The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
Abstract
Plastic changes occurring during wakefulness aid in the acquisition and consolidation of memories. For some memories, further consolidation requires sleep, but whether plastic processes during wakefulness and sleep differ is unclear. We show that, in rat cortex and hippocampus, GluR1-containing AMPA receptor (AMPAR) levels are high during wakefulness and low during sleep, and changes in the phosphorylation states of AMPARs, CamKII and GSK3beta are consistent with synaptic potentiation during wakefulness and depression during sleep. Furthermore, slope and amplitude of cortical evoked responses increase after wakefulness, decrease after sleep and correlate with changes in slow-wave activity, a marker of sleep pressure. Changes in molecular and electrophysiological indicators of synaptic strength are largely independent of the time of day. Finally, cortical long-term potentiation can be easily induced after sleep, but not after wakefulness. Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Levels of postsynaptic glutamatergic AMPA receptors containing the glutamate receptor (GluR1)-1 subunit reliably indicate synaptic plasticity and were revealed to be high during wakefulness and distinctly lower (by 40%) during sleep (1264).”
From About Sleep's Role in Memory (2013) · cites this paper as [1264]
In the citing paper
“Indeed, in rats, slope and amplitude of the electrically evoked cortical potential as indicators of synaptic strength progressively increased during sustained wakefulness and decreased after sleep, and these changes were correlated with SWA (1264).”
From About Sleep's Role in Memory (2013) · cites this paper as [1264]
In the citing paper
“Prolonged waking decreases the ability to induce further LTP in various models, which in turn should inhibit learning (Vyazovskiy et al., 2008);”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Vyazovskiy et al., 2008
Citations
Cites
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Self-citationSleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,546
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296
Cited by
Sorted by citations
Items 701–800 of 837
Paraciani, C., Havekes, R., Meerlo, P., & Gervais, N. J. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101205 · Cited by 1
“However, SD of shorter duration or using different SD methodologies do not always replicate these effects (for example, see Miyamoto et al., 2021; Vecsey et al., 2009; Vyazovskiy et al., 2008; Xie et al., 2015).”
Animal models for cognitive deficits induced by sleep deprivation
Seugnet, L., & Salin, P. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.019 · Cited by 1
The Need of Slow Wave Activity and Cognitive Functions
Halász, P., & Bódizs, R. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4333-8_8 · Cited by 1
Belang van slaap voor cognitief en psychologisch functioneren
Meerlo, P., & Havekes, R. (2020) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2524-5_2 · Cited by 1
Rise and shine (we are all morning people!)
Flight, M. H. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2348 · Cited by 1
Analysis of the sleep homeostat of the nematode Caenorhabditis elegans
Spies, J. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5437 · Cited by 1
Schneider, W. H. F., Matt, K., Irsigler, K., Lageder, H., & Schubert, H. (1975) · PubMed · Cited by 1
The processing of sounds in auditory cortex during sleep
Issa, E. B. (2008) · Cited by 1
Loss of Recall and the Hippocampal Circuit Effects Produced by Anesthetics
MacIver, M. B. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60761-462-3_9 · Cited by 1
Mouse Medial-prefrontal Cortex Involvement in Trace Fear Memory during Wakefulness and Sleep
Steenland, H. W. (2011) · TSpace (University of Toronto) · Cited by 1
Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autismPreprint
Bridi, M., Luo, N., Kim, G., O’Ferrall, C., Patel, R. V., Bertrand, S. J., Kannan, S., & Kirkwood, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.05.451213 · Cited by 1
“During the rest phase, sleep is required for decreased excitation and increased inhibition (Bridi et al., 2020; Liu et al., 2010; Vyazovskiy et al., 2008; Zong et al., 2023).”
Fontana, L. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734915175.793557003 · Cited by 1
Resting-state aperiodic neural activity as a novel objective marker of daytime somnolencePreprint
Cross, Z. R., Kang, T., Lushington, K., Sarkar, P., Singh, P., Johnston, S., Yeo, A., & Chatburn, A. (2022) · bioRxiv · doi:10.1101/2022.08.07.503118 · Cited by 1
Astrocyte Ca 2+ signalling mediates long-distance metaplasticity in the hippocampal CA1Preprint
Jones, O. D., Singh, A., Logan, B. J., & Abraham, W. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.19.545623 · Cited by 1
Effect of Insomnia on Repetitive Transcranial Magnetic Stimulation Treatment Outcomes for DepressionPreprint
Kweon, J., Fukuda, A. M., Gobin, A. P., Haq, L., Brown, J. C., & Carpenter, L. L. (2023) · medRxiv · doi:10.1101/2023.12.06.23299444 · Cited by 1
“For example, in a study using high-frequency electrical stimulation in the motor cortex of rats to induce synaptic plasticity, effects were partially occluded after prolonged wakefulness and restored after sleep (Vyazovskiy et al., 2008).”
