Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
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Central regulation of food intake is a key mechanism contributing to energy homeostasis. Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's reward circuitry both anatomically and functionally. Manipulation of numerous neural pathways can simultaneously influence food intake and reward. Two key systems underlying these processes-those controlling homeostatic and hedonic feeding-are often treated as independent. Homeostatic feeding is necessary for basic metabolic processes and survival, while hedonic feeding is driven by sensory perception or pleasure. Despite this distinction, their functional and anatomical overlap implies considerable interaction that is often overlooked. Here, we argue that the neurocircuits controlling homeostatic feeding and hedonic feeding are not completely dissociable given the current data and urge researchers to assess behaviors extending beyond food intake in investigations of the neural control of feeding.
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Feeding behavior is directed by motivational drives of opposing valence: the negative sensation of hunger and the positive hedonic value of palatable food.
“Feeding behavior, therefore, is directed by motivational drives of opposing valence: the negative sensation of hunger and the positive hedonic value of palatable food.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [217]
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Fu, O., Minokoshi, Y., & Nakajima, K. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.609824 · Cited by 30 · see citing works
Brown, R. M., & James, M. H. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110717 · Cited by 30 · see citing works
Kim, S.-R., & Kim, S. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0006 · Cited by 29 · see citing works
Peripheral and Central Nutrient Sensing Underlying Appetite Regulation
Augustine, V., Gökçe, S. K., & Oka, Y. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.003 · Cited by 29 · see citing works
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms
Engel, D. F., Bóbbo, V. C. D., Solon, C., Nogueira, G. A. S., Moura‐Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, T., & Velloso, L. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68110-2 · Cited by 28 · see citing works
- Authors
- Rossi, M. A., & Stuber, G. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Stuber, Garret D.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 27
- Issue
- 1
- Pages
- 42-56
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5762260
- OpenAlex
- W2765429334
- Cited by
- 415
- References
- 188
- Citations by year
- 2026: 38 · 2025: 57 · 2024: 68 · 2023: 54 · 2022: 56 · 2021: 44 · 2020: 39 · 2019: 37 · 2018: 22
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute on Drug Abuse (DA038168, DA032750)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK112564)
- Brain and Behavior Research Foundation
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- hedonic feeding, food intake regulation, energy homeostasis, reward systems, neural circuits, food reward
- MeSH terms
- Animals, Brain, Feeding Behavior, Homeostasis, Humans, Nerve Net, Neurons, Reward
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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