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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Open accessAbstract
Mutations in superoxide dismutase-1 (SOD1) cause a form of the fatal paralytic disorder amyotrophic lateral sclerosis (ALS), presumably by a combination of cell-autonomous and non-cell-autonomous processes. Here, we show that expression of mutated human SOD1 in primary mouse spinal motor neurons does not provoke motor neuron degeneration. Conversely, rodent astrocytes expressing mutated SOD1 kill spinal primary and embryonic mouse stem cell-derived motor neurons. This is triggered by soluble toxic factor(s) through a Bax-dependent mechanism. However, mutant astrocytes do not cause the death of spinal GABAergic or dorsal root ganglion neurons or of embryonic stem cell-derived interneurons. In contrast to astrocytes, fibroblasts, microglia, cortical neurons and myocytes expressing mutated SOD1 do not cause overt neurotoxicity. These findings indicate that astrocytes may play a role in the specific degeneration of spinal motor neurons in ALS. Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint.
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“Accumulating evidence has demonstrated that glia are involved in a variety of neurological diseases, including schizophrenia, autism spectrum disorders, epilepsy, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and stroke (Matute et al., 2005;Tian et al., 2005;Nagai et al., 2007;Chen et al., 2009;Li et al., 2011;Lioy et al., 2011;Molofsky et al., 2012;Z”
From An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014) · cites this paper as Nagai et al., 2007
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“Moreover, astrocytes seem to secrete toxic factor(s) that are detrimental to motor neuron health [23–26].”
From Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes (2017) · cites this paper as [23]
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“Consistent with previous studies [23–26], we validated that the conditioned media from these cultures is toxic to motor neurons.”
From Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes (2017) · cites this paper as [23]
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“Previous evidence suggested the toxic activity of reactive astrocytes is mediated by a secreted protein5,6”
From Neurotoxic reactive astrocytes induce cell death via saturated lipids (2021) · cites this paper as [5]
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1 retracted
Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70
Sawada, M., Hayes, P. L., & Matsuyama, S. (2003) · Nature Cell Biology · doi:10.1038/ncb955 · Cited by 162
RetractedPolazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792
Self-citationOnset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623
Amyotrophic Lateral Ssclerosis and Structural Defects in Cu,Zn Superoxide Dismutase
Deng, H., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W.-Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., et al. (1993) · Science · doi:10.1126/science.8351519 · Cited by 1,479
Wong, P. C., Pardo, C. A., Borchelt, D., Lee, M. K., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., Cleveland, D. W., & Price, D. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90259-7 · Cited by 1,439
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillée, S., Rule, M., McMahon, A. P., Doucette, W. T., Siwek, D. F., Ferrante, R. J., et al. (2003) · Science · doi:10.1126/science.1086071 · Cited by 1,131
Cited by
Sorted by citations
Items 201–300 of 999
Peviani, M., Salvaneschi, E., Bontempi, L., Petese, A., Manzo, A., Rossi, D., Salmona, M., Collina, S., Bigini, P., & Curti, D. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.010 · Cited by 136
Li, Y., Chigurupati, S., Holloway, H. W., Mughal, M. R., Tweedie, D., Bruestle, D. A., Mattson, M. P., Wang, Y., Harvey, B. K., Ray, B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032008 · Cited by 133
Inflammation in ALS and SMA: Sorting out the good from the evil
Papadimitriou, D. A., Verche, V. L., Jacquier, A., Ikiz, B., Przedborski, S., & Ré, D. B. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.005 · Cited by 137
Self-citationDodge, J. C., Treleaven, C. M., Fidler, J. A., Hester, M. E., Haidet, A. M., Handy, C. R., Rao, M., Eagle, A., Cowger, J. A., Taksir, T. V., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.206 · Cited by 130
Tripathi, P., Rodriguez-Muela, N., Klim, J. R., de Boer, A. S., Agrawal, S., Sandoe, J., Lopes, C. S., Ogliari, K. S., Williams, L. A., Shear, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.008 · Cited by 123
Pitzer, C., Krüger, C., Plaas, C., Kirsch, F., Dittgen, T., Müller, R., Laage, R., Kastner, S., Suess, S., Spoelgen, R., et al. (2008) · Brain · doi:10.1093/brain/awn243 · Cited by 129