BackgroundMettl5 coordinates protein production and degradation of PERIOD to regulate sleep in DrosophilaPreprint
Wu, X., Yang, X., Fu, T., Rong, Y. S., & Du, J. (2025) · eLife · doi:10.7554/elife.103427.1 · Cited by 1
Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in DrosophilaPreprint
Wu, X., Yang, X., Fu, T., Rong, Y. S., & Du, J. (2025) · eLife · doi:10.7554/elife.103427 · Cited by 1
“Indeed, synapse markers progressively decrease during sleep in both mammals and Drosophila brains ( López-Varea et al., 2021 ; Vyazovskiy et al., 2008 ; Gilestro et al., 2009 ; Liu et al., 2010 ).”
Valdivia, G., Moreno, C., He, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.15.682451 · Cited by 1
A molecular integrator of sleep duration and interruptionPreprint
Tilden, E. I., Fontenele, A. J., Goggans, K. M., Ma, S., Gorecki, D., Berriman-Rozen, Z. D., Oldenborg, A., Shew, W. L., & Chen, Y. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.03.736427 · Cited by 1
Buechel, H. M. (2013) · UKnowledge (University of Kentucky)
Neuroimaging of cognitive effects in obstructive sleep apnea
THOMAS, R. J., & Chan, S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139088268.036
Adam Knowlden, P., & Sharma, M. (2013) · webmedcentralplus · doi:10.9754/journal.wplus.2013.001
Insomnio crónico y funciones ejecutivas: Un estudio neuropsicológico
Ilioudi, C. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Alzheimer's disease: sleep, neuronal activation and the default mode network
Krajnc, A. M. (2012) · Utrecht University Repository (Utrecht University)
Regulating the information in spikes: a useful biasPreprint
Balduzzi, D. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1210.4695
“There is evidence that synaptic strengths increase on average during wakefulness and are downscaled during sleep [9, 20, 21].”
BackgroundSchlaf, Gedächtnisbildung & neuronale Plastizität
Maier, J.-G., & Nissen, C. (2015) · Schlaf · doi:10.1055/s-0038-1626137
“© 2015 2/2015 64 der Delta-Aktivität im Schlaf einher (31).”
BackgroundSleepphysiology and homeostasis
Shaw, P. J., Tafti, M., & Thorpy, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.016
Rolfe, J. T. (2012) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/ycb7-7x24
Using Phase Response Curves to Understand Neuronal Synchronization and Sleep.
Fink, T. C. G. (2012) · Deep Blue (University of Michigan)
Differential influence of sinusoidal and noisy inputs on synaptic connections in a network with STDP
Mayer, J., Schuster, H. G., Ngo, H.-V. V., et al. (2012) · Europhysics Letters (EPL) · doi:10.1209/0295-5075/98/48005
Astrocytic Regulation of Sleep Processes
Schmitt, L. I., & Wimmer, R. D. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-014-0005-5 · Cited by 1
“There are a variety of changes in gene expression [97–99], protein levels [100, 101], receptor surface expression [102], synaptic structure [103], and metabolic activity [71, 104] associated with these behavioral states.”
