The NuRD complex in neurodevelopment and disease: a case of sliding doors
Open accessAbstract
The Nucleosome Remodelling and Deacetylase (NuRD) complex represents one of the major chromatin remodelling complexes in mammalian cells, uniquely coupling the ability to "open" the chromatin by inducing nucleosome sliding with histone deacetylase activity. At the core of the NuRD complex are a family of ATPases named CHDs that utilise the energy produced by the hydrolysis of the ATP to induce chromatin structural changes. Recent studies have highlighted the prominent role played by the NuRD in regulating gene expression during brain development and in maintaining neuronal circuitry in the adult cerebellum. Importantly, components of the NuRD complex have been found to carry mutations that profoundly affect neurological and cognitive development in humans. Here, we discuss recent literature concerning the molecular structure of NuRD complexes and how the subunit composition and numerous permutations greatly determine their functions in the nervous system. We will also discuss the role of the CHD family members in an array of neurodevelopmental disorders. Special emphasis will be given to the mechanisms that regulate the NuRD complex composition and assembly in the cortex and how subtle mutations may result in profound defects of brain development and the adult nervous system.
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HDACs modulate key neurobiological processes, including neuronal differentiation, synaptic plasticity, learning, and memory formation.
“Through this regulatory mechanism, HDACs modulate key neurobiological processes, including neuronal differentiation, synaptic plasticity, learning, and memory formation (Boulasiki et al., 2023; Clapier et al., 2017).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Boulasiki et al., 2023
Section 2.1 identifies HDAC1 and HDAC2 as components of NuRD, and section 2.2 says NuRD participates in neuronal differentiation and the establishment and maintenance of neuronal connectivity. Section 3 links synaptic activity to chromatin accessibility, but the paper does not establish that HDACs themselves modulate synaptic plasticity, learning, or memory formation. Page numbers are unavailable in our copy. (LLM, conf=0.83)
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RNA Polymerase II Activity Control of Gene Expression and Involvement in Disease
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Novel CDKL5 targets identified in human iPSC-derived neurons
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- Authors
- Boulasiki, P., Tan, X. W., Spinelli, M., & Riccio, A.
- Affiliations
- University College London (GB)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Riccio, Antonella
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2023-04-18
- Volume
- 12
- Issue
- 8
- Pages
- 1179
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC10136855
- OpenAlex
- W4366286736
- Cited by
- 22
- References
- 80
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 7 · 2023: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion, cc-by)
- Funders
- Wellcome Trust Investigator Award (103717/Z/14/Z, 217213/Z/19/Z, MC/U12266B)
- MRC LMCB Core Grant (103717/Z/14/Z, 217213/Z/19/Z, MC/U12266B)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- NuRD complex, chromatin remodeling, histone deacetylase, nucleosome sliding, brain development, cerebellum, neural circuits, neurodevelopmental disorders, gene expression regulation, complex assembly, chromatin structure, cognitive development
- MeSH terms
- Animals, Chromatin, Humans, Mammals, Nucleosomes, Chromatin Assembly and Disassembly, Mi-2 Nucleosome Remodeling and Deacetylase Complex
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