The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Abstract
Dendritic arborization is required for proper neuronal connectivity. Rho GTPases have been implicated in the regulation of dendrite development. However, the signaling pathways that impinge on these molecular switches remain poorly understood. Here we show that Wnt7b, which is expressed in the mouse hippocampus, increases dendritic branching in cultured hippocampal neurons. This effect is mimicked by the expression of Dishevelled (Dvl) and is blocked by Sfrp1, a secreted Wnt antagonist. Consistent with these findings, hippocampal neurons from mice lacking Dvl1 show reduced dendritic arborization. Activation of the canonical Wnt-Gsk3beta pathway does not affect dendritic development. In contrast, Wnt7b and Dvl activate Rac and JNK in hippocampal neurons. Dominant-negative Rac, dominant-negative JNK or inhibition of JNK blocks Dvl-mediated dendritic growth. These findings demonstrate a new function for the non-canonical Wnt pathway in dendrite development and identify Dvl as a regulator of Rho GTPases and JNK during dendritic morphogenesis.
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“However, as clearly summarized by Kalkman (Kalkman, 2012), one must recognize the multiple roles of Wnt signaling, not only in cell adhesion and dendritic remodeling but also in early brain development (Rosso et al., 2005; Salinas and Zou, 2008; Ueda et al., 2008; Wayman et al., 2006; Yu and Malenka, 2003).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Rosso et al., 2005
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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
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The JNK signal transduction pathway
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Cell migration: Rho GTPases lead the way
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RHO GTPASES in neuronal morphogenesis
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GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
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“Signals that elicit dynamic actin rearrangements on activation of Rho GTPases, like the above-mentioned non-canonical Wnt–PCP pathway, were shown to also result in the activation of the Jun N-terminal kinases (JNKs”
Dishevelled: The hub of Wnt signaling
Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 780
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Metadata
- Authors
- Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C.
- Affiliations
- University of London (GB)
- University of Maryland, Baltimore (US)
- University of California San Diego (US)
- Corresponding author
- Salinas, Patricia C
- Venue
- Nature Neuroscience
- Published
- 2004-12-19
- Volume
- 8
- Issue
- 1
- Pages
- 34-42
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2087203385
- Cited by
- 485
- References
- 50
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 21 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 14 · 2018: 23 · 2017: 18 · 2016: 19 · 2015: 27 · 2014: 29 · 2013: 32 · 2012: 43
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institute of Neurological Disorders and Stroke (R01NS073159)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Wnt signaling, Dishevelled, dendritic branching, Wnt7b, SFRP1, non-canonical Wnt pathway, Rac, JNK, Rho GTPases, hippocampal neurons, dendrite morphogenesis, Wnt antagonists
- MeSH terms
- Dishevelled Proteins, Acute-Phase Proteins, Animals, Cells, Cultured, Cytoskeleton, Dendrites, Embryo, Mammalian, Glycoproteins, Hippocampus, Mutation, Neurons, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Tissue Distribution, Signal Transduction, Protein Structure, Tertiary, rac GTP-Binding Proteins, Intercellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Wnt Proteins, Mice
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