R) in the paraventricular nucleus of the hypothalamus (PVH). Although this population is critical to energy balance, the underlying neural circuitry remains unknown. Using mice expressing Cre recombinase in MC4R neurons, we demonstrate bidirectional control of feeding following real-time activation and inhibition of PVHMC4R neurons and further identify these cells as a functional exponent of ARCAgRP neuron–driven hunger. Moreover, we reveal this function to be mediated by a PVHMC4R→lateral parabrachial nucleus (LPBN) pathway. Activation of this circuit encodes positive valence, but only in calorically depleted mice. Thus, the satiating and appetitive nature of PVHMC4R→LPBN neurons supports the principles of drive reduction and highlights this circuit as a promising target for antiobesity drug development.
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Targeted disruption of the melanocortin-4 receptor results in obesity in mice
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Cited by
A molecular census of arcuate hypothalamus and median eminence cell types
Campbell, J. N., Macosko, E. Z., Fenselau, H., Pers, T. H., Lyubetskaya, A., Tenen, D., Goldman, M., Verstegen, A. M. J., Resch, J. M., McCarroll, S. A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4495 · Cited by 817
Self-citationNeuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding
Waterson, M. J., & Horvath, T. L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.026 · Cited by 434
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415
Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., et al. (2018) · Nature Genetics · doi:10.1038/s41588-017-0011-x · Cited by 409
Asprosin is a centrally acting orexigenic hormone
Duerrschmid, C., He, Y., Wang, C., Li, C., Bournat, J. C., Romere, C., Saha, P. K., Lee, M. E., Phillips, K. J., Jain, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4432 · Cited by 357
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Metadata
- Authors
- Garfield, A. S., Li, C., Madara, J. C., Shah, B. P., Webber, E., Steger, J. S., Campbell, J. N., Gavrilova, O., Lee, C. E., Olson, D. P., Elmquist, J. K., Tannous, B. A., Krashes, M. J., & Lowell, B. B.
- Venue
- Nature Neuroscience
- Published
- 2015-04-27
- Volume
- 18
- Issue
- 6
- Pages
- 863-871
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2092945320
- Cited by
- 440
- References
- 64
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Garfield, A. S., Li, C., Madara, J. C., Shah, B. P., Webber, E., Steger, J. S., Campbell, J. N., Gavrilova, O., Lee, C. E., Olson, D. P., Elmquist, J. K., Tannous, B. A., Krashes, M. J., & Lowell, B. B. (2015). A neural basis for melanocortin-4 receptor–regulated appetite. Nature Neuroscience. https://doi.org/10.1038/nn.4011
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