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Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Abstract
Dendritic arborization is required for proper neuronal connectivity. Rho GTPases have been implicated in the regulation of dendrite development. However, the signaling pathways that impinge on these molecular switches remain poorly understood. Here we show that Wnt7b, which is expressed in the mouse hippocampus, increases dendritic branching in cultured hippocampal neurons. This effect is mimicked by the expression of Dishevelled (Dvl) and is blocked by Sfrp1, a secreted Wnt antagonist. Consistent with these findings, hippocampal neurons from mice lacking Dvl1 show reduced dendritic arborization. Activation of the canonical Wnt-Gsk3beta pathway does not affect dendritic development. In contrast, Wnt7b and Dvl activate Rac and JNK in hippocampal neurons. Dominant-negative Rac, dominant-negative JNK or inhibition of JNK blocks Dvl-mediated dendritic growth. These findings demonstrate a new function for the non-canonical Wnt pathway in dendrite development and identify Dvl as a regulator of Rho GTPases and JNK during dendritic morphogenesis.
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“However, as clearly summarized by Kalkman (Kalkman, 2012), one must recognize the multiple roles of Wnt signaling, not only in cell adhesion and dendritic remodeling but also in early brain development (Rosso et al., 2005; Salinas and Zou, 2008; Ueda et al., 2008; Wayman et al., 2006; Yu and Malenka, 2003).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Rosso et al., 2005
Citations
Cites
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Gutkind, J. S. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,629
The JNK signal transduction pathway
Weston, C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,551
Cell migration: Rho GTPases lead the way
Raftopoulou, M., & Hall, A. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,494
Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481
RHO GTPASES in neuronal morphogenesis
Luo, L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044547 · Cited by 985
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842
GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
Meijer, L., Skaltsounis, A., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., Ryan, X. P., Vonica, A., Brivanlou, A. H., Dajani, R., et al. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.11.010 · Cited by 814
Nakayama, A. Y., Harms, M. B., & Luo, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05329.2000 · Cited by 708
Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling
Hall, A. C., Lucas, F. R., & Salinas, P. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80689-3 · Cited by 699
Self-citationSemaphorin 3A is a chemoattractant for cortical apical dendrites
Polleux, F., Morrow, T. A., & Ghosh, A. (2000) · Nature · doi:10.1038/35007001 · Cited by 699
A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675
Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603
Rattner, A., Hsieh, J.-C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2859 · Cited by 574
Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth
McAllister, A. K., Katz, L. C., & Lo, D. C. (1997) · Neuron · doi:10.1016/s0896-6273(00)80316-5 · Cited by 570
New aspects of Wnt signaling pathways in higher vertebrates
Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 561
The role of RhoA in tissue polarity and Frizzled signalling
Strutt, D. I., Weber, U., & Mlodzik, M. (1997) · Nature · doi:10.1038/387292a0 · Cited by 560
Winter, C. G., Wang, B., Ballew, A. C., Royou, A., Karess, R. E., Axelrod, J. D., & Luo, L. (2001) · Cell · doi:10.1016/s0092-8674(01)00298-7 · Cited by 555
Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42
Threadgill, R., Bobb, K., & Ghosh, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80376-1 · Cited by 492
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80354-2 · Cited by 470
Self-citationβ-catenin is critical for dendritic morphogenesis
Yu, X., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn1132 · Cited by 459
Wnt-mediated axon guidance via the Drosophila Derailed receptor
Yoshikawa, S., McKinnon, R. D., Kokel, M., & Thomas, J. B. (2003) · Nature · doi:10.1038/nature01522 · Cited by 416
The Drosophila Wnt, Wingless, Provides an Essential Signal for Pre- and Postsynaptic Differentiation
Packard, M. C., Koo, E. S., Gorczyca, M. G., Sharpe, J., Cumberledge, S., & Budnik, V. (2002) · Cell · doi:10.1016/s0092-8674(02)01047-4 · Cited by 415
The dishevelled protein is modified by wingless signaling in Drosophila.Preprint
Yanagawa, S.-I., van Leeuwen, F. N., Wodarz, A., Klingensmith, J., & Nusse, R. (1995) · Genes & Development · doi:10.1101/gad.9.9.1087 · Cited by 388
Chang, L., Jones, Y., Ellisman, M. H., Goldstein, L. S. B., & Karin, M. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00094-7 · Cited by 375
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos
Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kühl, M., & Moon, R. T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211094 · Cited by 350
The Control of Dendrite Development