BackgroundBowden, J. B., Abraham, W. C., & Harris, K. M. (2010) · Otago University Research Archive (University of Otago)
Consequences Of Brief Periods Of Sleep Loss On Hippocampus-Dependent Memory And Synaptic Plasticity
Prince, T.-M. N. (2013) · ScholarlyCommons (University of Pennsylvania)
The Role of Aerobic Glycolysis in the Resting Human Brain
Vaishnavi, S. (2010) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7n014jb
Ribeiro, S. T. G., Simões, C., & Nicolelis, M. A. L. (2008)
Ravassard, P., Pachoud, B., Comte, J., Mejia-Perez, C., Scoté-Blachon, C., Claustrat, B., Touret, M., Luppi, P., & Salin, P. A. (2009)
Restauración neuronal o plasticidad sináptica a lo largo del ciclo sueño-vigilia
Rodríguez, C. J. M., Martín, E. A. D., & García, Ó. P. (2008) · Revista Médica de la Universidad Veracruzana
Cellular Mechanisms of Sleep Homeostasis : Studies on Brain Energy Metabolism and Aging
Wigren, H. (2009) · Työväentutkimus Vuosikirja
Le rôle du sommeil dans la consolidation mnésique : effets de l’âge et de la maladie d’Alzheimer
Malle, C., Eustache, F., & Rauchs, G. (2015) · Biologie Aujourd hui · doi:10.1051/jbio/2015024
“Des études moléculaires chez le rongeur ont également montré une potentialisation synaptique à l’éveil et une dépotentialisation durant le sommeil (Vyazovskiy et al., 2008).”
LOCAL, EXPERIENCE-DEPENDENT EEG CHANGES AFTER PROLONGED WAKEFULNESS
Hung, C., Sarasso, S., Ferrarelli, F., Riedner, B. A., Cirelli, C., & Tononi, G. (2013)
Clinical View of Consciousness
Steck, A. J., & Steck, B. (2015) · Springer eBooks · doi:10.1007/978-3-319-21287-6_2
Alzheimer’s Disease and the Sleep–Wake Cycle
Bero, A. W., & Tsai, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802851-3.00010-3
Is autonomy working under unconscious state of sleep?
Nakao, M., Karashima, A., & Katayama, N. (2013) · International Joint Conference on Awareness Science and Technology & Ubi-Media Computing · doi:10.1109/icawst.2013.6765452
“In addition, the molecular biological study showed evidence that the longterm potentiation (LTP) and depression (LTD) are caused in wakefulness and sleep, respectively [16].”
BackgroundSleep and cargo reorganization: A hypothesis
McCloskey, R. J. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.01.006
Neural Synchrony and Memory In and Out of Sleep
Benchenane, K., & Peyrache, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21117-6 · Cited by 1
The slow oscillation as an intrinsic and emergent property of the neocortex
Lemieux, M. (2014) · Corpus Université Laval (Université Laval)
Sleep, Declarative Memory, and PTSD: Current Status and Future Directions
Lipinska, G., Thomas, K. G. F., Timol, R., & Stein, D. J. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7148-0_23
Article Sleep Interacts with Ab to Modulate Intrinsic Neuronal Excitability
Tabuchi, M., Lone, S. R., Liu, S., Liu, Q., Zhang, J., Spira, A. P., & Wu, M. N. (2015)
The modulatory effect of sleep on transcranial direct current stimulation-enhanced learning
Ebajemito, J. K. (2018) · Surrey Research Insight Open Access (The University of Surrey)
Does Sleep Play a Role in the Consolidation of Novelty- or Curiosity-Driven Memory Enhancement?
Stare, C. (2017) · UA Campus Repository (The University of Arizona)
Hypothalamic control of body temperature and sleep
Harding, E. C. (2016) · Spiral (Imperial College London) · doi:10.25560/68760
Seigneur, J. (2013) · Corpus Université Laval (Université Laval)
The Role of AMPA Receptors in Synaptic Plasticity by Drugs of Abuse
Kwak, M. J., & Kim, J. (2014) · 대한정신약물학회지
Experience Dependent Cross-modal Regulation of Cortical Circuitry
Petrus, E. (2014)
Zhao, B., Cao, J., Huang, K., Jiang, X., & Tang, J. (2019) · Journal of Model Based Research · doi:10.14302/issn.2643-2811.jmbr-19-2652
Hartnell, I. J. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Kyziridis, T. C., & Nimatoudis, I. (2019) · Springer eBooks · doi:10.1007/978-3-030-18323-3_8
Sleep homeostasis reflects temporally integrated local cortical neuronal activityPreprint
Thomas, C. W., Guillaumin, M. C. C., McKillop, L. E., Achermann, P., & Vyazovskiy, V. V. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/756270
Voldsbekk, I. (2018) · NORA - Norwegian Open Research Archives
Cognitive function in mice with segmental trisomy of human chromosome 21 Down Syndrome genes
Canonica, T. (2019) · ORCA Online Research @Cardiff (Cardiff University)
