Molecular disruption of hypothalamic nutrient sensing induces obesity
He, Wu, Lam, Tony K T, Obici, Silvana, Rossetti, Luciano·2006·Nature Neuroscience
DOI 10.1038/nn1626
Cited by (234)
Items 101–200 of 234
- A fatty acid-dependent hypothalamic–DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteinsYue, Jessica T. Y., Abraham, Mona A., LaPierre, Mary P., Mighiu, Patricia I., Light, Peter E., Filippi, Beatrice M., Lam, Tony K. T. · 2015 · Nature Communications
- Molecular Targets for Obesity Therapy in the BrainObici, Silvana · 2009 · Endocrinology
- Influence of Ghrelin and Growth Hormone Deficiency on AMP‐Activated Protein Kinase and Hypothalamic Lipid MetabolismSusana Sangiao‐Alvarellos, Luis Varela, Maria Jesus Vazquez, Katia D. Boit, Asish K. Saha, Fernando Cordido, Carlos Diéguez, Miguel López · 2010 · Journal of Neuroendocrinology
- Brainstem Thyrotropin-Releasing Hormone Regulates Food Intake through Vagal-Dependent Cholinergic Stimulation of Ghrelin SecretionYan Ao, Vay Liang W. Go, Natalie Toy, Tei Li, Yu Wang, Moon Ki Song, Joseph R. Reeve, Yan‐Yun Liu, Hong Yang · 2006 · Endocrinology
- Hypothalamic control of energy and glucose metabolismStephanie R. Sisley, Darleen A. Sandoval · 2011 · Reviews in Endocrine and Metabolic Disorders
- Fatty acid sensing in the gut and the hypothalamus: In vivo and in vitro perspectivesFrank Anthony Duca, Jessica T.Y. Yue · 2014 · Molecular and Cellular Endocrinology
- The receptive function of hypothalamic and brainstem centres to hormonal and nutrient signals affecting energy balanceThomas Riediger · 2012 · Proceedings of The Nutrition Society
- Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase–acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamusJunping Wen, Chune Liu, Yating Hu, Gang Chen, Lixiang Lin · 2010 · Molecular and Cellular Biochemistry
- Evidence for a Relationship between Body Mass and Energy Metabolism in the Human BrainAndré Schmoller, Torben Hass, Olga Strugovshchikova, Uwe H. Melchert, Harald G. Scholand-Engler, Achim Peters, Ulrich Schweiger, Fritz Hohagen, Kerstin M. Oltmanns · 2010 · Journal of Cerebral Blood Flow & Metabolism
- Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.Su Gao, N. Casals, Wendy Keung, T. Moran, G. Lopaschuk · 2013 · Physiology and Behavior
- Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clampTiffany D. Farmer, Erin C. Jenkins, Tracy P. O’Brien, Gregory A. McCoy, Allison E. Havlik, Erik R. Nass, Wendell E. Nicholson, Richard L. Printz, Masakazu Shiota · 2014 · American Journal of Physiology-Endocrinology and Metabolism
- Neuronal control of peripheral nutrient partitioningRomane Manceau, Danie Majeur, Thierry Alquier · 2020 · Diabetologia
- Photoperiodic regulation of glycogen metabolism, glycolysis, and glutamine synthesis in tanycytes of the Siberian hamster suggests novel roles of tanycytes in hypothalamic functionKanishka N. Nilaweera, Annika Herwig, Matei Bolborea, Gill Campbell, Claus Mayer, Peter J. Morgan, Francis J. P. Ebling, Perry Barrett · 2011 · Glia
- Antimyopathic effects of carnitine and nicotineAlessandro Laviano, Michael M. Meguid, Ana Isabel Guijarro, Maurizio Muscaritoli, Antonia Cascino, Isabella Preziosa, Alessio Molfino, Filippo Rossi Fanelli · 2006 · Current Opinion in Clinical Nutrition & Metabolic Care
- The Role of the Endocannabinoid System in Eating Disorders: Neurochemical and Behavioural Preclinical EvidenceMaría Scherma, Liana Fattore, M. Paola Castelli, Walter Fratta, Paola Fadda · 2014 · Current Pharmaceutical Design
- Hypothalamic Malonyl-Coenzyme A and the Control of Energy BalanceMichael J. Wolfgang, M. Daniel Lane · 2008 · Molecular Endocrinology
- Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in NeuroendocrinologyLim, Chung Thong, Kola, Blerina, Korbonits, Márta, Grossman, Ashley B. · 2010 · Progress in Brain Research
