The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Developmental switch from GABA to glycine release in single central synaptic terminals
Abstract
Early in postnatal development, inhibitory inputs to rat lateral superior olive (LSO) neurons change from releasing predominantly GABA to releasing predominantly glycine into the synapse. Here we show that spontaneous miniature inhibitory postsynaptic currents (mIPSCs) also change from GABAergic to glycinergic over the first two postnatal weeks. Many 'mixed' mIPSCs, resulting from co-release of glycine and GABA from the same vesicles, are seen during this transition. Immunohistochemistry showed that a large number of terminals contained both GABA and glycine at postnatal day 8 (P8). By P14, both the content of GABA in these mixed terminals and the contribution of GABA to the mixed mIPSCs had decreased. The content of glycine in terminals increased over the same period. Our results indicate that switching from GABAergic to glycinergic inputs to the LSO may occur at the level of a single presynaptic terminal. This demonstrates a new form of developmental plasticity at the level of a single central synapse.
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“The kinetics of glycine receptors are faster than those of GABA receptors, resulting in an inhibitory post synaptic current (IPSC) with fast and slow components.44,45,49”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [49]
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Cites
Quantal components of the end‐plate potential
del Castillo, J., & Katz, B. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005129 · Cited by 2,201
Corelease of Two Fast Neurotransmitters at a Central Synapse
Jonas, P., Bischofberger, J., & Sandkühler, J. (1998) · Science · doi:10.1126/science.281.5375.419 · Cited by 784
Ganguly, K., Schinder, A. F., Wong, S. T., & Poo, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00341-5 · Cited by 719
Matsubara, A., Laake, J. H., Davanger, S., Usami, S., & Ottersen, O. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04457.1996 · Cited by 424
Ottersen, O. P., Zhang, N., & Walberg, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90141-n · Cited by 335
Takahashi, T., Momiyama, A., Hirai, K., Hishinuma, F., & Akagi, H. (1992) · Neuron · doi:10.1016/0896-6273(92)90073-m · Cited by 319
Glycine-receptor activation is required for receptor clustering in spinal neurons
Kirsch, J., & Betz, H. (1998) · Nature · doi:10.1038/33694 · Cited by 263
Brain Glutamate Decarboxylase Cloned in λgt-11: Fusion Protein Produces γ-Aminobutyric Acid
Kaufman, D. L., McGinnis, J. F., Krieger, N. R., & Tobin, A. J. (1986) · Science · doi:10.1126/science.3518061 · Cited by 260
Otis, T. S., De Koninck, Y., & Mody, I. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7698 · Cited by 257
Regulation of Intracellular Chloride by Cotransporters in Developing Lateral Superior Olive Neurons
Kakazu, Y., Akaike, N., Komiyama, S., & Nabekura, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02843.1999 · Cited by 253
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo
Hnasko, T. S., Chuhma, N., Zhang, H., Goh, G. Y., Sulzer, D., Palmiter, R. D., Rayport, S., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.012 · Cited by 405
A shared vesicular carrier allows synaptic corelease of GABA and glycine
Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., & Rhee, J.-S. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.016 · Cited by 374
Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control
Zeilhofer, H. U., Wildner, H., & Yévenes, G. E. (2012) · Physiological Reviews · doi:10.1152/physrev.00043.2010 · Cited by 394
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P. A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1221 · Cited by 350
Metadata
- Authors
- Nabekura, J., Katsurabayashi, S., Kakazu, Y., Shibata, S., Matsubara, A., Jinno, S., Mizoguchi, Y., Sasaki, A., & Ishibashi, H.
- Affiliations
- Kyushu University (JP)
- Hirosaki University (JP)
- Corresponding author
- Nabekura, Junichi
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2003-12-21
- Volume
- 7
- Issue
- 1
- Pages
- 17-23
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2049978992
- Cited by
- 228
- References
- 41
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 10
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABA, glycine, lateral superior olive, postnatal development, presynaptic terminals, CO release, miniature inhibitory postsynaptic currents, synaptic plasticity, inhibitory synapses
- MeSH terms
- Animals, Animals, Newborn, Bicuculline, gamma-Aminobutyric Acid, Glycine, Synaptic Transmission, Olivary Nucleus, Rats, Wistar, Presynaptic Terminals, Rats
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