Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · see citing works

Ghrelin enhances appetite and increases food intake in humans

Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494 · see citing works

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106 · see citing works

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G. A., Ghatei, M. A., et al. (2000) · Endocrinology · doi:10.1210/endo.141.11.7873 · Cited by 1,593 · see citing works

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589 · see citing works

Leptin-regulated endocannabinoids are involved in maintaining food intake

Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559 · see citing works

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.

Gnanapavan, S., Kola, B., Bustin, S., Morris, D., McGee, P. J., Fairclough, P., Bhattacharya, S., Carpenter, R., Grossman, A., & Korbonits, M. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.6.8739 · Cited by 1,507 · see citing works

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Woods, A., Dickerson, K., Heath, R. B., Hong, S. P., Momcilovic, M., Johnstone, S. R., Carlson, M., & Carling, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.005 · Cited by 1,395 · see citing works

Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

Zhang, J. V., Ren, P.-G., Avsian-Kretchmer, O., Luo, C.-W., Rauch, R., Klein, C., & Hsueh, A. J. W. (2005) · Science · doi:10.1126/science.1117255 · Cited by 1,197 · see citing works

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

Yang, J., Brown, M. S., Liang, G., Grishin, N., & Goldstein, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.017 · Cited by 1,191 · see citing works

Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin

van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187 · see citing works

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185 · see citing works

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

Asakawa, A., Inui, A., Kaga, O., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22158 · Cited by 1,175 · see citing works

NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,127 · see citing works

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

Date, Y., Murakami, N., Toshinai, K., Matsukura, S., Niijima, A., Matsuo, H., Kangawa, K., & Nakazato, M. (2002) · Gastroenterology · doi:10.1053/gast.2002.35954 · Cited by 1,081 · see citing works

The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Pagotto, U., Marsicano, G., Cota, D., Lutz, B., & Pasquali, R. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0009 · Cited by 856 · see citing works

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.003 · Cited by 844 · see citing works

Ghrelin octanoylation mediated by an orphan lipid transferase

Gutierrez, J. A., Solenberg, P., Perkins, D., Willency, J. A., Knierman, M. D., Jin, Z., Witcher, D., Luo, S., Onyia, J. E., & Hale, J. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0800708105 · Cited by 827 · see citing works

Agouti-related peptide–expressing neurons are mandatory for feeding

Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800 · see citing works

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature · doi:10.1038/nature07181 · Cited by 710 · see citing works

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

Chen, H. Y., Trumbauer, M. E., Chen, A. S., Weingarth, D. T., Adams, J. R., Frazier, E. G., Shen, Z., Marsh, D. J., Feighner, S. D., Guan, X.-M., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1596 · Cited by 667 · see citing works

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 660 · see citing works

Genome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes

Nicholls, R. D., & Knepper, J. L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.153 · Cited by 625 · see citing works

Elevated plasma ghrelin levels in Prader–Willi syndrome

Cummings, D. E., Clément, K., Purnell, J., Vaisse, C., Foster, K. E., Frayo, R. S., Schwartz, M., Basdevant, A., & Weigle, D. (2002) · Nature Medicine · doi:10.1038/nm0702-643 · Cited by 622 · see citing works

Ghrelin and the short- and long-term regulation of appetite and body weight

Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620 · see citing works

Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats

Kamegai, J., Tamura, H., Shimizu, T., Ishii, S., Sugihara, H., & Wakabayashi, I. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2438 · Cited by 609 · see citing works

Ghrelin?a hormone with multiple functions

Korbonits, M. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.03.002 · Cited by 593 · see citing works

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548 · see citing works

Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues

Cummings, D. E., Frayo, R. S., Marmonier, C., Aubert, R., & Chapelot, D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2003 · Cited by 528 · see citing works

Peptidomimetic Regulation of Growth Hormone Secretion

Smith, R. G., der Ploeg, L. H. T. V., Howard, A. D., Feighner, S. D., Cheng, K., Hickey, G. J., Wyvratt, M. J., Fisher, M. H., Nargund, R. P., & Patchett, A. A. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0316 · Cited by 527 · see citing works

