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Cited by 228Neuroscience and Neuropharmacology ResearchHearing, Cochlea, Tinnitus, GeneticsNeural dynamics and brain function

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Developmental switch from GABA to glycine release in single central synaptic terminals

Nabekura, Junichi, Katsurabayashi, Shutaro, Kakazu, Yasuhiro, Shibata, Shumei, Matsubara, Atsushi, Jinno, Shozo, Mizoguchi, Yoshito, Sasaki, Akira, Ishibashi, Hitoshi·2004·Nature Neuroscience
DOI 10.1038/nn1170
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Abstract

Early in postnatal development, inhibitory inputs to rat lateral superior olive (LSO) neurons change from releasing predominantly GABA to releasing predominantly glycine into the synapse. Here we show that spontaneous miniature inhibitory postsynaptic currents (mIPSCs) also change from GABAergic to glycinergic over the first two postnatal weeks. Many 'mixed' mIPSCs, resulting from co-release of glycine and GABA from the same vesicles, are seen during this transition. Immunohistochemistry showed that a large number of terminals contained both GABA and glycine at postnatal day 8 (P8). By P14, both the content of GABA in these mixed terminals and the contribution of GABA to the mixed mIPSCs had decreased. The content of glycine in terminals increased over the same period. Our results indicate that switching from GABAergic to glycinergic inputs to the LSO may occur at the level of a single presynaptic terminal. This demonstrates a new form of developmental plasticity at the level of a single central synapse.

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Crossref · 10.1038/nn1170

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Metadata

Authors
Nabekura, J., Katsurabayashi, S., Kakazu, Y., Shibata, S., Matsubara, A., Jinno, S., Mizoguchi, Y., Sasaki, A., & Ishibashi, H.
Affiliations
  • Kyushu University (JP)
  • Hirosaki University (JP)
Corresponding author
Nabekura, Junichi
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2003-12-21
Volume
7
Issue
1
Pages
17-23
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1170
OpenAlex
W2049978992
Cited by
228
References
41
Citations by year
2026: 1 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 10
FWCI
4.40
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
GABA, glycine, lateral superior olive, postnatal development, presynaptic terminals, CO release, miniature inhibitory postsynaptic currents, synaptic plasticity, inhibitory synapses
MeSH terms
Animals, Animals, Newborn, Bicuculline, gamma-Aminobutyric Acid, Glycine, Synaptic Transmission, Olivary Nucleus, Rats, Wistar, Presynaptic Terminals, Rats

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