- Type 3 resistant starch from Canna edulis modulates obesity and obesity-related low-grade systemic inflammation in mice by regulating gut microbiota composition and metabolismJiahui Wu, Minyi Qiu, Chi Zhang, Caijuan Zhang, Nan Wang, Fangyuan Zhao, Liqiao LV, Junling Li, A. G. A. Lyu-Bu, Ting Wang et al. · 2021 · Food & Function
- Carnitine palmitoyltransferase‐1c gain‐of‐function in the brain results in postnatal microencephalyAmanda A. Reamy, Michael J. Wolfgang · 2011 · Journal of Neurochemistry
- Interaction of glucose sensing and leptin action in the brainRosa J.W. Li, Song‐Yang Zhang, Tony K.T. Lam · 2020 · Molecular Metabolism
- Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler ChicksLei Liu, Zhu LiXian · 2012 · Asian-Australasian Journal of Animal Sciences
- Determining the Bioenergetic Capacity for Fatty Acid Oxidation in the Mammalian Nervous SystemCory J. White, Jieun Lee, Joseph Choi, Tiffany Chu, Susanna Scafidi, Michael J. Wolfgang · 2020 · Molecular and Cellular Biology
- Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin ResistanceChristoph Buettner, Raul C. Camacho · 2008 · Endocrinology and Metabolism Clinics of North America
- The Brain-Gut-Islet ConnectionWoods, Stephen C., Benoit, Stephen C., Clegg, Deborah J. · 2006 · Diabetes
- Hypothalamic Lipids and the Regulation of Energy HomeostasisCarlos Diégueza,b, Gema Frühbeckb,c, b Miguel L oacute peza · 2009 · Obesity Facts
- Central Nervous System Nutrient Signaling: The Regulation of Energy Balance and the Future of Dietary TherapiesMargaret A. Stefater, Randy J. Seeley · 2010 · Annual Review of Nutrition
- Hypothalamic Nutrient Sensing and Energy BalanceTimothy H. Moran · 2009 · Forum of nutrition/Bibliotheca Nutritio et dieta
- Role of lipids in the control of food intakeMarc Fantino · 2011 · Current Opinion in Clinical Nutrition & Metabolic Care
- Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1aSu Gao, Wendy Keung, Dolors Serra, Wei Wang, Patricia Carrasco, Núria Casals, Fausto G. Hegardt, Timothy H. Moran, Gary D. Lopaschuk · 2011 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Role of the saturated fatty acid palmitate in the interconnected hypothalamic control of energy homeostasis and biological rhythmsErika K. Tse, Ashkan Salehi, Matthew N. Clemenzi, Denise D. Belsham · 2018 · American Journal of Physiology-Endocrinology and Metabolism
- Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing RatsAlessandro Laviano, Alessio Molfino, Marília Cerqueira Leite Seelaender, T. Frascaria, Giuseppe Bertini, Cesarina Ramaccini, Maria Rosa Bollea, Gennaro Citro, Filippo Rossi Fanelli · 2011 · Cancer Investigation
- Central nervous system and control of endogenous glucose productionGiovanna Demuro, Silvana Obici · 2006 · Current Diabetes Reports
- Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balanceRosalía Rodríguez‐Rodríguez, Anna Fosch, Jesús García-Chica, Sebastián Zagmutt, Núria Casals · 2023 · Journal of Neuroendocrinology
- Brain lipogenesis and regulation of energy metabolismMiguel López, Antonio Vidal‐Puig · 2008 · Current Opinion in Clinical Nutrition & Metabolic Care
- Appetite and Body Weight RegulationJoseph R. Vasselli · 2012 · Wiley eBooks
- Gut–brain signalling: how lipids can trigger the gutDanna M. Breen, Clair S. Yang, Tony K.T. Lam · 2010 · Diabetes/Metabolism Research and Reviews
- The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose MetabolismIsabel Arrieta‐Cruz, Roger Gutiérrez Juárez · 2016 · Advances in Nutrition
- Eat and Death: Chronic Over-EatingAtilla Engin · 2017 · Advances in experimental medicine and biology
- The Gly146Ala variation in human SF-1 gene: Its association with insulin resistance and type 2 diabetes in ChineseWei Liu, Min Liu, WuQiang Fan, Hajime Nawata, Toshihiko Yanase · 2006 · Diabetes Research and Clinical Practice