A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling

Hofmann, K. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01539-x · Cited by 495 · see citing works

Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro

Momcilovic, M., Hong, S. P., & Carlson, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604399200 · Cited by 474 · see citing works

Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase

Kola, B., Hubina, E., Tucci, S. A., Kirkham, T. C., García, E., Mitchell, S. E., Williams, L. M., Hawley, S. A., Hardie, D. G., Grossman, A. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500175200 · Cited by 468 · see citing works

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

López, M., Lage, R., Saha, A. K., Pérez–Tilve, D., Vazquez, M. J., Varela, L., Sangiao‐Alvarellos, S., Tovar, S. A., Raghay, K., Rodríguez‐Cuenca, S., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.006 · Cited by 466 · see citing works

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 462 · see citing works

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430 · see citing works

GOAT links dietary lipids with the endocrine control of energy balance

Kirchner, H., Gutierrez, J. A., Solenberg, P., Pfluger, P., Czyzyk, T. A., Willency, J. A., Schürmann, A., Joost, H., Jandacek, R., Hale, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1997 · Cited by 408 · see citing works

Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin.

Kohno, D., Gao, H.-Z., Muroya, S., Kikuyama, S., & Yada, T. (2003) · Diabetes · doi:10.2337/diabetes.52.4.948 · Cited by 390 · see citing works

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

Muccioli, G., Tschöp, M. H., Papotti, M., Deghenghi, R., Heiman, M. L., & Ghigo, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01432-2 · Cited by 386 · see citing works

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

Anderson, K. A., Ribar, T. J., Lin, F., Noeldner, P. K., Green, M. F., Muehlbauer, M. J., Witters, L. A., Kemp, B. E., & Means, A. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.011 · Cited by 385 · see citing works

Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans

Arvat, E., Vito, L. D., Broglio, F., Papotti, M. G., Muccioli, G., Diéguez, C., Casanueva, F. F., Deghenghi, R., Camanni, F., & Ghigo, E. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343763 · Cited by 384 · see citing works

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

Sun, Y.-X., Asnicar, M., Saha, P., Chan, L., & Smith, R. G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.004 · Cited by 368 · see citing works

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors

McKee, K. K., Palyha, O. C., Feighner, S. D., Hreniuk, D. L., Tan, C. P., Phillips, M. S., Smith, R. G., der Ploeg, L. H. T. V., & Howard, A. D. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9908 · Cited by 358 · see citing works

A Role of Ghrelin in Neuroendocrine and Behavioral Responses to Stress in Mice

Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Fujimiya, M., Katsuura, G., Makino, S., Fujino, M., & Kasuga, M. (2001) · Neuroendocrinology · doi:10.1159/000054680 · Cited by 357 · see citing works

Expression of Ghrelin and of the GH Secretagogue Receptor by Pancreatic Islet Cells and Related Endocrine Tumors

Volante, M., Allìa, E., Gugliotta, P., Funaro, A., Broglio, F., Deghenghi, R., Muccioli, G., Ghigo, E., & Papotti, M. G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8279 · Cited by 354 · see citing works

Ghrelin in the regulation of body weight and metabolism

Castañeda, T. R., Tong, J., Datta, R., Culler, M. D., & Tschöp, M. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.008 · Cited by 350 · see citing works

GH, GH Receptor, GH Secretagogue Receptor, and Ghrelin Expression in Human T Cells, B Cells, and Neutrophils

Hattori, N., Saito, T., Yagyu, T., Jiang, B., Kitagawa, K., & Inagaki, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7866 · Cited by 320 · see citing works

Ghrelin Directly Regulates Bone Formation

Fukushima, N., Hanada, R., Teranishi, H., Fukue, Y., Tachibana, T., Ishikawa, H., Takeda, S., Takeuchi, Y., Fukumoto, S., Kangawa, K., et al. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041237 · Cited by 319 · see citing works

The Expression of the Growth Hormone Secretagogue Receptor Ligand Ghrelin in Normal and Abnormal Human Pituitary and Other Neuroendocrine Tumors1

Korbonits, M., Bustin, S. A., Kojima, M., Jordan, S., Adams, E. F., Lowe, D. G., Kangawa, K., & Grossman, A. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7190 · Cited by 317 · see citing works