Towne, C. L., Raoul, C., Schneider, B. L., & Aebischer, P. (2008) · Molecular Therapy · doi:10.1038/mt.2008.73 · Cited by 137
González, D., Contreras, O., Rebolledo, D. L., Espinoza, J. P., van Zundert, B., & Brandan, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177649 · Cited by 128
Molecular and metabolic heterogeneity of astrocytes and microglia
Hasel, P., Aisenberg, W. H., Bennett, F. C., & Liddelow, S. A. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.006 · Cited by 135
Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS
Schreiner, B., Romanelli, E., Liberski, P. P., Ingold‐Heppner, B., Sobottka, B., Hartwig, T., Chandrasekar, V., Johannssen, H. C., Zeilhofer, H. U., Aguzzi, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.051 · Cited by 129
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
Tyzack, G. E., Hall, C. E., Sibley, C. R., Cymes, T., Forostyak, S., Carlino, G., Meyer, I. F., Schiavo, G., Zhang, S.-C., Gibbons, G. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01283-z · Cited by 128
The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
Tanaka, H., Shimazawa, M., Kimura, M., Takata, M., Tsuruma, K., Yamada, M., Takahashi, H., Hozumi, I., Niwa, J., Iguchi, Y., et al. (2012) · Scientific Reports · doi:10.1038/srep00573 · Cited by 129
Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis
Harten, A. C. M. V., Phatnani, H. P., & Przedborski, S. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.04.008 · Cited by 123
Self-citationPalliative Care for Patients With Amyotrophic Lateral Sclerosis
Mitsumoto, H., & Rabkin, J. G. (2007) · JAMA · doi:10.1001/jama.298.2.207 · Cited by 126
Diversity of astroglial responses across human neurodegenerative disorders and brain aging
Ferrer, I. (2017) · Brain Pathology · doi:10.1111/bpa.12538 · Cited by 135
Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo
Qian, K. X., Huang, H., Peterson, A., Hu, B., Maragakis, N. J., Ming, G., Chen, H., & Zhang, S. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.003 · Cited by 128
Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
Zhao, C. N., Devlin, A., Chouhan, A. K., Selvaraj, B. T., Stavrou, M., Burr, K., Brivio, V., He, X., Mehta, A. R., Story, D., et al. (2019) · Glia · doi:10.1002/glia.23761 · Cited by 129
CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?
Tefera, T. W., Steyn, F. J., Ngo, S. T., & Borges, K. (2021) · Cell & Bioscience · doi:10.1186/s13578-020-00511-2 · Cited by 122
CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs
Wang, L., Yi, F., Fu, L., Yang, J., Wang, S., Wang, Z., Suzuki, K., Sun, L., Xu, X., Yu, Y., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0397-3 · Cited by 124
Garcia, O., Torres, M., Helguera, P., Coskun, P., & Busciglio, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014200 · Cited by 122
Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis
Verma, S., Khurana, S., Vats, A., Sahu, B., Ganguly, N. K., Chakraborti, P., Gourie-Devi, M., & Taneja, V. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02658-6 · Cited by 127
Astrocyte heterogeneity in the brain: from development to disease
Schitine, C., Nogaroli, L., Costa, M. R., & Hedin‐Pereira, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00076 · Cited by 131
The adult human brain in preclinical drug development
Dragunow, M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2617 · Cited by 121
Logan, S., Arzua, T., Canfield, S. G., Seminary, E. R., Sison, S. L., Ebert, A. D., & Bai, X. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180025 · Cited by 143
ALS‐linked protein disulfide isomerase variants cause motor dysfunction
Woehlbier, U., Colombo, A., Saaranen, M. J., Pérez, V., Ojeda, J., Bustos, F. J., Andreu, C. I., Torres, M., Valenzuela, V., Medinas, D. B., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592224 · Cited by 118
Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model
Wang, R., Yang, B., & Zhang, D. (2011) · Glia · doi:10.1002/glia.21167 · Cited by 115
Contribution of astrocytes to neuropathology of neurodegenerative diseases
Acıoğlu, Ç., Li, L., & Elkabes, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147291 · Cited by 119
Neuropathogenesis-on-chips for neurodegenerative diseases
Amartumur, S., Nguyen, H. M., Huynh, T., Kim, T. S., Woo, R., Oh, E., Kim, K. K., Lee, L. P., & Heo, C. (2024) · Nature Communications · doi:10.1038/s41467-024-46554-8 · Cited by 131
Glial Dysfunction in Parkin Null Mice: Effects of Aging
Solano, R. M., Casarejos, M. J., Menéndez-Cuervo, J., Rodríguez‐Navarro, J. A., de Yébenes, J. G., & Mena, M. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4609-07.2008 · Cited by 119
Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand ?