Pandey, A., Oliver, R., & Kar, S. K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/515379
Niedobór snu a neuroplastyczność
Hess, G. (2020) · Kosmos · doi:10.36921/kos.2020_2681
Cortical neuronal activity determines the dynamics of local sleep homeostasisPreprint
Thomas, C. W., Guillaumin, M. C. C., McKillop, L. E., Achermann, P., & Vyazovskiy, V. V. (2019) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-174314 · Cited by 1
Stimulus-Specific Plasticity of Macaque V1 Spike Rates and GammaPreprint
Peter, A., Stauch, B. J., Shapcott, K. A., Kouroupaki, K., Schmiedt, J. T., Klein, L., Klon-Lipok, J., Dowdall, J. R., Schölvinck, M. L., Vinck, M. A., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3749650 · Cited by 2
Calafate, S., Özturan, G., Thrupp, N., Vanderlinden, J., Chen, W.-T., Fiers, M. W. E. J., Lu, A., Creemers, E., Craessaerts, K., Vandenbempt, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.21.445007
Realization of phosphorylation hypothesis of sleep by mammalian CaMKIIβPreprint
Tone, D., Ode, K. L., Zhang, Q., Fujishima, H., Yamada, R. G., Nagashima, Y., Matsumoto, K., Wen, Z., Yoshida, S. Y., Mitani, T. T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.11.463945
Role of NREM and REM Sleep in Visual Perceptual Learning
Tamaki, M. (2021) · Japanese Journal of Physiological Psychology and Psychophysiology · doi:10.5674/jjppp.2108si
Mistlberger, R. E., & Kent, B. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734915175.793555877
McEwen, B. S. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718000102.793474854
Kipnis, J., & Mesquita, S. D. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734915175.793556879
Hairston, I. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816658-1.00036-3
Frank, M. G. (2022) · Translational medicine research · doi:10.1007/978-94-024-2168-2_4
Aeschbach, D., & Santhi, N. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.10049-0
Metaplasticity of cortical glutamatergic LTP by diurnal intracellular chloride dynamicsPreprint
Alfonsa, H., Vyazovskiy, V. V., & Akerman, C. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.18.549465
State dependent constraints on claustrocortical communication and functionPreprint
Marriott, B. A., Do, A. D., Portet, C., Thellier, F., Goutagny, R., & Jackson, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.15.557951
Middle-infrared Modulation Of Sleep By Cardiometabolic FunctionPreprint
Sun, Y., Xian, G., Wang, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.28.569000
Chen, D., Yang, Z., Liao, X., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3870176/v1
Sleep regulation and host genetics
Odriozola, A., González, A., Álvarez‐Herms, J., & Corbi, F. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.02.002
Schechtman, E., Stickgold, R., & Paller, K. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00126-1
Effects of NREM sleep on cortical synapsesPreprint
Squarcio, F., Tononi, G., & Cirelli, C. (2024) · doi:10.22541/au.171628684.41660697/v1
Reviewer #2 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype
Vogt, K. E., Kulkarni, A., Pandey, R., et al. (2024) · eLife · doi:10.7554/elife.98280.1.sa0
eLife Assessment: Sleep need driven oscillation of glutamate synaptic phenotype
Sehgal, A. (2024) · eLife · doi:10.7554/elife.98280.1.sa2
Reviewer #1 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype
Vogt, K. E., Kulkarni, A., Pandey, R., et al. (2024) · eLife · doi:10.7554/elife.98280.1.sa1
Sleep need driven oscillation of glutamate synaptic phenotypePreprint
Vogt, K. E., Kulkarni, A., Pandey, R., Dehnad, M., Konopka, G., & Greene, R. W. (2024) · eLife · doi:10.7554/elife.98280.1
Hartnell, I. J., Simon, A., Hall, S. P., Ducotterd, F., Whittington, M. A., & Chawla, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.17.603872
“In the rodent cortex, evoked excitatory field potentials are larger in the wake state and decrease during sleep [3].”
BackgroundMulti-omics as a Strategy for Understanding Sleep’s Role in Memory
Aton, S. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-62723-1_18
Boundary conditions for synaptic homeodynamics during the sleep-wake cyclePreprint
Kinoshita, F. L., Yamada, R. G., Ode, K. L., & Ueda, H. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.14.607872
“Although studies, including anatomical and electrophysiological research, support SHY (22, 32, 33), several studies have reported contradictory results (4–6, 34).”
