Cited by 371Olfactory and Sensory Function StudiesIon Channels and ReceptorsNeurobiology and Insect Physiology Research

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Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors

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Grosmaitre, Xavier, Santarelli, Lindsey C, Tan, Jie, Luo, Minmin, Ma, Minghong·2007·Nature Neuroscience

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Abstract

Most sensory systems are primarily specialized to detect one sensory modality. Here we report that olfactory sensory neurons (OSNs) in the mammalian nose can detect two distinct modalities transmitted by chemical and mechanical stimuli. As revealed by patch-clamp recordings, many OSNs respond not only to odorants, but also to mechanical stimuli delivered by pressure ejections of odor-free Ringer solution. The mechanical responses correlate directly with the pressure intensity and show several properties similar to those induced by odorants, including onset latency, reversal potential and adaptation to repeated stimulation. Blocking adenylyl cyclase or knocking out the cyclic nucleotide-gated channel CNGA2 eliminates the odorant and the mechanical responses, suggesting that both are mediated by a shared cAMP cascade. We further show that this mechanosensitivity enhances the firing frequency of individual neurons when they are weakly stimulated by odorants and most likely drives the rhythmic activity (theta oscillation) in the olfactory bulb to synchronize with respiration.

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Additional file 6 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
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Additional file 5 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Chen, M., Chen, Y., Huo, Q., Wang, L., Tan, S., Misrani, A., Jiang, J., Chen, J., Chen, S., Zhang, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14167891
Additional file 7 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Chen, M., Chen, Y., Huo, Q., Wang, L., Tan, S., Misrani, A., Jiang, J., Chen, J., Chen, S., Zhang, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14167897
Additional file 2 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Chen, M., Chen, Y., Huo, Q., Wang, L., Tan, S., Misrani, A., Jiang, J., Chen, J., Chen, S., Zhang, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14167882
Additional file 1 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Chen, M., Chen, Y., Huo, Q., Wang, L., Tan, S., Misrani, A., Jiang, J., Chen, J., Chen, S., Zhang, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14167879
Additional file 3 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Chen, M., Chen, Y., Huo, Q., Wang, L., Tan, S., Misrani, A., Jiang, J., Chen, J., Chen, S., Zhang, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14167885
Additional file 4 of Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Chen, M., Chen, Y., Huo, Q., Wang, L., Tan, S., Misrani, A., Jiang, J., Chen, J., Chen, S., Zhang, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14167888
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Authors: Grosmaitre, X., Santarelli, L. C., Tan, J., Luo, M., & Ma, M.
Affiliations: Istituto Nazionale di Geofisica e Vulcanologia (IT)
World Bank (US)
Jet Propulsion Laboratory (US)
University of Pennsylvania (US)
Corresponding author: Ma, Minghong
ORCID: Tan, Jie
Luo, Minmin
Ma, Minghong
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-02-18
Volume: 10
Issue: 3
Pages: 348-354
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1856
PMC: PMC2227320
OpenAlex: W2120729067
Semantic Scholar: 54917ce60e3e9e3ade1f6a0be8605b162006b36d
Cited by: 371
References: 38
Citations by year: 2026: 16 · 2025: 26 · 2024: 27 · 2023: 23 · 2022: 23 · 2021: 39 · 2020: 20 · 2019: 16 · 2018: 29 · 2017: 11 · 2016: 18 · 2015: 14 · 2014: 20 · 2013: 18 · 2012: 11
FWCI: 7.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: Whitehall Foundation
University of Pennsylvania
Johns Hopkins University
National Institute on Deafness and Other Communication Disorders (R01DC006213)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: olfactory sensory neurons, mechanosensitivity, odor detection, cyclic nucleotide-gated channels, CNGA2, adenylate cyclase, cAMP signaling, neural adaptation, theta oscillations, olfactory bulb, neuronal firing rate
MeSH terms: Cyclic AMP, Animals, Dose-Response Relationship, Radiation, Enzyme Inhibitors, Female, Imines, Ion Channels, Male, Membrane Potentials, Neurons, Afferent, Odorants, Olfactory Bulb, Physical Stimulation, Smell, Stimulation, Chemical, Touch, Mice, Knockout, Patch-Clamp Techniques, Mice, Cyclic Nucleotide-Gated Cation Channels, In Vitro Techniques

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Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors

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