Germline Chd8 haploinsufficiency alters brain development in mouse
Gompers, Andrea L, Su-Feher, Linda, Ellegood, Jacob, Copping, Nycole A, Riyadh, M Asrafuzzaman, Stradleigh, Tyler W, Pride, Michael C, Schaffler, Melanie D +16 more·2017·Nature Neuroscience
DOI 10.1038/nn.4592
Cited by (265)
Items 101–200 of 265
- Characterization of a Mouse Model of Börjeson-Forssman-Lehmann SyndromeCheng Cheng, Pan‐Yue Deng, Yoshiho Ikeuchi, Carla M. Yuede, Daofeng Li, Nicholas R. Rensing, Ju Huang, Dustin Baldridge, Susan E. Maloney, Joseph D. Dougherty et al. · 2018 · Cell Reports
- Pten haploinsufficiency disrupts scaling across brain areas during development in miceAmy E. Clipperton‐Allen, Ori S. Cohen, Massimiliano Aceti, Aya Zucca, Jenna Levy, Jacob Ellegood, Jason P. Lerch, Damon T. Page · 2019 · Translational Psychiatry
- A Transcriptome‐Based Drug Discovery Paradigm for Neurodevelopmental DisordersRyan S. Dhindsa, Anthony William Zoghbi, Daniel K. Krizay, Chirag Vasavda, David B. Goldstein · 2020 · Annals of Neurology
- Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brainAtsuki Kawamura, Yoshifumi Abe, Fumiko Seki, Yuta Katayama, Masaaki Nishiyama, Norio Takata, Kenji F. Tanaka, Hideyuki Okano, Keiichi I. Nakayama · 2020 · Molecular Brain
- Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models ofCdkl5deficiencyAnna Adhikari, Fiona K B Buchanan, Timothy A. Fenton, David L. Cameron, Julian A. N. M. Halmai, Nycole A. Copping, Kyle D. Fink, Jill L. Silverman · 2022 · Human Molecular Genetics
- The NuRD complex in neurodevelopment and disease: a case of sliding doorsBoulasiki, Paraskevi, Tan, Xiao Wei, Spinelli, Matteo, Riccio, Antonella · 2023 · Cells
- Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain NeurogenesisChen Dong, Chuntao Zhao, Xiang 'Anthony' Chen, Kalen Berry, Jiajia Wang, Feng Zhang, Yunfei Liao, Rong Han, Sean Ogurek, Lingli Xu et al. · 2022 · Journal of Neuroscience
- Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expressionAndrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buneß, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer et al. · 2021 · Communications Biology
- Molecular dissection of CHARGE syndrome highlights the vulnerability of neural crest cells to problems with alternative splicing and other transcription-related processesFélix‐Antoine Bérubé‐Simard, Nicolas Pilon · 2018 · Transcription
- Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse modelJessica A. Jiménez, Jeremy M. Simon, Wenxin Hu, Sheryl S. Moy, Kathryn M. Harper, Chih‐Wei Liu, Kun Lü, Mark J. Zylka · 2022 · Scientific Reports
- Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neuronsAtsuki Kawamura, Masaaki Nishiyama · 2023 · Communications Biology
- Chromatin remodelling complexes in cerebral cortex development and neurodevelopmental disordersLeora D’Souza, Asha S Channakkar, Bhavana Muralidharan · 2021 · Neurochemistry International
- CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesisSong Ding, Xianchun Lan, Yajing Meng, Chenchao Yan, Mao Li, Xiang Li, Jian Chen, Wei Jiang · 2021 · Cell Death and Disease
- Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile miceKimberly P. Keil, Sunjay Sethi, Machelle Wilson, Jill L. Silverman, Isaac N. Pessah, Pamela J. Lein · 2018 · Genes Brain & Behavior
- The CHD Protein, Kismet, is Important for the Recycling of Synaptic Vesicles during EndocytosisNina K. Latcheva, Taylor L. Delaney, Jennifer M. Viveiros, Rachel A. Smith, Kelsey M. Bernard, Benjamin Harsin, Daniel R. Marenda, Faith L. W. Liebl · 2019 · Scientific Reports
- A Novel Chd8 Mutant Mouse Displays Altered Ultrasonic Vocalizations and Enhanced Motor CoordinationSamuel W. Hulbert, Xiaoming Wang, Simisola O. Gbadegesin, Qiong Xu, Xiu Xu, Yong‐hui Jiang · 2020 · Autism Research
- Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman SyndromeElizabeth L. Berg, Stela P. Petkova, Heather A. Born, Anna Adhikari, Anne E. Anderson, Jill L. Silverman · 2021 · Molecular Autism
- RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls dendritic spine maturation and intellectual disability-related behaviourMaria Lidia Mignogna, Stefano Musardo, Giulia Ranieri, Susanna Gelmini, Pedro Espinosa, Paolo Marra, Sara Belloli, Valentina Murtaj, Rosa Maria Moresco, Camilla Bellone et al. · 2021 · Molecular Psychiatry
- MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron typesJ. Russell Moore, Mati T. Nemera, Rinaldo D. D’Souza, Nicole Hamagami, Adam W. Clemens, Diana C. Beard, Alaina Urman, Yasmin Razia, Victoria Rodriguez Mendoza, Travis E. Law et al. · 2025 · Nature Neuroscience
- Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approachArushi Sandhu, Anil Kumar, Kajal Rawat, Vipasha Gautam, Antika Sharma, Lekha Saha · 2023 · World Journal of Clinical Cases
- CHD8short, a naturally-occurring truncated form of a chromatin remodeler lacking the helicase domain, is a potent transcriptional coregulatorGary R. Kunkel, Jessica A. Tracy, Frank L. Jalufka, Arne C. Lekven · 2017 · Gene
- Modification of GSK3β/β-catenin signaling on saikosaponins-d-induced inhibition of neural progenitor cell proliferation and adult neurogenesis.Ting-Ting Qin, Xinxin Fu, Jiayu Yu, Ru-Yi Zhang, Xue-Yang Deng, Qiang Fu, Zhan-Qiang Ma, Shi-Ping Ma · 2019 · Toxicology
- Chromatin modification and epigenetic control in functional nerve regenerationKalen Berry, Qing Richard Lu · 2019 · Seminars in Cell and Developmental Biology
- Neurodevelopmental phenotype associated with CHD8-SUPT16H duplicationThomas Smol, Caroline Thuillier, Elise Boudry‐Labis, Anne Dieux‐Coëslier, Bénédicte Duban‐Bedu, Roseline Caumes, Sonia Bouquillon, Sylvie Manouvrier‐Hanu, Catherine Roche‐Lestienne, Jamal Ghoumid · 2019 · Neurogenetics
- Exploring the biological role of postzygotic and germinal de novo mutations in ASDAitana Alonso-González, Manuel Calaza, Jorge Amigo, Javier González‐Peñas, Rocío Martínez-Regueiro, Montse Fernández‐Prieto, Mara Parellada, Celso Arango, Cristina Rodriguez‐Fontenla, Ángel Carracedo · 2021 · Scientific Reports
- Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disordersKaifang Pang, Li Wang, Wei Wang, Jian Zhou, Chao Cheng, Kihoon Han, Huda Yahya Zoghbi, Zhandong Liu · 2020 · Genome Research
- Neurodevelopmental functions of CHD8: new insights and questionsM. Albert Basson · 2024 · Biochemical Society Transactions
- The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell functionLena Wischhof, Simona Maida, Antonia Piazzesi, Anna Gioran, Kristina Barragán Sanz, Stephan H. Irsen, Marc Beyer, Joachim Ludwig Schultze, Martin J.S. Dyer, Paolo Salomoni et al. · 2017 · Scientific Reports
- Genetic factors associated with empathy in humans and miceSehoon Keum, Hee‐Sup Shin · 2019 · Neuropharmacology
- Exploring the role of RALYL in Alzheimer’s disease reserve by network-based approachesYixuan Zhang, Jiali Wang, Xiaoquan Liu, Haochen Liu · 2020 · Alzheimer s Research & Therapy
- Differential effects by sex with Kmt5b lossRochelle N. Wickramasekara, Brynn Robertson, Jason Hulen, Jodi Hallgren, Holly A.F. Stessman · 2021 · Autism Research
- Transcriptional Pathology Evolves over Time in Rat Hippocampus after Lateral Fluid Percussion Traumatic Brain InjuryRinaldo Catta-Preta, Iva Zdilar, Bradley N. Jenner, Emily T. Doisy, Kayleen G. Tercovich, Alex S. Nord, Gene G. Gurkoff · 2021 · Neurotrauma Reports
- Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycleEmma Coakley-Youngs, Susan A. Shorter, Medhavi Ranatunga, Simon Richardson, Giulia Getti, Marc L. Fivaz · 2022 · Biology Open
- Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expressionChaodong Ding, Wei Zhou, Yuhan Shi, Shifang Shan, Yiting Yuan, Yuefang Zhang, Fei Li, Zilong Qiu · 2024 · Cell Reports
- Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of CHD8 heterozygous cerebral organoidsMaider Astorkia, Yang Liu, Erika Pedrosa, Herbert M. Lachman, Deyou Zheng · 2024 · Heliyon
- Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disabilityTimothy A. Fenton, Olivia Y Haouchine, Elizabeth B Hallam, Emily M. Smith, Kiya C. Jackson, Darlene Rahbarian, César P. Canales, Anna Adhikari, Alex S. Nord, Roy Ben‐Shalom et al. · 2024 · Translational Psychiatry
- Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia, and psychiatric behavior in miceXiang 'Anthony' Chen, Tong Chen, Chen Dong, Huiyao Chen, Xinran Dong, Lin Yang, Liyuan Hu, Huijun Wang, Bingbing Wu, Ye Yao et al. · 2022 · Journal of genetics and genomics/Journal of Genetics and Genomics
- Imaging neural circuit pathology of autism spectrum disorders: autism-associated genes, animal models and the application of in vivo two-photon imagingHiroshi Terashima, Keiichiro Minatohara, Hisato Maruoka, Shigeo Okabe · 2021 · Microscopy
- Critical periods and Autism Spectrum Disorders, a role for sleepElizabeth Medina, Sarah Peterson, Kaitlyn Ford, Kristan G. Singletary, Lucı́a Peixoto · 2022 · Neurobiology of Sleep and Circadian Rhythms
- The complex etiology of autism spectrum disorder due to missense mutations of CHD8Taichi Shiraishi, Yuta Katayama, Masaaki Nishiyama, Hirotaka Shoji, Tsuyoshi Miyakawa, Taisuke Mizoo, Akinobu Matsumoto, Atsushi Hijikata, Tsuyoshi Shirai, Kouta Mayanagi et al. · 2024 · Molecular Psychiatry
- Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrationsGaurav Kaushik, Yu Xia, Jean C. Pfau, Michael A. Thomas · 2017 · Neuroscience Letters
- Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formationStela P. Petkova, Michael C. Pride, Carolyn R. Klocke, Timothy A. Fenton, Jeannine Logan White, Pamela J. Lein, Jacob Ellegood, Jason P. Lerch, Jill L. Silverman, Ben Waldau · 2020 · Scientific Reports
- SINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in autism spectrum disorder model systemsFrancesca Di Leva, Michele Arnoldi, Stefania Santarelli, Mathieu Massonot, Marianne Victoria Lemée, Carlotta Bon, Miguel Pellegrini, Maria Elena Castellini, Giulia Zarantonello, Andrea Messina et al. · 2024 · Molecular Therapy
- Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of functionFaith C.J. Davies, Jilly E. Hope, Fiona McLachlan, Grant F. Marshall, Laura Kaminioti-Dumont, Vesa Qarkaxhija, Francis Nunez, Owen Dando, Colin S. Smith, Emma R. Wood et al. · 2020 · Human Molecular Genetics
- Chromodomain helicase DNA-binding proteins and neurodevelopmental disordersHeba Yasin, Farah Zahir · 2020 · Journal of Translational Genetics and Genomics
- Transgenic mice with an R342X mutation in Phf6 display clinical features of Börjeson–Forssman–Lehmann SyndromeRaies Ahmed, Shihab Sarwar, Jinghua Hu, Valérie Turcotte-Cardin, Lily R. Qiu, Gerardo A. Zapata, Lucianne Vandeleur, Keqin Yan, Jason P. Lerch, Mark A Corbett et al. · 2021 · Human Molecular Genetics
- Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviorsSoo Yeon Lee, Hanseul Kweon, Hyojin Kang, Eunjoon Kim · 2022 · Frontiers in Molecular Neuroscience
- Translating genetic and preclinical findings into autism therapiesMaria H. Chahrour, Robin J. Kleiman, M. Chiara Manzini · 2017 · Dialogues in Clinical Neuroscience
- Functional Neurogenomics to Dissect Disease Mechanisms Across ModelsXinhe Zheng, Jiwen Li, Xin Jin · 2025 · Annual Review of Genomics and Human Genetics
- Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memoryBaicheng Zhao, Hang Zhang, Ying Liu, Gaoyu Zu, Yuxiao Zhang, Jiayi Hu, Shuai Liu, Linya You · 2023 · Neural Regeneration Research
