Cited by 228Neuroscience and Neuropharmacology ResearchHearing, Cochlea, Tinnitus, GeneticsNeural dynamics and brain function

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Developmental switch from GABA to glycine release in single central synaptic terminals

Nabekura, Junichi, Katsurabayashi, Shutaro, Kakazu, Yasuhiro, Shibata, Shumei, Matsubara, Atsushi, Jinno, Shozo, Mizoguchi, Yoshito, Sasaki, Akira, Ishibashi, Hitoshi·2004·Nature Neuroscience

DOI 10.1038/nn1170

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Abstract

Early in postnatal development, inhibitory inputs to rat lateral superior olive (LSO) neurons change from releasing predominantly GABA to releasing predominantly glycine into the synapse. Here we show that spontaneous miniature inhibitory postsynaptic currents (mIPSCs) also change from GABAergic to glycinergic over the first two postnatal weeks. Many 'mixed' mIPSCs, resulting from co-release of glycine and GABA from the same vesicles, are seen during this transition. Immunohistochemistry showed that a large number of terminals contained both GABA and glycine at postnatal day 8 (P8). By P14, both the content of GABA in these mixed terminals and the contribution of GABA to the mixed mIPSCs had decreased. The content of glycine in terminals increased over the same period. Our results indicate that switching from GABAergic to glycinergic inputs to the LSO may occur at the level of a single presynaptic terminal. This demonstrates a new form of developmental plasticity at the level of a single central synapse.

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Otis, T. S., De Koninck, Y., & Mody, I. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7698 · Cited by 257
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Authors: Nabekura, J., Katsurabayashi, S., Kakazu, Y., Shibata, S., Matsubara, A., Jinno, S., Mizoguchi, Y., Sasaki, A., & Ishibashi, H.
Affiliations: Kyushu University (JP)
Hirosaki University (JP)
Corresponding author: Nabekura, Junichi
ORCID: Nabekura, Junichi
Katsurabayashi, Shutaro
Matsubara, Atsushi
Jinno, Shozo
Mizoguchi, Yoshito
Sasaki, Akira
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2003-12-21
Volume: 7
Issue: 1
Pages: 17-23
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1170
OpenAlex: W2049978992
Cited by: 228
References: 41
Citations by year: 2026: 1 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 10
FWCI: 4.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: GABA, glycine, lateral superior olive, postnatal development, presynaptic terminals, CO release, miniature inhibitory postsynaptic currents, synaptic plasticity, inhibitory synapses
MeSH terms: Animals, Animals, Newborn, Bicuculline, gamma-Aminobutyric Acid, Glycine, Synaptic Transmission, Olivary Nucleus, Rats, Wistar, Presynaptic Terminals, Rats

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Developmental switch from GABA to glycine release in single central synaptic terminals

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