Central Effects of a Novel Acylated Peptide, Ghrelin, on Growth Hormone Release in Rats

Date, Y., Murakami, N., Kojima, M., Kuroiwa, T., Matsukura, S., Kangawa, K., & Nakazato, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3342 · Cited by 310 · see citing works

AMPK as a mediator of hormonal signalling

Lim, C. T., Kola, B., & Korbonits, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0063 · Cited by 298 · see citing works

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

Kola, B., Farkas, I., Christ‐Crain, M., Wittmann, G., Lolli, F., Amin, F., Harvey-White, J. D., Liposits, Z., Kunos, G., Grossman, A. B., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001797 · Cited by 295 · see citing works

Ghrelin promotes slow-wave sleep in humans

Weikel, J., Wichniak, A., Ising, M., Brünner, H., Frieß, E., Held, K., Mathias, S., Schmid, D. A., Uhr, M., & Steiger, A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00184.2002 · Cited by 292 · see citing works

Roles for Ghrelin in the Regulation of Appetite and Body Weight

Cummings, D. E. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.4.389 · Cited by 286 · see citing works

Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat

Trudel, L., Tomasetto, C., Rio, M., Bouin, M., Plourde, V., Eberling, P., & Poitras, P. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00339.2001 · Cited by 271 · see citing works

Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents

Nogueiras, R., Pfluger, P. T., Tovar, S. A., Arnold, M., Mitchell, S. E., Morris, A., Pérez–Tilve, D., Vazquez, M. J., Wiedmer, P., Castañeda, T. R., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0915 · Cited by 265 · see citing works

Gut hormones in the control of appetite

Murphy, K. G., & Bloom, S. R. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2004.027789 · Cited by 251 · see citing works

Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle.

Barazzoni, R., Bosutti, A., Stebel, M., Cattin, M. R., Roder, E., Visintin, L., Cattin, L., Biolo, G., Zanetti, M., & Guarnieri, G. (2005) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00115.2004 · Cited by 250 · see citing works

Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype

Bewick, G. A., Gardiner, J., Dhillo, W. S., Kent, A. S., White, N. E., Webster, Z., Ghatei, M. A., & Bloom, S. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3434fje · Cited by 235 · see citing works

Molecular disruption of hypothalamic nutrient sensing induces obesity

He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233 · see citing works

Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"

Chartrel, N., Alvear‐Perez, R., Leprince, J., Iturrioz, X., Goazigo, A. R.-L., Audinot, V., Chomarat, P., Cogé, F., Nosjean, O., Rodriguez, M., et al. (2007) · Science · doi:10.1126/science.1135047 · Cited by 227 · see citing works

The Endocrine Response to Ghrelin as a Function of Gender in Humans in Young and Elderly Subjects

Broglio, F., Benso, A. S., Castiglioni, C., Gottero, C., Prodam, F., Destefanis, S., Gauna, C., van der Lely, A. J., Deghenghi, R., Bo, M., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021504 · Cited by 218 · see citing works

RAPID COMMUNICATIONS: Mutations in the Preproghrelin/Ghrelin Gene Associated with Obesity in Humans

Ukkola, O. H., Ravussin, É., Jacobson, P., Snyder, E. E., Chagnon, M., Sjöström, L., & Bouchard, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7914 · Cited by 212 · see citing works

Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211 · see citing works

Design, Synthesis, and Biological Activity of Peptides which Release Growth Hormone in Vitro*

Momany, F. A., Bowers, C. Y., Reynolds, G. A., Chang, D.-M., Hong, A. L., & Newlander, K. A. (1981) · Endocrinology · doi:10.1210/endo-108-1-31 · Cited by 210 · see citing works

Expanding role of AMPK in endocrinology

Kola, B., Boscaro, M., Rutter, G. A., Grossman, A. B., & Korbonits, M. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.05.006 · Cited by 200 · see citing works

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

Fu, X., Wan, S., Lyu, Y. L., Liu, L. F., & Qi, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002009 · Cited by 183 · see citing works