ResultHarris, J. C., & Coyle, J. T. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780199928118.003.0007
The power of the rocking cradle: improving sleep function by gentle vibration
Hopkins, M. A., & Tabuchi, M. (2024) · SLEEP · doi:10.1093/sleep/zsae245
Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila
Wu, X., Yang, X., Fu, T., Rong, Y. S., & Du, J. (2026) · eLife · doi:10.7554/elife.103427.4
Sleep need driven oscillation of glutamate synaptic phenotypePreprint
Vogt, K. E., Kulkarni, A., Pandey, R., Dehnad, M., Konopka, G., & Greene, R. W. (2024) · eLife · doi:10.7554/elife.98280.2
Interleukin-12 modulates sleep–wake activity and improves performance in a memory task
Esumi, L. A., Queiroz, C. M., Ribeiro, D. A., & Hipólide, D. C. (2024) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-024-00580-z
“…of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and changes in the phosphorylation states of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), Ca2 + /calmodulin-dependent protein kinase II (CaMKII) and Glycogen synthase kinase-3 beta (GSK3B) [40].”
Sleep need driven oscillation of glutamate synaptic phenotypePreprint
Vogt, K. E., Kulkarni, A., Pandey, R., Dehnad, M., Konopka, G., & Greene, R. W. (2025) · eLife · doi:10.7554/elife.98280.3
Learning, Memory, and Synaptic Plasticity
Jan Born, A., & Diekelmann, S. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197756782.003.0023
Diering, G. H. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2506039122
“Indeed, synapse weakening during sleep and scaling - down share overlapping molecular mechanisms such as dephos - phorylation of GluA1 AMPA - type glutamate receptors and a requirement for Homer1a ( 17 – 22 ).”
Abrams, M. J., Ohdera, A. H., Francis, D. A., Donayre, O., Chen, H., Lu, K. Y., Hsu, C. Y., Zeigler, H., & Harland, R. M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2505074122
“Given the general importance of cholinergic systems in neural function and sleep homeostasis in other animals ( 12 , 14 – 20 ), we chose to explore the cholinergic pathway further.”
Lotlikar, M. S., Ayotte, B., Choi, A., Seo, F., Robertson, E. M., Maso, F. D., & Roig, M. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2528246123
Presynaptic Release Probability Determines the Need for SleepPreprint
Wu, Y., Wierda, K. D. B., Vints, K., Huang, Y.-C., Uytterhoeven, V., Loomba, S., Laenen, F., Hoekstra, M. M., Dyson, M. C., Huang, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.16.682770 · Cited by 2
“Previous studies have reported correlative changes in postsynaptic structure or receptor expression across sleep–wake states( 10 , 12 ), but direct functional measurements remain limited.”
InfluentialDiurnal modulation of optogenetically evoked neural signals
Donen, Y., Ikoma, Y., & Matsui, K. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.104981 · Cited by 1
Metadata
- Authors
- Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cirelli, Chiara
- Tononi, Giulio
- Venue
- Nature Neuroscience
- Published
- 2008-01-20
- Volume
- 11
- Issue
- 2
- Pages
- 200-208
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2109919607
- Cited by
- 837
- References
- 53
- Citations by year
- 2026: 27 · 2025: 48 · 2024: 49 · 2023: 28 · 2022: 44 · 2021: 48 · 2020: 40 · 2019: 60 · 2018: 37 · 2017: 57 · 2016: 36 · 2015: 43 · 2014: 45 · 2013: 62 · 2012: 53
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health (DP1OD000579)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic potentiation, synaptic depression, sleep, wakefulness, AMPA receptors, GluR1, receptor phosphorylation, CaMKII, GSK3β, slow-wave activity, sleep pressure, cortical evoked potentials, long-term potentiation, memory consolidation, hippocampus, cortex, synaptic plasticity
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Behavior, Animal, Cerebral Cortex, Electroencephalography, Electromyography, Gene Expression Regulation, Hippocampus, Male, Neuronal Plasticity, Phosphorylation, Rats, Inbred WKY, Serine, Sleep, Synapses, Temperature, Threonine, Wakefulness, Receptors, AMPA, Glycogen Synthase Kinase 3, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