Henriques (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00032 · Cited by 117
Signaling by death receptors in the nervous system
Haase, G., Pettmann, B., Raoul, C., & Henderson, C. E. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.07.013 · Cited by 122
Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic
Mancuso, R., & Navarro, X. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.004 · Cited by 125
Targeted Activation of Astrocytes: A Potential Neuroprotective Strategy
Escartin, C., & Bonvento, G. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8043-y · Cited by 118
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
Israelson, A., Ditsworth, D., Sun, S., Song, S., Liang, J., Hruška-Plocháň, M., McAlonis‐Downes, M., Abu‐Hamad, S., Zoltsman, G., Shani, T., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.034 · Cited by 114
Wang, L., Sharma, K., Grisotti, G., & Roos, R. P. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.002 · Cited by 121
Nitric Oxide-Mediated Oxidative Damage and the Progressive Demise of Motor Neurons in ALS
Drechsel, D. A., Estévez, Á. G., Barbeito, L., & Beckman, J. S. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9322-y · Cited by 117
Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium
Fornai, F., Longone, P., Ferrucci, M., Lenzi, P., Isidoro, C., Ruggieri, S., & Paparelli, A. (2008) · Autophagy · doi:10.4161/auto.5923 · Cited by 111
Rojas, F., Cortés, N., Abarzúa, S., Dyrda, A., & van Zundert, B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00024 · Cited by 120
The neuroprotective potential of carotenoids in vitro and in vivo
Manochkumar, J., Doss, C. G. P., El-Seedi, H. R., Efferth, T., & Ramamoorthy, S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153676 · Cited by 117
SIRT3 and mitochondrial metabolism in neurodegenerative diseases
Salvatori, I., Valle, C., Ferri, A., & Carrì, M. T. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.04.012 · Cited by 110
Smethurst, P., Risse, E., Tyzack, G. E., Mitchell, J. S., Taha, D. M., Chen, Y., Newcombe, J., Collinge, J., Sidle, K. C. L., & Patani, R. (2019) · Brain · doi:10.1093/brain/awz419 · Cited by 117
Multimodal Actions of Neural Stem Cells in a Mouse Model of ALS: A Meta-Analysis
Teng, Y. D., Benn, S. C., Kalkanis, S. N., Shefner, J. M., Onario, R. C., Cheng, B., Lachyankar, M. B., Marconi, M., Li, J., Yu, D., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004579 · Cited by 112
Self-citationGlial Cells in Amyotrophic Lateral Sclerosis
Lasiene, J., & Yamanaka, K. (2011) · Neurology Research International · doi:10.1155/2011/718987 · Cited by 110
Hefferan, M. P., Gálik, J., Kakinohana, O., Sekerková, G., Santucci, C., Marsala, S., Navarro, R., Hruška-Plocháň, M., Johe, K. K., Feldman, E. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042614 · Cited by 113
Xia, Q., Hu, Q., Wang, H., Yang, H., Gao, F., Ren, H., Chen, D., Fu, C., Zheng, L. P., Zhen, X., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.69 · Cited by 117
Control of glioblastoma tumorigenesis by feed-forward cytokine signaling
Jahani‐Asl, A., Yin, H., Soleimani, V. D., Haque, T., Luchman, H. A., Chang, N. C., Sincennes, M., Puram, S. V., Scott, A. M., Lorimer, I. A. J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4295 · Cited by 110
Abati, E., Bresolin, N., Comi, G. P., & Corti, S. P. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1738390 · Cited by 107
New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases
Scarian, E., Viola, C., Dragoni, F., Gerlando, R. D., Rizzo, B., Diamanti, L., Gagliardi, S., Bordoni, M., & Pansarasa, O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052698 · Cited by 118