Downregulation of AMP‐activated protein kinase by Cidea‐mediated ubiquitination and degradation in brown adipose tissue

Qi, J., Gong, J., Zhao, T., Zhao, J., Lam, P., Ye, J., Li, J. Z., Wu, J., Hai‐Meng, Z. H. O. U., & Li, P. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.92 · Cited by 166 · see citing works

Peptidomimetic Regulation of Growth Hormone Secretion

Smith, R. G. (1997) · Endocrine Reviews · doi:10.1210/er.18.5.621 · Cited by 166 · see citing works

The Expression of the Growth Hormone Secretagogue Receptor Ligand Ghrelin in Normal and Abnormal Human Pituitary and Other Neuroendocrine Tumors

Korbonits, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.881 · Cited by 162 · see citing works

Ghrelin, the peripheral hunger hormone

Higgins, S. C., Gueorguiev, M., & Korbonits, M. (2007) · Annals of Medicine · doi:10.1080/07853890601149179 · Cited by 158 · see citing works

Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli

Chan, C. B., & Cheng, C. H. K. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.11.020 · Cited by 154 · see citing works

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

Tschöp, M. H., Statnick, M. A., Suter, T. M., & Heiman, M. L. (2002) · Endocrinology · doi:10.1210/endo.143.2.8633 · Cited by 150 · see citing works

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

Costanzo-Garvey, D. L., Pfluger, P. T., Dougherty, M. K., Stock, J. L., Boehm, M. B., Chaika, O. V., Fernandez, M. R., Fisher, K. W., Kortum, R. L., Hong, E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.010 · Cited by 145 · see citing works

Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway

Nanzer, A., Khalaf, S., Mozid, A., Fowkes, R. C., Patel, M., Burrin, J., Grossman, A. B., & Korbonits, M. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510233 · Cited by 145 · see citing works

Calcium channels — basic aspects of their structure, function and gene encoding; anesthetic action on the channels — a review

Yamakage, M., & Namiki, A. (2002) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03020488 · Cited by 142 · see citing works

Reviews in Molecular Biology and Biotechnology: Transmembrane Signaling by G Protein-Coupled Receptors

Luttrell, L. M. (2008) · Molecular Biotechnology · doi:10.1007/s12033-008-9031-1 · Cited by 140 · see citing works

Physiological, pathological and potential therapeutic roles of ghrelin

Leite-Moreira, A. F., & Soares, J. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.02.009 · Cited by 140 · see citing works

Biologic Activities of Growth Hormone Secretagogues in Humans

Ghigo, E., Arvat, E., Giordano, R., et al. (2001) · Endocrine · doi:10.1385/endo:14:1:087 · Cited by 135 · see citing works

Ghrelin-Producing Endocrine Tumors of the Stomach and Intestine

Papotti, M. G., Cassoni, P., Volante, M., Deghenghi, R., Muccioli, G., & Ghigo, E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7918 · Cited by 131 · see citing works

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

Kohno, D., Sone, H., Minokoshi, Y., & Yada, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.166 · Cited by 131 · see citing works

Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice

Tsubone, T., Masaki, T., Katsuragi, I., Tanaka, K., Kakuma, T., & Yoshimatsu, H. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.04.004 · Cited by 125 · see citing works

Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity

Olszewski, P. K., Grace, M. K., Billington, C. J., & Levine, A. S. (2003) · Peptides · doi:10.1016/s0196-9781(03)00159-1 · Cited by 123 · see citing works

Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration.

Carlini, V., Martini, A., Schiöth, H., Ruiz, R., de Cuneo, M. F., & Debarioglio, S. R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.015 · Cited by 119 · see citing works

Gut hormones and the control of appetite

SMALL, C., & Bloom, S. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.06.002 · Cited by 118 · see citing works

Ligand Activation Domain of Human Orphan Growth Hormone (GH) Secretagogue Receptor (GHS-R) Conserved from Pufferfish to Humans

Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K. K., Hreniuk, D. L., Gao, Y., Schleim, K. D., Yang, L., Morriello, G. J., Nargund, R. P., et al. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.1.0412 · Cited by 116 · see citing works