- Central nervous system regulation of intestinal lipid and lipoprotein metabolismFarr, Sarah, Taher, Jennifer, Adeli, Khosrow · 2016 · Current Opinion in Lipidology
- The central signaling pathways related to metabolism-regulating hormones of the gut-brain axis: a reviewJiyuan Liu, Changqing Jing, Ying Guo, Zhou Shang, Baolin Zhang, Xinxiu Zhou, Jizhun Zhang, Guodong Lian, Feng Tian, Leping Li et al. · 2025 · Journal of Translational Medicine
- The skinny on brain-derived neurotrophic factor: evidence from animal models to GWASEmily G. Waterhouse, Baoji Xu · 2013 · Journal of Molecular Medicine
- Hypothalamic Fatty Acid Sensing in the Normal and Disease StatesMadhu Chari, Carol Lam, Tony K.T. Lam · 2009 · Frontiers in neuroscience
- The CPT1C 5′UTR Contains a Repressing Upstream Open Reading Frame That Is Regulated by Cellular Energy Availability and AMPKInes Lohse, Patrick T. Reilly, Kathrin Zaugg · 2011 · PLoS ONE
- Adipositas ist mehr als eine Essstörung - die multidimensionale Betrachtung einer PandemieStephan Herpertz · 2008 · Zeitschrift für psychosomatische Medizin und Psychotherapie
- Free fatty acids as mediators of adaptive compensatory responses to insulin resistance in dexamethasone‐treated ratsMichela Novelli, Alessandro Pocai, Chiara Chiellini, Margherita Maffei, Pellegrino Masiello · 2007 · Diabetes/Metabolism Research and Reviews
- Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinaseGoro Takami, Miyuki Ota, Akira Nakashima, Yoko S. Kaneko, Keiji Mori, Toshiharu Nagatsu, Akira Ota · 2010 · Journal of Neural Transmission
- Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissueJoelle M. Onorato, Luping Chen, Petia A. Shipkova, Zhengping Ma, Anthony V. Azzara, James J. Devenny, Ningning Liang, Tasir S. Haque, Dong Cheng · 2010 · Analytical and Bioanalytical Chemistry
- Effects of Neonatal Programming on Hypothalamic Mechanisms Controlling Energy BalanceCristina Contreras, Marta G. Novelle, Rosaura Leis, Carlos Diéguez, Silje Skrede, Miguel López · 2013 · Hormone and Metabolic Research
- Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesityNellie Taleux, Isabelle De Potter, Colin Deransart, Grégory Lacraz, Roland J. M. Favier, Xavier Maurice Leverve, Louis Hue, Bruno Guigas · 2007 · International Journal of Obesity
- Appetite and Feed IntakeMalcolm Jobling, Anders Alanärä, N Chris, Francisco Javier Sánchez‐Vázquez, Sunil Kadri, Felicity Anne Huntingford · 2012
- Delineating the regulation of energy homeostasis using hypothalamic cell modelsLeigh Wellhauser, Nicole M. Gojska, Denise D. Belsham · 2014 · Frontiers in Neuroendocrinology
- Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male MiceMacarena Pozo, Rosalía Rodríguez‐Rodríguez, Sara Ramírez, Patricia Seoane‐Collazo, Miguel López, Dolors Serra, Laura Herrero, Núria Casals · 2017 · Endocrinology
- To be, or not to be obese – That’s the challenge: A hypothesis on the cortical inhibition of the hypothalamus and its therapeutical consequencesFelix Kreier · 2010 · Medical Hypotheses
- Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamusGlenn C. Rowe, Vincent Vialou, Kazusa Sato, Hiroaki Saito, Min Yin, Thomas A. Green, Sutada Lotinun, Marie Kveiborg, William C. Horne, Eric J. Nestler et al. · 2012 · Journal of Bone and Mineral Research
- Molecular effects of dietary fatty acids on brain insulin action and mitochondrial functionChantal Chudoba, Kristina Wardelmann, André Kleinridders · 2019 · Biological Chemistry
- Changes in the Expression of Hypothalamic Lipid Sensing Genes in Rat Model of Intrauterine Growth Retardation (IUGR)Antonella Puglianiello, Daniela Germani, Sara Antignani, Gianpaolo Scalia Tomba, Stefano Cianfarani · 2007 · Pediatric Research
- Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intakeSu Gao, Dolors Serra, Wendy Keung, Fausto G. Hegardt, Gary D. Lopaschuk · 2013 · American Journal of Physiology-Endocrinology and Metabolism
- Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the LiteratureAnca Diana Maierean, Ioana Roxana Bordea, Tudor Sălăgean, Reem Hanna, Teodora Alexescu, Ana Florica Chiș, Doina Adina Todea · 2021 · Nature and Science of Sleep
- Central Control of Glucose HomeostasisPuglianiello, Antonella, Cianfarani, Stefano · 2006 · The Review of Diabetic Studies
- Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus)Christiane E. Koch, Simon Göddeke, Manon Krüger, Alexander Tups · 2012 · Journal of Comparative Physiology B
- Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced rewardKavya Devarakonda, Charles V. Mobbs · 2016 · Molecular and Cellular Endocrinology
- Does deep brain stimulation of the subthalamic nucleus induce metabolic syndrome in Parkinson’s disease?Isabelle Rieu, Bruno Pereira, Philippe Derost, Miguel Ulla, Ana Marquès, Jean‐Jacques Lemaire, Yves Boirie, Franck Durif · 2011 · e-SPEN the European e-Journal of Clinical Nutrition and Metabolism
- The role of the mTOR pathway in regulating food intake.Brian M. Wiczer, George Thomas · 2010 · PubMed
- Empagliflozin Attenuates High-Glucose-Induced Astrocyte Activation and Inflammation via NF-κB PathwayDong Hee Kim, Min Jin Lee, Dasol Kang, Ji Young Lee, Sujin Park, Ah Reum Khang, Ji Hyun Bae, Joo Yeon Kim, Su Hyun Kim, Yang Ho Kang et al. · 2024 · Current Issues in Molecular Biology
- Prolonged overnutrition with fructose or fat induces metabolic derangements in rats by disrupting the crosstalk between the hypothalamus and periphery: Possible amelioration with fenofibrateMohamed Nabil, Maha El Demellawy, Mona F. Mahmoud, Amr A. A. Mahmoud · 2020 · European Journal of Pharmacology
- Silencing of ventromedial hypothalamic neurons by glucose-stimulated K+ currentsRhîannan H. Williams, Denis Burdakov · 2009 · Pflügers Archiv - European Journal of Physiology
- Beyond Hunger: The Structure, Signaling, and Systemic Roles of GhrelinHlafira Polishchuk, Krzysztof Guzik, Tomasz Kantyka · 2025 · International Journal of Molecular Sciences
- Hypothalamic Akt PKB signaling in regulation of food intakeDong Hoon Kim · 2012 · Frontiers in Bioscience-Scholar
- Targeting Type 2 DiabetesChristina Schwanstecher, Mathias Schwanstecher · 2011 · Handbook of experimental pharmacology
- Acute Exposure of the Mediobasal Hypothalamus to Amyloid-β 25-35 Perturbs Hepatic Glucose MetabolismIsabel Arrieta‐Cruz, Colette M. Knight, Roger Gutiérrez Juárez · 2015 · Journal of Alzheimer s Disease
- Upper intestinal lipids regulate energy and glucose homeostasisGrace W.C. Cheung, Andrea Kokorovic, Tony K.T. Lam · 2009 · Cellular and Molecular Life Sciences
- Atomoxetine and Fluoxetine Activate AMPK-ACC-CPT1 Pathway in Human SH-SY5Y and U-87 MG CellsSonghee Jeon, Jeong-Eun Park, Young Ho Do, Renata Santos, Seong Mi Lee, Bung-Nyun Kim, Jae Hoon Cheong, Yeni Kim · 2023 · Psychiatry Investigation
- Adipokines and etiopathology of metabolic disordersLaila M AL-Dokhi · 2009 · Saudi Medical Journal
- Regulation of Peripheral Metabolism by Substrate Partitioning in the BrainCesar L. Moreno, Linda C. Yang, Penny A. Dacks, Fumiko Isoda, Michael M. Poplawski, Charles V. Mobbs · 2013 · Endocrinology and Metabolism Clinics of North America
- Diet-Induced Metabolic Dysfunction of Hypothalamic Nutrient Sensing in RodentsIsabel Arrieta‐Cruz, Blanca Samara Torres-Ávila, Hilda Martínez‐Coria, Héctor Eduardo López-Valdés, Roger Gutiérrez Juárez · 2022 · International Journal of Molecular Sciences
- CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesityAnna Fosch, D Pizarro, Sebastián Zagmutt, Ana Cristina Reguera, Gerard Batallé, Maria Rodríguez-García, Jesús García-Chica, Óscar Freire-Agulleiro, Cristina Miralpeix, Philippe Zizzari et al. · 2025 · Molecular Metabolism
