Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells
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Conditioned media from SOD1-G93A astrocytes is toxic to motor neurons.
“Consistent with previous studies [23–26], we validated that the conditioned media from these cultures is toxic to motor neurons.”
From Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes (2017) · cites this paper as [24]
Astrocytes seem to secrete toxic factor(s) that are detrimental to motor neuron health.
“Moreover, astrocytes seem to secrete toxic factor(s) that are detrimental to motor neuron health [23–26].”
From Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes (2017) · cites this paper as [24]
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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
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- Authors
- Marchetto, M. C. N., Muotri, A. R., Mu, Y., Smith, A. M., Cezar, G. G., & Gage, F. H.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 3
- Issue
- 6
- Pages
- 649-657
- ISSN
- 1934-5909
- Cited by
- 424
- References
- 5
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1725 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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