Expression of Ghrelin and of the GH Secretagogue Receptor by Pancreatic Islet Cells and Related Endocrine Tumors

Volante, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.3.1300 · Cited by 113 · see citing works

Circulating Ghrelin Levels in Patients with Pancreatic and Gastrointestinal Neuroendocrine Tumors: Identification of One Pancreatic Ghrelinoma

Corbetta, S., PERACCHI, M., Cappiello, V., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021842 · Cited by 111 · see citing works

Circulating Ghrelin Levels Are Suppressed by Meals and Octreotide Therapy in Children with Prader-Willi Syndrome

Haqq, A. M., Stadler, D. D., Rosenfeld, R. G., Pratt, K. L., Weigle, D. S., Frayo, R. S., LAFRANCHI, S. H., Cummings, D. E., & Purnell, J. Q. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030205 · Cited by 109 · see citing works

Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans

Otto, B., Tschöp, M. H., Heldwein, W., Pfeiffer, A. F. H., & Diederich, S. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510113 · Cited by 105 · see citing works

Malignant Gastric Ghrelinoma with Hyperghrelinemia

Tsolakis, A. V., Portela‐Gomes, G. M., Stridsberg, M., Grimelius, L., Sundin, A., Eriksson, B. K., Öberg, K. E., & Janson, E. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032118 · Cited by 104 · see citing works

Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect.

Neary, N. M., Druce, M. R., Small, C. J., & Bloom, S. R. (2006) · PubMed Central · Cited by 102 · see citing works

In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice

Tolle, V., & Low, M. J. (2007) · Diabetes · doi:10.2337/db07-0733 · Cited by 100 · see citing works

Expression of the Growth Hormone Secretagogue Receptor in Pituitary Adenomas and Other Neuroendocrine Tumors1

Korbonits, M., Jacobs, R. A., Aylwin, S. J. B., Burrin, J. M., Dahia, P. L. M., Monson, J. P., Honegger, J. B., Fahlbush, R., Trainer, P. J., Chew, S. L., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5210 · Cited by 99 · see citing works

Regulation of PIT-1 Expression By Ghrelin and GHRP-6 Through the GH Secretagogue Receptor

García, Á. G., Álvarez, C. V., Smith, R. G., & Diéguez, C. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0694 · Cited by 96 · see citing works

IGF-1 phosphorylates AMPK-α subunit in ATM-dependent and LKB1-independent manner

Suzuki, A., Kusakai, G.-I., Kishimoto, A., Shimojo, Y., Ogura, T., Lavin, M. F., & Esumi, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.145 · Cited by 95 · see citing works

Circulating ghrelin levels in basal conditions and during glucose tolerance test in acromegalic patients

Cappiello, V., Ronchi, C. L., Morpurgo, P., Epaminonda, P., Arosio, M., Beck-Peccoz, P., & Spada, A. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470189 · Cited by 92 · see citing works

Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening

Eglen, R. M., Bossé, R., & Reisine, T. (2007) · Assay and Drug Development Technologies · doi:10.1089/adt.2007.062 · Cited by 90 · see citing works

Variants in the Ghrelin Gene Are Associated with Metabolic Syndrome in the Old Order Amish

Steinle, N., Pollin, T. I., O’Connell, J. R., Mitchell, B. D., & Shuldiner, A. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0549 · Cited by 85 · see citing works

Serum Ghrelin Levels in Acromegaly: Effects of Surgical and Long-Acting Octreotide Therapy

Freda, P. U., Reyes, C. M., Conwell, I. M., Sundeen, R. E., & Wardlaw, S. L. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021683 · Cited by 82 · see citing works

Ghrelin: update on a novel hormonal system

Korbonits, M., & Grossman, A. B. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.151s067 · Cited by 82 · see citing works

Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms With Obesity

Gueorguiev, M., Lecœur, C., Meyre, D., Benzinou, M., Mein, C. A., Hinney, A., Vatin, V., Weill, J., Heude, B., Hebebrand, J., et al. (2009) · Obesity · doi:10.1038/oby.2008.589 · Cited by 78 · see citing works