Fritz, E., Izaurieta, P., Weiss, A., Mir, F. R., Rojas, P., González, D., Rojas, F., Brown, R. H., Madrid, R., & van Zundert, B. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00500.2012 · Cited by 116
Translational potential of astrocytes in brain disorders
Verkhratsky, A., Steardo, L., Parpura, V., & Montana, V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.003 · Cited by 115
Sareen, D., Gowing, G., Sahabian, A., Staggenborg, K., Paradis, R., Avalos, P., Latter, J., Ornelas, L., Garcia, L., & Svendsen, C. N. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23578 · Cited by 110
Degeneration and repair in central nervous system disease
Lo, E. H. (2010) · Nature Medicine · doi:10.1038/nm.2226 · Cited by 111
SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status
Sheng, Y., Chattopadhyay, M., Whitelegge, J. P., & Valentine, J. S. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611212220010 · Cited by 115
Wada, T., Honda, M., Minami, I., Tooi, N., Amagai, Y., Nakatsuji, N., & Aiba, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006722 · Cited by 107
Yang, E. J., Jiang, J. H., Lee, S. M., Yang, S. C., Hwang, H. S., Lee, M. S., & Choi, S. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-69 · Cited by 110
Bataveljić, D., Nikolic, L. M., Milosevic, M. M., Todorović, N. V., & Anđjus, P. R. (2012) · Glia · doi:10.1002/glia.22414 · Cited by 106
Stoica, L., Todeasa, S. H., Cabrera, G. T., Salameh, J. S., ElMallah, M. K., Mueller, C., Brown, R. H., & Sena‐Esteves, M. (2016) · Annals of Neurology · doi:10.1002/ana.24618 · Cited by 107
Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration
Harun‐Or‐Rashid, M., Pappenhagen, N., Palmer, P. G., Smith, M. A., Gevorgyan, V., Wilson, G. N., Crish, S. D., & Inman, D. M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3652-17.2018 · Cited by 104
Lewis, D. K., Johnson, A. B., Stohlgren, S., Harms, A. S., & Sohrabji, F. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.01.006 · Cited by 105
Greco, T. M., Seeholzer, S. H., Mak, A., Spruce, L. A., & Ischiropoulos, H. (2010) · Journal of Proteome Research · doi:10.1021/pr100134n · Cited by 104
Radford, R. A. W., Morsch, M., Rayner, S. L., Cole, N. J., Pountney, D. L., & Chung, R. S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00414 · Cited by 105
Surface chemistry governs cellular tropism of nanoparticles in the brain
Song, E., Gaudin, A., King, A. R., Seo, Y.-E., Suh, H., Deng, Y., Cui, J., Tietjen, G. T., Huttner, A. J., & Saltzman, W. M. (2017) · Nature Communications · doi:10.1038/ncomms15322 · Cited by 101
Miquel, E., Cassina, A., Palma, L. M., Bolatto, C., Trías, E., Gandelman, M., Radí, R., Barbeito, L., & Cassina, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034776 · Cited by 102
Boucherie, C., Schäfer, S., Lavand'homme, P. M., Maloteaux, J., & Hermans, E. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22038 · Cited by 100
Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling
Arai, K., & Lo, E. H. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22256 · Cited by 101
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Tian, F., Yang, W., Mordes, D. A., Wang, J., Salameh, J. S., Mok, J., Chew, J., Sharma, A., Leno‐Durán, E., Suzuki-Uematsu, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms13283 · Cited by 102
Tefera, T. W., & Borges, K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00611 · Cited by 100
Giacomelli, E., Vahsen, B. F., Calder, E. L., Xu, Y., Scaber, J., Gray, E., Dafinca, R., Talbot, K., & Studer, L. (2022) · Cell stem cell · doi:10.1016/j.stem.2021.12.008 · Cited by 100