- Heterozygous Nexmif female mice demonstrate mosaic NEXMIF expression, autism-like behaviors, and abnormalities in dendritic arborization and synaptogenesisMargaret G. O’Connor, Hui Qiao, KathrynAnn Odamah, Pedro Casariego Cerdeira, Heng‐Ye Man · 2024 · Heliyon
- Sex bias in autism: new insights from Chd8 mutant mice?Laura C. Andreae, M. Albert Basson · 2018 · Nature Neuroscience
- Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genesVahid Gazestani, Austin W.T. Chiang, Eric Courchesne, Nathan E. Lewis · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Enhancer-targeted CRISPR-A rescues haploinsufficiency and mutant phenotypes in organoid models of autismGeorge T Chen, Gayatri Nair, Aubrey J. Osorio, Sandra M. Holley, Kimiya Ghassemzadeh, Yixuan Zhou, Jose Gonzalez, Jacqueline M. Martin, Congyi Lu, Neville E. Sanjana et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal CortexRobert A. Ellingford, Mizuki Tojo, M. Albert Basson, Laura C. Andreae · 2024 · ACS Chemical Neuroscience
- Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in miceAtsuki Kawamura, Kazuki Fujii, Kota Tamada, Yoshifumi Abe, Kenta Nitahara, Tomoya Iwasaki, Sho Yagishita, Kenji F. Tanaka, Toru Takumi, Keizo Takao et al. · 2025 · Nature Communications
- Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse modelEmily Z. Huie, Xin Yang, Mengia S. Rioult-Pedotti, Kyle Tran, Emma R. Monsen, Kim M. Hansen, Michelle A. Erickson, Mandar T. Naik, Anna Y. Yotova, William A. Banks et al. · 2024 · Neuropsychopharmacology
- Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical developmentKristina Yim, Marybeth Baumgartner, Martina Krenzer, María F. Rosales Larios, Guillermina Hill-Terán, Timothy Nottoli, Rebecca Muhle, James P. Noonan · 2025 · Cell Genomics
- In vivo targeted DamID identifies CHD8 genomic targets in fetal mouse brainA. Ayanna Wade, Jelle van den Ameele, Seth W. Cheetham, Rebecca Yakob, Andrea H. Brand, Alex S. Nord · 2021 · iScience
- Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiencySarah A. Dugger, Ryan S. Dhindsa, Gabriela Louise de Almeida Sampaio, Andrew K. Ressler, Elizabeth E. Rafikian, Sabrina Petri, Verity A. Letts, Jia Jie Teoh, Junqiang Ye, Sophie Colombo et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms of brain overgrowth in autism spectrum disorder with macrocephalyLaura Currey, Tracey J. Harvey, Alexandra Pelenyi, Michael Piper, Stefan Thor · 2025 · Frontiers in Neuroscience
- Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain developmentNoémie Adès, Lamia Bouslama‐Oueghlani · 2026 · Molecular Psychiatry
- The Genetics of Chiari 1 MalformationRachel Yan, John K. Chae, Nadia Dahmane, Palma Ciaramitaro, Jeffrey Peter Greenfield · 2024 · Journal of Clinical Medicine
- Natural SINEUP RNAs in Autism Spectrum Disorders: RAB11B-AS1 Dysregulation in a Neuronal CHD8 Suppression Model Leads to RAB11B Protein IncreaseGiulia Zarantonello, Michele Arnoldi, Michele Filosi, Toma Tebaldi, Giovanni Spirito, Anna Barbieri, Stefano Gustincich, Remo Sanges, Enrico Domenici, Francesca Di Leva et al. · 2021 · Frontiers in Genetics
- A likely HOXC4 predisposition variant for Chiari malformationsDouglas L. Brockmeyer, Samuel Henry Cheshier, Jeff Stevens, Julio Cesar Facelli, Kerry G. Rowe, John D. Heiss, Anthony M. Musolf, David H. Viskochil, Kristina Allen‐Brady, Lisa Cannon‐Albright · 2022 · Journal of neurosurgery
- Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental DisordersAki Shigenaka, Eri Nitta, Tadashi Nakagawa, Makiko Nakagawa, Toru Hosoi · 2025 · Journal of Developmental Biology
- MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoAAlexia Cossard, Kirsten Stam, Aurore Smets, Yves Jossin · 2023 · Science Advances
- Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomesSoo Yeon Lee, Hanseul Kweon, Hyojin Kang, Eunjoon Kim · 2023 · Frontiers in Molecular Neuroscience
- CHD8 adulthood microglial knockdown in C57BL6 mice induces behavioral, morphological, and transcriptional changes in a sex-dependent mannerOrly Weissberg, Ram Harari, Chizim Dogun, Dmitriy Getselter, Evan Elliott · 2025 · Translational Psychiatry
- Progress in magnetic resonance imaging of autism model mice brainDingding Yang, Yan Zhao, Binbin Nie, Leiting An, Xiangdong Wan, Yazhou Wang, Wenting Wang, Guohong Cai, Shengxi Wu · 2022 · Wiley Interdisciplinary Reviews Cognitive Science
- A Blueprint for Translational Precision Medicine in Autism Spectrum Disorder and Related Neurogenetic SyndromesRobyn Pauline Thom, Tracy L. Warren, Suha Khan, Rebecca Muhle, Paul P. Wang, Kristen Brennand, Nicole R. Zürcher, Jeremy M. Veenstra-VanderWeele, Ellen J. Hoffman · 2025 · Journal of Child and Adolescent Psychopharmacology
- CHD8 haploinsufficiency alters the developmental trajectories of human excitatory and inhibitory neurons linking autism phenotypes with transient cellular defectsCarlo Emanuele Villa, Cristina Cheroni, Alejandro Tobon, Christoph P. Dotter, Bárbara Oliveira, Roberto Sacco, Aysan Çerağ Yahya, Jasmin Morandell, Michele Gabriele, Christoph Sommer et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutationsTimothy A. Fenton, Olivia Y Haouchine, Elizabeth L Hallam, Emily M. Smith, Kiya C. Jackson, Darlene Rahbarian, César P. Canales, Anna Adhikari, Alex S. Nord, Roy Ben‐Shalom et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- A CHD8-TRRAP axis facilitates MYC and E2F target gene regulation in human neural stem cellsLize Meert, Murilo Almeida, Mike R. Dekker, Dick H. W. Dekkers, Karol Nowosad, Danny Huylebroeck, Mirjam C. G. N. van den Hout, Zeliha Özgür, Wilfred F. J. van IJcken, Jeroen Demmers et al. · 2025 · iScience
- Animal models of autismElizabeth L. Berg, Jill L. Silverman · 2022 · Elsevier eBooks
- The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in MiceXiaojie Niu, Feifei Huang, Haizhen Lyu, Jiao Liu, Xinwei Zhang, Jiang Bian, Zhijie Gao, Binyu Liu · 2024 · Journal of Molecular Neuroscience
- Small SNPs, Big Effects: A Review of Single Nucleotide Variations and Polymorphisms in Key Genes Associated With Autism Spectrum DisorderSriharikrishnaa Srinath, Akanksha A. Kalal, Preethika Anand, Satyajit Mohapatra, Prabahan Chakraborty · 2025 · International Journal of Developmental Neuroscience
- Transcriptome-based classification in mice with ASD-risk mutationsJunyeop Daniel Roh, Yukyung Jun, Heesu Jeon, Junyoung Kim, Yunho Yi, Minji Kim, Heejin Cho, Yusang Oh, Heera Moon, Jinkyeong Kim et al. · 2026 · Science
- Emerging Role of Epigenetics in Human Neurodevelopmental DisordersGiuseppina Mastrototaro, Alessandro Sessa · 2018 · Elsevier eBooks
- Morphological study of embryonic Chd8+/− mouse brains using light-sheet microscopyHarold Fernando Gómez, Leonie Hodel, Odyssé Michos, Dagmar Iber · 2021 · BMC Research Notes
- Emerging role of epigenetics in human neurodevelopmental disordersGiuseppina Mastrototaro, Alessandro Sessa, Mattia Zaghi · 2023 · Elsevier eBooks
- The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular JunctionIreland R. Smith, Emily L. Hendricks, Nina K. Latcheva, Daniel R. Marenda, Faith L. W. Liebl · 2024 · International Journal of Molecular Sciences
- Understanding the Clotting Cascade, Regulators, and Clinical Modulators of CoagulationVijaya Satish Sekhar Pilli · 2018 · InTech eBooks
- The human chd8 gene is transcribed from two distant upstream promotersGary R. Kunkel, Hannah G. Lisciandro, Hannah L. Winter · 2020 · Biochemical and Biophysical Research Communications
- Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signalingMegha Amar, Akula Bala Pramod, Nam‐Kyung Yu, Victor Munive Herrera, Lily R. Qiu, Patricia Morán Losada, Pan Zhang, Cleber A. Trujillo, Jacob Ellegood, Jorge Urresti et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in miceCésar P. Canales, Myka L. Estes, Karol Cichewicz, Kartik Angara, John Paul Aboubechara, Scott Cameron, Kathryn Prendergast, Linda Su-Feher, Iva Zdilar, Ellie J. Kreun et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Rise of the Chromodomain Helicase DNA‐Binding (CHD) Chromatin Remodelling MachinesAndrej Alendar · 2023 · Wiley eBooks
- Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signallingLeticia Pérez‐Sisqués, S. Bhatt, Angela Caruso, Mohi U. Ahmed, Talia E. Gileadi, Shoshana Spring, Eleanor Hendy, Joyce Taylor‐Papadimitriou, Diana Cash, Nicholas E. Clifton et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Chd8 haploinsufficiency leads to molecular layer heterotopias and age-dependent cortical expansionFelix A. Kyere, Ian Curtin, Ziquan Wei, César P. Canales, Nicolas Seban, Lei Xing, Preslava P Todorova, Leticia Pérez-Sisqués, Maya Yilan Yin, Tao Wen et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male miceClaudio Peter D’Incal, Elisa Cappuyns, Flora Paldi, Mathijs B. van der Lei, Dale John Annear, Clara Milián Alastruey, Dimitra Sokolova, Ellen Elinck, Kevin De Man, Anthony Konings et al. · 2026 · EBioMedicine
- Autism and Neurodegeneration: Distinct Disorders or a Shared Biological Continuum?Jorge ge Manzo, María Elena Hernández‐Aguilar · 2026 · Brain Sciences
- Introduction of a de novo Creb-binding protein gene mutation in sperm to produce a Rubinstein-Taybi syndrome model using inbred C57BL/6 miceTsuyoshi Takagi, Yujiro Higashi, Masato Asai, Shunsuke Ishii · 2020 · Brain Research
- Identification of Therapeutic Targets in Autism Spectrum Disorder through CHD8-Notch Pathway Interaction AnalysisHewei Zhang, Shenghao Hua, Daiyan Jiao, Dong Chen, Qin Gu, Chao Bao · 2025 · PLoS ONE
- Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient micePhilipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L. H. Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- The riddle of CHD8 haploinsufficiency in autism spectrum disorderGaia Novarino · 2017 · Science Translational Medicine
- Non-monotonic regulation of gene expression, neural progenitor fate and brain growth by the chromatin remodeller CHD8Shaun Hurley, Conor Mohan, Philipp Suetterlin, Jacob Ellegood, Fabrizio Rudari, Jason P. Lerch, Cathy Fernandes, M. Albert Basson · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- CHD8 regulates the balance between proliferation and differentiation of human iPSCs in neural developmentWenzhong Liu, Weilai Dong, Ellen J. Hoffman, Thomas V. Fernandez, Abha R. Gupta · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Multi-hit autism genomic architecture evidenced from consanguineous families with involvement of FEZF2 and mutations in high-risk genesMounia Bensaid, Yann Loe-Mie, Aude-Marie Lepagnol-Bestel, Wenqi Han, Gabriel Santpere, Thomas Klarić, Christine Plançon, Rim Roudies, Imane Benhima, Nisrine Tarik et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Novel CHD8 genomic targets identified in fetal mouse brain by in vivo Targeted DamIDA. Ayanna Wade, Jelle van den Ameele, Seth W. Cheetham, Rebecca Yakob, Andrea H. Brand, Alex S. Nord · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- ASXL3 controls cortical neuron fate specification through extrinsic self-renewal pathwaysBT McGrath, P Wu, Shachi Salvi, Navjit S Girgla, Xin Chen, Jiaqiang Zhu, R KC, Yao-Chang Tsan, Amanda Moccia, Anshika Srivastava et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)