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Cited by 371Olfactory and Sensory Function StudiesIon Channels and ReceptorsNeurobiology and Insect Physiology Research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors

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Grosmaitre, Xavier, Santarelli, Lindsey C, Tan, Jie, Luo, Minmin, Ma, Minghong·2007·Nature Neuroscience
DOI 10.1038/nn1856PMC PMC2227320
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Abstract

Most sensory systems are primarily specialized to detect one sensory modality. Here we report that olfactory sensory neurons (OSNs) in the mammalian nose can detect two distinct modalities transmitted by chemical and mechanical stimuli. As revealed by patch-clamp recordings, many OSNs respond not only to odorants, but also to mechanical stimuli delivered by pressure ejections of odor-free Ringer solution. The mechanical responses correlate directly with the pressure intensity and show several properties similar to those induced by odorants, including onset latency, reversal potential and adaptation to repeated stimulation. Blocking adenylyl cyclase or knocking out the cyclic nucleotide-gated channel CNGA2 eliminates the odorant and the mechanical responses, suggesting that both are mediated by a shared cAMP cascade. We further show that this mechanosensitivity enhances the firing frequency of individual neurons when they are weakly stimulated by odorants and most likely drives the rhythmic activity (theta oscillation) in the olfactory bulb to synchronize with respiration.

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Crossref · 10.1038/nn1856

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  1. Rodolfo-Masera, T. Su 1'esistenza di un particolare organo olfacttivo nel setto nasale della cavia e di altri roditori. Arch. Ital. Anat. Embryol. 48, 157–212 (1943).

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Metadata

Authors
Grosmaitre, X., Santarelli, L. C., Tan, J., Luo, M., & Ma, M.
Affiliations
  • Istituto Nazionale di Geofisica e Vulcanologia (IT)
  • World Bank (US)
  • Jet Propulsion Laboratory (US)
  • University of Pennsylvania (US)
Corresponding author
Ma, Minghong
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2007-02-18
Volume
10
Issue
3
Pages
348-354
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1856
PMC
PMC2227320
OpenAlex
W2120729067
Semantic Scholar
54917ce60e3e9e3ade1f6a0be8605b162006b36d
Cited by
371
References
38
Citations by year
2026: 16 · 2025: 26 · 2024: 27 · 2023: 23 · 2022: 23 · 2021: 39 · 2020: 20 · 2019: 16 · 2018: 29 · 2017: 11 · 2016: 18 · 2015: 14 · 2014: 20 · 2013: 18 · 2012: 11
FWCI
7.18
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
  • Whitehall Foundation
  • University of Pennsylvania
  • Johns Hopkins University
  • National Institute on Deafness and Other Communication Disorders (R01DC006213)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
olfactory sensory neurons, mechanosensitivity, odor detection, cyclic nucleotide-gated channels, CNGA2, adenylate cyclase, cAMP signaling, neural adaptation, theta oscillations, olfactory bulb, neuronal firing rate
MeSH terms
Cyclic AMP, Animals, Dose-Response Relationship, Radiation, Enzyme Inhibitors, Female, Imines, Ion Channels, Male, Membrane Potentials, Neurons, Afferent, Odorants, Olfactory Bulb, Physical Stimulation, Smell, Stimulation, Chemical, Touch, Mice, Knockout, Patch-Clamp Techniques, Mice, Cyclic Nucleotide-Gated Cation Channels, In Vitro Techniques

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