The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration
Hinkle, J. T., Dawson, V. L., & Dawson, T. M. (2019) · Movement Disorders · doi:10.1002/mds.27718 · Cited by 100
Silverman, J. M., Fernando, S. M., Grad, L. I., Hill, A. F., Turner, B. J., Yerbury, J. J., & Cashman, N. R. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0294-3 · Cited by 99
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Gleichman, A. J., & Carmichael, S. T. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104957 · Cited by 90
Keller, A. F., Gravel, M., & Križ, J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.010 · Cited by 103
Afridi, R., Kim, J., Rahman, M. H., & Suk, K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00020 · Cited by 102
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Moser, J., Bigini, P., & Schmitt‐John, T. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0741-0 · Cited by 108
Rojas, F., González, D., Cortés, N., Ampuero, E., Hernández, D. E., Fritz, E., Abarzúa, S., Martinez, A. N., Elorza, Á. A., Alvarez, A. R., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00203 · Cited by 97
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Suzuki, M., & Svendsen, C. N. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.006 · Cited by 96
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Allodi, I., Comley, L. H., Nichterwitz, S., Nizzardo, M., Simone, C., Benitez, J. A., Cao, M., Corti, S. P., & Hedlund, E. (2016) · Scientific Reports · doi:10.1038/srep25960 · Cited by 96
Keller, A. F., Gravel, M., & Križ, J. (2008) · Glia · doi:10.1002/glia.20836 · Cited by 95
Markovinović, A., Cimbro, R., Ljutić, T., Križ, J., Rogelj, B., & Munitić, I. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.04.005 · Cited by 95
Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.001 · Cited by 95
Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1
Boillée, S., & Cleveland, D. W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34613 · Cited by 95
Wang, H., Yang, B., Qiu, L., Yang, C., Kramer, J. A., Su, Q., Guo, Y., Brown, R. H., Gao, G., & Xu, Z. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt454 · Cited by 99
Harlan, B. A., Pehar, M., Sharma, D. R., Beeson, G., Beeson, C. C., & Vargas, M. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698779 · Cited by 94
Su, X., Broach, J. R., Connor, J. R., Gerhard, G. S., & Simmons, Z. (2014) · Muscle & Nerve · doi:10.1002/mus.24198 · Cited by 94
Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
Rizzo, F., Riboldi, G. M., Salani, S., Nizzardo, M., Simone, C., Corti, S. P., & Hedlund, E. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1480-4 · Cited by 93
Targeted gene silencing in the nervous system with CRISPR-Cas13
Powell, J. E., Lim, C. K. W., Krishnan, R. S. G., McCallister, T. X., Saporito-Magriñá, C., C., M. A. Z., McPheron, G. D., & Gaj, T. (2022) · Science Advances · doi:10.1126/sciadv.abk2485 · Cited by 96
Lee, J. D., Kamaruzaman, N. A., Fung, J. N., Taylor, S. M., Turner, B. J., Atkin, J. D., Woodruff, T. M., & Noakes, P. G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-119 · Cited by 93
Kawamata, H., Ng, S. K., Diaz, N., Burstein, S., Morel, L., Osgood, A., Sider, B., Higashimori, H., Haydon, P. G., Manfredi, G., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2689-13.2014 · Cited by 97
Ziff, O. J., Clarke, B. E., Taha, D. M., Crerar, H., Luscombe, N. M., & Patani, R. (2021) · Genome Research · doi:10.1101/gr.275939.121 · Cited by 91
Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis
Corona, J. C., Tovar‐y‐Romo, L. B., & Tapia, R. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.11.1415 · Cited by 91