Modulation of neuropeptide Y expression in adult mice does not affect feeding

Marie, L. S., Luquet, S. H., Cole, T. B., & Palmiter, R. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509240102 · Cited by 73 · see citing works

Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA expression in human pituitary adenomas

Kim, K., Arai, K., Sanno, N., et al. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01286.x · Cited by 73 · see citing works

Preproghrelin‐derived Peptide, Obestatin, Fails to Influence Food Intake in Lean or Obese Rodents

Gourcerol, G., Coşkun, T., Craft, L. S., Mayer, J. P., Heiman, M. L., Wang, L., Million, M., St.‐Pierre, D. H., & Taché, Y. (2007) · Obesity · doi:10.1038/oby.2007.316 · Cited by 72 · see citing works

Ghrelin: a metabolic signal affecting the reproductive system

Lorenzi, T., Meli, R., Marzioni, D., Morroni, M., Baragli, A., Castellucci, M., Gualillo, O., & Muccioli, G. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.02.003 · Cited by 69 · see citing works

Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach

Kojima, M., Hosoda, H., & Kangawa, K. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.07.001 · Cited by 69 · see citing works

Endocannabinoids in Appetite Control and the Treatment of Obesity

Kirkham, T., & Tucci, S. A. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777452272 · Cited by 67 · see citing works

Ghrelin expression in gut endocrine growths

Rindi, G., Savio, A., Torsello, A., et al. (2002) · Histochemistry and Cell Biology · doi:10.1007/s00418-002-0416-0 · Cited by 66 · see citing works

Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women

Ando, T., Ichimaru, Y., Konjiki, F., Shoji, M., & Komaki, G. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.25 · Cited by 64 · see citing works

Introducing GOAT: a target for obesity and anti-diabetic drugs?

Gualillo, O., Lago, F., & Diéguez, C. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.06.003 · Cited by 64 · see citing works

Cellular Distribution and Regulation of Ghrelin Messenger Ribonucleic Acid in the Rat Pituitary Gland

Caminos, J. E., Nogueiras, R., Blanco, M., et al. (2003) · Endocrinology · doi:10.1210/en.2003-0529 · Cited by 62 · see citing works

Ghrelin Expression and Actions: A Novel Peptide for an Old Cell Type of the Diffuse Endocrine System

Rindi, G., Torsello, A., Locatelli, V., et al. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901004 · Cited by 61 · see citing works

Expression of the Growth Hormone Secretagogue Receptor in Pituitary Adenomas and Other Neuroendocrine Tumors

Korbonits, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.10.3624 · Cited by 61 · see citing works

Four Missense Mutations in the Ghrelin Receptor Result in Distinct Pharmacological Abnormalities

Liu, G., Fortin, J., Beinborn, M., & Kopin, A. S. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123141 · Cited by 60 · see citing works

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

Charoenthongtrakul, S., Giuliana, D. J., Longo, K. A., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.150193 · Cited by 60 · see citing works

Polymorphisms in the Ghrelin Gene Are Associated with Serum High-Density Lipoprotein Cholesterol Level and not with Type 2 Diabetes Mellitus in Koreans

Choi, H. J., Cho, Y. M., Moon, M. K., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2549 · Cited by 58 · see citing works

Ghrelin and adiponectin in patients with Cushing's disease before and after successful transsphenoidal surgery

Libé, R., Morpurgo, P. S., Cappiello, V., Maffini, A., Bondioni, S., Locatelli, M., Zavanone, M. L., Beck‐Peccoz, P., & Spada, A. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02169.x · Cited by 56 · see citing works

Large‐scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits

Bing, C., Ambye, L., Fenger, M., Jørgensen, T., Borch‐Johnsen, K., Madsbad, S., & Urhammer, S. A. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01575.x · Cited by 55 · see citing works

Growth Hormone-Releasing Hormone (GHRH) Neurons in the Arcuate Nucleus (Arc) of the Hypothalamus Are Decreased in Transgenic Rats Whose Expression of Ghrelin Receptor Is Attenuated: Evidence that Ghrelin Receptor Is Involved in the Up-Regulation of GHRH Expression in the Arc