- Paediatric endocrine aspects of ghrelin.Chung Thong Lim, Márta Korbonits · 2012 · PubMed
- The Role of Brain in Glucose MetabolismSilvana Obici, Paulo J.F. Martins · 2009 · Springer eBooks
- The Genetic Determinants of Ingestive BehaviorKaren M. Eny, Ahmed El‐Sohemy · 2010 · Elsevier eBooks
- Ethiopian coffee (Coffea arabica) improves glucose uptake and modulates metabolic enzyme activities linked to hyperglycemia-induced infertility in isolated rats’ testesAlmahi I. Mohamed, Kolawole Ayodapo Olofinsan, Veronica F. Salau, Ochuko Lucky Erukainure, Md. Shahidul Islam · 2024 · Food Production Processing and Nutrition
- How important are satiation and satiety for weight regulation?Marc Fantino · 2013 · Elsevier eBooks
- Salubrinal abrogates palmitate-induced leptin resistance and endoplasmic reticulum stress via nuclear factor kappa-light-chain-enhancer of activated B cell pathway in mHypoE-44 hypothalamic neuronsMin Zhang, Xiaohong Jiang, Meidi Qu, Hongliu Gu, Qi Sha, Fei Hua · 2018 · Diabetes Metabolic Syndrome and Obesity
- The Unrestrained Overeating Behavior and Clinical PerspectiveAtilla Engin · 2024 · Advances in experimental medicine and biology
- The hypothalamus and energy balanceStefano Benedini · 2009 · Sport Sciences for Health
- The Role of Adipose Tissue Vasculature in Energy BalanceHyun-Ju Kim, Sang-Hyun Choi, Boe‐Gwun Chun, Dong-Hoon Kim · 2011 · Journal of Korean Society of Pediatric Endocrinology
- Hypothalamic mitochondria in energy homeostasis and obesityXin Guo, Lei Wu, Weiqun Wang, Denis M. Medeiros, Stephen L. Clarke, Edralin A. Lucas, Brenda Jane Smith, Winyoo Chowanadisai, Dingbo Lin · 2016 · Integrative Molecular Medicine
- Modulation of the Plasma Ghrelin Level by Intraventromedial Hypothalamic Microinjection of D2 Receptors Agonist and AntagonistMaedeh Ghasemi, Nasrin Mehranfard, Afsaneh Eliassi, Hojjat Allah Alaei · 2018 · Neuropsychiatry
- Does FASing Out New Fat in the Hypothalamus Make You Slim?Christoph Buettner · 2007 · Cell Metabolism
- Genomic characterization and polymorphism analysis of genes involved in lipid- and energy metabolism in swineLi Lin · 2009 · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
- The endocannabinoid systemMaría Scherma, Valentina Satta, Walter Fratta, Paola Fadda · 2015 · Elsevier eBooks
- Insights into the mechanisms of body weight controlSandra Pereira · 2025 · AJP Advances in Physiology Education
- Regulation of Liver Glucose Metabolism by the Metabolic Sensing of Leucine in the HypothalamusRoger Gutiérrez Juárez · 2014 · Springer eBooks
- Desnutrição perinatal e o controle hipotalâmico do comportamento alimentar e do metabolismo do músculo esqueléticoAdriano Bento-Santos, Leonardo R. Silveira, Raul Manhães‐de‐Castro, Carol Góis Leandro · 2012 · Revista de Nutrição
- Food intake regulation by hypothalamic AMPKYasuhiko Minokoshi · 2011 · Folia Pharmacologica Japonica
- Energy Metabolism2007 · Nutrition in exercise and sport
- Regulation | Regulation of Body Weight by Malonyl-CoA in the CNSSusana Rodriguez, Michael J. Wolfgang · 2013 · Elsevier eBooks
- DEFICIENCY OF THE NUTRIENT SENSOR CPT1c IN SF1 NEURONS DISRUPTS THE ENDOCANNABINOID SYSTEM RESULTING IN COMPROMISED SATIETY AND FUEL SELECTION UPON FAT INTAKEAnna Fosch, DS Pizarro, Sebastián Zagmutt, Ana Cristina Reguera, Gerard Batallé, M Rodríguez-García, Jesús García-Chica, Óscar Freire-Agulleiro, Cristina Miralpeix, Philippe Zizzari et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Regulation of Body Weight by Malonyl-CoA in the CNSSusana Rodriguez, Michael J. Wolfgang · 2013 · Encyclopedia of Biological Chemistry
- Malonyl-CoA Signaling in the CNS: Hypothalamic Control of Feeding Behavior and Energy ExpenditureM. Daniel Lane, Seung Hun Cha · 2011 · Springer eBooks