The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Direct imaging of single-walled carbon nanotubes in cells
Abstract
The development of single-walled carbon nanotubes for various biomedical applications is an area of great promise. However, the contradictory data on the toxic effects of single-walled carbon nanotubes highlight the need for alternative ways to study their uptake and cytotoxic effects in cells. Single-walled carbon nanotubes have been shown to be acutely toxic in a number of types of cells, but the direct observation of cellular uptake of single-walled carbon nanotubes has not been demonstrated previously due to difficulties in discriminating carbon-based nanotubes from carbon-rich cell structures. Here we use transmission electron microscopy and confocal microscopy to image the translocation of single-walled carbon nanotubes into cells in both stained and unstained human cells. The nanotubes were seen to enter the cytoplasm and localize within the cell nucleus, causing cell mortality in a dose-dependent manner.
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“For example, MWCNTs have high toxicity and hydrophobicity [562]; therefore CNT/SMP have to be subjected to stringent evaluation before biomedical applications.”
From A review of stimuli-responsive shape memory polymer composites (2013) · cites this paper as [562]
In the citing paper
“For example, MWCNTs have high toxicity and hydrophobicity [562]; therefore CNT/SMP have to be subjected to stringent evaluation before biomedical applications.”
From A review of stimuli-responsive shape memory polymer composites (2013) · cites this paper as [562]
Citations
Cites
Kam, N. W. S., O’Connell, M. J., Wisdom, J. A., & Dai, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502680102 · Cited by 2,300
Shvedova, A. A., Castranova, V., Kisin, E. R., Schwegler‐Berry, D., Murray, A. R., Gandelsman, V., Maynard, A., & Baron, P. A. (2003) · Journal of Toxicology and Environmental Health · doi:10.1080/713853956 · Cited by 1,245
Pantarotto, D., Briand, J., Prato, M., & Bianco, A. (2003) · Chemical Communications · doi:10.1039/b311254c · Cited by 1,100
Oops they did it again! Carbon nanotubes hoax scientists in viability assays
Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
Kam, N. W. S., Liu, Z., & Dai, H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200503389 · Cited by 895
Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro
Sayes, C. M., Liang, F., Hudson, J. L., Mendez, J. S., Guo, W., Beach, J. M., Moore, V. C., Doyle, C. D., West, J. L., Billups, W. E., et al. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.08.011 · Cited by 856
Effect of single wall carbon nanotubes on human HEK293 cells
Cui, D., Tian, F., Ozkan, C. S., Wang, M., & Gao, H. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2004.08.015 · Cited by 825
Near-Infrared Fluorescence Microscopy of Single-Walled Carbon Nanotubes in Phagocytic Cells
Cherukuri, P., Bachilo, S. M., Litovsky, S. H., & Weisman, R. B. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0466311 · Cited by 817
Catalytic growth of single-wall carbon nanotubes from metal particles
Hafner, J. H., Bronikowski, M. J., Azamian, B. R., Nikolaev, P. N., Rinzler, A. G., Colbert, D. T., Smith, K. A., & Smalley, R. E. (1998) · Chemical Physics Letters · doi:10.1016/s0009-2614(98)01024-0 · Cited by 597
Manna, S. K., Sarkar, S., Barr, J., Wise, K., Barrera, E. V., Jejelowo, O., Rice-Ficht, A. C., & Ramesh, G. T. (2005) · Nano Letters · doi:10.1021/nl0507966 · Cited by 577
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1 of the 28 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Reimer, L. Energy-filtered transmission electron microscopy. Springer Ser. Opt. Sci. 71, 373–375 (1994).
Cited by
Sorted by citations
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
Nanotechnology in Sustainable Agriculture: Recent Developments, Challenges, and Perspectives
Prasad, R., Bhattacharyya, A., & Nguyen, Q. D. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01014 · Cited by 1,602
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Foroozandeh, P., & Aziz, A. A. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2728-6 · Cited by 1,438
A review of stimuli-responsive shape memory polymer composites
Meng, H., & Li, G. (2013) · Polymer · doi:10.1016/j.polymer.2013.02.023 · Cited by 1,190
NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials
Singh, N., Manshian, B. B., Jenkins, G. J. S., Griffiths, S. M., Williams, P. M., Maffeïs, T. G. G., Wright, C. J., & Doak, S. H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.04.009 · Cited by 1,212
Metadata
- Authors
- Porter, A. E., Gass, M., Muller, K., Skepper, J. N., Midgley, P. A., & Welland, M.
- Affiliations
- University of Cambridge (GB)
- Daresbury Laboratory (GB)
- Corresponding author
- Porter, Alexandra E.
- Venue
- Nature Nanotechnology
- Published
- 2007-10-28
- Volume
- 2
- Issue
- 11
- Pages
- 713-717
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2037122021
- Cited by
- 564
- References
- 28
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 14 · 2023: 10 · 2022: 22 · 2021: 8 · 2020: 14 · 2019: 19 · 2018: 65 · 2017: 28 · 2016: 34 · 2015: 31 · 2014: 44 · 2013: 47 · 2012: 54
- FWCI
- 28.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Leverhulme Trust
- Engineering and Physical Sciences Research Council (EP/D040396/1)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Keywords
- single-walled carbon nanotubes, cellular uptake, cytotoxicity, nuclear localization, dose-dependent cell death, nanotoxicology
- MeSH terms
- Cells, Cultured, Humans, Macrophages, Phagocytosis, Microscopy, Confocal, Nanotubes, Carbon, Microscopy, Electron, Transmission
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