Mano‐Otagiri, A., Nemoto, T., Sekino, A., Yamauchi, N., Shuto, Y., Sugihara, H., Oikawa, S., & Shibasaki, T. (2006) · Endocrinology · doi:10.1210/en.2005-1619 · Cited by 55 · see citing works

Ghrelin-Producing Endocrine Tumors of the Stomach and Intestine

Papotti, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.10.5052 · Cited by 55 · see citing works

Mutation analysis of the preproghrelin gene: No association with obesity and type 2 diabetes

Larsen, L. H., Gjesing, A. P., Sørensen, T. I. A., et al. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2005.01.008 · Cited by 54 · see citing works

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

El‐Salhy (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000285 · Cited by 51 · see citing works

Ghrelin Expression in Islet Cell Tumors: Augmented Expression of Ghrelin in a Case of Glucagonoma with Multiple Endocrine Neoplasm Type I

Iwakura, H., Hosoda, K., Doi, R., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020882 · Cited by 49 · see citing works

Ghrelin Is Produced by and Directly Activates Corticotrope Cells from Adrenocorticotropin-Secreting Adenomas

Martínez‐Fuentes, A. J., Moreno-Fernández, J., Vázquez‐Martínez, R., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0235 · Cited by 49 · see citing works

Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation

Kola, B., & Korbonits, M. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0056 · Cited by 48 · see citing works

Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort

Kuzuya, M., Ando, F., Iguchi, A., & Shimokata, H. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803296 · Cited by 47 · see citing works

Regulation of the pituitary-specific transcription factor GHF-1/Pit-1 messenger ribonucleic acid levels by growth hormone-secretagogues in rat anterior pituitary cells in monolayer culture.

Soto, J. L., Castrillo, J. L., Domı́nguez, F., et al. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649093 · Cited by 45 · see citing works

Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus

Kim, S., Jo, D. S., Hwang, P. H., Park, J. H., Park, S. K., Yi, H. K., & Lee, D. (2006) · Metabolism · doi:10.1016/j.metabol.2005.09.011 · Cited by 44 · see citing works

A new variation in the promoter region, the −604 C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance

Zavarella, S., Petrone, A., Zampetti, S., Gueorguiev, M., Spoletini, M., Mein, C. A., Leto, G., Korbonits, M., & Buzzetti, R. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803766 · Cited by 44 · see citing works

Cannabinoids enhance gastric X/A-like cells activity.

Zbucki, R. L., Sawicki, B., Hryniewicz, A., et al. (2008) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-008-0033-4 · Cited by 43 · see citing works

Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients

CICCARELLI, E., Grottoli, S., Razzore, P., et al. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.626446.x · Cited by 42 · see citing works

Ghrelin in neuroendocrine organs and tumours

Leontiou, C. A., Franchi, G., & Korbonits, M. (2007) · Pituitary · doi:10.1007/s11102-007-0023-0 · Cited by 40 · see citing works

The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes

García, E., King, P., Sidhu, K., Ohgusu, H., Walley, A. J., Lecœur, C., Gueorguiev, M., Khalaf, S., Davies, D. C., Grossman, A. B., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0122 · Cited by 37 · see citing works

Plasma ghrelin levels and malnutrition: A comparison of two etiologies

Kršek, M., Rosická, M., Papežová, H., et al. (2003) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/bf03325015 · Cited by 35 · see citing works

Ghrelin in Pathological Conditions

Katergari, S., Milousis, A., Pagonopoulou, O., et al. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07-106 · Cited by 30 · see citing works

Novel ghrelin analogs with improved affinity for the GH secretagogue receptor stimulate GH and prolactin release from human pituitary cells

Rubinfeld, H., Hadani, M., Taylor, J., Dong, J., Comstock, J. M., Shen, Y., Deoliveira, D., Datta, R., Culler, M. D., & Shimon, I. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510787 · Cited by 29 · see citing works

Ghrelin Receptor Gene Polymorphisms and Body Size in Children and Adults

García, E., Heude, B., Petry, C. J., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0366 · Cited by 27 · see citing works

The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes

Berthold, H. K., Giannakidou, E., Krone, W., et al. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.09.022 · Cited by 25 · see citing works

Application of ghrelin to gastrointestinal diseases.