Jan, Y. N., & Jan, L. Y. (2003) · Neuron · doi:10.1016/s0896-6273(03)00631-7 · Cited by 311
Lucas, F. R., Goold, R., Gordon‐Weeks, P. R., & Salinas, P. C. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.10.1351 · Cited by 307
Self-citationRho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
Li, Z., Aelst, L. V., & Cline, H. T. (2000) · Nature Neuroscience · doi:10.1038/72920 · Cited by 293
Lee, T., Winter, C. G., Marticke, S., Lee, A. M., & Luo, L. (2000) · Neuron · doi:10.1016/s0896-6273(00)80896-x · Cited by 287
Regulation of leading edge microtubule and actin dynamics downstream of Rac1
Wittmann, T., Bokoch, G., & Waterman, C. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303082 · Cited by 285
WNT-7a Induces Axonal Remodeling and Increases Synapsin I Levels in Cerebellar Neurons
Lucas, F. R., & Salinas, P. C. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8734 · Cited by 280
Self-citationRegulation of Cortical Dendrite Development by Slit-Robo Interactions
Whitford, K. L., Marillat, V., Stein, E., Goodman, C. S., Tessier‐Lavigne, M., Chédotal, A., & Ghosh, A. (2002) · Neuron · doi:10.1016/s0896-6273(01)00566-9 · Cited by 277
Molecular Control of Cortical Dendrite Development
Whitford, K. L., Dijkhuizen, P. A., Polleux, F., & Ghosh, A. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142932 · Cited by 266
Pokorny, J., & Yamamoto, T. (1981) · Brain Research Bulletin · doi:10.1016/0361-9230(81)90075-7 · Cited by 265
A divergent canonical WNT-signaling pathway regulates microtubule dynamics
Ciani, L., Krylova, O. Y., Smalley, M. J., Dale, T. C., & Salinas, P. C. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309096 · Cited by 226
Self-citationKrylova, O. Y., Herreros, J., Cleverley, K., Ehler, E., Henríquez, J. P., Hughes, S. M., & Salinas, P. C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00860-7 · Cited by 203
Self-citationThe Neuronal Architecture ofXenopusRetinal Ganglion Cells Is Sculpted by Rho-Family GTPasesIn Vivo
Ruchhoeft, M. L., Ohnuma, S., McNeill, L., Holt, C. E., & Harris, W. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08454.1999 · Cited by 193
Paglini, M. G., Pigino, G. F., Kunda, P. E., Morfini, G. A., Maccioni, R. B., Quiroga, S., Ferreira, A., & Cáceres, A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09858.1998 · Cited by 192
Coffey, E. T., Hongisto, V., Dickens, M., Davis, R. J., & Courtney, M. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07602.2000 · Cited by 191
Zhurinsky, J., Shtutman, M. S., & Ben‐Ze'ev, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4238-4252.2000 · Cited by 185
Sussman, D. J., Klingensmith, J., Salinas, P. C., Adams, P. S., Nusse, R., & Perrimon, N. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1297 · Cited by 183
Self-citationSignaling mechanisms underlying dendrite formation
Miller, F. D., & Kaplan, D. R. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00072-2 · Cited by 160
Dishevelled-1 Regulates Microtubule Stability
Krylova, O. Y., Messenger, M. J., & Salinas, P. C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.83 · Cited by 124
Self-citationKuwahara, K., Saito, Y., Nakagawa, O., Kishimoto, I., Harada, M., Ogawa, E., Miyamoto, Y., Hamanaka, I., Kajiyama, N., Takahashi, N., et al. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00680-8 · Cited by 113
Penton, A. L., Wodarz, A., & Nusse, R. (2002) · Genetics · doi:10.1093/genetics/161.2.747 · Cited by 112
Dendritic growth induced by BMP‐7 requires Smad1 and proteasome activity
Guo, X., Lin, Y., Horbinski, C., Drahushuk, K. M., Kim, I., Kaplan, P. L., Lein, P. J., Wang, T., & Higgins, D. M. (2001) · Journal of Neurobiology · doi:10.1002/neu.1046 · Cited by 48
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Metadata
- Authors
- Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C.
- Affiliations
- University of London (GB)
- University of Maryland, Baltimore (US)
- University of California San Diego (US)
- Corresponding author
- Salinas, Patricia C
- Venue
- Nature Neuroscience
- Published
- 2004-12-19
- Volume
- 8
- Issue
- 1
- Pages
- 34-42
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2087203385
- Cited by
- 485
- References
- 50
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 21 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 14 · 2018: 23 · 2017: 18 · 2016: 19 · 2015: 27 · 2014: 29 · 2013: 32 · 2012: 43
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institute of Neurological Disorders and Stroke (R01NS073159)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Wnt signaling, Dishevelled, dendritic branching, Wnt7b, SFRP1, non-canonical Wnt pathway, Rac, JNK, Rho GTPases, hippocampal neurons, dendrite morphogenesis, Wnt antagonists
- MeSH terms
- Dishevelled Proteins, Acute-Phase Proteins, Animals, Cells, Cultured, Cytoskeleton, Dendrites, Embryo, Mammalian, Glycoproteins, Hippocampus, Mutation, Neurons, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Tissue Distribution, Signal Transduction, Protein Structure, Tertiary, rac GTP-Binding Proteins, Intercellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Wnt Proteins, Mice
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