Chang, J., Qian, Z., Wang, B., Cao, J., Zhang, S., Jiang, F., Kong, R., Yu, X. H., Cao, X., Yang, L., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01036-6 · Cited by 94
Astrocyte-Mediated Neuroinflammation in Neurological Conditions
Zhao, Y., Huang, Y., Cao, Y., & Yang, J. H. (2024) · Biomolecules · doi:10.3390/biom14101204 · Cited by 106
Gibb, S. L., Boston-Howes, W., Lavina, Z. S., Gustincich, S., Brown, R. H., Pasinelli, P., & Trotti, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704314200 · Cited by 91
Cabanas, E. D., Hereu, M., Piedrafita, L., Casanovas, A., Calderó, J., & Esquerda, J. E. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31821cbd8b · Cited by 91
Neuroinflammation in motor neuron disease
Endo, F., Komine, O., & Yamanaka, K. (2016) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12309 · Cited by 95
Toll-like receptors in central nervous system injury and disease: A focus on the spinal cord
Heiman, A., Pallottie, A., Heary, R. F., & Elkabes, S. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.203 · Cited by 92
Park, S., Kim, H.-T., Yun, S., Kim, I., Lee, J., Lee, I.-S., & Park, K. I. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.7.054 · Cited by 90
Martorana, F., Brambilla, L., Valori, C. F., Bergamaschi, C., Roncoroni, C., Aronica, E., Volterra, A., Bezzi, P., & Rossi, D. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr513 · Cited by 94
Arredondo, C., Cefaliello, C., Dyrda, A., Jury, N., Martínez, P., Díaz, I. D. P., Amaro, A., Tran, H., Morales, D., Pertusa, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.010 · Cited by 89
VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
Bogaert, E., Damme, P. V., Poesen, K., Dhondt, J., Hersmus, N., Kiraly, D., Scheveneels, W., Robberecht, W., & Bosch, L. V. D. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.12.007 · Cited by 89
Metadata
- Authors
- Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S.
- Affiliations
- Columbia University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Przedborski, Serge
- Venue
- Nature Neuroscience
- Published
- 2007-04-15
- Volume
- 10
- Issue
- 5
- Pages
- 615-622
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3799799
- OpenAlex
- W2107660300
- Cited by
- 1,220
- References
- 39
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 59 · 2023: 52 · 2022: 50 · 2021: 52 · 2020: 65 · 2019: 53 · 2018: 58 · 2017: 72 · 2016: 53 · 2015: 64 · 2014: 81 · 2013: 84 · 2012: 89
- FWCI
- 57.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Muscular Dystrophy Association
- National Institutes of Health
- National Institute on Aging (R01AG021617, AG21617)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK58056, R01DK058056)
- National Institute of Neurological Disorders and Stroke (NS-11766, P01NS011766, R01NS042269, P50NS038370, NS 42269, NS38370)
- National Institute of Environmental Health Sciences (R21ES013177, ES013177)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- amyotrophic lateral sclerosis, SOD1 mutations, astrocytes, motor neuron degeneration, non-cell autonomous neurodegeneration, spinal motoneurons
- MeSH terms
- Amyotrophic Lateral Sclerosis, Animals, Astrocytes, Cell Survival, Cells, Cultured, Disease Models, Animal, Dose-Response Relationship, Drug, Embryo, Mammalian, Enzyme Inhibitors, Ganglia, Spinal, Humans, Mice, Transgenic, Motor Neurons, Mutation, Nerve Tissue Proteins, Superoxide Dismutase, Culture Media, Conditioned, In Situ Nick-End Labeling, Green Fluorescent Proteins, Mice, Embryonic Stem Cells
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