Venkova, K. M., & Meerveld, B. G. (2008) · PubMed · Cited by 25 · see citing works

A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature

Gueorguiev, M., Lecœur, C., Benzinou, M., Mein, C. A., Meyre, D., Vatin, V., Weill, J., Heude, B., Grossman, A. B., Froguel, P., et al. (2008) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2008.00484.x · Cited by 19 · see citing works

Regulation of the pituitary-specific transcription factor GHF-1/Pit-1 messenger ribonucleic acid levels by growth hormone-secretagogues in rat anterior pituitary cells in monolayer culture

Soto, J. L. (1995) · Endocrinology · doi:10.1210/en.136.9.3863 · Cited by 17 · see citing works

Role of AgRP on Ghrelin-induced feeding in the hypothalamic paraventricular nucleus

Shrestha, Y. B., Wickwire, K., & Giraudo, S. Q. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.09.021 · Cited by 13 · see citing works

Ghrelin Expression in Neuroendocrine Tumours of the Gastrointestinal Tract with Multiple Endocrine Neoplasia Type 1

Raffel, A., Krausch, M., Cupisti, K., et al. (2005) · Hormone and Metabolic Research · doi:10.1055/s-2005-870535 · Cited by 13 · see citing works

The CAMplexities of Central Ghrelin

Sleeman, M. W., & Latres, E. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.009 · Cited by 12 · see citing works

[Lowered ghrelin levels in acromegaly—normalization after treatment].

Kozakowski, J., Rabijewski, M., & Zgliczyński, W. (2006) · PubMed · Cited by 11 · see citing works

Examining the Candidacy of Ghrelin as a Gene Responsible for Variation in Adult Stature in a United Kingdom Population with Type 2 Diabetes

Gueorguiev, M., Wiltshire, S., García, E., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2657 · Cited by 9 · see citing works

Ghrelin concentrations in acromegalic patients in relation to the administered therapy.

Waśko, R., Jaskuła, M., Komarowska, H., et al. (2007) · PubMed · Cited by 8 · see citing works

Sleep and metabolic function

Morselli, L. L., Guyon, A., & Spiegel, K. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1053-z · Cited by 199 · see citing works

Twenty-Four-Hour Profiles of Acylated and Total Ghrelin: Relationship with Glucose Levels and Impact of Time of Day and Sleep

Spiegel, K., Tasali, E., Leproult, R., Scherberg, N., & Van Cauter, E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1978 · Cited by 106 · see citing works

Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss

Perreault, M., Istrate, N., Wang, L., Nichols, A., Tozzo, E., & Stricker‐Krongrad, A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802640 · Cited by 132 · see citing works

Regulation of Growth Hormone Secretagogue Receptor Gene Expression in the Arcuate Nuclei of the Rat by Leptin and Ghrelin

Nogueiras, R., Tovar, S. A., Mitchell, S. E., Rayner, D. V., Archer, Z. A., Diéguez, C., & Williams, L. M. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2552 · Cited by 140 · see citing works

GSK1614343, a Novel Ghrelin Receptor Antagonist, Produces an Unexpected Increase of Food Intake and Body Weight in Rodents and Dogs

Costantini, V. J. A., Vicentini, E., Sabbatini, F. M., Valerio, E., Lepore, S., Tessari, M., Sartori, M., Michielin, F., Melotto, S., Pich, E. M., et al. (2011) · Neuroendocrinology · doi:10.1159/000328968 · Cited by 55 · see citing works

Somatostatin Infusion Lowers Plasma Ghrelin without Reducing Appetite in Adults with Prader-Willi Syndrome

Tan, T., Vanderpump, M. P. J., Khoo, B. C. E., Patterson, M., Ghatei, M. A., & Goldstone, A. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0835 · Cited by 125 · see citing works

Effects of ghrelin administration on decreased growth hormone status in obese animals

Iwakura, H., Akamizu, T., Ariyasu, H., Irako, T., Hosoda, K., Nakao, K., & Kangawa, K. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00681.2006 · Cited by 30 · see citing works