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Carbon nanotubes as photoacoustic molecular imaging agents in living mice
Open accessAbstract
Photoacoustic imaging of living subjects offers higher spatial resolution and allows deeper tissues to be imaged compared with most optical imaging techniques1–7. As many diseases do not exhibit a natural photoacoustic contrast, especially in their early stages, it is necessary to administer a photoacoustic contrast agent. A number of contrast agents for photoacoustic imaging have been suggested previously8–15, but most were not shown to target a diseased site in living subjects. Here we show that single-walled carbon nanotubes conjugated with cyclic Arg-Gly-Asp (RGD) peptides can be used as a contrast agent for photoacoustic imaging of tumours. Intravenous administration of these targeted nanotubes to mice bearing tumours showed eight times greater photoacoustic signal in the tumour than mice injected with non-targeted nanotubes. These results were verified ex vivo using Raman microscopy. Photoacoustic imaging of targeted single-walled carbon nanotubes may contribute to non-invasive cancer imaging and monitoring of nanotherapeutics in living subjects16.
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Citations
Cited by
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Self-citationBiju, V. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60273g · Cited by 1,186
Metadata
- Authors
- De La Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B. R., Ma, T.-J., Oralkan, O., Cheng, Z., Chen, X., Dai, H., Khuri-Yakub, B. T., & Gambhir, S. S.
- Venue
- Nature Nanotechnology
- Published
- 2008-08-17
- Volume
- 3
- Issue
- 9
- Pages
- 557-562
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2079448771
- Cited by
- 1,271
- References
- 0
- FWCI
- 44.77
- Type
- journal article
- Language
- en
- Open access
- green
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- De La Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B. R., Ma, T.-J., Oralkan, O., Cheng, Z., Chen, X., Dai, H., Khuri-Yakub, B. T., & Gambhir, S. S. (2008). Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nature Nanotechnology. https://doi.org/10.1038/nnano.2008.231
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